The DOI matches its Crossref record; 81 of the 83 references it cites were found in a registry or an index.
Chronic pain epidemiology and its clinical relevance
Open accessAbstract
Chronic pain affects ∼20% of the European population and is commoner in women, older people, and with relative deprivation. Its management in the community remains generally unsatisfactory, partly because of lack of evidence for effective interventions. Epidemiological study of chronic pain, through an understanding of its distribution and determinants, can inform the development, targeting, and evaluation of interventions in the general population. This paper reviews current knowledge of risk markers associated with chronic pain and considers how these might inform management and prevention. Risk factors include socio-demographic, clinical, psychological, and biological factors. These are relevant to our understanding of chronic pain mechanisms and the nature of, and responses to, current and future treatments.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Chronic pain is highly prevalent worldwide and associated with major personal and societal burden.1–5”
Citations
Cites
Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment
Breivik, H., Collett, B., Ventafridda, V., Cohen, R., & Gallacher, D. (2006) · European Journal of Pain · doi:10.1016/j.ejpain.2005.06.009 · Cited by 5,486
Classification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms
Merskey, H. (1994) · Medical Entomology and Zoology · Cited by 3,362
Human brain mechanisms of pain perception and regulation in health and disease
Apkarian, A. V., Bushnell, M. C., Treede, R., & Zubieta, J. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.11.001 · Cited by 3,126
Classification of chronic pain
Merskey, H. (1994) · Medical Entomology and Zoology · Cited by 2,952
Porta, M. (2026) · doi:10.1093/acref/9780197663639.001.0001 · Cited by 2,175
Ellsberg, M., Jansen, H. A., Heise, L., Watts, C. H., & Garcia-Moreno, C. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60522-x · Cited by 1,820
Hill, J. C., Whitehurst, D. G., Lewis, M., Bryan, S., Dunn, K. M., Foster, N. E., Konstantinou, K., Main, C. J., Mason, E., Somerville, S., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60937-9 · Cited by 1,306
The epidemiology of chronic pain in the community
Elliott, A. M., Smith, B. H., Penny, K. I., Smith, W. C., & Chambers, W. A. (1999) · The Lancet · doi:10.1016/s0140-6736(99)03057-3 · Cited by 1,191
Self-citationA Comprehensive Review of the Placebo Effect: Recent Advances and Current Thought
Price, D. D., Finniss, D. G., & Benedetti, F. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.113006.095941 · Cited by 1,146
Studying sex and gender differences in pain and analgesia: a consensus report
Greenspan, J. D., Craft, R. M., LeResche, L., Arendt-Nielsen, L., Berkley, K. J., Fillingim, R. B., Gold, M. S., Holdcroft, A., Lautenbacher, S., Mayer, E. A., et al. (2007) · Pain · doi:10.1016/j.pain.2007.10.014 · Cited by 1,033
Pain catastrophizing and neural responses to pain among persons with fibromyalgia
Gracely, R. H. (2004) · Brain · doi:10.1093/brain/awh098 · Cited by 892
Sex differences in pain perception
Wiesenfeld‐Hallin, Z. (2005) · Gender Medicine · doi:10.1016/s1550-8579(05)80042-7 · Cited by 606
Brain gray matter decrease in chronic pain is the consequence and not the cause of pain
Rodriguez-Raecke, R., Niemeier, A., Ihle, K., Ruether, W., & May, A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3687-09.2009 · Cited by 527
Darlow, B. J. S., Fullen, B. M., Dean, S. G., Hurley, D. A., Baxter, D. G., & Dowell, A. C. (2011) · European Journal of Pain · doi:10.1016/j.ejpain.2011.06.006 · Cited by 496
Modulation of pain by estrogens
Craft, R. M. (2007) · Pain · doi:10.1016/j.pain.2007.09.028 · Cited by 466
How neuroimaging studies have challenged us to rethink: Is chronic pain a disease?
