S-Adenosyl-l-methionine (SAMe): from the bench to the bedside—molecular basis of a pleiotrophic molecule,,
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S-Adenosyl-L-methionine (SAMe), a metabolite present in all living cells, plays a central role in cellular biochemistry as a precursor to methylation, aminopropylation, and transsulfuration pathways. As such, SAMe has been studied extensively since its chemical structure was first described in 1952. Decades of research on the biochemical and molecular roles of SAMe in cellular metabolism have provided an extensive foundation for its use in clinical studies, including those on depression, dementia, vacuolar myelopathy, liver disease, and osteoarthritis. This article provides an overview of the biochemical, molecular, and therapeutic effects of this pleiotrophic molecule.
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SAMe is a major methyl donor required for the synthesis of several neurotransmitters and serves as a precursor molecule to the transsulfuration pathway, which leads to the synthesis of glutathione.
“SAMe is a major methyl donor required for the synthesis of several neurotransmitters and serves as a precursor molecule to the transsulfuration pathway, which leads to the synthesis of glutathione [126].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [126]
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- Authors
- Bottiglieri, T.
- Corresponding author
- Bottiglieri, Teodoro
- ORCID
- Bottiglieri, Teodoro
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 76
- Issue
- 5
- Pages
- 1151S-1157S
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W4229642588
- Cited by
- 286
- References
- 74
- Citations by year
- 2026: 15 · 2025: 11 · 2024: 12 · 2023: 14 · 2022: 11 · 2021: 19 · 2020: 20 · 2019: 17 · 2018: 8 · 2017: 16 · 2016: 15 · 2015: 16 · 2014: 16 · 2013: 11 · 2012: 13
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- American Journal of Clinical Nutrition (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- S-adenosylmethionine, methylation, transsulfuration, cellular metabolism, depression, dementia, vacuolar myelopathy, liver disease, osteoarthritis
- MeSH terms
- Animals, Depression, Diffusion of Innovation, Humans, Liver Diseases, Methylation, Nervous System Diseases, Osteoarthritis, S-Adenosylmethionine, Tissue Distribution
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