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Cited by 268Microbial Metabolites in Food BiotechnologyProbiotics and Fermented FoodsInfant Nutrition and Health

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Prebiotic evaluation of a novel galactooligosaccharide mixture produced by the enzymatic activity of Bifidobacterium bifidum NCIMB 41171, in healthy humans: a randomized, double-blind, crossover, placebo-controlled intervention study

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Depeint, Flore, Tzortzis, George, Vulevic, Jelena, I'Anson, Kerry, Gibson, Glenn R·2008·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/87.3.785
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Abstract

Background Galactooligosaccharides are selectively fermented by the beneficial member of the colonic microflora contributing to the health of the host.Objective We assessed the prebiotic potential of a novel galactooligosaccharide produced through the action of beta-galactosidases, originating from a probiotic Bifidobacterium bifidum strain, against a galactooligosaccharide produced through the action of an industrial beta-galactosidase and a placebo.Design Fifty-nine healthy human volunteers participated in this study. Initially, the effect of the matrix on the prebiotic properties of a commercially available galactooligosaccharide (7 g/d) was assessed during 7-d treatment periods with a 7-d washout period in between. During the second phase, 30 volunteers were assigned to a sequence of treatments (7 d) differing in the amount of the novel galactooligosaccharide (0, 3.6, or 7 g/d). Stools were recovered before and after each intervention, and bacteria numbers were determined by fluorescent in situ hybridization.Results Addition of the novel galactooligosaccharide mixture significantly increased the bifidobacterial population ratio compared with the placebo (P < 0.05), whereas 7 g/d of the novel galactooligosaccharide significantly increased the bifidobacterial ratio compared with the commercial galactooligosaccharide (P < 0.05). Moreover, a significant relation (P < 0.001) between the bifidobacteria proportion and the novel galactooligosaccharide dose (0, 3.6, and 7 g/d) was observed. This relation was similar to the effect of the novel galactooligosaccharide on the prebiotic index of each dose.Conclusions This study showed that galactooligosaccharide mixtures produced with different beta-galactosidases show different prebiotic properties and that, by using enzymes originating from bifidobacterial species, an increase in the bifidogenic properties of the prebiotic product is achievable.

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Metadata

Authors
Depeint, F., Tzortzis, G., Vulevic, J., I'Anson, K., & Gibson, G. R.
Affiliations
Quadram Institute (GB)
Corresponding author
Tzortzis, George
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2008-03
Volume
87
Issue
3
Pages
785-791
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/87.3.785
OpenAlex
W2153503726
Cited by
268
References
25
Citations by year
2026: 7 · 2025: 11 · 2024: 10 · 2023: 11 · 2022: 15 · 2021: 15 · 2020: 20 · 2019: 11 · 2018: 22 · 2017: 19 · 2016: 18 · 2015: 15 · 2014: 13 · 2013: 11 · 2012: 14
FWCI
17.81
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords
galactooligosaccharides, prebiotics, Bifidobacterium bifidum, beta-galactosidase, bifidogenic effect, Bifidobacterium, colonic microbiota, prebiotic index, dose-response relationship
MeSH terms
Adult, beta-Galactosidase, Bifidobacterium, Colon, Dose-Response Relationship, Drug, Double-Blind Method, Feces, Female, Fermentation, Galactose, Humans, Male, Oligosaccharides, In Situ Hybridization, Fluorescence, Cross-Over Studies, Probiotics

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