Tracey, I., & Bushnell, M. C. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.09.001 · Cited by 455
Racine, M., Tousignant-Laflamme, Y., Kloda, L. A., Dion, D., Dupuis, G., & Choinière, M. (2012) · Pain · doi:10.1016/j.pain.2011.11.026 · Cited by 451
Kroenke, K., Bair, M. J., Damush, T. M., Wu, J., Hoke, S., Sutherland, J., & Tu, W. (2009) · JAMA · doi:10.1001/jama.2009.723 · Cited by 447
Smith, B. H., Campbell, A., Linksted, P., Fitzpatrick, B., Jackson, C., Kerr, S. M., Deary, I. J., MacIntyre, D. J., Campbell, H., McGilchrist, M., et al. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dys084 · Cited by 401
Self-citation(1994) · Medical Entomology and Zoology · Cited by 393
The course of chronic pain in the community: Results of a 4-year follow-up study
Elliott, A. M., Smith, B. H., Hannaford, P. C., Smith, W. C., & Chambers, W. A. (2002) · Pain · doi:10.1016/s0304-3959(02)00138-0 · Cited by 384
Self-citationDoes back pain prevalence really decrease with increasing age? A systematic review
Dionne, C. E., Dunn, K. M., & Croft, P. R. (2006) · Age and Ageing · doi:10.1093/ageing/afj055 · Cited by 384
Individual differences in pain sensitivity: Genetic and environmental contributions
Nielsen, C. S., Stubhaug, A., Price, D. D., Vassend, O. M., Czajkowski, N. O., & Harris, J. R. (2007) · Pain · doi:10.1016/j.pain.2007.06.008 · Cited by 334
Collaborative Care for Chronic Pain in Primary Care: A Cluster Randomized Trial
Dobscha, S. K., Corson, K., Perrin, N. A., Hanson, G. C., Leibowitz, R. Q., Doak, M. N., Dickinson, K. C., Sullivan, M. D., & Gerrity, M. S. (2009) · JAMA · doi:10.1001/jama.2009.377 · Cited by 330
Pain genetics: past, present and future
Mogil, J. S. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.02.004 · Cited by 318
Last, J. M. (1993) · Journal of Epidemiology & Community Health · doi:10.1136/jech.47.5.430 · Cited by 306
Gwilym, S. E., Filippini, N., Douaud, G., Carr, A. J., & Tracey, I. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27585 · Cited by 302
Strigo, I. A., Simmons, A. N., Matthews, S. C., Craig, A. D. B., & Paulus, M. P. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.11.1275 · Cited by 277
Severe chronic pain is associated with increased 10 year mortality. A cohort record linkage study
Torrance, N., Elliott, A. M., Lee, A. J., & Smith, B. H. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2009.07.006 · Cited by 276
Self-citationMayer, E. A., Berman, S. M., Suyenobu, B. Y., Labus, J. S., Mandelkern, M. A., Naliboff, B. D., & Chang, L. (2005) · Pain · doi:10.1016/j.pain.2005.03.023 · Cited by 275
Dominick, C. H., Blyth, F., & Nicholas, M. K. (2011) · Pain · doi:10.1016/j.pain.2011.09.018 · Cited by 262
Self-management of chronic pain: a population-based study
Blyth, F., MARCH, L. M., Nicholas, M. K., & Cousins, M. J. (2004) · Pain · doi:10.1016/j.pain.2004.12.004 · Cited by 243
Expectancy, fear and pain in the prediction of chronic pain and disability: a prospective analysis
Boersma, K., & Linton, S. J. (2006) · European Journal of Pain · doi:10.1016/j.ejpain.2005.08.004 · Cited by 224
Genetic architecture of human pain perception
Diatchenko, L. B., Nackley, A. G., Tchivileva, I. E., Shabalina, S. A., & Maixner, W. D. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.09.004 · Cited by 211
Rainville, J., Smeets, R., Bendix, T., Tveito, T., Poiraudeau, S., & Indahl, A. (2011) · The spine journal · doi:10.1016/j.spinee.2011.08.006 · Cited by 209
Changes in brain gray matter due to repetitive painful stimulation
Teutsch, S., Herken, W., Bingel, U., Schoell, E. D., & May, A. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.05.044 · Cited by 202
Childhood abuse, chronic pain, and depression in the National Comorbidity Survey
Sachs‐Ericsson, N., Kendall-Tackett, K. A., & Hernandez, A. (2007) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2006.12.007 · Cited by 201
Socioeconomic disadvantage and pain
Poleshuck, E. L., & Green, C. R. (2008) · Pain · doi:10.1016/j.pain.2008.04.003 · Cited by 196
Heritability of responses to painful stimuli in women: a classical twin study
Norbury, T. A., MacGregor, A. J., Urwin, J., Spector, T. D., & McMahon, S. B. (2007) · Brain · doi:10.1093/brain/awm233 · Cited by 190
Chronic widespread pain: a three year followup of pain distribution and risk factors.
