Cited by 599Physical Activity and HealthExercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic Diseases

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Association between Physical Activity and Markers of Inflammation in a Healthy Elderly Population

Geffken, Dominic F., Cushman, Mary, Burke, Gregory L., Polak, Joseph F., Sakkinen, Pamela A., Tracy, Russell P.·2001·American Journal of Epidemiology

DOI 10.1093/aje/153.3.242

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Abstract

Higher levels of physical activity are associated with lower risk of cardiovascular disease. There is growing evidence that the development of the atherosclerotic plaque is associated with inflammation. In this study, the authors investigated the cross-sectional association between physical activity and markers of inflammation in a healthy elderly population. Data obtained in 1989–1990 and 1992–1993 from the Cardiovascular Health Study, a cohort of 5,888 men and women aged ≥65 years, were analyzed. Concentrations of the inflammation markers–C-reactive protein, fibrinogen, Factor VIII activity, white blood cells, and albumin–were compared cross-sectionally by quartile of self-reported physical activity. Compared with persons in the lowest quartile, those in the highest quartile of physical activity had 19%, 6%, 4%, and 3% lower concentrations of C-reactive protein, white blood cells, fibrinogen, and Factor VIII activity, respectively, after adjustment for gender, the presence of cardiovascular disease, age, race, smoking, body mass index, diabetes, and hypertension. Multivariate regression models suggested that the association of higher levels of physical activity with lower levels of inflammation markers may be mediated by body mass index and glucose. There was no association between physical activity and albumin. Higher levels of physical activity were associated with lower concentrations of four out of five inflammation markers in this elderly cohort. These data suggest that increased exercise is associated with reduced inflammation. Prospective studies will be required for verification of these findings.

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The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
Self-citation
The Cardiovascular Health Study: design and rationale.
Fried, L. P., Borhani, N. O., Enright, P., Furberg, C. D., Gardin, J. M., Kronmal, R. A., Kuller, L. H., Manolio, T. A., Mittelmark, M. B., Newman, A., et al. (1991) · Annals of Epidemiology · doi:10.1016/1047-2797(91)90005-w · Cited by 3,652
Self-citation
Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens
Clauss, A. (2009) · Acta Haematologica · doi:10.1159/000205234 · Cited by 3,239
Association of Fibrinogen, C-reactive Protein, Albumin, or Leukocyte Count With Coronary Heart Disease
Danesh, J., Collins, R., Appleby, P. N., & Peto, R. (1998) · JAMA · doi:10.1001/jama.279.18.1477 · Cited by 2,027
A questionnaire for the assessment of leisure time physical activities
Taylor, H. L., Jacobs, D. R., Schucker, B., Knudsen, J., Leon, A. S., & Debacker, G. (1978) · Journal of Chronic Diseases · doi:10.1016/0021-9681(78)90058-9 · Cited by 1,848
Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid
Fried, S. K., Bunkin, D. A., & Greenberg, A. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4660 · Cited by 1,756
Atherosclerosis: Basic Mechanisms
Berliner, J. A., Navab, M., Fogelman, A. M., Frank, J. S., Demer, L. L., Edwards, P. A., Watson, A. D., & Lusis, A. J. (1995) · Circulation · doi:10.1161/01.cir.91.9.2488 · Cited by 1,730
Adipogenesis and Obesity: Rounding Out the Big Picture
Spiegelman, B. M., & Flier, J. S. (1996) · Cell · doi:10.1016/s0092-8674(00)81359-8 · Cited by 1,262
NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X
Pickup, J. C., Mattock, M. B., Chusney, G. D., & Burt, D. J. (1997) · Diabetologia · doi:10.1007/s001250050822 · Cited by 1,246

Show all 55 references

Research works printed but not linked: 1

Howard G, Tracy R, Wagenknecht L, et al. Predictors of inflammatory status in a middle-aged population. (Abstract). Circulation 1999;99:1108.

