Cited by 178Histone Deacetylase Inhibitors ResearchEpigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cancers with wrong HATs: the impact of acetylation

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Di Cerbo, V., Schneider, R.·2013·Briefings in Functional Genomics

Abstract

Lysine N-ε-acetylation is a post-translational modification that regulates the function of histone and non-histone proteins. In several malignancies, histone acetyltransferase (HAT) activities are disturbed as a consequence of various genetic or epigenetic alterations. In particular, HATs can function as tumor suppressors, helping cells control cellular proliferation and cell cycle, and also as oncogenes, because abnormal acetylation can activate malignant proteins and contribute to cancer. An impaired acetylation profile can be indicative of a pathological process, and thus evaluation of histone acetylation could be used as a predictive index of patient survival or therapy outcome. Therefore, epigenetic therapy might be a very effective strategy to defeat cancer. With the use of histone deacetylase inhibitors and acetylation modulators (e.g. HAT inhibitors, bromodomain inhibitors), we are paving the way for a future epigenetic drug control of human diseases.

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Crossref · 10.1093/bfgp/els065

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Authors
Di Cerbo, V., & Schneider, R.
Affiliations
The Gurdon Institute (GB)
Venue
Briefings in Functional Genomics
Published
2013-01-15
Volume
12
Issue
3
Pages
231-243
ISSN
  • 2041-2647 (ISSN-L)
  • 2041-2649
  • 2041-2657
OpenAlex
W2146329289
Cited by
178
References
96
Citations by year
2026: 10 · 2025: 11 · 2024: 21 · 2023: 21 · 2022: 17 · 2021: 19 · 2020: 15 · 2019: 23 · 2018: 6 · 2017: 10 · 2016: 8 · 2015: 7 · 2014: 5 · 2013: 5
FWCI
0.78
Type
journal article
Language
en
Open access
Locations
  • Briefings in Functional Genomics (publishedVersion)
  • PubMed (publishedVersion)
  • Site cant be reached (submittedVersion)
Funders
  • Deutsche Forschungsgemeinschaft (SFB-746)
  • Institut National de la Santé et de la Recherche Médicale
  • Centre National de la Recherche Scientifique
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
histone acetyltransferase, histone acetylation, cancer epigenetics, histone deacetylase inhibitors, bromodomain inhibitors, epigenetic therapy, predictive biomarkers, patient survival
MeSH terms
Acetylation, Histones, Humans, Neoplasms, Epigenesis, Genetic, Histone Acetyltransferases

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