The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Evidence that microRNA precursors, unlike other non-coding RNAs, have lower folding free energies than random sequences
Abstract
Motivation: Most non-coding RNAs are characterized by a specific secondary and tertiary structure that determines their function. Here, we investigate the folding energy of the secondary structure of non-coding RNA sequences, such as microRNA precursors, transfer RNAs and ribosomal RNAs in several eukaryotic taxa. Statistical biases are assessed by a randomization test, in which the predicted minimum free energy of folding is compared with values obtained for structures inferred from randomly shuffling the original sequences. Results: In contrast with transfer RNAs and ribosomal RNAs, the majority of the microRNA sequences clearly exhibit a folding free energy that is considerably lower than that for shuffled sequences, indicating a high tendency in the sequence towards a stable secondary structure. A possible usage of this statistical test in the framework of the detection of genuine miRNA sequences is discussed. Availability: The dataset, software and additional data files are freely available as supplementary information on our Website. Supplementary information: http://www.psb.ugent.be/bioinformatics/
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The microRNAs of Caenorhabditis elegans
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miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades
Friedländer, M. R., Mackowiak, S. D., Li, N., Chen, W., & Rajewsky, N. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr688 · Cited by 3,207
Principles of MicroRNA–Target Recognition
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Phylogenetic Shadowing and Computational Identification of Human microRNA Genes
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Fast and reliable prediction of noncoding RNAs
Washietl, S., Hofacker, I. L., & Stadler, P. F. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409169102 · Cited by 665
Metadata
- Authors
- Bonnet, E., Wuyts, J., Rouzé, P., & Van de Peer, Y.
- Venue
- Bioinformatics
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-06-23
- Volume
- 20
- Issue
- 17
- Pages
- 2911-2917
- ISSN
- 1367-4803 (ISSN-L)
- 1367-4811
- OpenAlex
- W2152327613
- Cited by
- 550
- References
- 7
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bonnet, E., Wuyts, J., Rouzé, P., & Van de Peer, Y. (2004). Evidence that microRNA precursors, unlike other non-coding RNAs, have lower folding free energies than random sequences. Bioinformatics. https://doi.org/10.1093/bioinformatics/bth374
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