Cancers with wrong HATs: the impact of acetylation
Open accessAbstract
Lysine N-ε-acetylation is a post-translational modification that regulates the function of histone and non-histone proteins. In several malignancies, histone acetyltransferase (HAT) activities are disturbed as a consequence of various genetic or epigenetic alterations. In particular, HATs can function as tumor suppressors, helping cells control cellular proliferation and cell cycle, and also as oncogenes, because abnormal acetylation can activate malignant proteins and contribute to cancer. An impaired acetylation profile can be indicative of a pathological process, and thus evaluation of histone acetylation could be used as a predictive index of patient survival or therapy outcome. Therefore, epigenetic therapy might be a very effective strategy to defeat cancer. With the use of histone deacetylase inhibitors and acetylation modulators (e.g. HAT inhibitors, bromodomain inhibitors), we are paving the way for a future epigenetic drug control of human diseases.
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Acetylation is catalyzed by histone acetyltransferases, which neutralize lysine residues, loosen DNA-histone interactions, and promote chromatin accessibility.
“Acetylation is catalyzed by histone acetyltransferases (HATs), which neutralize lysine residues, loosen DNA–histone interactions, and promote chromatin accessibility.”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Di Cerbo and Schneider, 2013
Major HAT families include GNAT, p300/CBP, MYST, and Rtt109.
“Major HAT families include GNAT, p300/CBP, MYST, and Rtt109 (Poziello et al., 2021; Sabnis, 2021; Di Cerbo and Schneider, 2013).”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Di Cerbo and Schneider, 2013
Cites
Lysine acetylation targets protein complexes and co-regulates major cellular functions
Choudhary, C., Kumar, C., Gnad, F., Nielsen, M. L., Rehman, M., Walther, T. C., Olsen, J. V., & Mann, M. (2009) · Science · doi:10.1126/science.1175371 · Cited by 4,040 · see citing works
The Role of Chromatin during Transcription
Li, B., Carey, M., & Workman, J. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.015 · Cited by 3,503 · see citing works
Mapping and analysis of chromatin state dynamics in nine human cell types
Ernst, J., Kheradpour, P., Mikkelsen, T. S., Shoresh, N., Ward, L. D., Epstein, C. B., Zhang, X., Wang, L., Issner, R., Coyne, M., et al. (2011) · Nature · doi:10.1038/nature09906 · Cited by 2,898 · see citing works
A decade of exploring the cancer epigenome—biological and translational implications
Baylin, S. B., & Jones, P. A. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3130 · Cited by 2,871 · see citing works
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
Minucci, S., & Pelicci, P. G. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1779 · Cited by 2,211 · see citing works
Cancer epigenomics: DNA methylomes and histone-modification maps
Esteller, M. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2005 · Cited by 2,150 · see citing works
Fraga, M. F., Ballestar, E., Villar‐Garea, A., Boix-Chornet, M., Espada, J., Schotta, G., Bonaldi, T., Haydon, C. E., Ropero, S., Petrie, K. R., et al. (2005) · Nature Genetics · doi:10.1038/ng1531 · Cited by 1,926 · see citing works
Smithers, D. W. (1956) · The Lancet · doi:10.1016/s0140-6736(56)91184-9 · Cited by 1,796 · see citing works
Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family
Filippakopoulos, P., Picaud, S., Mangos, M., Keates, T., Lambert, J., Baršytė-Lovejoy, D., Felletár, I., Volkmer, R., Müller, S., Pawson, T. J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.013 · Cited by 1,719 · see citing works
Phenotypic plasticity and the epigenetics of human disease
Feinberg, A. P. (2007) · Nature · doi:10.1038/nature05919 · Cited by 1,613 · see citing works
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
Dawson, M. A., Prinjha, R. K., Dittmann, A., Giotopoulos, G., Bantscheff, M., Chan, W.-I., Robson, S. C., Chung, C., Hopf, C., Savitski, M. M., et al. (2011) · Nature · doi:10.1038/nature10509 · Cited by 1,512 · see citing works
Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast
Pokholok, D., Harbison, C. T., Levine, S. S., Cole, M. F., Hannett, N. M., Lee, T. I., Bell, G. W., Walker, K., Rolfe, A., Herbolsheimer, E., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.026 · Cited by 1,433 · see citing works
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
Peifer, M., Fernandez‐Cuesta, L., Sos, M. L., George, J., Seidel, D., Kasper, L. H., Plenker, D., Leenders, F., Sun, R., Zander, T., et al. (2012) · Nature Genetics · doi:10.1038/ng.2396 · Cited by 1,390 · see citing works
Self-citationGenome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
Wang, Z., Zang, C., Cui, K., Schones, D. E., Barski, A., Peng, W., & Zhao, K. (2009) · Cell · doi:10.1016/j.cell.2009.06.049 · Cited by 1,344 · see citing works
Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer
Dhillon, N., Aggarwal, B. B., Newman, R. A., Wolff, R. A., Kunnumakkara, A. B., Abbruzzese, J. L., Ng, C. S., Badmaev, V., & Kurzrock, R. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0024 · Cited by 1,337 · see citing works
MLL translocations, histone modifications and leukaemia stem-cell development
Krivtsov, A., & Armstrong, S. (2007) · Nature Reviews. Cancer · doi:10.1038/nrc2253 · Cited by 1,294 · see citing works
Cancer Genetics and Epigenetics: Two Sides of the Same Coin?