Bergman, S., Herrström, P., Jacobsson, L., & Petersson, I. F. (2002) · PubMed · Cited by 184
Severity of musculoskeletal pain: relations to socioeconomic inequality
Brekke, M., Hjortdahl, P., & Kvien, T. K. (2002) · Social Science & Medicine · doi:10.1016/s0277-9536(01)00018-1 · Cited by 183
Andersson, H. I. (2004) · European Journal of Pain · doi:10.1016/s1090-3801(03)00064-8 · Cited by 181
Recurrent pain in children, socio-economic factors and accumulation in families
Grøholt, E.-K., Stigum, H., Nordhagen, R., & Köhler, L. (2003) · European Journal of Epidemiology · doi:10.1023/a:1025889912964 · Cited by 164
Straube, S., Moore, A. R., Derry, S., & McQuay, H. J. (2008) · Pain · doi:10.1016/j.pain.2008.11.010 · Cited by 156
Increased Prefrontal Activation During Pain Perception in Major Depression
Bär, K., Wagner, G., Koschke, M., Boettger, S., Boettger, M. K., Schlösser, R. G. M., & Sauer, H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.02.011 · Cited by 147
Current challenges in translational pain research
Mao, J. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.08.001 · Cited by 136
Lötsch, J., von Hentig, N., Freynhagen, R., Grießinger, N., Zimmermann, M., Doehring, A., Rohrbacher, M., Sittl, R., & Geißlinger, G. (2009) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e32832b89da · Cited by 124
Experience and Management of Chronic Pain Among Patients With Other Complex Chronic Conditions
Butchart, A., Kerr, E. A., Heisler, M., Piette, J. D., & Krein, S. L. (2009) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e31818bf574 · Cited by 124
Do psychological factors predict outcome in both low-back pain and shoulder pain?
van der Windt, D., Kuijpers, T., Jellema, P., van der Heijden, G. J. M. G., & Bouter, L. M. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.053553 · Cited by 123
Population based intervention to change back pain beliefs: three year follow up population survey
Buchbinder, R., & Jolley, D. (2004) · BMJ · doi:10.1136/bmj.328.7435.321 · Cited by 122
Factors Related to the Onset and Persistence of Chronic Back Pain in the Community
Smith, B. H., Elliott, A. M., Hannaford, P. C., Chambers, W. A., & Smith, W. C. (2004) · Spine · doi:10.1097/00007632-200405010-00016 · Cited by 118
Self-citationShaw, W. S., Linton, S. J., & Pransky, G. (2006) · Journal of Occupational Rehabilitation · doi:10.1007/s10926-006-9061-0 · Cited by 115
Peters, M., Broer, L., Willemen, H., Eiriksdottir, G., Hocking, L., Holliday, K., Horan, M., Meulenbelt, I., Neogi, T., Popham, M., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-201742 · Cited by 115
Self-citationThe genetic influence on radiographic osteoarthritis is site specific at the hand, hip and knee
MacGregor, A. J., Li, Q., Spector, T. D., & Williams, F. M. K. (2008) · Lara D. Veeken · doi:10.1093/rheumatology/ken475 · Cited by 110
An additional dimension to health inequalities: disease severity and socioeconomic position.
