Molecular signatures database (MSigDB) 3.0

Liberzon, Arthur, Subramanian, Aravind, Pinchback, Reid, Thorvaldsdóttir, Helga, Tamayo, Pablo, Mesirov, Jill P.·2011·Bioinformatics

DOI 10.1093/bioinformatics/btr260

Cited by (1,039)

Items 701–800 of 1,039

Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity
Kay Hänggi, Jie Li, Achintyan Gangadharan, Xiaoxian Liu, Daiana Pamela Celias, Olabisi Osunmakinde, Aysenur Keske, Joshua Davis, Faiz F. Ahmad, Auriane Giron et al. · 2024 · Cancer Cell
Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes
Tonje Husby Haukaas, Leslie R. Euceda, Guro Fanneløb Giskeødegård, Santosh Lamichhane, Marit Krohn, Sandra Jernström, Miriam R. R. Aure, Ole Christian Lingjærde, Ellen Schlichting, Øystein Garred et al. · 2016 · Cancer & Metabolism
Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions
Lerma-Martin, Celia, Badia-i-Mompel, Pau, Ramirez Flores, Ricardo O., Sekol, Patricia, Schäfer, Philipp S. L., Riedl, Christian J., Hofmann, Annika, Thäwel, Thomas, Wünnemann, Florian, Ibarra-Arellano, Miguel A. et al. · 2024 · Nature Neuroscience
Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese
Ruijuan Zheng, Zhiqiang Li, Fusheng He, Haipeng Liu, Jianhua Chen, Jiayu Chen, Xuefeng Xie, Juan Zhou, Hao Chen, Xiangyang Wu et al. · 2018 · Nature Communications
Blood–brain barrier opening by intracarotid artery hyperosmolar mannitol induces sterile inflammatory and innate immune responses
Scott Robert Burks, Cymon N. Kersch, Jaclyn A. Witko, Michael A. Pagel, Maggie Sundby, Leslie L. Muldoon, Edward A. Neuwelt, Joseph Alan Frank · 2021 · Proceedings of the National Academy of Sciences
A global overview of genetically interpretable multimorbidities among common diseases in the UK Biobank
Guiying Dong, Jianfeng Feng, Fengzhu Sun, Jingqi Chen, Xing‐Ming Zhao · 2021 · Genome Medicine
Immunosuppressive Traits of the Hybrid Epithelial/Mesenchymal Phenotype
Sarthak Sahoo, Sonali Priyadarshini Nayak, Kishore Hari, Prithu Purkait, Susmita Mandal, Akash Kishore, Herbert Levine, Mohit Kumar Jolly · 2021 · Frontiers in Immunology
Multivariate genomic analysis of 5 million people elucidates the genetic architecture of shared components of the metabolic syndrome
Sanghyeon Park, Soyeon Kim, Beomsu Kim, Dan Say Kim, Jaeyoung Kim, Yeeun Ahn, Hyejin Kim, Minku Song, Injeong Shim, Sang‐Hyuk Jung et al. · 2024 · Nature Genetics
QUBIC2: a novel and robust biclustering algorithm for analyses and interpretation of large-scale RNA-Seq data
Juan Xie, Anjun Ma, Yu Zhang, Bingqiang Liu, Sha Cao, Cankun Wang, Jennifer Xu, Chi Zhang, Qin Ma · 2019 · Bioinformatics
Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression
Elena Illica Magrini, Sabrina Di Marco, Sarah N. Mapelli, Chiara Perucchini, Fabio Pasqualini, Alessia Donato, Maria de la Luz Guevara Lopez, Roberta Carriero, Andrea Ponzetta, Piergiuseppe Colombo et al. · 2021 · Nature Cancer
Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy
Bradley N. Mills, Haoming Qiu, Michael G. Drage, Chunmo Chen, Jocelyn S. Mathew, Jesse Garrett-Larsen, Jian Ye, Taylor Paige Uccello, Joseph D. Murphy, Brian A. Belt et al. · 2021 · Clinical Cancer Research
Oxytocin receptor expression patterns in the human brain across development