You, J. S., & Jones, P. A. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.06.008 · Cited by 1,163 · see citing works
Global histone modification patterns predict risk of prostate cancer recurrence
Seligson, D. B., Horvath, S., Shi, T., Yu, H., Tze, S., Grunstein, M. R., & Kurdistani, S. K. (2005) · Nature · doi:10.1038/nature03672 · Cited by 1,090 · see citing works
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
Williams, K., Christensen, J., Pedersen, M. T., Johansen, J. V., Cloos, P. A. C., Rappsilber, J., & Helin, K. (2011) · Nature · doi:10.1038/nature10066 · Cited by 1,021 · see citing works
Inactivating mutations of acetyltransferase genes in B-cell lymphoma
Pasqualucci, L., Dominguez-Sola, D., Chiarenza, A., Fabbri, G., Grunn, A., Trifonov, V., Kasper, L. H., Lerach, S., Tang, H., Ma, J., et al. (2011) · Nature · doi:10.1038/nature09730 · Cited by 949 · see citing works
Jin, Q., Yu, L., Wang, L., Zhang, Z., Kasper, L. H., Lee, J., Wang, C., Brindle, P. K., Dent, S. Y. R., & Ge, K. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.318 · Cited by 877 · see citing works
Comprehensive analysis of the chromatin landscape in Drosophila melanogaster
Kharchenko, P. V., Alekseyenko, A. A., Schwartz, Y. B., Minoda, A., Riddle, N. C., Ernst, J., Sabo, P. J., Larschan, E., Gorchakov, A. A., Gu, T., et al. (2010) · Nature · doi:10.1038/nature09725 · Cited by 853 · see citing works
Acetylation Is Indispensable for p53 Activation
Tang, Y., Zhao, W., Chen, Y., Zhao, Y., & Gu, W. (2008) · Cell · doi:10.1016/j.cell.2008.03.025 · Cited by 838 · see citing works
CBP/p300-mediated acetylation of histone H3 on lysine 56
Das, C., Lucia, M. S., Hansen, K. C., & Tyler, J. K. (2009) · Nature · doi:10.1038/nature07861 · Cited by 698 · see citing works
Iyer, N. G., Özdağ, H., & Caldas, C. (2004) · Oncogene · doi:10.1038/sj.onc.1207118 · Cited by 645 · see citing works
CREBBP mutations in relapsed acute lymphoblastic leukaemia
Mullighan, C. G., Zhang, J., Kasper, L. H., Lerach, S., Payne-Turner, D., Phillips, L. A., Heatley, S. L., Holmfeldt, L., Collins-Underwood, J. R., Ma, J., et al. (2011) · Nature · doi:10.1038/nature09727 · Cited by 628 · see citing works
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation
Barber, M. F., Michishita-Kioi, E., Xi, Y., Tasselli, L., Kioi, M., Moqtaderi, Z., Tennen, R. I., Paredes, S., Young, N. L., Chen, K., et al. (2012) · Nature · doi:10.1038/nature11043 · Cited by 621 · see citing works
A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response
Masumoto, H., Hawke, D. H., Kobayashi, R., & Verreault, A. (2005) · Nature · doi:10.1038/nature03714 · Cited by 595 · see citing works
Mutations truncating the EP300 acetylase in human cancers
Gayther, S. A., Batley, S. J., Linger, L., Bannister, A. J., Thorpe, K. L., Chin, S., Daigo, Y., Russell, P. A., Wilson, A., Sowter, H., et al. (2000) · Nature Genetics · doi:10.1038/73536 · Cited by 587 · see citing works
Kunnumakkara, A. B., Guha, S., Krishnan, S., Diagaradjane, P., Gelovani, J. G., & Aggarwal, B. B. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4257 · Cited by 579 · see citing works
Epigenetic modifications in cancer
Kanwal, R., & Gupta, S. (2011) · Clinical Genetics · doi:10.1111/j.1399-0004.2011.01809.x · Cited by 551 · see citing works
Aoki, H., Takada, Y., Kondo, S., Sawaya, R. A., Aggarwal, B. B., & Kondo, Y. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.033167 · Cited by 523 · see citing works
Small Molecule Modulators of Histone Acetyltransferase p300
Balasubramanyam, K., Swaminathan, V., Ranganathan, A., & Kundu, T. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301580200 · Cited by 518 · see citing works
Global Levels of Histone Modifications Predict Prognosis in Different Cancers
Seligson, D. B., Horvath, S., McBrian, M. A., Mah, V. H., Yu, H., Tze, S., Wang, Q., Chia, D., Goodglick, L., & Kurdistani, S. K. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080874 · Cited by 511 · see citing works
Karmodiya, K., Krebs, A. R., Oulad‐Abdelghani, M., Kimura, H., & Tora, L. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-424 · Cited by 506 · see citing works
CBP and p300: HATs for different occasions
Kalkhoven, E. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.03.045 · Cited by 499 · see citing works
HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications
Khan, O., & La Thangue, N. B. (2012) · Immunology & Cell Biology · doi:10.1038/icb.2011.100 · Cited by 450 · see citing works
Structure and acetyl-lysine recognition of the bromodomain
Mujtaba, S., Zeng, L., & Zhou, M.-M. (2007) · Oncogene · doi:10.1038/sj.onc.1210618 · Cited by 419 · see citing works
Chromatin remodeling and cancer, part I: covalent histone modifications
Wang, G. G., Allis, C. D., & Chi, P. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.07.003 · Cited by 416 · see citing works
The MYST family of histone acetyltransferases and their intimate links to cancer
Avvakumov, N., & Côté, J. (2007) · Oncogene · doi:10.1038/sj.onc.1210608 · Cited by 356 · see citing works
Screen for DNA‐damage‐responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells
Tjeertes, J. V., Miller, K. M., & Jackson, S. P. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.119 · Cited by 347 · see citing works
Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response
Gorrini, C., Squatrito, M., Luise, C., Syed, N., Perna, D., Wark, L., Martinato, F., Sardella, D., Verrecchia, A., Bennett, S., et al. (2007) · Nature · doi:10.1038/nature06055 · Cited by 341 · see citing works
Chromatin modifier enzymes, the histone code and cancer
Santos-Rosa, H., & Caldas, C. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.08.010 · Cited by 336 · see citing works
DNA methylomes, histone codes and miRNAs: Tying it all together
Guil, S., & Esteller, M. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.09.005 · Cited by 317 · see citing works
Piña, I. C., Gautschi, J. T., Wang, G.-Y.-S., Sanders, M. L., Schmitz, F. J., France, D. S., Cornell-Kennon, S., Sambucetti, L. C., Remiszewski, S., Perez, L. B., et al. (2003) · The Journal of Organic Chemistry · doi:10.1021/jo034248t · Cited by 314 · see citing works
Füllgrabe, J., Kavanagh, E. T., & Joseph, B. (2011) · Oncogene · doi:10.1038/onc.2011.121 · Cited by 307 · see citing works
Wei, Y., Xia, W., Zhang, Z., Liu, J., Wang, H., Adsay, V. N., Albarracin, C. T., Yu, D., Abbruzzese, J. L., Mills, G. B., et al. (2008) · Molecular Carcinogenesis · doi:10.1002/mc.20413 · Cited by 303 · see citing works
p300 gene alterations in colorectal and gastric carcinomas.
