Dangers, and benefits of the cytokine mediated response to injury and infection

Soeters, Peter B.; Grimble, Robert F.

doi:10.1016/j.clnu.2009.05.014

Cited by 57Immune Response and InflammationExercise and Physiological ResponsesDietary Effects on Health

Dangers, and benefits of the cytokine mediated response to injury and infection

Soeters, Peter B., Grimble, Robert F.·2009·Clinical Nutrition

DOI 10.1016/j.clnu.2009.05.014

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Abstract

The inflammatory response is essential for survival in an environment where continuous exposure to noxious events threaten the integrity of the organism. However, the beneficial effects of the response are influenced by factors, which disadvantage individuals within a population. These factors include malnutrition, infection, genotype, gender, pre-existing inflammation, and chronic intoxication. Although the inflammatory response is generally successful in dealing with noxious events, life-long exposure to these events takes its toll on the integrity of the body and becomes apparent as chronic disease, atherosclerosis, organ failure, and frailty. Progress in ameliorating the consequences of lifetime exposure to inflammatory events can only occur if a fuller understanding can be obtained of the factors, which influence the persistence and outcome of the inflammatory response at an individual level. A multitude of studies has shown that specific nutrients, diets, and dietary restriction are able to modulate the inflammatory response in the population as a whole. To advance in this area, precise knowledge is needed of how the disadvantageous factors, mentioned above, affect the individual's response to anti-inflammatory nutrients.

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Fluid retention occurs in wounds and at the whole-body level after trauma and burns; it may be beneficial to some extent but may become harmful when the inflammatory stimulus cannot be adequately overcome or treated.
“The fact that fluid retention inevitably and visibly occurs in wounds as well as at the whole‐body level after trauma and burns could reflect that this response is beneficial to some extent, but may become harmful when the inflammatory stimulus cannot be adequately overcome or treated.6, 7”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [7]

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Hypoalbuminemia: Pathogenesis and Clinical Significance
Soeters, P. B., Wolfe, R. R., & Shenkin, A. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1451 · Cited by 1,448 · see citing works
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The conditional role of inflammation in pregnancy and cancer
Soeters, P. B., & Grimble, R. F. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2012.07.010 · Cited by 24 · see citing works
Self-citation

Authors: Soeters, P. B., & Grimble, R. F.
Affiliations: Maastricht University Medical Centre (NL)
University of Southampton (GB)
Corresponding author: Soeters, Peter B.
Grimble, Robert F.
ORCID: Soeters, Peter B.
Venue: Clinical Nutrition
Publisher: Elsevier BV
Published: 2009-12
Volume: 28
Issue: 6
Pages: 583-596
ISSN: 0261-5614 (ISSN-L)
DOI: 10.1016/j.clnu.2009.05.014
OpenAlex: W2048405028
Cited by: 57
References: 183
Citations by year: 2026: 2 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 2 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 5
FWCI: 0.39
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion)
Research Publications (Maastricht University) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords: cytokine response, inflammation, injuries, infection, malnutrition, dietary restriction, anti-inflammatory nutrients, diet, chronic inflammation, frailty, atherosclerosis, organ failure, chronic disease, genotypes, sex differences
MeSH terms: Animals, Chronic Disease, Humans, Infections, Inflammation, Nutritional Status, Wounds and Injuries, Cytokines

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Dangers, and benefits of the cytokine mediated response to injury and infection

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