Pain catastrophizing and neural responses to pain among persons with fibromyalgia

Gracely, R. H.

doi:10.1093/brain/awh098

Cited by 892Fibromyalgia and Chronic Fatigue Syndrome ResearchPain Management and Placebo EffectPain Mechanisms and Treatments

Pain catastrophizing and neural responses to pain among persons with fibromyalgia

Gracely, R. H.·2004·Brain

DOI 10.1093/brain/awh098

Open this paper in CoChat — free account

Abstract

Pain catastrophizing, or characterizations of pain as awful, horrible and unbearable, is increasingly being recognized as an important factor in the experience of pain. The purpose of this investigation was to examine the association between catastrophizing, as measured by the Coping Strategies Questionnaire Catastrophizing Subscale, and brain responses to blunt pressure assessed by functional MRI among 29 subjects with fibromyalgia. Since catastrophizing has been suggested to augment pain perception through enhanced attention to painful stimuli, and heightened emotional responses to pain, we hypothesized that catastrophizing would be positively associated with activation in structures believed to be involved in these aspects of pain processing. As catastrophizing is also strongly associated with depression, the influence of depressive symptomatology was statistically removed. Residual scores of catastrophizing controlling for depressive symptomatology were significantly associated with increased activity in the ipsilateral claustrum (r = 0.51, P < 0.05), cerebellum (r = 0.43, P < 0.05), dorsolateral prefrontal cortex (r = 0.47, P < 0.05), and parietal cortex (r = 0.41, P < 0.05), and in the contralateral dorsal anterior cingulate gyrus (ACC; r = 0.43, P < 0.05), dorsolateral prefrontal cortex (r = 0.41, P < 0.05), medial frontal cortex (r = 0.40, P < 0.05) and lentiform nuclei (r = 0.40, P < 0.05). Analysis of subjects classified as high or low catastrophizers, based on a median split of residual catastrophizing scores, showed that both groups displayed significant increases in ipsilateral secondary somatosensory cortex (SII), although the magnitude of activation was twice as large among high catastrophizers. Both groups also had significant activations in contralateral insula, SII, primary somatosensory cortex (SI), inferior parietal lobule and thalamus. High catastrophizers displayed unique activation in the contralateral anterior ACC, and the contralateral and ipsilateral lentiform. Both groups also displayed significant ipsilateral activation in SI, anterior and posterior cerebellum, posterior cingulate gyrus, and superior and inferior frontal gyrus. These findings suggest that pain catastrophizing, independent of the influence of depression, is significantly associated with increased activity in brain areas related to anticipation of pain (medial frontal cortex, cerebellum), attention to pain (dorsal ACC, dorsolateral prefrontal cortex), emotional aspects of pain (claustrum, closely connected to amygdala) and motor control. These results support the hypothesis that catastrophizing influences pain perception through altering attention and anticipation, and heightening emotional responses to pain. Activation associated with catastrophizing in motor areas of the brain may reflect expressive responses to pain that are associated with greater pain catastrophizing.

Integrity signals

Registry

Crossref · 10.1093/brain/awh098

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Pain catastrophizing is associated with cognitive and emotional aspects of pain that alter pain perception.
“Pain catastrophizing has been also associated with cognitive and emotional aspects of pain that alter pain perception [14].”
From Nocebo hyperalgesia and other expectancy-related factors in daily fibromyalgia pain: Combining experimental and electronic diary methods (2024) · cites this paper as [14]
The direction of the finding that pain catastrophizing predicts between-person differences in moment-to-moment pain increase corresponds with the literature [14,15].
“Although the contribution found is small, the direction of our finding corresponds with the literature [14,15].”
From Nocebo hyperalgesia and other expectancy-related factors in daily fibromyalgia pain: Combining experimental and electronic diary methods (2024) · cites this paper as [14]
Lack of workplace social support, dissatisfaction with co-workers, and interactions with the disability compensation system are among the strongest predictors of pain-related work disability.
“Lack of social support at work, dissatisfaction with co-workers, and interactions with the disability compensation system are among the most potent predictors of pain-related work disability 89, 131, 132.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [132]