Jaroslav Rokicki, Tobias Kaufmann, Ann‐Marie G. de Lange, Dennis van der Meer, Shahram Bahrami, Alina M. Sartorius, Unn Kristin Haukvik, Nils Eiel Steen, Emanuel Schwarz, Dan Joseph Stein et al. · 2022 · Neuropsychopharmacology
Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model
Sameer Aryal, Kevin Bonanno, Bryan J. Song, D.R. Mani, Hasmik Keshishian, Steven A. Carr, Morgan Sheng, Borislav Dejanovic · 2023 · Cell Reports
ATR inhibition activates cancer cell cGAS/STING-interferon signaling and promotes antitumor immunity in small-cell lung cancer
Hirokazu Taniguchi, Subhamoy Chakraborty, Nobuyuki Takahashi, Avisek Banerjee, Rebecca Caeser, Yingqian Ada Zhan, Sam E. Tischfield, Andrew T. Chow, Evelyn M. Nguyen, Àlvaro Quintanal-Villalonga et al. · 2024 · Science Advances
Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator
Anna M. Puzio‐Kuter, Lizhong Xu, Mary Kate McBrayer, Romyr Dominique, Hongju H. Li, Bruce J. Fahr, Alyssa M. Brown, Amy E. Wiebesiek, Brandon M. Russo, Chris L. Mulligan et al. · 2025 · Cancer Discovery
Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11–JAK/STAT3 pathway
Saara Ollila, Eva Domènech‐Moreno, Kaisa Laajanen, Iris P.L. Wong, Sushil Tripathi, Nalle Pentinmikko, Yajing Gao, Yan Yan, Elina H. Niemelä, Timothy Cragin Wang et al. · 2017 · Journal of Clinical Investigation
Radiogenomics of breast cancer using dynamic contrast enhanced MRI and gene expression profiling
Albert C. Yeh, Hui Li, Yitan Zhu, Jing Zhang, Galina F. Khramtsova, Karen Drukker, Alexandra V. Edwards, Stephanie M. McGregor, Toshio F. Yoshimatsu, Yonglan Zheng et al. · 2019 · Cancer Imaging
CXCL16 positively correlated with M2-macrophage infiltration, enhanced angiogenesis, and poor prognosis in thyroid cancer
Min Joo Kim, Hyun Jin Sun, Young Shin Song, Seong‐Keun Yoo, Young A Kim, Jeong‐Sun Seo, Young Joo Park, Sun Wook Cho · 2019 · Scientific Reports
The Clinical Kinase Index: A Method to Prioritize Understudied Kinases as Drug Targets for the Treatment of Cancer
Derek J. Essegian, Rimpi Khurana, Vasileios Stathias, Stephan C. Schürer · 2020 · Cell Reports Medicine
Explainable drug sensitivity prediction through cancer pathway enrichment
Yi-Ching Tang, Assaf Gottlieb · 2021 · Scientific Reports
Patient similarity network of newly diagnosed multiple myeloma identifies patient subgroups with distinct genetic features and clinical implications
Sherry Bhalla, David T. Melnekoff, Adolfo Aleman, Violetta V. Leshchenko, Paula Restrepo, Jonathan J. Keats, Kenan Onel, Jeffrey R. Sawyer, Deepu Madduri, Joshua Ryan Richter et al. · 2021 · Science Advances
The SETDB1–TRIM28 Complex Suppresses Antitumor Immunity
Jianhuang Lin, Dajiang Guo, Heng Liu, Wei Zhou, Chen Wang, Iris I. Müller, Andrew V. Kossenkov, Ronny Drapkin, Benjamin Guy Bitler, Kristian Helin et al. · 2021 · Cancer Immunology Research
Temporal dynamics of HCMV gene expression in lytic and latent infections
Batsheva Rozman, Aharon Nachshon, Roi Levi Samia, Michael Lavi, Michal Schwartz, Noam Stern‐Ginossar · 2022 · Cell Reports
Signatures of EMT, immunosuppression, and inflammation in primary and recurrent human cutaneous squamous cell carcinoma at single-cell resolution
Xin Li, Shuang Zhao, Xiaohui Bian, Lining Zhang, Lixia Lu, Shiyao Pei, Liang Dong, Wensheng Shi, Lingjuan Huang, Xiyuan Zhang et al. · 2022 · Theranostics
A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo
Atsunori Kaneshige, Longchuan Bai, Mi Wang, Donna McEachern, Jennifer L. Meagher, Renqi Xu, Yu Wang, Wei Jiang, Hoda Metwally, Paul D. Kirchhoff et al. · 2023 · Nature Chemical Biology
Single-cell sequencing reveals the landscape of the human brain metastatic microenvironment
Qianqian Song, Jimmy Ruiz, Fei Xing, Hui‐Wen Lo, Lou Craddock, Ashok Pullikuth, Lance David Miller, Michael Henry Soike, Stacey S. O’Neill, Kounosuke Watabe et al. · 2023 · Communications Biology
Suppression of Activated FOXO Transcription Factors in the Heart Prolongs Survival in a Mouse Model of Laminopathies
Gaelle E Auguste, Priyatansh Gurha, Raffaella Lombardi, Cristian Coarfa, James T. Willerson, Ali J. Marian · 2018 · Circulation Research
FET family fusion oncoproteins target the SWI/SNF chromatin remodeling complex
Malin Lindén, Christer Thomsen, Pernilla Grundevik, Emma Jonasson, Daniel Andersson, Rikard Runnberg, Soheila Dolatabadi, Christoffer Vannas, Manuel Luna Santamaría, Henrik Fagman et al. · 2019 · EMBO Reports
The core transcriptome of mammalian placentas and the divergence of expression with placental shape
Don L Armstrong, Michael R. McGowen, Amy L. Weckle, Priyadarshini Pantham, Jason Caravas, Dalen Agnew, Kurt Benirschke, Sue Savage‐Rumbaugh, Eviatar Nevo, Chong J. Kim et al. · 2017 · Placenta
Repeated clinical malaria episodes are associated with modification of the immune system in children
Yaw Bediako, Rhys Adams, Adam James Reid, John Joseph Valletta, Francis Maina Ndungu, Jan Sodenkamp, Jedidah K. Mwacharo, Joyce Mwongeli Ngoi, Domtila Kimani, Oscar K. Kai et al. · 2019 · BMC Medicine
Wnt/β-catenin signaling is critical for regenerative potential of distal lung epithelial progenitor cells in homeostasis and emphysema
Yan Hu, John-Poul Ng-Blichfeldt, Chiharu Ota, Chiara Ciminieri, Wenhua Ren, Pieter Sicco Hiemstra, Jan N Stolk, Reinoud Gosens, Mélanie Königshoff · 2020 · Stem Cells
Genome-wide association studies of antidepressant class response and treatment-resistant depression
Qingqin S. Li, Chao Tian, David A. Hinds, Michelle Agee, Babak Alipanahi, Adam Auton, Robert K. Bell, Katarzyna Bryc, Sarah L. Elson, Pierre Fontanillas et al. · 2020 · Translational Psychiatry
Dynamics of primitive streak regression controls the fate of neuromesodermal progenitors in the chicken embryo
Charlène Guillot, Yannis Djeffal, Arthur Michaut, Brian A. Rabe, Olivier Pourquié · 2021 · eLife
Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination
Yu Gao, Curtis Cai, David Wullimann, Julia Niessl, Olga Rivera‐Ballesteros, Puran Chen, Joshua Lange, Angélica Cuapio, Ola Blennow, Lotta Hansson et al. · 2022 · Immunity
Tumor-infiltrated activated B cells suppress liver metastasis of colorectal cancers
Yuqiu Xu, Zhuang Wei, Mei Feng, Dexiang Zhu, Shenglin Mei, Zhongen Wu, Qingyang Feng, Wenju Chang, Meiling Ji, Chenglong Liu et al. · 2022 · Cell Reports
ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells
David Gallego‐Ortega, Anita Ledger, Daniel Lee Roden, Andrew M. K. Law, Astrid Magenau, Zoya Kikhtyak, Christina Cho, Stephanie L. Allerdice, Heather J Lee, Fátima Valdés‐Mora et al. · 2015 · PLoS Biology
Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease
Wang, Zixi, Zhu, Shijia, Jia, Yuemeng, Wang, Yunguan, Kubota, Naoto, Fujiwara, Naoto, Gordillo, Ruth, Lewis, Cheryl, Zhu, Min, Sharma, Tripti et al. · 2023 · Cell
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia
Shade, Lincoln M. P., Katsumata, Yuriko, Abner, Erin L., Aung, Khine Zin, Claas, Steven A., Qiao, Qi, Heberle, Bernardo Aguzzoli, Brandon, J. Anthony, Page, Madeline L., Hohman, Timothy J. et al. · 2024 · Nature Genetics
Unique metabolomic signature associated with hepatorenal dysfunction and mortality in cirrhosis
Ayse L. Mindikoglu, Antone R. Opekun, Nagireddy Putluri, Sridevi Devaraj, David Sheikh‐Hamad, John Moore Vierling, John A. Goss, Abbas A. Rana, Gagan Sood, Prasun K. Jalal et al. · 2017 · Translational research
Transcriptomic Differences between Primary Colorectal Adenocarcinomas and Distant Metastases Reveal Metastatic Colorectal Cancer Subtypes
Yasmin Kamal, Stephanie L. Schmit, Hannah J. Hoehn, Christopher Ian Amos, Hildreth Robert Frost · 2019 · Cancer Research
Innate immune evasion revealed in a colorectal zebrafish xenograft model
Vanda Póvoa, Cátia Rebelo de Almeida, Mariana Maia-Gil, Daniel Sobral, Micaela Domingues, Mayra Fernanda Martínez-López, Miguel de Almeida Fuzeta, Carlos Silva, Ana Rita Grosso, Rita Fior · 2021 · Nature Communications
DeepFeature: feature selection in nonimage data using convolutional neural network
Alok K. Sharma, Artem Lysenko, Keith A. Boroevich, Edwin Vans, Tatsuhiko Tsunoda · 2021 · Briefings in Bioinformatics
Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study
Cristiana Cruceanu, Leander Dony, Anthi C. Krontira, David S. Fischer, Simone Roeh, Rossella Di Giaimo, Christina Kyrousi, Lea Kaspar, Janine Arloth, Darina Czamara et al. · 2021 · American Journal of Psychiatry
Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer
Dongqing Huang, Shrabanti Chowdhury, Hong Wang, Sara R. Savage, Richard G. Ivey, Jacob J. Kennedy, Jeffrey R. Whiteaker, Chenwei Lin, Xiaonan Hou, Ann L. Oberg et al. · 2021 · Cell Reports Medicine
Single-cell analysis and functional characterization uncover the stem cell hierarchies and developmental origins of rhabdomyosarcoma
Yun Wei, Qian Qin, Chuan Yan, Madeline N. Hayes, Sara P. Garcia, Haibin Xi, Daniel Do, Alexander Jin, Tiffany C.Y. Eng, Karin M. McCarthy et al. · 2022 · Nature Cancer
Neuroimmune transcriptome changes in patient brains of psychiatric and neurological disorders
Yu Chen, Rujia Dai, Longfei Tang, Tatiana Mikhailova, Qiuman Liang, Miao Li, Jiaqi Zhou, Richard F. Kopp, Cynthia Shannon Weickert, Chao Chen et al. · 2022 · Molecular Psychiatry
Granzyme K+CD8+ T cells interact with fibroblasts to promote neutrophilic inflammation in nasal polyps
Cuilian Guo, Chongshu Wang, Zhichao Wang, Feifan Liu, Lin Liu, Yang Yang, Xia Li, Bei Guo, Ruo-Yu Lu, Bo Liao et al. · 2024 · Nature Communications
Gene set analysis approaches for RNA-seq data: performance evaluation and application guideline
Yasir Rahmatallah, Frank Emmert‐Streib, Galina V. Glazko · 2015 · Briefings in Bioinformatics
Primary Cell Culture of Live Neurosurgically Resected Aged Adult Human Brain Cells and Single Cell Transcriptomics
Jennifer M. Spaethling, Young-Ji Na, Jaehee Lee, Alexandra V. Ulyanova, Gordon H. Baltuch, Thomas J. Bell, Steven S. Brem, H. Isaac Chen, Hannah Dueck, Stephen A. Fisher et al. · 2017 · Cell Reports
Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer
Anna Trigos, Richard B. Pearson, Anthony T. Papenfuss, David L. Goode · 2019 · eLife
Network embedding: Taxonomies, frameworks and applications