Eachus, J., Chan, P. V., Pearson, N., Propper, C., & Smith, G. D. (1999) · Journal of Epidemiology & Community Health · doi:10.1136/jech.53.10.603 · Cited by 106
Thomas, E., Mottram, S., Peat, G., Wilkie, R., & Croft, P. R. (2006) · Pain · doi:10.1016/j.pain.2006.09.027 · Cited by 102
Hocking, L. J., Smith, B. H., Jones, G. T., Reid, D. M., Strachan, D. P., & Macfarlane, G. J. (2010) · Pain · doi:10.1016/j.pain.2010.01.023 · Cited by 95
Self-citationSmith, B. H., Macfarlane, G. J., & Torrance, N. (2006) · Pain · doi:10.1016/j.pain.2006.11.001 · Cited by 92
Self-citationHeritability of chronic pain in 2195 extended families
Hocking, L. J., Scotland, G., Morris, A. D., Dominiczak, A. F., Porteous, D. J., & Smith, B. H. (2012) · European Journal of Pain · doi:10.1002/j.1532-2149.2011.00095.x · Cited by 91
Self-citationNitter, A. K., Pripp, A. H., & Forseth, K. Ø. (2012) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2012.04.001 · Cited by 81
Hwang, C. K., Song, K. Y., Kim, C. S., Choi, H. S., Guo, X., Law, P., Wei, L., & Loh, H. H. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00535.x · Cited by 66
van der Windt, D., Croft, P. R., & Penninx, B. W. J. H. (2002) · PubMed · Cited by 65
Chronic pain – Is it a public health problem?
Blyth, F. (2008) · Pain · doi:10.1016/j.pain.2008.04.013 · Cited by 64
Management of chronic pain in primary care
Smith, B. H., & Torrance, N. (2011) · Current Opinion in Supportive & Palliative Care · doi:10.1097/spc.0b013e328345a3ec · Cited by 63
Self-citationFrequency and Priority of Pain Patients' Health Care Use
Korff, M. V., Lin, E. H. B., Fenton, J. J., & Saunders, K. W. (2007) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31804ac020 · Cited by 62
Chronic Pain Epidemiology: From Aetiology to Public Health
Blyth, F., & Croft, P. R. (2010) · Cited by 62
Chronic Pain Epidemiology from Aetiology to Public Health
Williams, N. H. (2011) · Occupational Medicine · doi:10.1093/occmed/kqr002 · Cited by 58
Davis, K. D., Racine, É., & Collett, B. (2012) · Pain · doi:10.1016/j.pain.2012.02.037 · Cited by 54
Neuroimaging of pain: what does it tell us?
Davis, K. D. (2011) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e3283458f96 · Cited by 51
Telomeres and epigenetics: potential relevance to chronic pain
Sibille, K. T., Witek-Janusek, L., Mathews, H. L., & Fillingim, R. B. (2012) · Pain · doi:10.1016/j.pain.2012.06.003 · Cited by 45
TRP channel antagonists for pain--opportunities beyond TRPV1.
