CoChat
Sign Up
Cited by 203Fatty Acid Research and HealthOvarian function and disordersNutritional Studies and Diet

The DOI matches its Crossref record; 48 of the 52 references it cites were found in a registry or an index.

Dietary fatty acid intakes and the risk of ovulatory infertility

Open access
Chavarro, Jorge E, Rich-Edwards, Janet W, Rosner, Bernard A, Willett, Walter C·2007·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/85.1.231
Open this paper in CoChat — free accountOpen PDF

Abstract

Background Pharmacologic activation of the peroxisome proliferator-activated receptor gamma (PPAR-gamma) improves ovulatory function in women with polycystic ovary syndrome, and specific dietary fatty acids can affect PPAR-gamma activity. Objective The objective of the study was to assess whether the intakes of total fat, cholesterol, and major types of fatty acids affect the risk of ovulatory infertility. Design We conducted a prospective cohort study of 18 555 married, premenopausal women without a history of infertility who attempted a pregnancy or became pregnant between 1991 and 1999. Diet was assessed twice during follow-up by using a food-frequency questionnaire. Results During follow-up, 438 incidents of ovulatory infertility were reported. In logistic regression analyses, intakes of total fat, cholesterol, and most types of fatty acids were not related to ovulatory infertility. Each 2% increase in the intake of energy from trans unsaturated fats, as opposed to that from carbohydrates, was associated with a 73% greater risk of ovulatory infertility after adjustment for known and suspected risk factors for this condition [relative risk (RR) = 1.73; 95% CI: 1.09, 2.73]. Obtaining 2% of energy intake from trans fats rather than from n-6 polyunsaturated fats was associated with a similar increase in the risk of ovulatory infertility (RR = 1.79; 95% CI: 1.11, 2.89). In addition, obtaining 2% of energy from trans fats rather than from monounsaturated fats was associated with a more than doubled risk of ovulatory infertility (RR = 2.31; 95% CI: 1.09, 4.87). Conclusion trans Unsaturated fats may increase the risk of ovulatory infertility when consumed instead of carbohydrates or unsaturated fats commonly found in nonhydrogenated vegetable oils.

Overview

Integrity signals

Registry

Crossref · 10.1093/ajcn/85.1.231

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 52 references

4 of the 52 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. 2004, The Practice Committee of the American Society for Reproductive Medicine. Definition of “infertility.”, Fertil Steril, 82, S206
  2. Hjollund, 1999, Is glycosilated haemoglobin a marker of fertility?, A follow-up study of first-pregnancy planners. Hum Reprod, 14, 1478
  3. 2002, Iron deficiency—United States, 1999–2000, MMWR Morb Mortal Wkly Rep, 51, 987

Cited by

Sorted by citations

Items 101–200 of 201

Related

See all

Metadata

Authors
Chavarro, J. E., Rich-Edwards, J. W., Rosner, B. A., & Willett, W. C.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Chavarro, Jorge E
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2007-01
Volume
85
Issue
1
Pages
231-237
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/85.1.231
OpenAlex
W2161583600
Cited by
203
References
52
Citations by year
2026: 5 · 2025: 21 · 2024: 11 · 2023: 10 · 2022: 12 · 2021: 9 · 2020: 7 · 2019: 7 · 2018: 15 · 2017: 15 · 2016: 10 · 2015: 13 · 2014: 9 · 2013: 6 · 2012: 10
FWCI
8.51
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (CA67262, CA55075)
  • National Institute on Aging (AG/CA14742)
  • National Heart, Lung, and Blood Institute (K08HL003804, R01HL064108, HL-03804, HL64108)
  • National Cancer Institute (R01CA065725, CA-55075, CA67262, CA 65725, CA50385, R01CA067883, CA67883, R01CA050385)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK052866, DK52866, T32DK007703, P30DK040561)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
ovulatory infertility, dietary fatty acids, monounsaturated fatty acids, total fat intake, dietary cholesterol, PPARγ, polycystic ovary syndrome, premenopausal women, vegetable oils, carbohydrate intake
MeSH terms
Adult, Diet Surveys, Dietary Fats, Dietary Fats, Unsaturated, Female, Humans, Infertility, Female, Ovulation, Prospective Studies, Surveys and Questionnaires, Risk Factors, Cohort Studies, Logistic Models, Trans Fatty Acids, PPAR gamma

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review