The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267 · see citing works
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798 · see citing works
The american college of rheumatology 1990 criteria for the classification of fibromyalgia
Wolfe, F., Smythe, H. A., Yunus, M. B., Bennett, R. M., Bombardier, C., Goldenberg, D. L., Tugwell, P., Campbell, S. M., Abeles, M., Clark, P., et al. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330203 · Cited by 9,563 · see citing works
The short-form McGill pain questionnaire
Melzack, R. (1987) · Pain · doi:10.1016/0304-3959(87)91074-8 · Cited by 4,368 · see citing works
Theoretical perspectives on the relation between catastrophizing and pain
Sullivan, M. J. L., Thorn, B., Haythornthwaite, J. A., Keefe, F., Martin, M., Bradley, L. A., & Lefebvre, J. C. (2001) · The Clinical Journal of Pain · doi:10.1097/00002508-200103000-00008 · Cited by 2,472 · see citing works
The use of coping strategies in chronic low back pain patients: Relationship to patient characteristics and current adjustment
Rosenstiel, A. K., & Keefe, F. J. (1983) · Pain · doi:10.1016/0304-3959(83)90125-2 · Cited by 2,314 · see citing works
Functional imaging of brain responses to pain. A review and meta-analysis (2000)
Peyron, R., Laurent, B., & García-Larrea, L. (2000) · Neurophysiologie Clinique/Clinical Neurophysiology · doi:10.1016/s0987-7053(00)00227-6 · Cited by 2,171 · see citing works
Studies with pain rating scales.
Downie, W., Leatham, P. A., Rhind, V. M., Wright, V. A., Branco, J. A., & Anderson, J. (1978) · Annals of the Rheumatic Diseases · doi:10.1136/ard.37.4.378 · Cited by 1,987 · see citing works
Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation
Flor, H., Elbert, T. R., Knecht, S., Wienbruch, C., Pantev, C., Birbaumer, N., Larbig, W., & Taub, E. (1995) · Nature · doi:10.1038/375482a0 · Cited by 1,845 · see citing works
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia
Gracely, R. H., Petzke, F., Wolf, J. M., & Clauw, D. J. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10225 · Cited by 1,263 · see citing works
Self-citation
The reliability of a linear analogue for evaluating pain
REVILL, S. I., ROBINSON, J. O., Rosen, M. A., & Hogg, M. (1976) · Anaesthesia · doi:10.1111/j.1365-2044.1976.tb11971.x · Cited by 1,257 · see citing works
Dissociating pain from its anticipation in the human brain
Ploghaus, A., Tracey, I., Gati, J. S., Clare, S., Menon, R. S., Matthews, P. M., & Rawlins, J. N. P. (1999) · Science · doi:10.1126/science.284.5422.1979 · Cited by 1,151 · see citing works
Depression: Perspectives from Affective Neuroscience
Davidson, R. J., Pizzagalli, D., Nitschke, J. B., & Putnam, K. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135148 · Cited by 1,138 · see citing works
Pain intensity processing within the human brain: a bilateral, distributed mechanism
Coghill, R. C., Sang, C. N., Maisog, J. M., & Iadarola, M. J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.4.1934 · Cited by 1,077 · see citing works
DEPRESSIVE SYMPTOMS IN RELATION TO PHYSICAL HEALTH AND FUNCTIONING IN THE ELDERLY
Berkman, L. F., Berkman, C., Kasl, S. V., FREEMAN, D. H., Leo-Summers, L. S., Ostfeld, A. M., Cornoni‐Huntley, J. C., & Brody, J. A. (1986) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114408 · Cited by 812 · see citing works
Psychosocial Predictors of Outcome in Acute and Subchronic Low Back Trouble
Burton, A. K., Tillotson, K. M., Main, C. J., & Hollis, S. (1995) · Spine · doi:10.1097/00007632-199503150-00014 · Cited by 700 · cited 2× · see citing works
