Cited by 776Probiotics and Fermented FoodsInfant Nutrition and HealthComplementary and Alternative Medicine Studies

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Probiotic use in clinical practice: what are the risks?

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Boyle, Robert J, Robins-Browne, Roy M, Tang, Mimi LK·2006·The American Journal of Clinical Nutrition

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Abstract

Probiotics have been advocated for the prevention and treatment of a wide range of diseases, and there is strong evidence for their efficacy in some clinical scenarios. Probiotics are now widely used in many countries by consumers and in clinical practice. Given the increasingly widespread use of probiotics, a thorough understanding of their risks and benefits is imperative. In this article we review the safety of probiotics and discuss areas of uncertainty regarding their use. Although probiotics have an excellent overall safety record, they should be used with caution in certain patient groups-particularly neonates born prematurely or with immune deficiency. Because of the paucity of information regarding the mechanisms through which probiotics act, appropriate administrative regimens, and probiotic interactions, further investigation is needed in these areas. Finally, note that the properties of different probiotic species vary and can be strain-specific. Therefore, the effects of one probiotic strain should not be generalized to others without confirmation in separate studies. Careful consideration should be given to these issues before patients are advised to use probiotic supplements in clinical practice.

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Authors: Boyle, R. J., Robins-Browne, R. M., & Tang, M. L.
Affiliations: Royal Children's Hospital (AU)
Corresponding author: Tang, Mimi LK
ORCID: Boyle, Robert J
Robins-Browne, Roy M
Tang, Mimi LK
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2006-06
Volume: 83
Issue: 6
Pages: 1256-1264
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/83.6.1256
OpenAlex: W2170210827
Cited by: 776
References: 75
Citations by year: 2026: 21 · 2025: 38 · 2024: 37 · 2023: 46 · 2022: 32 · 2021: 48 · 2020: 39 · 2019: 36 · 2018: 32 · 2017: 45 · 2016: 40 · 2015: 37 · 2014: 50 · 2013: 45 · 2012: 52
FWCI: 4.64
Type: journal article
Language: en
Open access: bronze
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Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6121 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
Keywords: probiotics, probiotic safety, preterm infants, immunodeficiency, probiotic supplements
MeSH terms: Adult, Aged, Aged, 80 and over, Bifidobacterium, Child, Child, Preschool, Diarrhea, Female, Gastrointestinal Diseases, Humans, Infant, Infant, Newborn, Lactobacillus, Male, Middle Aged, Fungemia, Sepsis, Probiotics

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Probiotic use in clinical practice: what are the risks?

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