The DOI matches its Crossref record; 81 of the 83 references it cites were found in a registry or an index.
Chronic pain epidemiology and its clinical relevance
Open accessAbstract
Chronic pain affects ∼20% of the European population and is commoner in women, older people, and with relative deprivation. Its management in the community remains generally unsatisfactory, partly because of lack of evidence for effective interventions. Epidemiological study of chronic pain, through an understanding of its distribution and determinants, can inform the development, targeting, and evaluation of interventions in the general population. This paper reviews current knowledge of risk markers associated with chronic pain and considers how these might inform management and prevention. Risk factors include socio-demographic, clinical, psychological, and biological factors. These are relevant to our understanding of chronic pain mechanisms and the nature of, and responses to, current and future treatments.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Chronic pain is highly prevalent worldwide and associated with major personal and societal burden.1–5”
Citations
Cites
Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment
Breivik, H., Collett, B., Ventafridda, V., Cohen, R., & Gallacher, D. (2006) · European Journal of Pain · doi:10.1016/j.ejpain.2005.06.009 · Cited by 5,486
Classification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms
Merskey, H. (1994) · Medical Entomology and Zoology · Cited by 3,362
Human brain mechanisms of pain perception and regulation in health and disease
Apkarian, A. V., Bushnell, M. C., Treede, R., & Zubieta, J. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.11.001 · Cited by 3,126
Classification of chronic pain
Merskey, H. (1994) · Medical Entomology and Zoology · Cited by 2,952
Porta, M. (2026) · doi:10.1093/acref/9780197663639.001.0001 · Cited by 2,175
Ellsberg, M., Jansen, H. A., Heise, L., Watts, C. H., & Garcia-Moreno, C. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60522-x · Cited by 1,820
Hill, J. C., Whitehurst, D. G., Lewis, M., Bryan, S., Dunn, K. M., Foster, N. E., Konstantinou, K., Main, C. J., Mason, E., Somerville, S., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60937-9 · Cited by 1,306
The epidemiology of chronic pain in the community
Elliott, A. M., Smith, B. H., Penny, K. I., Smith, W. C., & Chambers, W. A. (1999) · The Lancet · doi:10.1016/s0140-6736(99)03057-3 · Cited by 1,191
Self-citationA Comprehensive Review of the Placebo Effect: Recent Advances and Current Thought
Price, D. D., Finniss, D. G., & Benedetti, F. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.113006.095941 · Cited by 1,146
Studying sex and gender differences in pain and analgesia: a consensus report
Greenspan, J. D., Craft, R. M., LeResche, L., Arendt-Nielsen, L., Berkley, K. J., Fillingim, R. B., Gold, M. S., Holdcroft, A., Lautenbacher, S., Mayer, E. A., et al. (2007) · Pain · doi:10.1016/j.pain.2007.10.014 · Cited by 1,033
Flagged first, then by citations
2 of the 83 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Chronic pain: a review of its epidemiology and associated factors in population-based studies
Mills, S. E. E., Nicolson, K. P., & Smith, B. H. (2019) · British Journal of Anaesthesia · doi:10.1016/j.bja.2019.03.023 · Cited by 1,728
“biological factors.(8) Insight into these risk factors will allow the identification of specific prevention and management approaches that take into account these predisposing factors and the impact of pain on those affected.”