“Among persons with chronic pain, psychosocial factors may play a signi®cant role in the development and maintenance of the disorder (Bigos et al., 1992; Burton et al., 1995; Gatchel et al., 1995).”
Background
Coping with rheumatoid arthritis pain: catastrophizing as a maladaptive strategy
Keefe, F. J., Brown, G. K., Wallston, K. A., & Caldwell, D. S. (1989) · Pain · doi:10.1016/0304-3959(89)90152-8 · Cited by 694 · see citing works
Catastrophizing, pain, and disability in patients with soft-tissue injuries
Sullivan, M. J. L., Stanish, W., Waite, H., Sullivan, M., & Tripp, D. A. (1998) · Pain · doi:10.1016/s0304-3959(98)00097-9 · Cited by 593 · see citing works
The Dominant Role of Psychosocial Risk Factors in the Development of Chronic Low Back Pain Disability
Gatchel, R. J., Polatin, P. B., & Mayer, T. G. (1995) · Spine · doi:10.1097/00007632-199512150-00011 · Cited by 532 · see citing works
Expectation of Pain Enhances Responses to Nonpainful Somatosensory Stimulation in the Anterior Cingulate Cortex and Parietal Operculum/Posterior Insula: an Event-Related Functional Magnetic Resonance Imaging Study
Sawamoto, N., Honda, M., Okada, T., Hanakawa, T., Kanda, M., Fukuyama, H., Konishi, J., & Shibasaki, H. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07438.2000 · Cited by 519 · see citing works
Assessing Depression among Persons with Chronic Pain Using the Center for Epidemiological Studies-Depression Scale and the Beck Depression Inventory: A Comparative Analysis
Geisser, M. E., Roth, R. S., & Robinson, M. E. (1997) · The Clinical Journal of Pain · doi:10.1097/00002508-199706000-00011 · Cited by 515 · see citing works
Comparison of human cerebral activation pattern during cutaneous warmth, heat pain, and deep cold pain
Casey, K. L., Minoshima, S., Morrow, T., & Koeppe, R. A. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.1.571 · Cited by 477 · see citing works
Measurement properties of the center for epidemiological studies depression scale (CES-D) in older populations.
Hertzog, C., Van Alstine, J., Usala, P. D., Hultsch, D. F., & Dixon, R. (1990) · Psychological Assessment: A Journal of Consulting and Clinical Psychology · doi:10.1037/1040-3590.2.1.64 · Cited by 452 · see citing works
fMRI of Thermal Pain: Effects of Stimulus Laterality and Attention
Brooks, J. C. W., Nurmikko, T. J., Bimson, W. E., Singh, K. D., & Roberts, N. (2002) · NeuroImage · doi:10.1006/nimg.2001.0974 · Cited by 402 · see citing works
When somatic information threatens, catastrophic thinking enhances attentional interference
Crombez, G., Eccleston, C., Baeyens, F., & Eelen, P. (1998) · Pain · doi:10.1016/s0304-3959(97)00219-4 · Cited by 366 · see citing works
The Subjective Experience of Acute Pain An Assessment of the Utility of 10 Indices
Jensen, M. P., Karoly, P., OʼRiordan, E. F., Bland, F., & Burns, R. S. (1989) · Clinical Journal of Pain · doi:10.1097/00002508-198906000-00005 · Cited by 362 · see citing works
Relation between catastrophizing and depression in chronic pain patients.
Sullivan, M. J. L., & D’Eon, J. L. (1990) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.99.3.260 · Cited by 316 · see citing works
Catastrophizing, depression and the sensory, affective and evaluative aspects of chronic pain
Geisser, M. E., Robinson, M. E., Keefe, F. J., & Weiner, M. L. (1994) · Pain · doi:10.1016/0304-3959(94)90050-7 · Cited by 283 · see citing works
Detecting depression in chronic pain patients: Adequacy of self-reports
Turk, D. C., & Okifuji, A. (1994) · Behaviour Research and Therapy · doi:10.1016/0005-7967(94)90078-7 · Cited by 256 · see citing works
Cognitions, coping and social environment predict adjustment to phantom limb pain