Mingliang Hou, Jing Fei Ren, Da Zhang, Xiangjie Kong, Dongyu Zhang, Feng Xia · 2020 · Computer Science Review
Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers
Joseph Rosenbluh, Johnathan Mercer, Yashaswi Shrestha, Rachel Oliver, Pablo Tamayo, John G. Doench, Itay Tirosh, Federica Piccioni, Ella Hartenian, Heiko Horn et al. · 2016 · Cell Systems
CD161 contributes to prenatal immune suppression of IFN-γ–producing PLZF+ T cells
Joanna Halkias, Elze Rackaityte, Sara L. Hillman, Dvir Aran, Ventura F. Mendoza, Lucy R. Marshall, Tippi C. MacKenzie, Trevor D. Burt · 2019 · Journal of Clinical Investigation
Novel immune signatures associated with dysplastic naevi and primary cutaneous melanoma in human skin
Bernice Y. Yan, Sandra Garcet, Nicholas Gulati, Felix Kiecker, Judilyn Fuentes‐Duculan, Patricia Gilleaudeau, Mary M Sullivan-Whalen, Avner Shemer, Hiroshi Mitsui, James G. Krueger · 2018 · Experimental Dermatology
STAT3‐dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer
Monika Oberhuber, Matteo Pecoraro, Mate Rusz, Georg Oberhuber, Maritta Wieselberg, Peter Haslinger, Elisabeth Gurnhofer, Michaela Schlederer, Tanja Limberger, Sabine Lagger et al. · 2020 · Molecular Systems Biology
The effect of a novel glycolysis-related gene signature on progression, prognosis and immune microenvironment of renal cell carcinoma
Fangshi Xu, Yibing Guan, Xue Li, Shanlong Huang, Ke Gao, Zhen Yang, Tie Chong · 2020 · BMC Cancer
Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption
Phoebe K. Mondala, Ashni A. Vora, Tianyuan Zhou, Elisa Lazzari, Luisa Ladel, Xiaolin Luo, Youngsoo Kim, Caitlin L. Costello, A. Robert MacLeod, Catriona H. M. Jamieson et al. · 2021 · Cell stem cell
A Machine Learning Model to Predict the Triple Negative Breast Cancer Immune Subtype
Zihao Chen, Maoli Wang, Rudy Leon De Wilde, Ruifa Feng, Mingqiang Su, Luz Angela Torres-de la Roche, Wenjie Shi · 2021 · Frontiers in Immunology
Long COVID involves activation of proinflammatory and immune exhaustion pathways
Malika Aïd, Valentin Boero-Teyssier, Katherine McMahan, Rammy Dang, Michael Doyle, Nazim A. Belabbaci, Erica N. Borducchi, Ai-ris Yonekura Collier, Janet M. Mullington, Dan H. Barouch · 2025 · Nature Immunology
p53-Regulated Networks of Protein, mRNA, miRNA, and lncRNA Expression Revealed by Integrated Pulsed Stable Isotope Labeling With Amino Acids in Cell Culture (pSILAC) and Next Generation Sequencing (NGS) Analyses
Sabine Hünten, Markus Kaller, Friedel Drepper, Silke Oeljeklaus, Thomas Bonfert, Florian Erhard, Anne Dueck, Norbert Eichner, Caroline C. Friedel, Gunter Meister et al. · 2015 · Molecular & Cellular Proteomics
Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood
Lindsey S. Treviño, Jianrong Dong, Akhilesh Kaushal, Tiffany A. Katz, Rahul Kumar Jangid, Matthew J. Robertson, Sandra L. Grimm, Chandrashekar R. Ambati, Vasanta Putluri, Aaron R. Cox et al. · 2020 · Nature Communications
Differential network analysis for the identification of condition-specific pathway activity and regulation
Gennaro Gambardella, Maria Nicoletta Moretti, Rossella De Cegli, Luca Cardone, Adriano Peron, Diego di Bernardo · 2013 · Bioinformatics
Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes
Francis Grafton, Jaclyn J. Ho, Sara Ranjbarvaziri, Farshad Farshidfar, Ana Budan, Stephanie S. Steltzer, Mahnaz Maddah, Kevin E. Loewke, Kristina Green, Snahel D. Patel et al. · 2021 · eLife