BackgroundSelf-citationDescending pain modulation and chronification of pain
Ossipov, M. H., Morimura, K., & Porreca, F. (2014) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000055 · Cited by 875
Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews
Geneen, L. J., Moore, R. A., Clarke, C., Martin, D., Colvin, L. A., & Smith, B. H. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011279.pub2 · Cited by 719
Self-citationColvin, L., Bull, F. A., & Hales, T. G. (2019) · The Lancet · doi:10.1016/s0140-6736(19)30430-1 · Cited by 602
Non-invasive brain stimulation techniques for chronic pain
O'Connell, N. E., Wand, B. M., Marston, L., Spencer, S., & DeSouza, L. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008208.pub3 · Cited by 488
Reward and motivation in pain and pain relief
Navratilova, E., & Porreca, F. (2014) · Nature Neuroscience · doi:10.1038/nn.3811 · Cited by 501
TFOS DEWS II Sex, Gender, and Hormones Report
Sullivan, D. A., Rocha, E. M., Aragona, P., Clayton, J. A., Ding, J., Golebiowski, B., Hampel, U., McDermott, A. M., Schaumberg, D. A., Srinivasan, S., et al. (2017) · The Ocular Surface · doi:10.1016/j.jtos.2017.04.001 · Cited by 472
Woldeamanuel, Y. W., & Cowan, R. P. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.11.071 · Cited by 437
Flatters, S. J. L., Dougherty, P. M., & Colvin, L. (2017) · British Journal of Anaesthesia · doi:10.1093/bja/aex229 · Cited by 393
Opening paths to novel analgesics: the role of potassium channels in chronic pain
Tsantoulas, C., & McMahon, S. B. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2013.12.002 · Cited by 334
Wang, L., Hong, P. J., May, C., Rehman, Y., Oparin, Y., Hong, C. J. H., Hong, B. Y., AminiLari, M., Gallo, L., Kaushal, A., et al. (2021) · BMJ · doi:10.1136/bmj.n1034 · Cited by 318
Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews
Geneen, L. J., Moore, R. A., Clarke, C., Martin, D., Colvin, L. A., & Smith, B. H. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011279.pub3 · Cited by 1,222
Self-citationNon-invasive brain stimulation techniques for chronic pain
O'Connell, N. E., Marston, L., Spencer, S., DeSouza, L., & Wand, B. M. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008208.pub5 · Cited by 272
Immune Cytokines and Their Receptors in Inflammatory Pain
Cook, A. D., Christensen, A. D., Tewari, D., McMahon, S. B., & Hamilton, J. A. (2018) · Trends in Immunology · doi:10.1016/j.it.2017.12.003 · Cited by 275
“It represents a very significant medical problem with a high social cost [1].”
BackgroundOpioid Prescribing at Hospital Discharge Contributes to Chronic Opioid Use
Calcaterra, S. L., Yamashita, T. E., Min, S.-J., Keniston, A., Frank, J. W., & Binswanger, I. A. (2016) · Journal of General Internal Medicine · doi:10.1007/s11606-015-3539-4 · Cited by 236
Chronic pain in older adults: prevalence, incidence, and risk factors
Larsson, C., Hansson, E., Sundquist, K., & Jakobsson, U. (2016) · Scandinavian Journal of Rheumatology · doi:10.1080/03009742.2016.1218543 · Cited by 231
“anxiety, depression, and catastrophic beliefs of pain), as well as co-morbidity, genetic factors, and heritability (12).”
BackgroundPain as a disease: an overview
Raffaeli, W., & Arnaudo, E. (2017) · Journal of Pain Research · doi:10.2147/jpr.s138864 · Cited by 225
“Moreover, the fact that today pain is not recognized as a public health care priority(47) hinders scientific research on pain, including its risk factors and comorbidities.(48) Thus, a vicious circle is created: without a definition of pain as a disease, despite the scientific knowledge already available on the pathol…”
The TRPA1 Channel in Inflammatory and Neuropathic Pain and Migraine
Nassini, R., Materazzi, S., Benemei, S., & Geppetti, P. (2014) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2014_18 · Cited by 210
Chronic pain, psychopathology, and DSM-5 Somatic Symptom Disorder
Katz, J., Rosenbloom, B. N., & Fashler, S. (2015) · The Canadian Journal of Psychiatry · doi:10.1177/070674371506000402 · Cited by 195
Tong, H., Yang, M., Song, H., Kong, E., Deng, M., Li, Y., Li, J., Liu, Z., Fu, H., Wang, Y., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01522-6 · Cited by 203
The Role of the Locus Coeruleus in Pain and Associated Stress-Related Disorders
Suárez‐Pereira, I., Llorca-Torralba, M., Bravo, L., Camarena-Delgado, C., Soriano‐Mas, C., & Berrocoso, E. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.11.023 · Cited by 181
“It has been noted that chronic pain is very often comorbid with stress-related disorders, which is particularly significant given that chronic pain is thought to affect 20% to 30% of the adult population in Europe and the United States (2,3), more than half of whom display comorbid depression and anxiety (4).”