Jensen, M. P., Ehde, D. M., Hoffman, A. J., Patterson, D. R., Czerniecki, J. M., & Robinson, L. R. (2002) · Pain · doi:10.1016/s0304-3959(01)00390-6 · Cited by 241 · see citing works
Perception of noxious and innocuous heat stimulation among healthy women and women with fibromyalgia: association with mood, somatic focus, and catastrophizing
Geisser, M. E., Casey, K. L., Brucksch, C. B., Ribbens-Grimm, C., Appleton, B. E., & Crofford, L. J. (2003) · Pain · doi:10.1016/s0304-3959(02)00417-7 · Cited by 233 · see citing works
Narcotic Analgesia: Fentanyl Reduces the Intensity But Not the Unpleasantness of Painful Tooth Pulp Sensations
Gracely, R. H., Dubner, R. A., & McGrath, P. A. (1979) · Science · doi:10.1126/science.424753 · Cited by 228 · see citing works
Self-citation
A Longitudinal, Prospective Study of Industrial Back Injury Reporting
Bigos, S. J., Battié, M. C., Spengler, D. M., Fisher, L. D., Fordyce, W. E., HANSSON, T. H., NACHEMSON, A. L., & Zeh, J. E. (1992) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199206000-00004 · Cited by 213 · see citing works
Pain coping skills training in the management of osteoarthritic knee pain-II: Follow-up results
Keefe, F. J., Caldwell, D. S., Williams, D. A., Gil, K. M., Mitchell, D., Robertson, C. L., Martinez, S., Nunley, J., Beckham, J. C., & Helms, M. J. (1990) · Behavior Therapy · doi:10.1016/s0005-7894(05)80357-0 · Cited by 174 · see citing works
A multiple random staircase method of psychophysical pain assessment
Gracely, R. H., Lota, L., Walter, D. J., & Dubner, R. A. (1988) · Pain · doi:10.1016/0304-3959(88)90023-1 · Cited by 163 · see citing works
Self-citation
Unidimensional pain rating scales: a multidimensional affect and pain survey (MAPS) analysis of what they really measure
Clark, C. W., Yang, J., Tsui, S.-L., Ng, K. F. J., & Clark, S. B. (2002) · Pain · doi:10.1016/s0304-3959(01)00474-2 · Cited by 162 · see citing works
Human Anterior Cingulate Cortex Neurons Modulated by Attention-Demanding Tasks
Davis, K. D., Hutchison, W. D., Lozano, A. M., Tasker, R. R., & Dostrovsky, J. O. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.6.3575 · Cited by 157 · see citing works
Advances in Low-Back Pain
NACHEMSON, A. L. (1985) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198511000-00031 · Cited by 156 · see citing works
What do tender points measure? Influence of distress on 4 measures of tenderness.
Petzke, F. W., Gracely, R. H., Park, K. M., Ambrose, K., & Clauw, D. J. (2003) · PubMed · Cited by 153 · see citing works
Self-citation
Do fibromyalgia patients display hypervigilance for innocuous somatosensory stimuli? Application of a body scanning reaction time paradigm
Peters, M. L., Vlaeyen, J. W. S., & van Drunen, C. (2000) · Pain · doi:10.1016/s0304-3959(00)00259-1 · Cited by 151 · see citing works
Temporal and Spatial Dynamics of Human Forebrain Activity During Heat Pain: Analysis by Positron Emission Tomography
Casey, K. L., Morrow, T., Lorenz, J., & Minoshima, S. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.2.951 · Cited by 145 · see citing works
Reliability and validity of the evaluation of pain in patients with total knee replacement
Boeckstyns, M. E. H., & Backer, M. (1989) · Pain · doi:10.1016/0304-3959(89)90069-9 · Cited by 94 · see citing works
The Effects of Catastrophic Thinking about Pain on Attentional Interference by Pain: No Mediation of Negative Affectivity in Healthy Volunteers and in Patients with Low Back Pain
Crombez, G., Eccleston, C., den Broeck, A. V., Houdenhove, B. V., & Goubert, L. (2002) · Pain Research and Management · doi:10.1155/2002/576792 · Cited by 87 · see citing works
Untitled work
Lurito (2000) · doi:10.1002/1097-0193(200007)10:3