Muraoka, M., Konishi, M., Kikuchi‐Yanoshita, R., Tanaka, K., Shitara, N., Chong, J., Iwama∥, T., & Miyaki, M. (1996) · PubMed · Cited by 282 · see citing works
Global Histone Modifications Predict Prognosis of Resected Non–Small-Cell Lung Cancer
Barlési, F., Giaccone, G., Gallegos-Ruiz, M. I., Loundou, A., Span, S. W., Lefesvre, P., Kruyt, F. A. E., & Rodríguez, J. A. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.11.2599 · Cited by 280 · see citing works
Requirement of Hos2 Histone Deacetylase for Gene Activity in Yeast
Wang, A., Kurdistani, S. K., & Grunstein, M. R. (2002) · Science · doi:10.1126/science.1077790 · Cited by 272 · see citing works
Differential expression of selected histone modifier genes in human solid cancers
Özdağ, H., Teschendorff, A. E., Ahmed, A. A., Hyland, S. J., Blenkiron, C., Bobrow, L., Veerakumarasivam, A., Burtt, G. J., Subkhankulova, T., Arends, M. J., et al. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-90 · Cited by 258 · see citing works
Cancer genetics of epigenetic genes
Miremadi, A., Oestergaard, M. Z., Pharoah, P. D. P., & Caldas, C. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm021 · Cited by 249 · see citing works
The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation
Wang, L., Gural, A., Sun, X.-J., Zhao, X., Perna, F., Huang, G., Hatlen, M. A., Vu, L., Liu, F., Xu, H., et al. (2011) · Science · doi:10.1126/science.1201662 · Cited by 242 · see citing works
Santer, F. R., Höschele, P. P. S., Oh, S. J., Erb, H. H. H., Bouchal, J., Cavarretta, I. T. R., Parson, W., Meyers, D. J., Cole, P. A., & Čulig, Z. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0182 · Cited by 236 · see citing works
Activation of AML1‐mediated transcription by MOZ and inhibition by the MOZ–CBP fusion protein
Kitabayashi, I., Aikawa, Y., Nguyen, L. A., Yokoyama, A., & Ohki, M. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.7184 · Cited by 235 · see citing works
Epigenetic Reprogramming by Adenovirus e1a
Ferrari, R., Pellegrini, M. A., Horwitz, G. A., Xie, W., Berk, A. J., & Kurdistani, S. K. (2008) · Science · doi:10.1126/science.1155546 · Cited by 230 · see citing works
Deguchi, K., Ayton, P. M., Carapeti, M., Kutok, J. L., Snyder, C. S., Williams, I. R., Cross, N. C. P., Glass, C. K., Cleary, M. L., & Gilliland, D. G. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00051-5 · Cited by 224 · see citing works
p300 in prostate cancer proliferation and progression.
Debes, J. D., Sebo, T. J., Lohse, C. M., Murphy, L. M., Haugen, D. A. L., & Tindall, D. J. (2003) · PubMed · Cited by 219 · see citing works
Acetylation-Dependent Regulation of Skp2 Function
Inuzuka, H., Gao, D., Finley, L. W. S., Yang, W., Wan, L., Fukushima, H., Chin, Y. R., Zhai, B., Shaik, S., Lau, A. W., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.038 · Cited by 218 · see citing works
Manuyakorn, A., Paulus, R., Farrell, J. J., Dawson, N. A., Tze, S., Cheung-Lau, G. C., Hines, O. J., Reber, H. A., Seligson, D. B., Horvath, S., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.24.5639 · Cited by 216 · see citing works
Adenovirus Small e1a Alters Global Patterns of Histone Modification
Horwitz, G. A., Zhang, K., McBrian, M. A., Grunstein, M. R., Kurdistani, S. K., & Berk, A. J. (2008) · Science · doi:10.1126/science.1155544 · Cited by 209 · see citing works
Yang, G., Ayala, G., Marzo, A. D., Tian, W., Frolov, A., Wheeler, T. M., Thompson, T. C., & Harper, J. W. (2002) · PubMed · Cited by 203 · see citing works
Specific Inhibition of p300-HAT Alters Global Gene Expression and Represses HIV Replication
Mantelingu, K., Reddy, B. A., Swaminathan, V., Kishore, A. H., Siddappa, N. B., Kumar, G. V. P., Nagashankar, G., Natesh, N., Roy, S., Sadhale, P. P., et al. (2007) · Chemistry & Biology · doi:10.1016/j.chembiol.2007.04.011 · Cited by 193 · see citing works
Epi-drugs to fight cancer: From chemistry to cancer treatment, the road ahead
Mai, A., & Altucci, L. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.08.020 · Cited by 190 · see citing works
Iacobuzio–Donahue, C. A. (2008) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.3.121806.151442 · Cited by 188 · see citing works
Valdés‐Mora, F., Song, J. Z., Statham, A. L., Strbenac, D., Robinson, M. D., Nair, S. S., Patterson, K., Tremethick, D. J., Stirzaker, C., & Clark, S. J. (2011) · Genome Research · doi:10.1101/gr.118919.110 · Cited by 186 · see citing works
Park, Y. S., Jin, M. Y., Kim, Y. J., Yook, J. H., Kim, B. S., & Jang, S. J. (2008) · Annals of Surgical Oncology · doi:10.1245/s10434-008-9927-9 · Cited by 182 · see citing works
Pfister, S. M., Rea, S., Taipale, M., Mendrzyk, F., Straub, B. K., Ittrich, C., Olaf, T., Sinn, H., Akhtar, A., & Lichter, P. (2007) · International Journal of Cancer · doi:10.1002/ijc.23283 · Cited by 167 · see citing works
Protein N-terminal acetyltransferases in cancer
Kalvik, T. V., & Arnesen, T. (2012) · Oncogene · doi:10.1038/onc.2012.82 · Cited by 159 · see citing works
MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells
Yang, X.-J., & Ullah, M. (2007) · Oncogene · doi:10.1038/sj.onc.1210609 · Cited by 152 · see citing works
p300 Modulates the BRCA1 inhibition of estrogen receptor activity.