BackgroundA biopsychosocial model of chronic pain for older adults
Miaskowski, C., Blyth, F., Nicosia, F., Haan, M., Keefe, F., Smith, A., & Ritchie, C. (2020) · Pain Medicine · doi:10.1093/pm/pnz329 · Cited by 159
Roughan, W. H., Campos, A. I., García‐Marín, L. M., Cuéllar-Partida, G., Lupton, M. K., Hickie, I. B., Medland, S. E., Wray, N. R., Byrne, E. M., Ngô, T. T., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.643609 · Cited by 174
Non-invasive brain stimulation techniques for chronic pain
O'Connell, N. E., Marston, L., Spencer, S., DeSouza, L., & Wand, B. M. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008208.pub4 · Cited by 154
Fayaz, A., Ayis, S. A., Panesar, S. S., Langford, R., & Donaldson, L. (2016) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2016.06.005 · Cited by 135
Interindividual variability and lateralization of μ-opioid receptors in the human brain
Kantonen, T., Karjalainen, T., Isojärvi, J., Nuutila, P., Tuisku, J., Rinne, J. K. A., Hietala, J. A., Kaasinen, V., Kalliokoski, K. K., Scheinin, H., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116922 · Cited by 138
Socioeconomic status and occurrence of chronic pain: a meta-analysis
Prego-Domínguez, J., Khazaeipour, Z., Mallah, N., & Takkouche, B. (2020) · Rheumatology · doi:10.1093/rheumatology/keaa758 · Cited by 138
Depression Prevalence in Neuropathic Pain and Its Impact on the Quality of Life
Cherif, F., Zouari, H. G., Cherif, W., Hadded, M., Cheour, M., & Damak, R. (2020) · Pain Research and Management · doi:10.1155/2020/7408508 · Cited by 124
“Pain is a reason for frequent consultations in medicine [1].”
BackgroundRometsch, C., Martin, A., Junne, F., & Cosci, F. (2024) · Pain · doi:10.1097/j.pain.0000000000003406 · Cited by 131
Nelson, S., Cunningham, N. R., & Kashikar‐Zuck, S. (2016) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000397 · Cited by 113
Dueñas, M., Salazar, A., Ojeda, B., Fernández-Palacín, F., Micó, J. A., Torres, L. M., & Failde, I. (2015) · Pain Medicine · doi:10.1111/pme.12640 · Cited by 104
Preoperative Opioids and 1-year Patient-reported Outcomes After Spine Surgery
Hills, J. M., Pennings, J. S., Archer, K. R., Wick, J. B., Daryoush, J. R., Butler, M., Sivaganesan, A., Khan, I., Call, R., & Devin, C. J. (2018) · Spine · doi:10.1097/brs.0000000000002964 · Cited by 101
“To minimize this bias, we used surrogate covariates for chronic pain including duration of symptoms, preoperative pain scores, anxiety, depression, and NDI scores.(30,31)”
MethodPregnancy outcome following maternal exposure to pregabalin may call for concern
Winterfeld, U., Merlob, P., Baud, D., Rousson, V., Panchaud, A., Rothuizen, L. E., Bernard, N., Vial, T., Yates, L. M., Pistelli, A., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000002767 · Cited by 96
Mutz, J., Roscoe, C., & Lewis, C. M. (2021) · BMC Medicine · doi:10.1186/s12916-021-02097-z · Cited by 102
Health literacy, pain intensity and pain perception in patients with chronic pain
Köppen, P. J., Dorner, T. E., Stein, K. V., Simon, J., & Crevenna, R. (2018) · Wiener klinische Wochenschrift · doi:10.1007/s00508-017-1309-5 · Cited by 100
“Chronic pain causes huge financial costs for the society and imposes a significant emotional and physical burden on the individuals concerned [1].”
