Cited by 286Folate and B Vitamins ResearchSulfur Compounds in BiologyMetabolism and Genetic Disorders

S-Adenosyl-l-methionine (SAMe): from the bench to the bedside—molecular basis of a pleiotrophic molecule,,

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Bottiglieri, Teodoro·2002·The American Journal of Clinical Nutrition

Abstract

S-Adenosyl-L-methionine (SAMe), a metabolite present in all living cells, plays a central role in cellular biochemistry as a precursor to methylation, aminopropylation, and transsulfuration pathways. As such, SAMe has been studied extensively since its chemical structure was first described in 1952. Decades of research on the biochemical and molecular roles of SAMe in cellular metabolism have provided an extensive foundation for its use in clinical studies, including those on depression, dementia, vacuolar myelopathy, liver disease, and osteoarthritis. This article provides an overview of the biochemical, molecular, and therapeutic effects of this pleiotrophic molecule.

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  • SAMe is a major methyl donor required for the synthesis of several neurotransmitters and serves as a precursor molecule to the transsulfuration pathway, which leads to the synthesis of glutathione.

    “SAMe is a major methyl donor required for the synthesis of several neurotransmitters and serves as a precursor molecule to the transsulfuration pathway, which leads to the synthesis of glutathione [126].”

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Cites

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Research works printed but not linked: 16

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  2. Cheng X, Blumenthal RM. S-Adenosylmethionine-dependent methyl- transferases: structures and functions. World Scientific Publication Co, 1999.
  3. Chiang PK, Gordon RK, Tal J, et al. S-Adenosylmethionine and methylation. FASEB J 1996;10:471-80.
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  11. Castagna A, Le Grazie C, Giulidori P, Bottiglieri T, Lazzarin A. Defi- ciency of CSF S-adenosylmethionine (SAMe) and glutathione in HIV infected patients: the effect of parenteral treatment with SAMe. Neu- rology 1995;45:1678-83.
  12. Horne DW, Holloway RS, Wagner C.Transport of S-adenosylmethio- nine in isolated rat liver mitochondria. Arch Biochem Biophys 1997; 343:201-6.
  13. Crellin R, Bottiglieri T, Reynolds EH. Folates and psychiatric disor- ders. Clinical potential. Drugs 1993;45:623-36.
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Authors
Bottiglieri, T.
Corresponding author
Bottiglieri, Teodoro
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2002-11
Volume
76
Issue
5
Pages
1151S-1157S
ISSN
0002-9165 (ISSN-L)
OpenAlex
W4229642588
Cited by
286
References
74
Citations by year
2026: 15 · 2025: 11 · 2024: 12 · 2023: 14 · 2022: 11 · 2021: 19 · 2020: 20 · 2019: 17 · 2018: 8 · 2017: 16 · 2016: 15 · 2015: 16 · 2014: 16 · 2013: 11 · 2012: 13
FWCI
2.21
Type
journal article
Language
en
Open access
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • American Journal of Clinical Nutrition (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
Keywords
S-adenosylmethionine, methylation, transsulfuration, cellular metabolism, depression, dementia, vacuolar myelopathy, liver disease, osteoarthritis
MeSH terms
Animals, Depression, Diffusion of Innovation, Humans, Liver Diseases, Methylation, Nervous System Diseases, Osteoarthritis, S-Adenosylmethionine, Tissue Distribution

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