The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Coronary Artery Calcium Score and Coronary Heart Disease Events in a Large Cohort of Asymptomatic Men and Women
Open accessAbstract
Coronary artery calcium (CAC), a measure of subclinical coronary heart disease (CHD), may be useful in identifying asymptomatic persons at risk of CHD events. The current study included 10,746 adults who were 22-96 years of age, were free of known CHD, and had their CAC quantified by electron-beam tomography at baseline as part of a preventive medical examination at the Cooper Clinic (Dallas, Texas) during 1995-2000. During a mean follow-up of 3.5 years, 81 hard events (CHD death, nonfatal myocardial infarction) and 287 total events (hard events plus coronary revascularization) occurred. Age-adjusted rates (per 1,000 person-years) of hard events were computed according to four CAC categories: no detectable CAC and incremental sex-specific thirds of detectable CAC; these rates were, respectively, 0.4, 1.5, 4.8, and 8.7 (trend p<0.0001) for men and 0.7, 2.3, 3.1, and 6.3 (trend p=0.02) for women. CAC levels also were positively associated with rates of total CHD events for women and men (trend p<0.0001 each). The association between CAC and CHD events remained significant after adjustment for CHD risk factors. CAC was associated with CHD events in persons with no baseline CHD risk factors and in younger (aged <40 years) and older (aged >65 years) study participants. These findings show that CAC is associated with an increased risk of CHD events in asymptomatic women and men.
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Cites
Quantification of coronary artery calcium using ultrafast computed tomography
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“Although the use of self-reported risk factors is not ideal in research settings, they have been shown to provide a valid assessment of study participants’ overall risk profiles (40), particularly in well-educated populations (41).”
BackgroundFuster, V (1994) · Circulation · doi:10.1161/01.cir.90.4.2126 · Cited by 848
Prediction of coronary events with electron beam computed tomography
Arad, Y., Spadaro, L. A., Goodman, K., Newstein, D., & Guerci, A. D. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00872-x · Cited by 744 · cited 19×
“A priori hypotheses related to sex differences in the association between CAC and CHD events were not tested.”
BackgroundResultInfluential
Cited by
Coronary Calcium as a Predictor of Coronary Events in Four Racial or Ethnic Groups
Detrano, R., Guerci, A. D., Carr, J. J., Bild, D. E., Burke, G., Folsom, A. R., Liu, K., Shea, S., Szklo, M., Bluemke, D. A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa072100 · Cited by 2,989
Greenland, P., Bonow, R. O., Brundage, B. H., Budoff, M. J., Eisenberg, M. J., Grundy, S. M., Lauer, M. S., Post, W. S., Raggi, P., Redberg, R. F., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.10.001 · Cited by 962
Kronmal, R. A., McClelland, R. L., Detrano, R., Shea, S., Lima, J. A., Cushman, M., Bild, D. E., & Burke, G. L. (2007) · Circulation · doi:10.1161/circulationaha.106.674143 · Cited by 560
Vascular calcifications as a marker of increased cardiovascular risk: A meta-analysis
Rennenberg, R., Kessels, Schurgers, Engelshoven, V., de Leeuw, P., & Kroon (2009) · Vascular Health and Risk Management · doi:10.2147/vhrm.s4822 · Cited by 469
Metadata
- Authors
- LaMonte, M. J., FitzGerald, S. J., Church, T. S., Barlow, C. E., Radford, N. B., Levine, B. D., Pippin, J. J., Gibbons, L. W., Blair, S. N., & Nichaman, M. Z.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-09-01
- Volume
- 162
- Issue
- 5
- Pages
- 421-429
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2104335422
- Cited by
- 341
- References
- 5
- FWCI
- 18.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- LaMonte, M. J., FitzGerald, S. J., Church, T. S., Barlow, C. E., Radford, N. B., Levine, B. D., Pippin, J. J., Gibbons, L. W., Blair, S. N., & Nichaman, M. Z. (2005). Coronary Artery Calcium Score and Coronary Heart Disease Events in a Large Cohort of Asymptomatic Men and Women. American Journal of Epidemiology. https://doi.org/10.1093/aje/kwi228
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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