Monoamines as Drug Targets in Chronic Pain: Focusing on Neuropathic Pain
Bravo, L., Llorca-Torralba, M., Berrocoso, E., & Micó, J. A. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01268 · Cited by 89
“Chronic pain is one of the most frequent reasons for visits to a physician and its estimated financial cost exceeds €200 billion per annum in Europe and $150 billion per annum in the United States (Tracey and Bushnell, 2009).”
BackgroundChronic pain disorders in HIV primary care
Jiao, J. M., So, E., Jebakaran, J., George, M. C., Simpson, D. M., & Robinson‐Papp, J. (2015) · Pain · doi:10.1097/j.pain.0000000000000462 · Cited by 88
“Our findings are also consistent with the known epidemiology of chronic pain outside the realm of HIV which has been shown to be associated with female gender, older age, certain psychiatric conditions particularly anxiety and depression, and greater healthcare utilization.(3,31) The high prevalence of chronic pain di…”
ResultFoley, H. E., KNIGHT, J. C., Ploughman, M., Asghari, S., & Audas, R. P. (2021) · Pain · doi:10.1097/j.pain.0000000000002264 · Cited by 88
Chronic Pain-Induced Depression: A Review of Prevalence and Management
Meda, R. T., Nuguru, S. P., Rachakonda, S., Sripathi, S., Khan, M. I., & Patel, N. (2022) · Cureus · doi:10.7759/cureus.28416 · Cited by 99
Huygen, F. J. P. M., Kallewaard, J. W., Nijhuis, H., Liem, L., Vesper, J., Fahey, M. E., Blomme, B., Morgalla, M. H., Deer, T. R., & Capobianco, R. A. (2019) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13074 · Cited by 85
Physical Activity to Reduce Systemic Inflammation Associated With Chronic Pain and Obesity
Paley, C. A., & Johnson, M. I. (2015) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000258 · Cited by 79
Does diet play a role in reducing nociception related to inflammation and chronic pain?
Bjørklund, G., Aaseth, J., Doşa, M. D., Pivina, L. M., Dadar, M., Pen, J. J., & Chirumbolo, S. (2019) · Nutrition · doi:10.1016/j.nut.2019.04.007 · Cited by 81
Neurofeedback for pain management: a systematic review
Roy, R., de la Vega, R., Jensen, M. P., & Miró, J. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00671 · Cited by 77
Epigenetic regulation of persistent pain
Bai, G., Ren, K., & Dubner, R. A. (2014) · Translational research · doi:10.1016/j.trsl.2014.05.012 · Cited by 74
“[8].”
BackgroundInfluentialEmerging potassium channel targets for the treatment of pain
Tsantoulas, C. (2015) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000131 · Cited by 69
“able in up to two-thirds of patients with current treatments [1].”
