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Association Between Blood Lead and the Risk of Amyotrophic Lateral Sclerosis

Fang, F., Kwee, L. C., Allen, K. D., Umbach, D. M., Ye, W., Watson, M., Keller, J., Oddone, E. Z. +3 more·2010·American Journal of Epidemiology
DOI 10.1093/aje/kwq063
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  • It has been theorized that the deterioration in bone health may be due to increased bone turnover, exposure to environmental toxins such as lead, or vitamin D deficiency.

    “It has been theorized that the deterioration in bone health may be due to increased bone turnover, exposure to environmental toxins such as lead, or vitamin D deficiency [73,74,75,76].”

    From Head Injury and Amyotrophic Lateral Sclerosis: Population-Based Study from the National ALS Registry (2025) · cites this paper as [73]

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Research works printed but not linked: 31

  1. Kamel F, Umbach DM, Hu H, et al. Lead exposure as a risk factor for amyotrophic lateral sclerosis. Neurodegener Dis. 2005;2(3-4):195-201.
  2. Deapen DM, Henderson BE. A case-control study of amyotro- phic lateral sclerosis. Am J Epidemiol. 1986;123(5):790-799.
  3. McGuire V, Longstreth WT Jr, Nelson LM, et al. Occupational exposures and amyotrophic lateral sclerosis. A population- based case-control study. Am J Epidemiol. 1997;145(12): 1076-1088.
  4. Gunnarsson LG, Bodin L, So ¨derfeldt B, et al. A case-control study of motor neurone disease: its relation to heritability, and occupational exposures, particularly to solvents. Br J Ind Med. 1992;49(11):791-798.
  5. Campbell AM, Williams ER, Barltrop D. Motor neurone dis- ease and exposure to lead. J Neurol Neurosurg Psychiatry. 1970;33(6):877-885.
  6. Felmus MT, Patten BM, Swanke L. Antecedent events in amyotrophic lateral sclerosis. Neurology. 1976;26(2):167-172.
  7. Pierce-Ruhland R, Patten BM. Repeat study of antecedent events in motor neuron disease. Ann Clin Res. 1981;13(2):102-107.
  8. Gresham LS, Molgaard CA, Golbeck AL, et al. Amyotrophic lateral sclerosis and occupational heavy metal exposure: a case-control study. Neuroepidemiology. 1986;5(1):29-38.
  9. Armon C, Kurland LT, Daube JR, et al. Epidemiologic corre- lates of sporadic amyotrophic lateral sclerosis. Neurology. 1991;41(7):1077-1084.
  10. Chancellor AM, Slattery JM, Fraser H, et al. Risk factors for motor neuron disease: a case-control study based on patients from the Scottish Motor Neuron Disease Register. J Neurol Neurosurg Psychiatry. 1993;56(11):1200-1206.
  11. Kamel F, Umbach DM, Lehman TA, et al. Amyotrophic lateral sclerosis, lead, and genetic susceptibility: polymorphisms in the delta-aminolevulinic acid dehydratase and vitamin D receptor genes. Environ Health Perspect. 2003;111(10):1335-1339.
  12. Kamel F, Umbach DM, Munsat TL, et al. Lead exposure and amyotrophic lateral sclerosis. Epidemiology. 2002;13(3): 311-319.
  13. Albers K, Nelson L, Tanner C, et al. Lead exposure and amyotrophic lateral sclerosis in a Northern California popu- lation [abstract]. Neuroepidemiology. 2009;33:74.
  14. Hu H, Payton M, Korrick S, et al. Determinants of bone and blood lead levels among community-exposed middle-aged to elderly men. The Normative Aging Study. Am J Epidemiol. 1996;144(8):749-759.
  15. Kelada SN, Shelton E, Kaufmann RB, et al. Delta-aminolevulinic acid dehydratase genotype and lead toxicity: a HuGE review. Am J Epidemiol. 2001;154(1):1-13.
