Determinants of Serum Adiponectin in Persons with and without Type 1 Diabetes
Abstract
Low levels of adiponectin have been related to coronary heart disease, but adiponectin is higher in persons with type 1 diabetes who have an increased rate of coronary disease. In the Coronary Artery Calcification in Type 1 Diabetes Study (2000-2002), the authors investigated potential determinants of elevated adiponectin levels in persons with type 1 diabetes and whether a difference exists compared with nondiabetic persons. Serum adiponectin was measured in 1,393 persons (sex: 48% male; age: 38 (standard deviation: 9) years; diabetes duration: 23 (standard deviation: 9) years; 54% nondiabetic and 46% with type 1 diabetes). Determinants of log-transformed adiponectin levels were evaluated by multiple linear regression analysis with interaction terms to determine whether predictors of adiponectin levels differed by diabetes status. Adiponectin levels were higher in type 1 diabetic than nondiabetic persons (13.5 (standard deviation: 1.0) vs. 8.8 (standard deviation: 1.0) microg/ml; p < 0.0001), adjusting for age, gender, body mass index, and glomerular filtration rate. The final regression model explained 67% of the difference in adiponectin levels between type 1 diabetic and nondiabetic persons. The variables explaining this difference included high density lipoprotein cholesterol, albumin excretion rate, plasminogen activator inhibitor-1, and hemoglobin A1c level. Adiponectin is higher in type 1 diabetic than nondiabetic persons. Although some of the difference can be explained, further study is needed to better understand the relation between elevated adiponectin levels and patient outcomes, including coronary heart disease.
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Patients with type 1 diabetes have higher than expected adiponectin levels: an observation that is poorly understood.
“In contrast, patients with type 1 diabetes have higher than expected adiponectin levels: an observation that is poorly understood.66”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [66]
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- Chudek J, Adamczak M, Karkoszka H, et al. Plasma adipo- nectin concentration before and after successful kidney trans- plantation. Transplant Proc 2003;35:2186-9.
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- Authors
- Maahs, D. M., Ogden, L. G., Snell-Bergeon, J. K., Kinney, G. L., Wadwa, R. P., Hokanson, J. E., Dabelea, D., Kretowski, A., Eckel, R. H., & Rewers, M.
- Affiliations
- University of Colorado Health (US)
- ORCID
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-06-24
- Volume
- 166
- Issue
- 6
- Pages
- 731-740
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2164721123
- Cited by
- 46
- References
- 43
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 2 · 2022: 1 · 2021: 1 · 2019: 1 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 4 · 2012: 4
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL61753, R01HL61753, R01HL061753)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK057516, P30 DK 57516)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- adiponectin, type 1 diabetes, coronary artery disease, coronary artery calcification, HDL cholesterol, urinary albumin excretion rate, plasminogen activator inhibitor-1, HbA1c, diabetic nephropathy
- MeSH terms
- Adult, Age Factors, Coronary Disease, Diabetes Mellitus, Type 1, Female, Glomerular Filtration Rate, Humans, Male, Middle Aged, Surveys and Questionnaires, Risk Factors, Sex Factors, Linear Models, Case-Control Studies, Adiponectin
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