BackgroundManhapra, A., & Becker, W. C. (2018) · Medical Clinics of North America · doi:10.1016/j.mcna.2018.02.013 · Cited by 62
Wong, K. P., Tse, M. Y. M., & Qin, J. (2022) · Healthcare · doi:10.3390/healthcare10102047 · Cited by 70
The biopsychosocial model of pain in physiotherapy: past, present and future
Smart, K. M. (2023) · Physical Therapy Reviews · doi:10.1080/10833196.2023.2177792 · Cited by 72
Martínez, L. C., Carrascosa, A. J., García, M. F., Fernández, M., Calvo, A. C., Monsalve, V., Soriano, J.-F., & Empathy Study Group (2017) · Pain Medicine · doi:10.1093/pm/pnx160 · Cited by 60
Approach to Diagnosis and Management of Chronic Pelvic Pain in Women
Till, S. R., Nakamura, R., Schrepf, A., & As‐Sanie, S. (2022) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2022.02.006 · Cited by 60
Smith, J. S., Faux, S. G., Gardner, T., Hobbs, M. J., James, M., Joubert, A. E., Kladnitski, N., Newby, J. M., Schultz, R., Shiner, C. T., et al. (2019) · Pain Medicine · doi:10.1093/pm/pnz208 · Cited by 59
Chang, Y., Compton, P. A., Almeter, P., & Fox, C. H. (2014) · Perspectives In Psychiatric Care · doi:10.1111/ppc.12082 · Cited by 58
Pagé, M. G., Fortier, M., Ware, M. A., & Choinière, M. (2018) · Journal of Pain Research · doi:10.2147/jpr.s149262 · Cited by 58
Corneal pain and experimental model development
McKay, T. B., Seyed‐Razavi, Y., Ghezzi, C. E., Dieckmann, G., Nieland, T. J. F., Cairns, D. M., Pollard, R. E., Hamrah, P., & Kaplan, D. L. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.11.005 · Cited by 58
Noninvasive targeted modulation of pain circuits with focused ultrasonic waves
Riis, T. S., Feldman, D. A., Losser, A. J., Okifuji, A., & Kubanek, J. (2024) · Pain · doi:10.1097/j.pain.0000000000003322 · Cited by 63
“13,61,68 Chronic pain is often recalcitrant, greatly diminishes the quality of life, and frequently results in psychiatric disorders 3,66 and, in some cases, suicide.”
Tatu, K., Costa, T., Nani, A., Diano, M., Quarta, D. G., Duca, S., Apkarian, A. V., Fox, P. T., & Cauda, F. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.12.029 · Cited by 58
“Chronic pain is a severe and disabling condition (frequently associated with physical and psychological comorbidities) that negatively impacts on the quality of life (Dominick et al., 2012; Gatchel, 2004; van Hecke et al., 2013; Walker et al., 2014).”
BackgroundThe impacts of anxiety and depression on outcomes in orthopaedic trauma surgery: a narrative review
Weinerman, J. R., Vazquez, A., Schurhoff, N. A., Shatz, C., Goldenberg, B. T., Constantinescu, D. S., & Hernandez, G. M. (2023) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000001307 · Cited by 59
“There is a growing body of research on the impact of mental health disorders on musculoskeletal health, particularly concerning anxiety and depression [1] .”
BackgroundMultidimensional Frailty and Pain in Community Dwelling Elderly
Coelho, T., Paúl, C., Gobbens, R. J. J., & Fernandes, L. P. N. S. (2015) · Pain Medicine · doi:10.1111/pme.12746 · Cited by 56
Ortolá, R., García‐Esquinas, E., Sotos‐Prieto, M., Struijk, E. A., Caballero, F. F., López‐García, E., & Rodríguez‐Artalejo, F. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab109 · Cited by 57
Review on biomarkers in the resting-state networks of chronic pain patients
Pfannmöller, J., & Lotze, M. (2019) · Brain and Cognition · doi:10.1016/j.bandc.2018.06.005 · Cited by 55
Chronic Pain Treatment Strategies in Parkinson’s Disease
Edinoff, A. N., Sathivadivel, N., McBride, T., Parker, A., Okeagu, C. N., Kaye, A. D., Kaye, A. M., Kaye, J. S., Kaye, R. J., Sheth, M. M., et al. (2020) · Neurology International · doi:10.3390/neurolint12030014 · Cited by 58
