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Cited by 127Coffee research and impactsDiet, Metabolism, and DiseaseMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.

Caffeinated coffee consumption impairs blood glucose homeostasis in response to high and low glycemic index meals in healthy men

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Moisey, Lesley L, Kacker, Sita, Bickerton, Andrea C, Robinson, Lindsay E, Graham, Terry E·2008·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/87.5.1254
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Abstract

Background The ingestion of caffeine (5 mg/kg body weight) and a 75-g oral glucose load has been shown to elicit an acute insulin-insensitive environment in healthy and obese individuals and in those with type 2 diabetes.Objective In this study we investigated whether a similar impairment in blood glucose management exists when coffee and foods typical of a Western diet were used in a similar protocol.Design Ten healthy men underwent 4 trials in a randomized order. They ingested caffeinated (5 mg/kg) coffee (CC) or the same volume of decaffeinated coffee (DC) followed 1 h later by either a high or low glycemic index (GI) cereal (providing 75 g of carbohydrate) mixed meal tolerance test.Results CC with the high GI meal resulted in 147%, 29%, and 40% greater areas under the curve for glucose (P < 0.001), insulin (NS), and C-peptide (P < 0.001), respectively, compared with the values for DC. Similarly, with the low GI treatment, CC elicited 216%, 44%, and 36% greater areas under the curve for glucose (P < 0.001), insulin (P < 0.01), and C-peptide (P < 0.01), respectively. Insulin sensitivity was significantly reduced (40%) with the high GI treatment after CC was ingested compared with DC; with the low GI treatment, CC ingestion resulted in a 29% decrease in insulin sensitivity, although this difference was not significant.Conclusion The ingestion of CC with either a high or low GI meal significantly impairs acute blood glucose management and insulin sensitivity compared with ingestion of DC. Future investigations are warranted to determine whether CC is a risk factor for insulin resistance.

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Crossref · 10.1093/ajcn/87.5.1254

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  1. 2003, Canadian Diabetes Association 2003 clinical practice guidelines for the prevention and management of diabetes in Canada., Can J Diabetes, 27, S1

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Metadata

Authors
Moisey, L. L., Kacker, S., Bickerton, A. C., Robinson, L. E., & Graham, T. E.
Affiliations
University of Guelph (CA)
Corresponding author
Graham, Terry E
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2008-05
Volume
87
Issue
5
Pages
1254-1261
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/87.5.1254
OpenAlex
W1905122931
Cited by
127
References
42
Citations by year
2026: 2 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 9 · 2018: 4 · 2017: 5 · 2016: 6 · 2015: 9 · 2014: 8 · 2013: 15 · 2012: 9
FWCI
7.49
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
caffeinated coffee, caffeine, blood glucose homeostasis, glycemic index, insulin sensitivity, insulin resistance, mixed meal tolerance test, C-peptide, decaffeinated coffee, Western diet
MeSH terms
Adolescent, Adult, Blood Glucose, C-Peptide, Caffeine, Edible Grain, Coffee, Dietary Carbohydrates, Glucose Tolerance Test, Humans, Insulin, Male, Middle Aged, Cross-Over Studies, Area Under Curve, Glycemic Index

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