Protein kinetic differences between children with edematous and nonedematous severe childhood undernutrition in the fed and postabsorptive states
Open accessAbstract
Background Pathogenic factors that cause a child to develop the edematous instead of the nonedematous form of severe childhood undernutrition (SCU) during food deprivation are not clear. It was hypothesized that, in edematous but not nonedematous SCU, impaired protein breakdown leading to inadequate amino acids for maintenance of important organ systems was a factor. Objective We measured protein kinetics in children with edematous and nonedematous SCU. Design Endogenous leucine flux, an index of whole-body protein breakdown rate, was determined in 4 groups of children with edematous or nonedematous SCU in the malnourished and recovered states. Two groups were studied in the postabsorptive state, and 2 groups were studied in the fed state. Results In the postabsorptive state, leucine flux was slower (P < 0.01) in the edematous group than in the nonedematous group in the malnourished state, but in the recovered state, it was faster (P < 0.05) in the children who previously had edematous SCU. When compared with the malnourished state value, leucine flux at recovery doubled in the group that previously had edematous SCU, but it did not change in the other group. In the fed state, leucine flux was slower (P < 0.01) in the edematous group than in the nonedematous group in the malnourished state but not in the recovered state. In the recovered state, enteral leucine extraction by splanchnic tissues trended higher in the group that previously had edematous SCU than in the nonedematous group. Conclusion These findings indicate different protein breakdown responses to food deprivation between children with edematous and nonedematous SCU and inherent differences in protein metabolism when they have recovered.
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Hypoalbuminemia is more severe in children with kwashiorkor than with marasmus.
“Hypoalbuminemia is more severe in children with kwashiorkor (edema, fatty liver, skin lesions, discolored hair) than with marasmus (less edema, child more active and attentive).95”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [95]
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- Authors
- Jahoor, F., Badaloo, A., Reid, M., & Forrester, T.
- Affiliations
- Agricultural Research Service (US)
- Corresponding author
- Jahoor, Farook
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 82
- Issue
- 4
- Pages
- 792-800
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W1918488740
- Cited by
- 60
- References
- 23
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 6 · 2013: 1 · 2012: 4
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture (58-6250-6001)
- National Institutes of Health (5r01dk056689-12)
- Agricultural Research Service (58-6250-6-001)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK 056689)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Child Nutrition and Water Access
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- protein kinetics, protein degradation, postabsorptive state, food deprivation, recovery from malnutrition, children
- MeSH terms
- Adolescent, Amino Acids, Carbon Isotopes, Child, Edema, Female, Food Deprivation, Humans, Kwashiorkor, Leucine, Male, Protein-Energy Malnutrition, Proteins, Protein Biosynthesis, Child Nutrition Disorders, Weight Gain, Postprandial Period
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