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Cited by 599Physical Activity and HealthExercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 53 of the 55 references it cites were found in a registry or an index.

Association between Physical Activity and Markers of Inflammation in a Healthy Elderly Population

Geffken, Dominic F., Cushman, Mary, Burke, Gregory L., Polak, Joseph F., Sakkinen, Pamela A., Tracy, Russell P.·2001·American Journal of Epidemiology
DOI 10.1093/aje/153.3.242
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Abstract

Higher levels of physical activity are associated with lower risk of cardiovascular disease. There is growing evidence that the development of the atherosclerotic plaque is associated with inflammation. In this study, the authors investigated the cross-sectional association between physical activity and markers of inflammation in a healthy elderly population. Data obtained in 1989–1990 and 1992–1993 from the Cardiovascular Health Study, a cohort of 5,888 men and women aged ≥65 years, were analyzed. Concentrations of the inflammation markers–C-reactive protein, fibrinogen, Factor VIII activity, white blood cells, and albumin–were compared cross-sectionally by quartile of self-reported physical activity. Compared with persons in the lowest quartile, those in the highest quartile of physical activity had 19%, 6%, 4%, and 3% lower concentrations of C-reactive protein, white blood cells, fibrinogen, and Factor VIII activity, respectively, after adjustment for gender, the presence of cardiovascular disease, age, race, smoking, body mass index, diabetes, and hypertension. Multivariate regression models suggested that the association of higher levels of physical activity with lower levels of inflammation markers may be mediated by body mass index and glucose. There was no association between physical activity and albumin. Higher levels of physical activity were associated with lower concentrations of four out of five inflammation markers in this elderly cohort. These data suggest that increased exercise is associated with reduced inflammation. Prospective studies will be required for verification of these findings.

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Crossref · 10.1093/aje/153.3.242

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  1. Howard G, Tracy R, Wagenknecht L, et al. Predictors of inflammatory status in a middle-aged population. (Abstract). Circulation 1999;99:1108.

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Metadata

Authors
Geffken, D. F., Cushman, M., Burke, G. L., Polak, J. F., Sakkinen, P. A., & Tracy, R. P.
Affiliations
University of Vermont (US)
ORCID
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2001-02-01
Volume
153
Issue
3
Pages
242-250
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
DOI
10.1093/aje/153.3.242
OpenAlex
W2145710413
Cited by
599
References
55
Citations by year
2026: 7 · 2025: 14 · 2024: 9 · 2023: 8 · 2022: 20 · 2021: 14 · 2020: 11 · 2019: 19 · 2018: 10 · 2017: 22 · 2016: 31 · 2015: 30 · 2014: 32 · 2013: 30 · 2012: 30
FWCI
14.15
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01hc085079-024, 5k08hl003618-05)
  • National Heart, Lung, and Blood Institute (R01HL046696, T32-HL07594, R01-HL-46696, K08 HL-03618, N01-HC85079-85086, T32HL007594)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
physical activity, inflammatory markers, C-reactive protein, fibrinogen, factor VIII activity, white blood cell count, albumin, older adults, body mass index, glucose, atherosclerosis, Cardiovascular Health Study
MeSH terms
Aged, Analysis of Variance, C-Reactive Protein, Cardiovascular Diseases, Physical Exertion, Factor VIII, Female, Fibrinogen, Humans, Inflammation, Leukocyte Count, Male, Sex Factors, Smoking, Biomarkers

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