Triage and priority-based healthcare diagnosis using artificial intelligence for autism spectrum disorder and gene contribution: A systematic review
Shahad Sabbar Joudar, Ahmed Shihab Albahri, Rula Amjed Hamid · 2022 · Computers in Biology and Medicine
Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease
Yaoxian Xu, Christoph Kuppe, Javier Perales-Patón, Sikander Hayat, Jennifer Kranz, Ali Taleb Abdallah, James Shiniti Nagai, Zhijian Li, Fabian Peisker, Turgay Saritas et al. · 2022 · Nature Genetics
Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk
Naomi Wilcox, Martine Dumont, Anna González‐Neira, Sara Carvalho, Charles Joly Beauparlant, Marco Crotti, Craig Luccarini, Penny Soucy, Stéphane Dubois, Rocío Núñez‐Torres et al. · 2023 · Nature Genetics
Blocking IL-6 signaling prevents astrocyte-induced neurodegeneration in an iPSC-based model of Parkinson’s disease
Meritxell Pons‐Espinal, Lucas Blasco-Agell, Irene Fernández‐Carasa, Pol Andrés‐Benito, Angelique di Domenico, Yvonne Richaud‐Patín, Valentina Baruffi, Laura Marruecos, Lluı́s Espinosa, Alícia Garrido et al. · 2024 · JCI Insight
Family Based Whole Exome Sequencing Reveals the Multifaceted Role of Notch Signaling in Congenital Heart Disease
Christoph Preuß, Mélanie Capredon, Florian Wünnemann, Philippe Chétaille, Andrea Prince, Béatrice Godard, Séverine Leclerc, Nara Lygia de Macena Sobreira, Hua Ling, Philip Awadalla et al. · 2016 · PLoS Genetics
Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors
Johanna M. Schafer, Brian David Lehmann, Paula I. González Ericsson, Clayton B. Marshall, J. Scott Beeler, Lindsay N. Redman, Hailing Jin, Violeta M. Sanchez, Matthew C. Stubbs, Peggy Scherle et al. · 2020 · Science Translational Medicine
A pan-cancer analysis of HER2 index revealed transcriptional pattern for precise selection of HER2-targeted therapy
Ziteng Li, Siyuan Chen, Wanjing Feng, Yixiao Luo, Hongyan Lai, Qin Li, Bingqiu Xiu, Yuchen Li, Yan Li, Shenglin Huang et al. · 2020 · EBioMedicine
Global microRNA depletion suppresses tumor angiogenesis
Sidi Chen, Yuan Xue, Xuebing Wu, Le Cong, Arjun J. Bhutkar, Eric L. Bell, Feng Zhang, Róbert Langer, Phillip A. Sharp · 2014 · Genes & Development
Systematic review of human post‐mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease
Viejo, Lucía, Noori, Ayush, Merrill, Emily, Das, Sudeshna, Hyman, Bradley T., Serrano‐Pozo, Alberto · 2022 · Neuropathology and Applied Neurobiology
Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk
Reshef, Yakir A., Finucane, Hilary K., Kelley, David R., Gusev, Alexander, Kotliar, Dylan, Ulirsch, Jacob C., Hormozdiari, Farhad, Nasser, Joseph, O’Connor, Luke, van de Geijn, Bryce et al. · 2018 · Nature Genetics
Systems approaches identify the consequences of monosomy in somatic human cells
Narendra Kumar Chunduri, Paul Menges, Xiaoxiao Zhang, Angela Wieland, Vincent Leon Gotsmann, Balca R. Mardin, Christopher Buccitelli, Jan O. Korbel, Felix Willmund, Maik Kschischo et al. · 2021 · Nature Communications
Alloantigen-specific type 1 regulatory T cells suppress through CTLA-4 and PD-1 pathways and persist long-term in patients
Pauline P. Chen, Alma‐Martina Cepika, Rajni Agarwal, Gopin Saini, Molly Javier Uyeda, David M. Louis, Brandon Cieniewicz, Mansi Narula, Laura Amaya, Nicholas Harre et al. · 2021 · Science Translational Medicine