Fan, S., Ma, Y. X., Wang, C., Yuan, R., Meng, Q., Wang, J., Erdos, M. R., Goldberg, I. D., Webb, P., Kushner, P. J., et al. (2002) · PubMed · Cited by 148 · see citing works
Mai, A., Cheng, D., Bedford, M. T., Valente, S., Nebbioso, A., Perrone, A., Brosch, G., Sbardella, G., Bellis, F. D., Miceli, M., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm701595q · Cited by 136 · see citing works
Metabolic regulation by SIRT3: implications for tumorigenesis
Finley, L. W. S., & Haigis, M. C. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.05.004 · Cited by 130 · see citing works
Li, M., Luo, R.-Z., Chen, J.-W., Cao, Y., Lu, J.-B., He, J., Wu, Q., & Cai, M.-Y. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-5 · Cited by 127 · see citing works
Selvi, R. B., & Kundu, T. K. (2009) · Biotechnology Journal · doi:10.1002/biot.200900032 · Cited by 120 · see citing works
Tuning acetylation levels with HAT activators: Therapeutic strategy in neurodegenerative diseases
Selvi, B. R., Cassel, J., Kundu, T. K., & Boutillier, A. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.08.012 · Cited by 117 · see citing works
Sen, G. S., Mohanty, S., Hossain, D. M. S., Bhattacharyya, S., Banerjee, S., Chakraborty, J., Saha, S., Ray, P., Bhattacharjee, P., Mandal, D. P., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.262295 · Cited by 107 · see citing works
Ahn, M. Y., Jung, J. H., Na, Y. J., & Kim, H. S. (2007) · Gynecologic Oncology · doi:10.1016/j.ygyno.2007.08.098 · Cited by 102 · see citing works
Histone Modifications in Cancer Biology and Prognosis
Kurdistani, S. K. (2010) · Springer eBooks · doi:10.1007/978-3-7643-8989-5_5 · Cited by 102 · see citing works
New p53 related genes in human tumors: significant downregulation in colon and lung carcinomas
LLeonart, M. E., Vidal, F., Gallardo, D., Díaz-Fuertes, M., Rojo, F., Cuatrecasas, M., López-Vicente, L., Kondoh, H., Blanco, C., Carnero, A., et al. (2006) · Oncology Reports · doi:10.3892/or.16.3.603 · Cited by 99 · see citing works
ChromoHub: a data hub for navigators of chromatin-mediated signalling
Liu, L., Zhen, X. T., Denton, E., Marsden, B. D., & Schapira, M. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts340 · Cited by 95 · see citing works
Global histone acetylation levels: Prognostic relevance in patients with renal cell carcinoma
Mosashvilli, D., Kahl, P., Mertens, C., Holzapfel, S., Rogenhofer, S., Hauser, S., Büttner, R., von Ruecker, A., Müller, S. C., & Ellinger, J. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01717.x · Cited by 94 · see citing works
A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activationPreprint
Kamieniarz, K., Izzo, A., Dundr, M., Tropberger, P., Ozretić, L., Kirfel, J., Scheer, E., Tropel, P., Wiśniewski, J. R., Tora, L., et al. (2012) · Genes & Development · doi:10.1101/gad.182014.111 · Cited by 93 · see citing works
Self-citationLiu, X., & Marmorstein, R. (2007) · Genes & Development · doi:10.1101/gad.1590607 · Cited by 92 · see citing works
Singh, S. A., Isken, F., Agelopoulos, K., Klein, H., Thoennissen, N. H., Koehler, G., Hascher, A., Bäumer, N., Berdel, W. E., Thiede, C., et al. (2011) · Blood · doi:10.1182/blood-2011-06-358705 · Cited by 86 · see citing works
Xiao, X.-S., Cai, M.-Y., Chen, J.-W., Guan, X., Kung, H., Zeng, Y.-X., & Xie, D. (2011) · Chinese Journal of Cancer Research · doi:10.1007/s11670-011-0201-5 · Cited by 84 · see citing works
Prognostic impact of Skp2 and p27 in human breast cancer
Traub, F., Mengel, M., Lück, H. J., Kreipe, H. H., & von Wasielewski, R. (2006) · Breast Cancer Research and Treatment · doi:10.1007/s10549-006-9202-3 · Cited by 80 · see citing works
Rozman, M., Camós, M., Colomer, D., Villamor, N., Esteve, J., Costa, D., Carrió, A., Aymerich, M., Aguilar, J. L., Domingo, A., et al. (2004) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20022 · Cited by 79 · see citing works
HDAC modulation and cell death in the clinic
Dell’Aversana, C., Lepore, I., & Altucci, L. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.01.025 · Cited by 61 · see citing works
Varier, R. A., Swaminathan, V., Balasubramanyam, K., & Kundu, T. K. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.05.038 · Cited by 52 · see citing works
Hou, X., Li, Y., Luo, R., Fu, J., He, J., Zhang, L., & Yang, H.-X. (2012) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2012.02.180 · Cited by 52 · see citing works
Going global: Novel histone modifications in the globular domain of H3
Tropberger, P., & Schneider, R. (2010) · Epigenetics · doi:10.4161/epi.5.2.11075 · Cited by 46 · see citing works
Self-citationDiab, A. K., Zickl, L., Abdel-Wahab, O. I., Jhanwar, S. C., Gulam, M. A., Panageas, K. S., Patel, J. P., Jurcic, J. G., Maslak, P. G., Paietta, E. M., et al. (2012) · Leukemia Research · doi:10.1016/j.leukres.2012.08.025 · Cited by 33 · see citing works
Hobbs, C. A., Wei, G., DeFeo, K., Paul, B. A., Hayes, C. S., & Gilmour, S. K. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0359 · Cited by 32 · see citing works
Tuning acetylated chromatin with HAT inhibitors: A novel tool for therapy
Vernarecci, S., Tosi, F., & Filetici, P. (2010) · Epigenetics · doi:10.4161/epi.5.2.10942 · Cited by 18 · see citing works
Mathew, S., Head, D., Rubnitz, J. E., & Raimondi, S. C. (2000) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(200006)28:2 · Cited by 16 · see citing works
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Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