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Lakka, H.-M., Lakka, T. A., Rankinen, T., Rice, T., Rao, D. C., Leon, A. S., Skinner, J. S., & Bouchard, C. (2006) · Vascular Pharmacology · doi:10.1016/j.vph.2006.02.002 · Cited by 32
Biological Markers in Older People at Risk of Mobility Limitations
Lippi, G., Sanchis‐Gomar, F., & Montagnana, M. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660697 · Cited by 32
Impact of aerobic exercise versus resisted exercise on endothelial activation markers and inflammatory cytokines among elderly
El-Kader, S. M. A., Al-Shreef, F. M., & Al-Jiffri, O. H. (1970) · African Health Sciences · doi:10.4314/ahs.v19i4.9 · Cited by 30
Persistent low-grade inflammation and regular exercise
Pedersen, B. K. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s48 · Cited by 30
Occupational physical activity, not leisure-time physical activity, is associated with increased high-sensitivity C reactive protein levels
Lee, J., Kim, H., Jang, T. W., Lee, D., Lee, Y. M., & Kang, M. (2020) · Occupational and Environmental Medicine · doi:10.1136/oemed-2020-106753 · Cited by 30
Impact of physical activity on the association between lipid profiles and mortality among older people
Ou, S., Chen, Y., Shih, C.-J., & Tarng, D. (2017) · Scientific Reports · doi:10.1038/s41598-017-07857-7 · Cited by 30
Physical activity across the lifespan and liver cancer incidence in the NIH‐AARP Diet and Health Study cohort
Arem, H. E., Loftfield, E., Saint‐Maurice, P. F., Freedman, N. D., & Matthews, C. E. (2018) · Cancer Medicine · doi:10.1002/cam4.1343 · Cited by 30
C-reactive protein: The pawn has been promoted to queen
Yeh, E. T. H., & Palusiński, R. (2003) · Current Atherosclerosis Reports · doi:10.1007/s11883-003-0080-4 · Cited by 30
Complex Exercise Improves Anti-Inflammatory and Anabolic Effects in Osteoarthritis-Induced Sarcopenia in Elderly Women
Park, J., Bae, J.-J., & Lee, J. (2021) · Healthcare · doi:10.3390/healthcare9060711 · Cited by 28
Moderate Intensities of Leisure-Time Physical Activity Are Associated With Lower Levels of High-Sensitivity C-Reactive Protein in Healthy Middle-Aged Men
Bergström, G. M. L., Behre, C. J., & Schmidt, C. (2011) · Angiology · doi:10.1177/0003319711423386 · Cited by 30
Disparity of Gut Microbiota Composition Among Elite Athletes and Young Adults With Different Physical Activity Independent of Dietary Status: A Matching Study
Xu, Y., Zhong, F., Zheng, X., Lai, H., Wu, C., & Huang, C. X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.843076 · Cited by 33
Adiposity in Childhood Is Related to C‐Reactive Protein and Adiponectin in Young Adulthood: From the Bogalusa Heart Study
Toprak, D., Toprak, A. C., Chen, W., Xu, J. H., Srinivasan, S. R., & Berenson, G. S. (2010) · Obesity · doi:10.1038/oby.2010.75 · Cited by 28
Systemic low-grade inflammation and subsequent depressive symptoms: Is there a mediating role of physical activity?
Frank, P., Kaushal, A., Poole, L., Lawes, S., Chalder, T., & Cadar, D. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.05.017 · Cited by 29
Cardiovascular Fitness and Vascular Inflammatory Markers after Acute Aerobic Exercise
Plaisance, E. P., Taylor, K. J., Alhassan, S., Abebe, A., Mestek, M. L., & Grandjean, P. W. (2007) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.17.2.152 · Cited by 28
Exercise frequency and arterial compliance in non-diabetic and type 1 diabetic individuals
Mason, N. J., Jenkins, A. J., Best, J. D., & Rowley, K. (2006) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000216546.07432.b2 · Cited by 27
Exercise Reduces C-reactive Protein and Improves Physical Function in Automotive Workers with Low Back Pain
Kim, S. K., Jung, I., & Kim, J. H. (2008) · Journal of Occupational Rehabilitation · doi:10.1007/s10926-007-9120-1 · Cited by 27
Does orthodontic tooth movement cause an elevation in systemic inflammatory markers?
MacLaine, J., Rabie, A. B. M., & Wong, R. (2009) · European Journal of Orthodontics · doi:10.1093/ejo/cjp108 · Cited by 29
Longitudinal Relationships between Caloric Expenditure and Gray Matter in the Cardiovascular Health Study
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Type 2 diabetes in Singapore: the role of exercise training for its prevention and management.
Lim, J. G., Kang, H., & Stewart, K. J. (2004) · PubMed · Cited by 27
Systemic Inflammation in the Genesis of Frailty and Sarcopenia: An Overview of the Preventative and Therapeutic Role of Exercise and the Potential for Drug Treatments
Allen, S. (2017) · Geriatrics · doi:10.3390/geriatrics2010006 · Cited by 29
Obesity and White Matter Neuroinflammation Related Edema in Alzheimer’s Disease Dementia Biomarker Negative Cognitively Normal Individuals
Ly, M. J., Raji, C. A., Yu, G. Z., Wang, Q., Wang, Y., Schindler, S. E., An, H., Samara, A., Eisenstein, S. A., Hershey, T. G., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201242 · Cited by 26
Association between physical activity and cancer risk among Chinese adults: a 10-year prospective study
Su, J., Jiang, Y., Fan, X., Tao, R., Wu, M. T., Lu, Y., Hua, Y., Jin, J., Guo, Y., Lv, J., et al. (2022) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-022-01390-1 · Cited by 26
Contributions of body mass index and exercise habits on inflammatory markers: a cohort study of middle-aged adults living in the USA
Strohacker, K. A., Wing, R. R., & McCaffery, J. M. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-002623 · Cited by 26
Aerobic versus resistance exercises on systemic inflammation and sleep parameters in obese subjects with chronic insomnia syndrome
Al-Jiffri, O. H., & El-Kader, S. M. A. (2021) · African Health Sciences · doi:10.4314/ahs.v21i3.30 · Cited by 31
Altered Kinetics of Interleukin-6 and other Inflammatory Mediators during Exercise in Children with Type 1 Diabetes
Duque, J. S. R., Oliver, S. R., Mitsuhashi, M., Flores, R. L., Pontello, A. M., Zaldivar, F. P., & Galassetti, P. R. (2008) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e31816c0fba · Cited by 25
Inflammatory markers are unrelated to physical activity, performance, and functioning in hemodialysis
Hung, A. M., Chertow, G. M., Young, B. S., Carey, S., & Johansen, K. L. (2002) · Journal of Renal Nutrition · doi:10.1053/jren.2002.33513 · Cited by 25
Association Between Aspects of Oral Health–Related Quality of Life and Body Mass Index in Community‐Dwelling Older Adults
Makhija, S. K., Gilbert, G. H., Litaker, M. S., Allman, R. M., Sawyer, P., Locher, J. L., & Ritchie, C. S. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01391.x · Cited by 25
Physical Activity and Markers of Inflammation and Thrombosis Related to Coronary Heart Disease
Panagiotakos, D. B., Kokkinos, P. F., Μanios, Y., & Pitsavos, C. (2004) · Preventive Cardiology · doi:10.1111/j.1520-037x.2004.03539.x · Cited by 24
Effect of moderate aerobic cycling on some systemic inflammatory markers in healthy active collegiate men
Akhtari-Shojaei, E. (2011) · International Journal of General Medicine · doi:10.2147/ijgm.s15065 · Cited by 23
Acute, Exercise-Induced Alterations in Cytokines and Chemokines in the Blood Distinguish Physically Active and Sedentary Aging
MacNeil, L., Tarnopolsky, M. A., & Crane, J. D. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa310 · Cited by 25
Sleep problems and risk of cancer incidence and mortality in an older cohort: The Cardiovascular Health Study (CHS)
Sillah, A., Watson, N. F., Peters, U., Biggs, M. L., Nieto, F. J., Li, C. I., Gozal, D., Thornton, T. A., Barrie, S., & Phipps, A. I. (2021) · Cancer Epidemiology · doi:10.1016/j.canep.2021.102057 · Cited by 24

