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Chronic pain epidemiology and its clinical relevance
Open accessAbstract
Chronic pain affects ∼20% of the European population and is commoner in women, older people, and with relative deprivation. Its management in the community remains generally unsatisfactory, partly because of lack of evidence for effective interventions. Epidemiological study of chronic pain, through an understanding of its distribution and determinants, can inform the development, targeting, and evaluation of interventions in the general population. This paper reviews current knowledge of risk markers associated with chronic pain and considers how these might inform management and prevention. Risk factors include socio-demographic, clinical, psychological, and biological factors. These are relevant to our understanding of chronic pain mechanisms and the nature of, and responses to, current and future treatments.
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“Chronic pain is highly prevalent worldwide and associated with major personal and societal burden.1–5”
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BackgroundVedvarende bruk av opioider og samtidig bruk av andre vanedannende legemidler
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Tang, S., Xue, Y., Dengqi, X., & Shao, L. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114901 · Cited by 10
Pain self-efficacy moderates the association between pain and somatization in a community sample
Karkkola, P., Sinikallio, S., Flink, N., Honkalampi, K. M., & Kuittinen, M. (2018) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2018-0052 · Cited by 10
Understanding Pain in Order to Treat Patients in Pain
Catley, M. J., Moseley, G. L., & Jones, M. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-7020-5976-6.00007-3 · Cited by 10
Terhorst, Y., Braun, L., Titzler, I., Buntrock, C., Freund, J., Thielecke, J., Ebert, D., & Baumeister, H. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-034271 · Cited by 10
Brown, L., Mossabir, R., Harrison, N., Lam, N., Grice, A., Clegg, A. P., Williams, A. C. D. C., Antcliff, D., Schofield, P., Suleman, A., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-074785 · Cited by 8
Naik, A., Bah, M. G., Govande, M., Palsgaard, P. K., Dharnipragada, R., Shaffer, A. L., Air, E. L., Cramer, S. W., Croarkin, P. E., & Arnold, P. M. (2024) · World Neurosurgery · doi:10.1016/j.wneu.2024.01.010 · Cited by 9
Causal relationship between educational attainment and chronic pain: A Mendelian randomization study
Liu, S., & Xu, D. (2024) · Medicine · doi:10.1097/md.0000000000039301 · Cited by 14
“[26] The mainstream explanation of the relationship between education and socioeconomic status originates from Weberian theory, which suggested that education has become a popular singular indicator of socioeconomic status primarily due to its association with various lifestyle characteristics and…”
BackgroundWu, R., Gao, P., Liu, S., Yang, Q., Wang, J., Liang, F., Chen, Y., & Yang, L. (2024) · Journal of orthopaedic surgery · doi:10.1177/10225536241280190 · Cited by 10
Structural Determinants of Buprenorphine Partial Agonism at the μ-Opioid Receptor
Gomes, A. A. S., & Giraldo, J. (2025) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5c00078 · Cited by 9
SBA 2020: Atualização na diretriz da anestesia regional em uso de anticoagulantes
Fonseca, N. M., Pontes, J. P. J., Perez, M. V., Alves, R. R., & Fonseca, G. G. (2020) · Brazilian Journal of Anesthesiology · doi:10.1016/j.bjan.2020.02.006 · Cited by 12
Vaughan, R., Galley, H. F., & Kanakarajan, S. (2021) · British Journal of Pain · doi:10.1177/20494637211054698 · Cited by 9
Prevalence of self-referred chronic pain and intercurrences in the health of the elderly
Lini, E. V., Tomicki, C., Giacomazzi, R. B., Dellani, M. P., Doring, M., & Portella, M. R. (2016) · Revista Dor · doi:10.5935/1806-0013.20160089 · Cited by 9
Malafoglia, V., Celi, M., Muscoli, C., Ilari, S., Lauro, F., Giancotti, L. A., Morabito, C., Feola, M., Tarantino, U., & Raffaeli, W. (2017) · Trials · doi:10.1186/s13063-017-2363-z · Cited by 9
Kurniawan, S. N., Suriani, N., Marhaendraputro, E. A., & Rahmawati, D. (2020) · JPHV (Journal of Pain Vertigo and Headache) · doi:10.21776/ub.jphv.2020.001.01.5 · Cited by 2
Sato, S., Ukimoto, S., Kanamoto, T., Sasaki, N., Hashimoto, T., Saito, H., Hida, E., Sato, T., Mae, T., & Nakata, K. (2021) · Scientific Reports · doi:10.1038/s41598-021-91731-0 · Cited by 11
How does semantic pain and words condition pain perception? A short communication
Lena, F., Pappaccogli, M., Santilli, M., Torre, M., Modugno, N., & Perrotta, A. (2021) · Neurological Sciences · doi:10.1007/s10072-021-05577-5 · Cited by 9
“Pain is the most common reason people turn to healthcare professionals and more than 20% of the population are affected by chronic pain [13].”
BackgroundTrends in transdermal fentanyl utilisation and fatal fentanyl overdose across Australia (2003–2015)
Rahman, S., Trussell, A., Pearson, S., Buckley, N. A., Karanges, E. A., Cairns, R. F., Litchfield, M. J., Todd, A., & Gisev, N. (2021) · Drug and Alcohol Review · doi:10.1111/dar.13391 · Cited by 9
Treating co-occurring chronic low back pain & generalized anxiety disorder.
Janzen, K., & Peters-Watral, B. (2016) · The Nurse Practitioner · doi:10.1097/01.npr.0000475373.08924.04 · Cited by 6
Metadata
- Authors
- van Hecke, O., Torrance, N., & Smith, B. H.
- Affiliations
- University of Dundee (GB)
- Corresponding author
- Smith, B.H.
- Venue
- British Journal of Anaesthesia
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 111
- Issue
- 1
- Pages
- 13-18
- ISSN
- 0007-0912 (ISSN-L)
- OpenAlex
- W1972647407
- Cited by
- 632
- References
- 83
- Citations by year
- 2026: 22 · 2025: 42 · 2024: 59 · 2023: 55 · 2022: 58 · 2021: 77 · 2020: 72 · 2019: 61 · 2018: 48 · 2017: 47 · 2016: 38 · 2015: 28 · 2014: 22 · 2013: 2
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- British Journal of Anaesthesia (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- chronic pain, pain epidemiology, risk factors, sociodemographic factors, psychological factors, biological factors, pain prevention, pain management, women, older adults, relative deprivation
- MeSH terms
- Age Factors, Mental Disorders, Europe, Female, Humans, Male, Pain Measurement, Risk Factors, Sex Factors, Socioeconomic Factors, Comorbidity, Genetic Predisposition to Disease, Chronic Pain
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