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Prebiotic evaluation of a novel galactooligosaccharide mixture produced by the enzymatic activity of Bifidobacterium bifidum NCIMB 41171, in healthy humans: a randomized, double-blind, crossover, placebo-controlled intervention study
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Background Galactooligosaccharides are selectively fermented by the beneficial member of the colonic microflora contributing to the health of the host.Objective We assessed the prebiotic potential of a novel galactooligosaccharide produced through the action of beta-galactosidases, originating from a probiotic Bifidobacterium bifidum strain, against a galactooligosaccharide produced through the action of an industrial beta-galactosidase and a placebo.Design Fifty-nine healthy human volunteers participated in this study. Initially, the effect of the matrix on the prebiotic properties of a commercially available galactooligosaccharide (7 g/d) was assessed during 7-d treatment periods with a 7-d washout period in between. During the second phase, 30 volunteers were assigned to a sequence of treatments (7 d) differing in the amount of the novel galactooligosaccharide (0, 3.6, or 7 g/d). Stools were recovered before and after each intervention, and bacteria numbers were determined by fluorescent in situ hybridization.Results Addition of the novel galactooligosaccharide mixture significantly increased the bifidobacterial population ratio compared with the placebo (P < 0.05), whereas 7 g/d of the novel galactooligosaccharide significantly increased the bifidobacterial ratio compared with the commercial galactooligosaccharide (P < 0.05). Moreover, a significant relation (P < 0.001) between the bifidobacteria proportion and the novel galactooligosaccharide dose (0, 3.6, and 7 g/d) was observed. This relation was similar to the effect of the novel galactooligosaccharide on the prebiotic index of each dose.Conclusions This study showed that galactooligosaccharide mixtures produced with different beta-galactosidases show different prebiotic properties and that, by using enzymes originating from bifidobacterial species, an increase in the bifidogenic properties of the prebiotic product is achievable.
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“Although not tested with GLP-1RAs, GOS consistently increases Bifidobacterium and Lactobacillus, while reducing potentially pathogenic bacteria such as Bacteroides spp., Clostridium perfringens, Escherichia coli, Prevotella, and Gardnerella [135-138]”
From Nutritional Approaches to Enhance GLP-1 Analogue Therapy in Obesity: A Narrative Review (2025) · cites this paper as [138]
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Metadata
- Authors
- Depeint, F., Tzortzis, G., Vulevic, J., I'Anson, K., & Gibson, G. R.
- Affiliations
- Quadram Institute (GB)
- Corresponding author
- Tzortzis, George
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 87
- Issue
- 3
- Pages
- 785-791
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2153503726
- Cited by
- 268
- References
- 25
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 10 · 2023: 11 · 2022: 15 · 2021: 15 · 2020: 20 · 2019: 11 · 2018: 22 · 2017: 19 · 2016: 18 · 2015: 15 · 2014: 13 · 2013: 11 · 2012: 14
- FWCI
- 17.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- galactooligosaccharides, prebiotics, Bifidobacterium bifidum, beta-galactosidase, bifidogenic effect, Bifidobacterium, colonic microbiota, prebiotic index, dose-response relationship
- MeSH terms
- Adult, beta-Galactosidase, Bifidobacterium, Colon, Dose-Response Relationship, Drug, Double-Blind Method, Feces, Female, Fermentation, Galactose, Humans, Male, Oligosaccharides, In Situ Hybridization, Fluorescence, Cross-Over Studies, Probiotics
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