Cheng, Y., He, C., Wang, M., Ma, X., Mo, F., Yang, S., Han, J., & Wei, X. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0095-0 · Cited by 1,097 · see citing works
Histone Modifications and CancerPreprint
Audia, J. E., & Campbell, R. M. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019521 · Cited by 1,024 · see citing works
Towards targeting of shared mechanisms of cancer metastasis and therapy resistance
Weiß, F., Lauffenburger, D. A., & Friedl, P. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-021-00427-0 · Cited by 294 · see citing works
The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer
Spangle, J. M., Roberts, T. M., & Zhao, J. J. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.03.002 · Cited by 169 · see citing works
Mammalian DNA repair: HATs and HDACs make their mark through histone acetylation
Gong, F., & Miller, K. M. (2013) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2013.07.002 · Cited by 171 · see citing works
Epigenetic modifications: Key players in cancer heterogeneity and drug resistance
Sadida, H. Q., Abdulla, A., Marzooqi, S. A., Hashem, S., Macha, M. A., Akil, A. S. A.-S., & Bhat, A. A. (2024) · Translational Oncology · doi:10.1016/j.tranon.2023.101821 · Cited by 151 · see citing works
Acetylation Reader Proteins: Linking Acetylation Signaling to Genome Maintenance and Cancer
Gong, F., Chiu, L.-Y., & Miller, K. M. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006272 · Cited by 132 · see citing works
Zheng, Y., Thomas, P. M., & Kelleher, N. L. (2013) · Nature Communications · doi:10.1038/ncomms3203 · Cited by 115 · see citing works
Multigene signature for predicting prognosis of patients with 1p19q co-deletion diffuse glioma
Hu, X., Martínez-Ledesma, E., Zheng, S., Kim, H., Barthel, F. P., Jiang, T., Hess, K. R., & Verhaak, R. G. W. (2017) · Neuro-Oncology · doi:10.1093/neuonc/now285 · Cited by 114 · see citing works
Targeting post-translational histone modifying enzymes in glioblastoma
Kunadis, E., Lakiotaki, E., Korkolopoulou, P. A., & Piperi, C. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107721 · Cited by 111 · see citing works
The recent insights into the function of ACAT1: A possible anti-cancer therapeutic target
Goudarzi, A. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116592 · Cited by 101 · see citing works
Targeting p38 MAP kinase signaling in cancer through post-translational modifications
Zou, X., & Blank, M. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.10.008 · Cited by 102 · see citing works
Preserving genome integrity and function: the DNA damage response and histone modifications
Kim, J. J., Lee, S. Y., & Miller, K. M. (2019) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2019.1620676 · Cited by 95 · see citing works
A novel histone H4 variant H4G regulates rDNA transcription in breast cancer
Long, M., Sun, X., Shi, W., An, Y., Leung, S. T. C., Ding, D., Cheema, M. S., Macpherson, N. A., Nelson, C. J., Ausió, J., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz547 · Cited by 81 · see citing works
Acetylation and deacetylation in cancer stem-like cells
Liu, N., Li, S., Wu, N., & Cho, K. (2017) · Oncotarget · doi:10.18632/oncotarget.19167 · Cited by 81 · see citing works
Epigenetic Regulation of microRNAs in Cancer: Shortening the Distance from Bench to Bedside
Pajares, M. J., Alemany-Cosme, E., Goñi, S., Bandrés, E., Palanca-Ballester, C., & Sandoval, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147350 · Cited by 82 · see citing works
Small Molecules Targeting HATs, HDACs, and BRDs in Cancer Therapy
Wu, D., Qiu, Y., Jiao, Y., Qiu, Z., & Liu, D. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.560487 · Cited by 81 · see citing works
An efficient and multiple target transgenic RNAi technique with low toxicity in Drosophila
Qiao, H., Wang, F., Xu, R., Sun, J., Zhu, R., Mao, D., Ren, X., Wang, X., Jia, Y., Peng, P., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06537-y · Cited by 74 · see citing works
Identification of lysine isobutyrylation as a new histone modification mark
Zhu, Z., Han, Z. H., Halabelian, L., Yang, X., Ding, J., Zhang, N., Ngo, L., Song, J., Zeng, H., He, M., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa1176 · Cited by 74 · see citing works
Consiglio, M., Destefanis, M., Morena, D., Foglizzo, V., Forneris, M., Pescarmona, G., & Silvagno, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115816 · Cited by 74 · see citing works
Role of Flavonoids as Epigenetic Modulators in Cancer Prevention and Therapy
Fatima, N., Baqri, S. S. R., Bhattacharya, A., Koney, N. K., Husain, K. M., Abbas, A., & Ansari, R. A. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.758733 · Cited by 64 · see citing works
Functional Roles of Bromodomain Proteins in Cancer
Boyson, S. P., Gao, C., Quinn, K. M., Boyd, J. R., Paculová, H., Frietze, S. E., & Glass, K. C. (2021) · Cancers · doi:10.3390/cancers13143606 · Cited by 58 · see citing works
Beyond genetics: Exploring the role of epigenetic alterations in breast cancer
Prabhu, K. S., Sadida, H. Q., Kuttikrishnan, S., Junejo, K., Bhat, A. A., & Shahab Uddin, M. S. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155174 · Cited by 53 · see citing works
Regulation of epigenetic homeostasis in uveal melanoma and retinoblastoma
Chai, P., Jia, R., Li, Y., Zhou, C., Gu, X., Yang, L., Shi, H., Tian, H., Lin, H., Yu, J., et al. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.101030 · Cited by 52 · see citing works
New mechanism of LncRNA: In addition to act as a ceRNA