Physical activity and exercise for chronic pain in adults: an overview of Cochrane reviews
Geneen, L. J., Smith, B. H., Clarke, C., Martin, D., Colvin, L., & Moore, A. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011279 · Cited by 59
Self-citationJeddi, H. M., Busse, J. W., Sadeghirad, B., Levine, M., Zoratti, M. J., Wang, L., Noori, A., Couban, R., & Tarride, J. (2024) · BMJ Open · doi:10.1136/bmjopen-2022-068182 · Cited by 62
Chronic pain among community-dwelling elderly: a population-based clinical study
Rapo-Pylkkö, S., Haanpää, M. L., & Liira, H. (2016) · Scandinavian Journal of Primary Health Care · doi:10.3109/02813432.2016.1160628 · Cited by 50
Disambiguating Pharmacodynamic Efficacy from Behavior with Neuroimaging
Wanigasekera, V., Mezue, M., Andersson, J., Kong, Y., & Tracey, I. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000924 · Cited by 51
Pain: A content review of undergraduate pre-registration nurse education in the United Kingdom
Mackintosh, C. (2016) · Nurse Education Today · doi:10.1016/j.nedt.2016.08.035 · Cited by 51
Chronic Pain and Analgesic Use in CKD
Wu, J., Ginsberg, J. S., Zhan, M., Diamantidis, C. J., Chen, J., Woods, C. M., & Fink, J. C. (2015) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.06520714 · Cited by 49
“These designations were (1) appropriate dosing, or one of two DRPs as follows: (2) dosing of an opioid or nonopioid improperly at a participant’s eGFR at the time of dosing, or (3) a NSAID, which were considered a DRP, regardless of eGFR (16).”
BackgroundNaji, L., Dennis, B. B., Bawor, M., Varenbut, M., Daiter, J., Plater, C., Paré, G., Marsh, D. C., Worster, A., Desai, D., et al. (2017) · Addiction Science & Clinical Practice · doi:10.1186/s13722-017-0074-0 · Cited by 53
“Moreover, chronic pain, which is the most prevalent physical comorbidity included in our composite outcome, is also more commonly found in women than in men in the general population [30, 31].”
BackgroundFarmer, A. D., Gallagher, J., Holt, C. E. M. B., & Aziz, Q. (2017) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(16)30217-5 · Cited by 49
Cellular and Molecular Mechanisms of Calcium/Calmodulin-Dependent Protein Kinase II in Chronic Pain
Zhou, Y., Liu, D.-Q., Chen, S., Sun, J., Zhou, X.-R., Luo, F., Tian, Y., & Ye, D. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.243048 · Cited by 50
“Introduction Chronic pain represents a major public health concern with a high prevalence ranging from 19–50% of the population (van Hecke et al., 2013; Macfarlane, 2016; Zhou et al., 2016b).”
Brenner-Fließer, M., Huberts, J. D. W., & Wippert, P. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-020207 · Cited by 49
“Moreover, the development of chronic pain has a multidimensional aetiology and is moderated by health behaviour,(11) as well as social(12) and psychological factors.(13) For these reasons, we hypothesise that different SES indicators will lead to different degrees of association in the genesis of CBLP.”
BackgroundHCN Channels: New Therapeutic Targets for Pain Treatment
Ramírez, D., Zúñiga, R., Concha, G., & Zúñiga, L. (2018) · Molecules · doi:10.3390/molecules23092094 · Cited by 50
BRD4 Inhibition Attenuates Inflammatory Pain by Ameliorating NLRP3 Inflammasome-Induced Pyroptosis
Hua, T., Wang, H., Fan, X., An, N., Li, J., Song, H., Kong, E., Li, Y., & Yuan, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.837977 · Cited by 45
“One fifth of the European population is affected by chronic pain, and most of the afflicted are women and elderly people (1).”
