The DOI matches its Crossref record; 53 of the 55 references it cites were found in a registry or an index.
Association between Physical Activity and Markers of Inflammation in a Healthy Elderly Population
Abstract
Higher levels of physical activity are associated with lower risk of cardiovascular disease. There is growing evidence that the development of the atherosclerotic plaque is associated with inflammation. In this study, the authors investigated the cross-sectional association between physical activity and markers of inflammation in a healthy elderly population. Data obtained in 1989–1990 and 1992–1993 from the Cardiovascular Health Study, a cohort of 5,888 men and women aged ≥65 years, were analyzed. Concentrations of the inflammation markers–C-reactive protein, fibrinogen, Factor VIII activity, white blood cells, and albumin–were compared cross-sectionally by quartile of self-reported physical activity. Compared with persons in the lowest quartile, those in the highest quartile of physical activity had 19%, 6%, 4%, and 3% lower concentrations of C-reactive protein, white blood cells, fibrinogen, and Factor VIII activity, respectively, after adjustment for gender, the presence of cardiovascular disease, age, race, smoking, body mass index, diabetes, and hypertension. Multivariate regression models suggested that the association of higher levels of physical activity with lower levels of inflammation markers may be mediated by body mass index and glucose. There was no association between physical activity and albumin. Higher levels of physical activity were associated with lower concentrations of four out of five inflammation markers in this elderly cohort. These data suggest that increased exercise is associated with reduced inflammation. Prospective studies will be required for verification of these findings.
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“Cross-sectional studies demonstrate an association between physical inactivity and low-grade systemic inflammation in healthy subjects [71–75], in elderly people [76, 77], and in patients with intermittent claudication [78].”
From Exercise as a Mean to Control Low‐Grade Systemic Inflammation (2008) · cites this paper as [73]
Citations
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2 of the 55 references couldn’t be matched to a known paper.
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- Howard G, Tracy R, Wagenknecht L, et al. Predictors of inflammatory status in a middle-aged population. (Abstract). Circulation 1999;99:1108.
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The anti-inflammatory effect of exercise
Petersen, A. M. W., & Pedersen, B. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00164.2004 · Cited by 3,100
Chronic obstructive pulmonary disease in non-smokers
Salvi, S., & Barnes, P. J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61303-9 · Cited by 1,384
The Effects of Physical Activity on Serum C-Reactive Protein and Inflammatory Markers
Kasapis, C., & Thompson, P. D. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.12.077 · Cited by 1,149
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Inflammatory Markers and Physical Performance in Older Persons: The InCHIANTI Study
Cesari, M., Penninx, B. W. J. H., Pahor, M., Lauretani, F., Corsi, A. M., Williams, G. R., Guralnik, J. M., & Ferrucci, L. (2004) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/59.3.m242 · Cited by 901
Metadata
- Authors
- Geffken, D. F., Cushman, M., Burke, G. L., Polak, J. F., Sakkinen, P. A., & Tracy, R. P.
- Affiliations
- University of Vermont (US)
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-02-01
- Volume
- 153
- Issue
- 3
- Pages
- 242-250
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2145710413
- Cited by
- 599
- References
- 55
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 9 · 2023: 8 · 2022: 20 · 2021: 14 · 2020: 11 · 2019: 19 · 2018: 10 · 2017: 22 · 2016: 31 · 2015: 30 · 2014: 32 · 2013: 30 · 2012: 30
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01hc085079-024, 5k08hl003618-05)
- National Heart, Lung, and Blood Institute (R01HL046696, T32-HL07594, R01-HL-46696, K08 HL-03618, N01-HC85079-85086, T32HL007594)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- physical activity, inflammatory markers, C-reactive protein, fibrinogen, factor VIII activity, white blood cell count, albumin, older adults, body mass index, glucose, atherosclerosis, Cardiovascular Health Study
- MeSH terms
- Aged, Analysis of Variance, C-Reactive Protein, Cardiovascular Diseases, Physical Exertion, Factor VIII, Female, Fibrinogen, Humans, Inflammation, Leukocyte Count, Male, Sex Factors, Smoking, Biomarkers
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