Machine learning in bioinformatics
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This article reviews machine learning methods for bioinformatics. It presents modelling methods, such as supervised classification, clustering and probabilistic graphical models for knowledge discovery, as well as deterministic and stochastic heuristics for optimization. Applications in genomics, proteomics, systems biology, evolution and text mining are also shown.
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Machine learning methods have been widely used in bioinformatics and computational and systems biology.
“Machine learning methods have been widely used in bioinformatics [218,219] and computational and systems biology [220,221].”
From Reverse engineering and identification in systems biology: strategies, perspectives and challenges (2014) · cites this paper as [219]
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- Authors
- Larrañaga, P., Calvo, B., Santana, R., Bielza, C., Galdiano, J., Inza, I., Lozano, J. A., Armañanzas, R., Santafé, G., Pérez, A., & Robles, V.
- Affiliations
- University of the Basque Country (ES)
- Universidad Complutense de Madrid (ES)
- Rubén Armañanzas received his MS in Computer Science from the University of the Basque Country in 2004. At present, he is a PhD student and member of the Intelligent Systems Group. His research interests include feature selection, computational biology and bioinformatics.
- Universidad Politécnica de Madrid (ES)
- Pedro Larrañaga is Professor of Computer Science and Artificial Intelligence at the University of the Basque Country. He received MS degree in mathematics from the University of Valladolid in 1981, and PhD in computer science from the University of the Basque Country in 1995. He has published over 40 refereed journal papers. His main research interests are in the areas of evolutionary computation
- ORCID
- Venue
- Briefings in Bioinformatics
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-03-01
- Volume
- 7
- Issue
- 1
- Pages
- 86-112
- ISSN
- 1467-5463 (ISSN-L)
- OpenAlex
- W2098740506
- Cited by
- 867
- References
- 285
- Citations by year
- 2026: 24 · 2025: 31 · 2024: 39 · 2023: 70 · 2022: 78 · 2021: 68 · 2020: 84 · 2019: 67 · 2018: 41 · 2017: 41 · 2016: 40 · 2015: 37 · 2014: 39 · 2013: 45 · 2012: 31
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Briefings in Bioinformatics (publishedVersion)
- PubMed (publishedVersion)
- UPM Digital Archive (Technical University of Madrid) (submittedVersion, cc-by-nc-nd)
- Hispana (submittedVersion, cc-by-nc-nd)
- Funders
- Eusko Jaurlaritza (TIN2005-03824)
- Euskal Herriko Unibertsitatea
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Machine Learning in Bioinformatics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Keywords
- machine learning, bioinformatics, supervised classification, clustering, probabilistic graphical models, knowledge discovery, optimization heuristics, genomics, proteomics, systems biology, evolution, text mining
- MeSH terms
- Artificial Intelligence, Models, Theoretical, Computational Biology, Genomics, Proteomics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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