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Cited by 439Diet and metabolism studiesDietary Effects on HealthMuscle metabolism and nutrition

The DOI matches its Crossref record; 50 of the 52 references it cites were found in a registry or an index.

Effect of a high-protein, energy-restricted diet on body composition, glycemic control, and lipid concentrations in overweight and obese hyperinsulinemic men and women

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Farnsworth, Emma, Luscombe, Natalie D, Noakes, Manny, Wittert, Gary, Argyiou, Eleni, Clifton, Peter M·2003·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/78.1.31
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Abstract

Background It is not clear whether varying the protein-to-carbohydrate ratio of weight-loss diets benefits body composition or metabolism.Objective The objective was to compare the effects of 2 weight-loss diets differing in protein-to-carbohydrate ratio on body composition, glucose and lipid metabolism, and markers of bone turnover.Design A parallel design included either a high-protein diet of meat, poultry, and dairy foods (HP diet: 27% of energy as protein, 44% as carbohydrate, and 29% as fat) or a standard-protein diet low in those foods (SP diet: 16% of energy as protein, 57% as carbohydrate, and 27% as fat) during 12 wk of energy restriction (6-6.3 MJ/d) and 4 wk of energy balance ( approximately 8.2 MJ/d). Fifty-seven overweight volunteers with fasting insulin concentrations > 12 mU/L completed the study.Results Weight loss (7.9 +/- 0.5 kg) and total fat loss (6.9 +/- 0.4 kg) did not differ between diet groups. In women, total lean mass was significantly (P = 0.02) better preserved with the HP diet (-0.1 +/- 0.3 kg) than with the SP diet (-1.5 +/- 0.3 kg). Those fed the HP diet had significantly (P < 0.03) less glycemic response at weeks 0 and 16 than did those fed the SP diet. After weight loss, the glycemic response decreased significantly (P < 0.05) more in the HP diet group. The reduction in serum triacylglycerol concentrations was significantly (P < 0.05) greater in the HP diet group (23%) than in the SP diet group (10%). Markers of bone turnover, calcium excretion, and systolic blood pressure were unchanged.Conclusion Replacing carbohydrate with protein from meat, poultry, and dairy foods has beneficial metabolic effects and no adverse effects on markers of bone turnover or calcium excretion.

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  1. Reaven, 2001, Syndrome X, J Clin Endocrinol Metab, 3, 323

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Metadata

Authors
Farnsworth, E., Luscombe, N. D., Noakes, M., Wittert, G., Argyiou, E., & Clifton, P. M.
Affiliations
Commonwealth Scientific and Industrial Research Organisation (AU)
Corresponding author
Clifton, Peter M
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2003-07
Volume
78
Issue
1
Pages
31-39
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/78.1.31
OpenAlex
W2167607978
Cited by
438
References
52
Citations by year
2026: 2 · 2025: 6 · 2024: 15 · 2023: 2 · 2022: 8 · 2021: 15 · 2020: 14 · 2019: 14 · 2018: 11 · 2017: 12 · 2016: 25 · 2015: 14 · 2014: 21 · 2013: 24 · 2012: 37
FWCI
16.10
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
  • Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords
high-protein diet, caloric restriction, weight loss, protein-carbohydrate ratio, body composition, lean mass preservation, glycemic control, insulin resistance, hyperinsulinemia, obesity, overweight, lipid metabolism, triglycerides, bone turnover, calcium excretion, systolic blood pressure
MeSH terms
Blood Glucose, Body Composition, Energy Intake, Diet, Dietary Proteins, Fatty Acids, Nonesterified, Female, Humans, Hyperinsulinism, Insulin Resistance, Lipids, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Obesity, Triglycerides

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