Bevan, S., & Andersson, D. A. (2009) · PubMed · Cited by 39
Pain and mortality risk among elderly persons in Sweden
Kåreholt, I., & Brattberg, G. (1998) · Pain · doi:10.1016/s0304-3959(98)00103-1 · Cited by 37
Whether the weather influences pain? Results from the EpiFunD study in North West England
Macfarlane, T. V., McBeth, J., Jones, G. T., Nicholl, B. I., & Macfarlane, G. J. (2010) · Lara D. Veeken · doi:10.1093/rheumatology/keq099 · Cited by 37
Prediction of outcome in patients presenting with fatigue in primary care
Nijrolder, I., van der Windt, D., & van der Horst, H. E. (2009) · British Journal of General Practice · doi:10.3399/bjgp09x420329 · Cited by 34
The global occurrence of chronic pain: an introduction
Croft, P. R., Blyth, F., & van der Windt, D. (2010) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199235766.003.0002 · Cited by 33
Smith, B. H., Elliott, A. M., & Hannaford, P. C. (2003) · Europe PMC (PubMed Central) · Cited by 27
Self-citationNeuroimaging as a tool to investigate how cognitive factors influence analgesic drug outcomes
Bingel, U., Tracey, I., & Wiech, K. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.04.043 · Cited by 27
Effective neuropathic pain relief through sciatic nerve administration of GAD65-expressing rAAV2
Kim, J., Kim, S. J., Lee, H., & Chang, J. W. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.07.120 · Cited by 25
Introduction to chronic pain as a public health problem
Blyth, F., van der Windt, D., & Croft, P. R. (2010) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199235766.003.0022 · Cited by 13
The Genetic Epidemiology of Pain
MacGregor, A. J., & Reavley, C. M. (2008) · Springer eBooks · doi:10.1007/978-0-387-78323-9_3 · Cited by 3
Jones, G. T., Macfarlane, G. J., Silman, A. J., & Power, C. (2006) · American Journal of Epidemiology · doi:10.1093/aje/163.suppl_11.s14-b · Cited by 3
Flagged first, then by citations
2 of the 83 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Chronic pain: a review of its epidemiology and associated factors in population-based studies
Mills, S. E. E., Nicolson, K. P., & Smith, B. H. (2019) · British Journal of Anaesthesia · doi:10.1016/j.bja.2019.03.023 · Cited by 1,728
“biological factors.(8) Insight into these risk factors will allow the identification of specific prevention and management approaches that take into account these predisposing factors and the impact of pain on those affected.”
BackgroundSelf-citationDescending pain modulation and chronification of pain
Ossipov, M. H., Morimura, K., & Porreca, F. (2014) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000055 · Cited by 875
Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews
Geneen, L. J., Moore, R. A., Clarke, C., Martin, D., Colvin, L. A., & Smith, B. H. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011279.pub2 · Cited by 719
Self-citationColvin, L., Bull, F. A., & Hales, T. G. (2019) · The Lancet · doi:10.1016/s0140-6736(19)30430-1 · Cited by 602
Non-invasive brain stimulation techniques for chronic pain
O'Connell, N. E., Wand, B. M., Marston, L., Spencer, S., & DeSouza, L. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008208.pub3 · Cited by 488
Metadata
- Authors
- van Hecke, O., Torrance, N., & Smith, B. H.
- Affiliations
- University of Dundee (GB)
- Corresponding author
- Smith, B.H.
- Venue
- British Journal of Anaesthesia
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 111
- Issue
- 1
- Pages
- 13-18
- ISSN
- 0007-0912 (ISSN-L)
- OpenAlex
- W1972647407
- Cited by
- 632
- References
- 83
- Citations by year
- 2026: 22 · 2025: 42 · 2024: 59 · 2023: 55 · 2022: 58 · 2021: 77 · 2020: 72 · 2019: 61 · 2018: 48 · 2017: 47 · 2016: 38 · 2015: 28 · 2014: 22 · 2013: 2
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- British Journal of Anaesthesia (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- chronic pain, pain epidemiology, risk factors, sociodemographic factors, psychological factors, biological factors, pain prevention, pain management, women, older adults, relative deprivation
- MeSH terms
- Age Factors, Mental Disorders, Europe, Female, Humans, Male, Pain Measurement, Risk Factors, Sex Factors, Socioeconomic Factors, Comorbidity, Genetic Predisposition to Disease, Chronic Pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review