The DOI matches its Crossref record; 48 of the 52 references it cites were found in a registry or an index.
Dietary fatty acid intakes and the risk of ovulatory infertility
Open accessAbstract
Background Pharmacologic activation of the peroxisome proliferator-activated receptor gamma (PPAR-gamma) improves ovulatory function in women with polycystic ovary syndrome, and specific dietary fatty acids can affect PPAR-gamma activity. Objective The objective of the study was to assess whether the intakes of total fat, cholesterol, and major types of fatty acids affect the risk of ovulatory infertility. Design We conducted a prospective cohort study of 18 555 married, premenopausal women without a history of infertility who attempted a pregnancy or became pregnant between 1991 and 1999. Diet was assessed twice during follow-up by using a food-frequency questionnaire. Results During follow-up, 438 incidents of ovulatory infertility were reported. In logistic regression analyses, intakes of total fat, cholesterol, and most types of fatty acids were not related to ovulatory infertility. Each 2% increase in the intake of energy from trans unsaturated fats, as opposed to that from carbohydrates, was associated with a 73% greater risk of ovulatory infertility after adjustment for known and suspected risk factors for this condition [relative risk (RR) = 1.73; 95% CI: 1.09, 2.73]. Obtaining 2% of energy intake from trans fats rather than from n-6 polyunsaturated fats was associated with a similar increase in the risk of ovulatory infertility (RR = 1.79; 95% CI: 1.11, 2.89). In addition, obtaining 2% of energy from trans fats rather than from monounsaturated fats was associated with a more than doubled risk of ovulatory infertility (RR = 2.31; 95% CI: 1.09, 4.87). Conclusion trans Unsaturated fats may increase the risk of ovulatory infertility when consumed instead of carbohydrates or unsaturated fats commonly found in nonhydrogenated vegetable oils.
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“Consuming trans fats and unsaturated lipids with double bonds that exhibit internal resonance has been associated in recent studies with a higher risk of ovulatory infertility [103].”
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4 of the 52 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- 2004, The Practice Committee of the American Society for Reproductive Medicine. Definition of “infertility.”, Fertil Steril, 82, S206
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Madureira, E. (2025) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/p4vf-q470
Metadata
- Authors
- Chavarro, J. E., Rich-Edwards, J. W., Rosner, B. A., & Willett, W. C.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Chavarro, Jorge E
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 85
- Issue
- 1
- Pages
- 231-237
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2161583600
- Cited by
- 203
- References
- 52
- Citations by year
- 2026: 5 · 2025: 21 · 2024: 11 · 2023: 10 · 2022: 12 · 2021: 9 · 2020: 7 · 2019: 7 · 2018: 15 · 2017: 15 · 2016: 10 · 2015: 13 · 2014: 9 · 2013: 6 · 2012: 10
- FWCI
- 8.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (CA67262, CA55075)
- National Institute on Aging (AG/CA14742)
- National Heart, Lung, and Blood Institute (K08HL003804, R01HL064108, HL-03804, HL64108)
- National Cancer Institute (R01CA065725, CA-55075, CA67262, CA 65725, CA50385, R01CA067883, CA67883, R01CA050385)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK052866, DK52866, T32DK007703, P30DK040561)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- ovulatory infertility, dietary fatty acids, monounsaturated fatty acids, total fat intake, dietary cholesterol, PPARγ, polycystic ovary syndrome, premenopausal women, vegetable oils, carbohydrate intake
- MeSH terms
- Adult, Diet Surveys, Dietary Fats, Dietary Fats, Unsaturated, Female, Humans, Infertility, Female, Ovulation, Prospective Studies, Surveys and Questionnaires, Risk Factors, Cohort Studies, Logistic Models, Trans Fatty Acids, PPAR gamma
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