Flagged first, then by citations

1 of the 45 references couldn’t be matched to a known paper.

Sorted by citations

The Cerebral Signature for Pain Perception and Its Modulation
Tracey, I., & Mantyh, P. W. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.012 · Cited by 1,843 · see citing works
Pain catastrophizing: a critical review.
Quartana, P. J., Campbell, C. M., & Edwards, R. R. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.34 · Cited by 1,405 · see citing works
The role of psychosocial processes in the development and maintenance of chronic pain
Edwards, R. R., Dworkin, R. H., Sullivan, M. D., Turk, D. C., & Wasan, A. D. (2016) · The Journal of Pain · doi:10.1016/j.jpain.2016.01.001 · Cited by 954 · see citing works
The pain matrix reloaded
Legrain, V., Iannetti, G. D., Plaghki, L., & Mouraux, A. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.10.005 · Cited by 854 · see citing works
Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment
Sarzi‐Puttini, P., Giorgi, V., Marotto, D., & Atzeni, F. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-00506-w · Cited by 837 · see citing works
Fibromyalgia and overlapping disorders: The unifying concept of central sensitivity syndromes
Yunus, M. B. (2007) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2006.12.009 · Cited by 780 · see citing works
Neurocognitive aspects of pain perception
Wiech, K., Ploner, M., & Tracey, I. (2008) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2008.05.005 · Cited by 737 · see citing works
Evaluating psychosocial contributions to chronic pain outcomes
Meints, S. M., & Edwards, R. R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.017 · Cited by 719 · see citing works
Neurobiology of fibromyalgia and chronic widespread pain
Sluka, K. A., & Clauw, D. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.006 · Cited by 671 · see citing works
Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update
Siracusa, R., Paola, R. D., Cuzzocrea, S., & Impellizzeri, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083891 · Cited by 710 · see citing works
Central Sensitivity Syndromes: A New Paradigm and Group Nosology for Fibromyalgia and Overlapping Conditions, and the Related Issue of Disease versus Illness
Yunus, M. B. (2008) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2007.09.003 · Cited by 648 · see citing works
Chronic pain epidemiology and its clinical relevance
van Hecke, O., Torrance, N., & Smith, B. H. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet123 · Cited by 632 · see citing works
Pain, catastrophizing, and depression in the rheumatic diseases
Edwards, R. R., Cahalan, C., Mensing, G., Smith, M., & Haythornthwaite, J. A. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.2 · Cited by 596 · see citing works
From the neuromatrix to the pain matrix (and back)
Iannetti, G. D., & Mouraux, A. (2010) · Experimental Brain Research · doi:10.1007/s00221-010-2340-1 · Cited by 554 · see citing works
Overlapping Chronic Pain Conditions: Implications for Diagnosis and Classification
Maixner, W., Fillingim, R. B., Williams, D. A., Smith, S. B., & Slade, G. D. (2016) · The Journal of Pain · doi:10.1016/j.jpain.2016.06.002 · Cited by 558 · see citing works
A multisensory investigation of the functional significance of the “pain matrix”
Mouraux, A., Diukova, A., Lee, M., Wise, R. G., & Iannetti, G. D. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.084 · Cited by 556 · see citing works
Untitled work
Fishman (2006) · doi:10.1097/01 · Cited by 547 · see citing works
Catastrophizing and pain in arthritis, fibromyalgia, and other rheumatic diseases
Edwards, R. R., Bingham, C. O., Bathon, J. M., & Haythornthwaite, J. A. (2006) · Arthritis Care & Research · doi:10.1002/art.21865 · Cited by 511 · see citing works
How neuroimaging studies have challenged us to rethink: Is chronic pain a disease?
Tracey, I., & Bushnell, M. C. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.09.001 · Cited by 455 · see citing works
Validación de la versión española de la escala de la catastrofización ante el dolor (Pain Catastrophizing Scale) en la fibromialgia
García Campayo, J., Rodero, B., Alda, M., Sobradiel, N., Montero, J., & Moreno, S. (2008) · Medicina Clínica · doi:10.1157/13127277 · Cited by 422 · see citing works