BackgroundWen, Y.-R., Shi, J., Hu, Z.-Y., Lin, Y., Lin, Y.-T., Jiang, X., Wang, R., Wang, X., & Wang, Y. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1056966 · Cited by 46
Santos, P. L., de Brito, R. G., Matos, J. P. S. C. F., Quintans, J. D. S. S., & Quintans‐Júnior, L. J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0658-4 · Cited by 46
“Further studies about the pathophysiology of pain, including its sensory and emotional aspects, are still needed for a better understanding of its etiology [2].”
BackgroundPain characteristics in fibromyalgia: understanding the multiple dimensions of pain
Plazier, M., Ost, J., Stassijns, G., De Ridder, D., & Vanneste, S. (2015) · Clinical Rheumatology · doi:10.1007/s10067-014-2736-6 · Cited by 45
Neurotrophic factors and their inhibitors in chronic pain treatment
Kelleher, J. H., Tewari, D., & McMahon, S. B. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.03.025 · Cited by 46
“For all types of chronic pain, estimates of prevalence have risen to 20% (van Hecke, Torrance, and Smith 2013; Breivik et al. 2006).”
BackgroundSocial Factors, Disability, and Depressive Symptoms in Adults With Chronic Pain
Solé, E., Racine, M., Tomé‐Pires, C., Galán, S., Jensen, M. P., & Miró, J. (2020) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000815 · Cited by 53
“The inclusion criteria were (1) being able to speak, read, and write Spanish, (2) being at least 18 years old, and (3) having chronic pain (ie, reporting a persistent pain problem for the last 3 mo or longer, and having pain on at least half of the days in the past 6 mo).”
BackgroundMethodQiu, Y., Ma, Y., & Huang, X. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.881779 · Cited by 44
Tong, H., Kong, E., Zhang, H., Lu, J., Huang, K., Ding, R., Wang, H., Li, J., Han, C., & Yuan, H. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.02.027 · Cited by 47
“As one of the most common and complex health problems, NP generates a huge socioeconomic burden [2] .”
BackgroundMore than meets the eye: visual attention biases in individuals reporting chronic pain
Fashler, S. R., & Katz, J. D. (2014) · Journal of Pain Research · doi:10.2147/jpr.s67431 · Cited by 49
Levels of physical activity in people with chronic pain
Parker, R., Bergman, E., Mntambo, A., Stubbs, S., & Wills, M. (2017) · South African Journal of Physiotherapy · doi:10.4102/sajp.v73i1.323 · Cited by 43
Miller, R. M., & Kaiser, R. S. (2018) · Current Pain and Headache Reports · doi:10.1007/s11916-018-0663-y · Cited by 42
Prevention of chronic post-surgical pain: the importance of early identification of risk factors
Tawfic, Q. A., Kumar, K., Pirani, Z., & Armstrong, K. (2017) · Journal of Anesthesia · doi:10.1007/s00540-017-2339-x · Cited by 44
“The burden to the healthcare system is both in terms of financial cost, and resource utilization [17, 18].”