  16. Allen KD, Kasarskis EJ, Bedlack RS, et al. The National Registry of Veterans with Amyotrophic Lateral Sclerosis. Neuroepidemiology. 2008;30(3):180-190.
  17. Brooks BR, Miller RG, Swash M, et al. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral scle- rosis. Amyotroph Lateral Scler Other Motor Neuron Disord. 2000;1(5):293-299.
  18. Schmidt S, Allen KD, Loiacono VT, et al. Genes and Envi- ronmental Exposures in Veterans with Amyotrophic Lateral Sclerosis: the GENEVA study. Rationale, study design and demographic characteristics. Neuroepidemiology. 2008;30(3): 191-204.
  19. Hansen TV, Simonsen MK, Nielsen FC, et al. Collection of blood, saliva, and buccal cell samples in a pilot study on the Danish nurse cohort: comparison of the response rate and quality of genomic DNA. Cancer Epidemiol Biomarkers Prev. 2007;16(10):2072-2076.
  20. Rylander-Rudqvist T, Ha ˚kansson N, Tybring G, et al. Quality and quantity of saliva DNA obtained from the self-administrated oragene method-a pilot study on the cohort of Swedish men. Cancer Epidemiol Biomarkers Prev. 2006;15(9):1742-1745.
  21. Kamel F, Umbach DM, Munsat TL, et al. Association of cigarette smoking with amyotrophic lateral sclerosis. Neuro- epidemiology. 1999;18(4):194-202.
  22. Weisskopf MG, McCullough ML, Calle EE, et al. Prospective study of cigarette smoking and amyotrophic lateral sclerosis. Am J Epidemiol. 2004;160(1):26-33.
  23. Nelson LM, McGuire V, Longstreth WT Jr, et al. Population- based case-control study of amyotrophic lateral sclerosis in western Washington State. I. Cigarette smoking and alcohol consumption. Am J Epidemiol. 2000;151(2):156-163.
  24. Bondy SC, Komulainen H. Intracellular calcium as an index of neurotoxic damage. Toxicology. 1988;49(1):35-41.
  25. Adonaylo VN, Oteiza PI. Lead intoxication: antioxidant de- fenses and oxidative damage in rat brain. Toxicology. 1999; 135(2-3):77-85.
  26. Mancuso JD, McCoy J, Pelka B, et al. The challenge of con- trolling lead and silica exposures from firing ranges in a spe- cial operations force. Mil Med. 2008;173(2):182-186.
  27. Horner RD, Kamins KG, Feussner JR, et al. Occurrence of amyotrophic lateral sclerosis among Gulf War veterans. Neurology. 2003;61(6):742-749.
  28. Haley RW. Excess incidence of ALS in young Gulf War vet- erans. Neurology. 2003;61(6):750-756.
  29. Coffman CJ, Horner RD, Grambow SC, et al. Estimating the occurrence of amyotrophic lateral sclerosis among Gulf War (1990-1991) veterans using capture-recapture methods. Neuroepidemiology. 2005;24(3):141-150.
  30. Weisskopf MG, O'Reilly EJ, McCullough ML, et al. Pro- spective study of military service and mortality from ALS. Neurology. 2005;64(1):32-37.
  31. Hu H, Wu MT, Cheng Y, et al. The delta-aminolevulinic acid dehydratase (ALAD) polymorphism and bone and blood lead levels in community-exposed men: the Normative Aging Study. Environ Health Perspect. 2001;109(8): 827-832.

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Authors
Fang, F., Kwee, L. C., Allen, K. D., Umbach, D. M., Ye, W., Watson, M., Keller, J., Oddone, E. Z., Sandler, D. P., Schmidt, S., & Kamel, F.
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2010-04-20
Volume
171
Issue
10
Pages
1126-1133
ISSN
  • 0002-9262
  • 1476-6256
DOI
10.1093/aje/kwq063
Cited by
100
References
0
Language
en

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