Cortical responses to pain in healthy individuals depends on pain catastrophizing
Seminowicz, D. A., & Davis, K. D. (2006) · Pain · doi:10.1016/j.pain.2005.11.008 · Cited by 407 · see citing works
The neurobiology of central sensitization
Harte, S. E., Harris, R. E., & Clauw, D. J. (2018) · Journal of Applied Biobehavioral Research · doi:10.1111/jabr.12137 · Cited by 404 · see citing works
The comorbidity of insomnia, chronic pain, and depression: Dopamine as a putative mechanism
Finan, P. H., & Smith, M. T. (2012) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.03.003 · Cited by 367 · see citing works
Psychological impact of fibromyalgia: current perspectives
Galvez-Sánchez, C. M., Duschek, S., & del Paso, G. A. R. (2019) · Psychology Research and Behavior Management · doi:10.2147/prbm.s178240 · Cited by 366 · see citing works
Assessment of Psychosocial and Functional Impact of Chronic Pain
Turk, D. C., Fillingim, R. B., Ohrbach, R., & Patel, K. V. (2016) · The Journal of Pain · doi:10.1016/j.jpain.2016.02.006 · Cited by 350 · see citing works
Fibromyalgia: an overview
Clauw, D. J. (2009) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.09.006 · Cited by 350 · see citing works
Brain changes associated with cognitive and emotional factors in chronic pain: A systematic review
Malfliet, A., Coppieters, I., Van Wilgen, P., Kregel, J., De Pauw, R., Dolphens, M., & Ickmans, K. (2017) · European Journal of Pain · doi:10.1002/ejp.1003 · Cited by 342 · see citing works
A key role of the basal ganglia in pain and analgesia - insights gained through human functional imaging
Borsook, D., Upadhyay, J., Chudler, E. H., & Becerra, L. (2010) · Molecular Pain · doi:10.1186/1744-8069-6-27 · Cited by 326 · see citing works
Idiopathic pain disorders – Pathways of vulnerability
Diatchenko, L., Nackley, A. G., Slade, G. D., Fillingim, R. B., & Maixner, W. (2006) · Pain · doi:10.1016/j.pain.2006.04.015 · Cited by 398 · see citing works
Dimensions of catastrophic thinking associated with pain experience and disability in patients with neuropathic pain conditions
Sullivan, M. J. L., Lynch, M. E., & Clark, A. J. (2004) · Pain · doi:10.1016/j.pain.2004.11.003 · Cited by 315 · see citing works
Cognitive-behavioral therapy increases prefrontal cortex gray matter in patients with chronic pain
Seminowicz, D. A., Shpaner, M., Keaser, M. L., Krauthamer, G. M., Mantegna, J., Dumas, J. A., Newhouse, P. A., Filippi, C. G., Keefe, F. J., & Naylor, M. R. (2013) · The Journal of Pain · doi:10.1016/j.jpain.2013.07.020 · Cited by 305 · see citing works
“Functional neuroimaging studies of acute pain paradigms in healthy control participants and in chronic pain populations have reported catastrophizing-related activations primarily within networks engaged in anticipation of and attention to pain.(21,66) Furthermore, a recent diffusion tensor imaging study revealed nega…”
Background
Pain Catastrophizing and Pain-Related Fear in Osteoarthritis Patients: Relationships to Pain and Disability
Somers, T. J., Keefe, F. J., Pells, J. J., Dixon, K. E., Waters, S. J., Riordan, P. A., Blumenthal, J. A., McKee, D. C., LaCaille, L. J., Tucker, J. M., et al. (2008) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2008.05.009 · Cited by 306 · see citing works
Striatal grey matter increase in patients suffering from fibromyalgia – A voxel-based morphometry study
Schmidt‐Wilcke, T., Luerding, R., Weigand, T., Jürgens, T. P., Schuierer, G. R., Leinisch, E., & Bogdahn, U. (2007) · Pain · doi:10.1016/j.pain.2007.05.010 · Cited by 301 · see citing works
Effects of unilateral repetitive transcranial magnetic stimulation of the motor cortex on chronic widespread pain in fibromyalgia
Passard, A., Attal, N., Benadhira, R., Brasseur, L., Saba, G., Sichère, P., Perrot, S., Januel, D., & Bouhassira, D. (2007) · Brain · doi:10.1093/brain/awm189 · Cited by 299 · see citing works
Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions
Staud, R. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.41 · Cited by 290 · see citing works
Pain Catastrophizing: An Updated Review
Leung, L. (2012) · Indian Journal of Psychological Medicine · doi:10.4103/0253-7176.106012 · Cited by 295 · see citing works
Catastrophizing: a predictive factor for postoperative pain