The onset of PI3K‐related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib
Piotr Kobialka, Helena Sabata, Odena Vilalta, Leonor Gouveia, Ana Angulo‐Urarte, Laia Muixí, Jasmina Zanoncello, Oscar Muñoz‐Aznar, Nagore Gené Olaciregui, Lucía Fanlo et al. · 2022 · EMBO Molecular Medicine
SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir
Pinar Mesci, Janaína Sena de Souza, Laura Martin‐Sancho, Ángela Macia, Aurian Saleh, Xin Yin, Cedric E. Snethlage, Jason W. Adams, Simoni Helena Avansini, Roberto H. Herai et al. · 2022 · PLoS Biology
Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis
Nathan Richoz, Zewen Kelvin Tuong, Kevin W. Loudon, Eduardo Patiño‐Martínez, John R. Ferdinand, Jorge Romo‐Tena, Anaïs Portet, Kathleen R Bashant, Emeline Thevenon, Francesca Rucci et al. · 2022 · JCI Insight
Single-cell RNA sequencing and lineage tracing confirm mesenchyme to epithelial transformation (MET) contributes to repair of the endometrium at menstruation
Phoebe M. Kirkwood, Douglas A Gibson, Isaac Shaw, Ross Dobie, Olympia Kelepouri, Neil Cowan Henderson, Philippa T. K. Saunders · 2022 · eLife
Genetic architecture of the white matter connectome of the human brain
Zhiqiang Sha, Dick Schijven, Simon E. Fisher, Clyde Francks · 2023 · Science Advances
EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models
Patrizia Porazzi, Siena Nason, Ziqi Yang, Alberto Carturan, Guido Ghilardi, Puneeth Guruprasad, Ruchi P. Patel, Melody T. Tan, Anushka Anant Padmanabhan, Jean Lemoine et al. · 2025 · Cancer Cell
Molecular classification and prediction in gastric cancer
Xiandong Lin, Yongzhong Zhao, Won‐Min Song, Bin Zhang · 2015 · Computational and Structural Biotechnology Journal
Differentially Expressed miRNAs in Hepatocellular Carcinoma Target Genes in the Genetic Information Processing and Metabolism Pathways
Thomas Thurnherr, Way-Champ Mah, Zhengdeng Lei, Jin Hui Yu, Steve Rozen, Caroline Guat Lay Lee · 2016 · Scientific Reports
Multi-institutional Analysis Shows that Low PCAT-14 Expression Associates with Poor Outcomes in Prostate Cancer
Nicole M. A. White, Shuang George Zhao, Jin Zhang, Emily B. Rozycki, Ha X. Dang, Sandra D. McFadden, Abdallah M. Eteleeb, Mohammed Alshalalfa, Ismael A. Vergara, Nicholas Erho et al. · 2016 · European Urology
Cellular responses to human cytomegalovirus infection: Induction of a mesenchymal-to-epithelial transition (MET) phenotype
Adam Oberstein, Thomas E. Shenk · 2017 · Proceedings of the National Academy of Sciences
Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells
Juliane Hitzel, Eunjee Lee, Yi Zhang, Sofia Iris Bibli, Xiaogang Li, Sven Zukunft, Beatrice Pflüger, Jiong Hu, Christoph Schürmann, Andrea E Vasconez et al. · 2018 · Nature Communications
Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation
Chao Liu, Sayed H. Sadat, Koji Ebisumoto, Akihiro Sakai, Bharat Akhanda Panuganti, Shuling Ren, Yusuke Goto, Sunny J. Haft, Takahito Fukusumi, Mizuo Ando et al. · 2020 · Clinical Cancer Research
Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease
Bo Zhang, M. Yvonne Kim, GiNell Elliot, Yan Zhou, Guangfeng Zhao, Daofeng Li, Rebecca F. Lowdon, Matthew J. Gormley, Mirhan Kapidzic, Joshua F. Robinson et al. · 2021 · Developmental Cell
Human cytomegalovirus expands a CD8 + T cell population with loss of BCL11B expression and gain of NK cell identity