Zhang, J., Zhu, H., Li, L., Gao, Y., Yu, B., Ma, G., Jin, X., & Sun, Y. (2024) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.06.002 · Cited by 51 · see citing works
Acetylation of histone H3 in cancer progression and prognosis
Miziak, P., Baran, M., Borkiewicz, L., Trombik, T., & Stepulak, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252010982 · Cited by 49 · see citing works
Tracing the Origin of Cell-Free DNA Molecules through Tissue-Specific Epigenetic Signatures
Oberhofer, A., Bronkhorst, A. J., Uhlig, C., Ungerer, V., & Holdenrieder, S. (2022) · Diagnostics · doi:10.3390/diagnostics12081834 · Cited by 45 · see citing works
Bromodomain proteins: repairing DNA damage within chromatin
Chiu, L.-Y., Gong, F., & Miller, K. M. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0286 · Cited by 47 · see citing works
Oh, J. H., Lee, J., Kim, K. H., Kim, C. Y., Jeong, D. S., Cho, Y., Nam, K. T., & Kim, M. H. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.09.017 · Cited by 47 · see citing works
Ghosh, K. K., Chatterjee, B., Jayaprasad, A. G., & Kanade, S. R. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.10.058 · Cited by 45 · see citing works
Nonenzymatic Protein Acetylation Detected by NAPPA Protein Arrays
Olia, A. S., Barker, K., McCullough, C. E., Tang, H., Speicher, D. W., Qiu, J., LaBaer, J., & Marmorstein, R. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00342 · Cited by 44 · see citing works
Epigenetics of Most Aggressive Solid Tumors: Pathways, Targets and Treatments
Martínez‐Useros, J., Martin-Galan, M., Florez-Cespedes, M., & García‐Foncillas, J. (2021) · Cancers · doi:10.3390/cancers13133209 · Cited by 44 · see citing works
Hyperinsulinemia promotes aberrant histone acetylation in triple-negative breast cancer
Senapati, P., Kato, H., Lee, M., Leung, A., Thai, C., Sanchez, A., Gallagher, E. J., LeRoith, D., Seewaldt, V. L., Ann, D. K., et al. (2019) · Epigenetics & Chromatin · doi:10.1186/s13072-019-0290-9 · Cited by 42 · see citing works
The remodel of the “central dogma”: a metabolomics interaction perspective
dos Santos, G. C., Renovato‐Martins, M., & de Brito, N. M. (2021) · Metabolomics · doi:10.1007/s11306-021-01800-8 · Cited by 41 · see citing works
Féron, O. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.11.140 · Cited by 38 · see citing works
Szczepanek, J., & Tretyn, A. (2023) · Biomolecules · doi:10.3390/biom13111590 · Cited by 40 · see citing works
Shukla, H. D. (2017) · Proteomes · doi:10.3390/proteomes5040028 · Cited by 40 · see citing works
Paydar, P., Asadikaram, G., Nejad, H. Z., Akbari, H., Abolhassani, M., Moazed, V., Nematollahi, M. H., Ebrahimi, G., & Fallah, H. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28645 · Cited by 40 · see citing works
Impact of Histone Deacetylase Inhibitors on microRNA Expression and Cancer Therapy: A Review
Ali, S. R., Humphreys, K. J., McKinnon, R. A., & Michael, M. (2015) · Drug Development Research · doi:10.1002/ddr.21268 · Cited by 39 · see citing works
Ye, X., Yuan, L., Zhang, L., Zhao, J., Zhang, C., & Deng, H. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.12.5001 · Cited by 39 · see citing works
Ranganna, K., Selvam, C., Shivachar, A. C., & Yousefipour, Z. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218198 · Cited by 39 · see citing works
Kumar, V., Lakshman, P. K. C., Prasad, T. K., Manjunath, K., Bairy, S. G., Vasu, A. S., Ganavi, B., Jasti, S., & Kamariah, N. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e23864 · Cited by 40 · see citing works
Epigenetic Properties of Compounds Contained in Functional Foods Against Cancer
Casari, G., Romaldi, B., Scirè, A., Minnelli, C., Marzioni, D., Ferretti, G., & Armeni, T. (2024) · Biomolecules · doi:10.3390/biom15010015 · Cited by 37 · see citing works
Calcagno, D. Q., Wisnieski, F., Mota, E. R. D. S., de Sousa, S. B. M., da Silva, J. M. C., Leal, M. F., Gigek, C. O., Santos, L. C., Rasmussen, L. T., de Assumpção, P. P., et al. (2019) · Epigenomics · doi:10.2217/epi-2018-0081 · Cited by 36 · see citing works
The impact of CBP expression in estrogen receptor-positive breast cancer
Ramadan, W. S. H., Talaat, I. M., Hachim, M. Y., Lischka, A., Gemoll, T., & El‐Awady, R. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01060-2 · Cited by 36 · see citing works
Lobo, J., Henrique, R., & Jerónimo, C. (2018) · Cancers · doi:10.3390/cancers11010006 · Cited by 35 · see citing works
Pang, M. Y. H., Sun, X., Ausió, J., & Ishibashi, T. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29770 · Cited by 35 · see citing works
Chemical Catalysis Intervening to Histone Epigenetics
Nozaki, T., & Kanai, M. (2021) · Accounts of Chemical Research · doi:10.1021/acs.accounts.1c00144 · Cited by 34 · see citing works
Ong, B. X., Brunmeir, R., Zhang, Q., Xu, P., Idris, M., Liu, C., & Xu, F. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00095 · Cited by 33 · see citing works
Curcumin's prevention of inflammation-driven early gastric cancer and its molecular mechanism
Zhang, W., Cui, N., Ye, J., Yang, B., Sun, Y., & Kuang, H. (2022) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2021.11.003 · Cited by 31 · see citing works
Profiling of Epigenetic Features in Clinical Samples Reveals Novel Widespread Changes in Cancer
Noberini, R., Restellini, C., Savoia, E. O., Raimondi, F., Ghiani, L., Jodice, M. G., Bertalot, G., Bonizzi, G., Capra, M. C., Maffini, F. A., et al. (2019) · Cancers · doi:10.3390/cancers11050723 · Cited by 29 · see citing works