BackgroundKetamine for the Treatment of Chronic Pain: A Comprehensive Review
Israel, J. E., Pierre, S. S., Ellis, E., Hanukaai, J. S., Noor, N., Varrassi, G., Wells, M., & Kaye, A. D. (2021) · Health Psychology Research · doi:10.52965/001c.25535 · Cited by 48
Mohammadi, S. A., & Christie, M. J. (2014) · Molecular Pain · doi:10.1186/1744-8069-10-64 · Cited by 40
Roizenblatt, S., de Souza, A. A. L., Palombini, L., Godoy, L. M., Tufik, S. B., & Bittencourt, L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142726 · Cited by 40
Prevalence and Risk Factors for Chronic Abdominal Pain After Roux-en-Y Gastric Bypass Surgery
Gormsen, J., Burcharth, J., Gögenür, I., & Helgstrand, F. (2019) · Annals of Surgery · doi:10.1097/sla.0000000000003356 · Cited by 39
“Other confounders could be health-seeking behavioral traits and individual perception, which would lead to underestimation of the prevalence of chronic abdominal pain.(45,46) Overall 68% of the patients answered”
BackgroundFactors associated with chronic and acute back pain in Wales, a cross-sectional study
Jonsdottir, S., Ahmed, H., Tómasson, K., & Carter, B. (2019) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-019-2477-4 · Cited by 39
Muhammad, T., & Rashid, M. (2021) · Depression and Anxiety · doi:10.1002/da.23239 · Cited by 40
Karlsson, L., Gerdle, B. U. C., Takala, E., Andersson, G., & Larsson, B. K. (2018) · Journal of Pain Research · doi:10.2147/jpr.s149826 · Cited by 44
Effect of mito-TEMPO, a mitochondria-targeted antioxidant, in rats with neuropathic pain
Li, Z., Li, R., Sun, Y., Dou, M., Yang, W., He, S., & Zhang, Y. (2018) · Neuroreport · doi:10.1097/wnr.0000000000001105 · Cited by 38
The Role of Toxins in the Pursuit for Novel Analgesics
Maatuf, Y., Geron, M., & Priel, A. (2019) · Toxins · doi:10.3390/toxins11020131 · Cited by 38
Pain in neuropsychiatry: Insights from animal models
Bravo, L., Llorca-Torralba, M., Suárez‐Pereira, I., & Berrocoso, E. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.029 · Cited by 41
Muralidharan, A., Kuo, A., Jacob, M., Lourdesamy, J., Carvalho, L. M. S. P. D., Nicholson, J. R., Corradini, L., & Smith, M. T. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00088 · Cited by 37
Chronic pain impact on rodents’ behavioral repertoire
Cunha, A. M., Pereira-Mendes, J., Almeida, A., Guimarães, M. R., & Leite‐Almeida, H. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.09.022 · Cited by 38
Pain and chronic pain epidemiology
Dorner, T. E. (2017) · Wiener klinische Wochenschrift · doi:10.1007/s00508-017-1301-0 · Cited by 37
Quality of life in chronic pain patients: Illness‐ and wellness‐focused coping as moderators
Pereira, M. G., Carvalho, C., Costa, E. C. V., Leite, Â. M. T., & Almeida, V. M. (2020) · PsyCh Journal · doi:10.1002/pchj.410 · Cited by 46
Buehlmann, D., Ielacqua, G. D., Xandry, J., & Rudin, M. (2018) · Pain · doi:10.1097/j.pain.0000000000001388 · Cited by 36
Recent trends in acupuncture for chronic pain: A bibliometric analysis and review of the literature
Huang, L., Xu, G., Sun, M., Yang, C., Luo, Q., Tian, H., Zhou, Z., Liu, Y., Huang, F., Liang, F., et al. (2023) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2023.102915 · Cited by 41
Metadata
- Authors
- van Hecke, O., Torrance, N., & Smith, B. H.
- Affiliations
- University of Dundee (GB)
- Corresponding author
- Smith, B.H.
- Venue
- British Journal of Anaesthesia
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 111
- Issue
- 1
- Pages
- 13-18
- ISSN
- 0007-0912 (ISSN-L)
- OpenAlex
- W1972647407
- Cited by
- 632
- References
- 83
- Citations by year
- 2026: 22 · 2025: 42 · 2024: 59 · 2023: 55 · 2022: 58 · 2021: 77 · 2020: 72 · 2019: 61 · 2018: 48 · 2017: 47 · 2016: 38 · 2015: 28 · 2014: 22 · 2013: 2
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- British Journal of Anaesthesia (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- chronic pain, pain epidemiology, risk factors, sociodemographic factors, psychological factors, biological factors, pain prevention, pain management, women, older adults, relative deprivation
- MeSH terms
- Age Factors, Mental Disorders, Europe, Female, Humans, Male, Pain Measurement, Risk Factors, Sex Factors, Socioeconomic Factors, Comorbidity, Genetic Predisposition to Disease, Chronic Pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