Rosa Sottile, M. Kazim Panjwani, Colleen M. Lau, Anthony F. Daniyan, Kento Tanaka, Juliet N. Barker, Renier J. Brentjens, Joseph Chai-Yuen Sun, Jean-Benoît Le Luduec, Katharine C. Hsu · 2021 · Science Immunology
Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells
Yu Wei Zhang, Julian Mess, Nadim Aizarani, Pankaj Mishra, Carys Johnson, Mari Carmen Romero-Mulero, Jasmin Rettkowski, Katharina Schönberger, Nadine Obier, Karin Jäcklein et al. · 2022 · Nature Cell Biology
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence
Yulong Wei, Timothy C. Davenport, Jack A. Collora, Haocong Katherine Ma, Delia Pinto-Santini, Javier R. Lama, Ricardo Alfaro, Ann C. Duerr, Ya‐Chi Ho · 2023 · Immunity
Large-scale bioreactor production of extracellular vesicles from mesenchymal stromal cells for treatment of acute radiation syndrome
John A. Kink, Michael A. Bellio, Matthew H. Forsberg, Alexandra K. Lobo, Anna S. Thickens, Bryson M. Lewis, Irene M. Ong, Aisha Khan, Christian M. Capitini, Peiman Hematti · 2024 · Stem Cell Research & Therapy
Mitochondrial complex I deficiency stratifies idiopathic Parkinson’s disease
Irene Hana Flønes, Lilah Toker, Dagny Ann Sandnes, Martina Castelli, Sepideh Mostafavi, Njål Gjærde Lura, Omnia Shadad, Erika Fernández‐Vizarra, Cèlia Painous, Alexandra Pérez‐Soriano et al. · 2024 · Nature Communications
Mutations in CHD2 cause defective association with active chromatin in chronic lymphocytic leukemia
David Rodrı́guez, Gabriel Bretones, Vı́ctor Quesada, Neus Villamor, Javier R. Arango, Armando López‐Guillermo, Andrew J. Ramsay, Tycho Baumann, Pedro M. Quirós, Alba Navarro et al. · 2015 · Blood
DNA methylation profiling identifies two splenic marginal zone lymphoma subgroups with different clinical and genetic features
Alberto J. Arribas, Andrea Rinaldi, Afua A. Mensah, Ivo Kwee, Luciano Cascione, Eloy F. Robles, Jose Angel Martinez-Climent, David Graham Oscier, Luca Arcaini, Luca Baldini et al. · 2015 · Blood
Genomic Models of Short-Term Exposure Accurately Predict Long-Term Chemical Carcinogenicity and Identify Putative Mechanisms of Action
Daniel Gusenleitner, Scott S. Auerbach, Tisha Melia, Harold F. Gómez, David H. Sherr, Stefano Monti · 2014 · PLoS ONE
c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses
Dana Piovesan, Jessica C. Tempany, Andrea Di Pietro, Inge Baas, Callisthenis Yiannis, Kristy O’Donnell, Yunshun Chen, Victor Peperzak, Gabrielle Therese Belz, Charles Reay Mackay et al. · 2017 · Cell Reports
Placental transcriptional and histologic subtypes of normotensive fetal growth restriction are comparable to preeclampsia
Isaac Gibbs, Katherine Leavey, Samantha J. Benton, David Grynspan, Shannon A. Bainbridge, Brian Cox · 2018 · American Journal of Obstetrics and Gynecology
A mechanistic model captures the emergence and implications of non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells
Sarthak Sahoo, Ashutosh Mishra, Harsimran Kaur, Kishore Hari, Srinath Muralidharan, Susmita Mandal, Mohit Kumar Jolly · 2021 · NAR Cancer
Non-pathogenic E. coli displaying decoy-resistant IL18 mutein boosts anti-tumor and CAR NK cell responses
Yang, Shaobo, Sheffer, Michal, Kaplan, Isabel E., Wang, Zongqi, Tarannum, Mubin, Dinh, Khanhlinh, Abdulhamid, Yasmin, Bobilev, Eden, Shapiro, Roman, Porter, Rebecca et al. · 2025 · Nature Biotechnology