Targeting histone modifiers in bladder cancer therapy — preclinical and clinical evidence
Zhang, S., Lin, T., Xiong, X., Chen, C., Tan, P., & Wei, Q. (2024) · Nature Reviews Urology · doi:10.1038/s41585-024-00857-z · Cited by 30 · see citing works
Recent advances in biosensor for histone acetyltransferase detection
Chen, Y., Zhou, Y., & Yin, H. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112880 · Cited by 28 · see citing works
Hamajima, W., Fujimura, A., Fujiwara, Y., Yamatsugu, K., Kawashima, S. A., & Kanai, M. (2019) · ACS Chemical Biology · doi:10.1021/acschembio.9b00102 · Cited by 27 · see citing works
Epigenetic regulation of prostate cancer
Wang, R., & Liu, X. (2019) · Genes & Diseases · doi:10.1016/j.gendis.2019.10.018 · Cited by 27 · see citing works
Zhang, G., Huang, R., Zhao, H., Xia, Y., Huang, H., Qian, M., Fu, Y., & Cui, Y. (2023) · Genes and Immunity · doi:10.1038/s41435-023-00202-1 · Cited by 27 · see citing works
Gronkowska, K., & Robaszkiewicz, A. (2024) · Molecular Therapy Oncology · doi:10.1016/j.omton.2024.200871 · Cited by 26 · see citing works
The Role of Resveratrol in Cancer Management: From Monotherapy to Combination Regimens
Ribeiro, E., & Vale, N. (2024) · Targets · doi:10.3390/targets2040018 · Cited by 28 · see citing works
Pramodh, S., Raina, R., Hussain, A., Bagabir, S. A., Haque, S., Raza, S. T., Ajmal, M. R., Behl, S., & Bhagavatula, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23074067 · Cited by 26 · see citing works
Epigenetic regulation of RTK signaling
Spangle, J. M., & Roberts, T. M. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1546-0 · Cited by 26 · see citing works
Unlocking the epigenetic code: new insights into triple-negative breast cancer
Mahendran, G., Shangaradas, A. D., Romero-Moreno, R., Dona, N. W., Sarasija, S. H. G. S., Perera, S., & Silva, G. N. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1499950 · Cited by 25 · see citing works
Singh, A. A., Mandoli, A., Prange, K. H. M., Laakso, M., & Martens, J. H. A. (2016) · Oncotarget · doi:10.18632/oncotarget.14150 · Cited by 26 · see citing works
Cancer plasticity: Investigating the causes for this agility
Saha, S., Pradhan, N., Neha, B., Mahadevappa, R., Minocha, S., & Kumar, S. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.12.005 · Cited by 25 · see citing works
Rembiałkowska, N., Rekiel, K., Urbanowicz, P., Mamala, M. B., Marczuk, K. M., Wojtaszek, M., Żywica, M., Radzevičiūtė-Valčiukė, E., Novickij, V., & Kulbacka, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136531 · Cited by 24 · see citing works
Recent Advances in the Development of CBP/p300 Bromodomain Inhibitors
Xiong, Y., Zhang, M., & Li, Y. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867326666190731141055 · Cited by 23 · see citing works
Synergistic targeting strategies for prostate cancer
Li, X., Han, Z., & Ai, J. (2025) · Nature Reviews Urology · doi:10.1038/s41585-025-01042-6 · Cited by 21 · see citing works
CDKN1A histone acetylation and gene expression relationship in gastric adenocarcinomas
Wisnieski, F., Calcagno, D. Q., Leal, M. F., Santos, L. C., Gigek, C. O., Chen, E., Demachki, S., Artigiani, R., de Assumpção, P. P., Lourenço, L. G., et al. (2015) · Clinical and Experimental Medicine · doi:10.1007/s10238-015-0400-3 · Cited by 21 · see citing works
Paro, R., Grossniklaus, U., Santoro, R., & Wutz, A. (2021) · Learning materials in biosciences · doi:10.1007/978-3-030-68670-3 · Cited by 21 · see citing works
Myasoedova, V. A., Sukhorukov, V. N., Grechko, A. V., Zhang, D., Romanenko, E. B., Orekhov, V., & Orekhov, A. N. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190405144026 · Cited by 20 · see citing works
Alterations of Histone Modifications in Cancer
Hosseini, A., & Minucci, S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812215-0.00006-6 · Cited by 20 · see citing works
Histone acetyltransferases as promising therapeutic targets in glioblastoma resistance
Pathikonda, S., Amirmahani, F., Mathew, D., & Muthukrishnan, S. D. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217269 · Cited by 19 · see citing works
Targeting epigenetic regulation for cancer therapy using small molecule inhibitors
Kumar, A., Emdad, L., Fisher, P. B., & Das, S. K. (2023) · Advances in cancer research · doi:10.1016/bs.acr.2023.01.001 · Cited by 19 · see citing works
Genomic landscape and gene expression profiles of feline oral squamous cell carcinoma
Rodney, A. R., Skidmore, Z. L., Grenier, J. K., Griffith, O. L., Miller, A. D., Chu, S., Ahmed, F., Bryan, J. N., Peralta, S., & Warren, W. C. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1079019 · Cited by 19 · see citing works
Kuo, Y., Henry, R. A., & Andrews, A. J. (2014) · Methods · doi:10.1016/j.ymeth.2014.08.003 · Cited by 19 · see citing works
Targeting KAT6A/B as a New Therapeutic Strategy for Cancer Therapy
Zheng, T., Wang, S., Liu, W., & Lu, Y. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02613 · Cited by 18 · see citing works
An Assessment on Ethanol-Blended Gasoline/Diesel Fuels on Cancer Risk and Mortality
Mueller, S., Dennison, G., & Liu, S. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18136930 · Cited by 18 · see citing works
Histone lysine modifying enzymes and their critical roles in DNA double-strand break repair
Zhang, J., Lu, X., MoghaddamKohi, S., Shi, L., Xu, X., & Zhu, W. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103206 · Cited by 18 · see citing works
RNAi screening identifies KAT8 as a key molecule important for cancer cell survival.