Authors: Geffken, D. F., Cushman, M., Burke, G. L., Polak, J. F., Sakkinen, P. A., & Tracy, R. P.
Affiliations: University of Vermont (US)
ORCID: Cushman, Mary
Burke, Gregory L.
Polak, Joseph F.
Tracy, Russell P.
Venue: American Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 2001-02-01
Volume: 153
Issue: 3
Pages: 242-250
ISSN: 0002-9262 (ISSN-L)
1476-6256
DOI: 10.1093/aje/153.3.242
OpenAlex: W2145710413
Cited by: 599
References: 55
Citations by year: 2026: 7 · 2025: 14 · 2024: 9 · 2023: 8 · 2022: 20 · 2021: 14 · 2020: 11 · 2019: 19 · 2018: 10 · 2017: 22 · 2016: 31 · 2015: 30 · 2014: 32 · 2013: 30 · 2012: 30
FWCI: 14.15
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Epidemiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01hc085079-024, 5k08hl003618-05)
National Heart, Lung, and Blood Institute (R01HL046696, T32-HL07594, R01-HL-46696, K08 HL-03618, N01-HC85079-85086, T32HL007594)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: physical activity, inflammatory markers, C-reactive protein, fibrinogen, factor VIII activity, white blood cell count, albumin, older adults, body mass index, glucose, atherosclerosis, Cardiovascular Health Study
MeSH terms: Aged, Analysis of Variance, C-Reactive Protein, Cardiovascular Diseases, Physical Exertion, Factor VIII, Female, Fibrinogen, Humans, Inflammation, Leukocyte Count, Male, Sex Factors, Smoking, Biomarkers

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Association between Physical Activity and Markers of Inflammation in a Healthy Elderly Population

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