Zhang, S., Liu, X., Zhang, Y., Cheng, Y., & Li, Y. (2013) · Europe PMC (PubMed Central) · Cited by 18 · see citing works
Targeting apoptosis in clear cell renal cell carcinoma
Kowalewski, A., Borowczak, J., Maniewski, M., Gostomczyk, K., Grzanka, D., & Szylberg, Ł. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116805 · Cited by 18 · see citing works
Aflatoxin B1 induced multiple epigenetic modulators in human epithelial cell lines
Soni, P., Ghufran, M. S., & Kanade, S. R. (2018) · Toxicon · doi:10.1016/j.toxicon.2018.07.011 · Cited by 17 · see citing works
HAT1: Landscape of Biological Function and Role in Cancer
Capone, V., Torre, L. D., Carannante, D., Babaei, M., Altucci, L., Benedetti, R., & Carafa, V. (2023) · Cells · doi:10.3390/cells12071075 · Cited by 17 · see citing works
Romhányi, D., Szabó, K., Kemény, L. V., & Groma, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914551 · Cited by 16 · see citing works
Najem, S. A., Khawaja, G., Hodroj, M. H., Babikian, P., & Rizk, S. E. (2019) · Cells · doi:10.3390/cells8121480 · Cited by 16 · see citing works
Single-Cell Epigenomics in Cancer: Charting a Course to Clinical Impact
Bond, D. R., Uddipto, K., Enjeti, A. K., & Lee, H. J. (2020) · Epigenomics · doi:10.2217/epi-2020-0046 · Cited by 15 · see citing works
The dysregulation of lncRNAs by epigenetic factors in human pathologies
Zhang, Y., Wang, X., Zhang, C., & Yi, H. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103664 · Cited by 14 · see citing works
Structural Variants as a Basis for Targeted Therapies in Hematological Malignancies
Schütte, J., Reusch, J., Khandanpour, C., & Eisfeld, C. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00839 · Cited by 14 · see citing works
Bioorthogonal Reporters for Detecting and Profiling Protein Acetylation and Acylation
Song, J., & Zheng, Y. G. (2019) · SLAS DISCOVERY · doi:10.1177/2472555219887144 · Cited by 14 · see citing works
Holubeková, V., Kolková, Z., Kašubová, I., Samec, M., Mazuráková, A., Koklesová, L., Kubatka, P., Rokos, T., Kozubík, E., Biringer, K., et al. (2022) · BioMolecular Concepts · doi:10.1515/bmc-2022-0005 · Cited by 13 · see citing works
dos Santos, G. C., da Silva, A. P., Feldman, L., Ventura, G. M., Vassetzky, Y. S., & Gallo, C. V. D. M. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25003 · Cited by 13 · see citing works
Using Histone Deacetylase Inhibitors to Analyze the Relevance of HDACs for Translation
Hutt, D. M., Roth, D., Marchal, C., & Bouchecareilh, M. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6527-4_6 · Cited by 13 · see citing works
Basic science: Epigenetic programming and the respiratory system
Durham, A. L., & Adcock, I. M. (2013) · Breathe · doi:10.1183/20734735.000413 · Cited by 12 · see citing works
Lim, J. Y., & Kwan, H. Y. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.80788 · Cited by 12 · see citing works
Patent Spotlight: small-molecule Lysine Acetyltransferase Inhibitors (KATi)
Brown, J. A. L. (2020) · Pharmaceutical Patent Analyst · doi:10.4155/ppa-2019-0025 · Cited by 12 · see citing works
Human papillomavirus-mediated cervical cancer: epigenetic interplay and clinical implications
Sisodiya, S., Singh, P., Joshi, T., Aftab, M., Firdausi, N., Khan, A., Mishra, N., Khan, N. J., Tanwar, P., Gupta, V., et al. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1633283 · Cited by 11 · see citing works
Sein, H., Reinmets, K., Peil, K., Kristjuhan, K., Värv, S., & Kristjuhan, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-21110-9 · Cited by 11 · see citing works
Xie, L., Wu, S., He, R. X., Li, S., Lai, X., & Wang, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.901662 · Cited by 11 · see citing works
The Expression of Histone Acetyltransferase KAT6A in Non-small Cell Lung Cancer
Partyńska, A., Piotrowska, A., Pawełczyk, K., Rzechonek, A., Ratajczak‐Wielgomas, K., Podhorska‐Okołów, M., & Dzięgiel, P. (2022) · Anticancer Research · doi:10.21873/anticanres.16080 · Cited by 11 · see citing works
The landscape of histone acetylation involved in epithelial-mesenchymal transition in lung cancer
Liu, Z., Zhang, L., Ma, W., & Wang, B. (2013) · Journal of Cancer Research and Therapeutics · doi:10.4103/0973-1482.119113 · Cited by 10 · see citing works
A Mini Review on Post-Translational Histone Modifications
SÜT, B. B. (2016) · MOJ Cell Science & Report · doi:10.15406/mojcsr.2016.03.00047 · Cited by 10 · see citing works
Montalbano, S., Raboni, S., Sidoli, S., Mozzarelli, A., Bettati, S., & Buschini, A. (2023) · Cancers · doi:10.3390/cancers15020527 · Cited by 9 · see citing works
- Authors
- Di Cerbo, V., & Schneider, R.
- Affiliations
- The Gurdon Institute (GB)
- ORCID
- Schneider, R.
- Venue
- Briefings in Functional Genomics
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-01-15
- Volume
- 12
- Issue
- 3
- Pages
- 231-243
- ISSN
- 2041-2647 (ISSN-L)
- 2041-2649
- 2041-2657
- OpenAlex
- W2146329289
- Cited by
- 178
- References
- 96
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 21 · 2023: 21 · 2022: 17 · 2021: 19 · 2020: 15 · 2019: 23 · 2018: 6 · 2017: 10 · 2016: 8 · 2015: 7 · 2014: 5 · 2013: 5
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Briefings in Functional Genomics (publishedVersion)
- PubMed (publishedVersion)
- Site cant be reached (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB-746)
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- histone acetyltransferase, histone acetylation, cancer epigenetics, histone deacetylase inhibitors, bromodomain inhibitors, epigenetic therapy, predictive biomarkers, patient survival
- MeSH terms
- Acetylation, Histones, Humans, Neoplasms, Epigenesis, Genetic, Histone Acetyltransferases
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