Khan, R. S., Ahmed, K., Blakeway, E., Skapinakis, P., Nihoyannopoulos, L., Macleod, K., Sevdalis, N., Ashrafian, H., Platt, M., Darzi, A., et al. (2011) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2010.02.007 · Cited by 289 · see citing works
Central Sensitization and Altered Central Pain Processing in Chronic Low Back Pain
Roussel, N. A., Nijs, J., Meeus, M., Mylius, V., Fayt, C., & Oostendorp, R. A. B. (2013) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31826f9a71 · Cited by 289 · see citing works
Long-term maintenance of the analgesic effects of transcranial magnetic stimulation in fibromyalgia
Mhalla, A., Baudic, S., de Andrade, D. C., Gautron, M., Perrot, S., Teixeira, M. J., Attal, N., & Bouhassira, D. (2011) · Pain · doi:10.1016/j.pain.2011.01.034 · Cited by 288 · see citing works
Pain and Depression: An Integrative Review of Neurobiological and Psychological Factors
Goesling, J., Clauw, D. J., & Hassett, A. L. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0421-0 · Cited by 285 · see citing works
White and gray matter abnormalities in the brain of patients with fibromyalgia: a diffusion-tensor and volumetric imaging study.
Lutz, J., Jäger, L., de Quervain, D., Krauseneck, T., Padberg, F., Wichnalek, M., Beyer, A., Stahl, R., Zirngibl, B., Morhard, D., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.24070 · Cited by 291 · see citing works
Individual differences in endogenous pain modulation as a risk factor for chronic pain
Edwards, R. R. (2005) · Neurology · doi:10.1212/01.wnl.0000171862.17301.84 · Cited by 283 · see citing works
Nociceptive processing in the human brain
Tracey, I. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.06.010 · Cited by 278 · see citing works
Fibromyalgia: A Critical and Comprehensive Review
Borchers, A. T., & Gershwin, M. E. (2015) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8509-4 · Cited by 279 · see citing works
The Development of Persistent Pain and Psychological Morbidity After Motor Vehicle Collision: Integrating the Potential Role of Stress Response Systems Into a Biopsychosocial Model
McLean, S. A., Clauw, D. J., Abelson, J. L., & Liberzon, I. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000181276.49204.bb · Cited by 273 · see citing works
Structural Brain Anomalies and Chronic Pain: A Quantitative Meta-Analysis of Gray Matter Volume
Smallwood, R. F., Laird, A. R., Ramage, A. E., Parkinson, A. L., Lewis, J. D., Clauw, D. J., Williams, D. A., Schmidt‐Wilcke, T., Farrell, M. J., Eickhoff, S. B., et al. (2013) · Journal of Pain · doi:10.1016/j.jpain.2013.03.001 · Cited by 273 · see citing works
Association of Major Depressive Disorder With Altered Functional Brain Response During Anticipation and Processing of Heat Pain
Strigo, I. A., Simmons, A. N., Matthews, S. C., Craig, A. D. B., & Paulus, M. P. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.11.1275 · Cited by 272 · see citing works
Weak but Critical Links between Primary Somatosensory Centers and Motor Cortex during Movement
Wei, P., Bao, R., Lv, Z., & Jing, B. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00001 · Cited by 267 · see citing works
Reframing chronic pain as a disease, not a symptom: rationale and implications for pain management
Clauw, D. J., Essex, M. N., Pitman, V. W., & Jones, K. D. (2019) · Postgraduate Medicine · doi:10.1080/00325481.2019.1574403 · Cited by 262 · see citing works
Towards a neurophysiological signature for fibromyalgia
López‐Solà, M., Woo, C., Pujol, J., Deus, J., Harrison, B. J., Monfort, J., & Wager, T. D. (2016) · Pain · doi:10.1097/j.pain.0000000000000707 · Cited by 255 · see citing works
Catastrophizing as a mediator of sex differences in pain: differential effects for daily pain versus laboratory-induced pain
Edwards, R. R., Haythornthwaite, J. A., Sullivan, M. J., & Fillingim, R. B. (2004) · Pain · doi:10.1016/j.pain.2004.07.012 · Cited by 250 · see citing works
Understanding fibromyalgia: lessons from the broader pain research community.
Williams, D. A., & Clauw, D. J. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.06.001 · Cited by 250 · see citing works
rTMS for suppressing neuropathic pain: a meta-analysis.
Leung, A., Donohue, M., Xu, R.-H., Lee, R., Lefaucheur, J., Khedr, E., Saitoh, Y., André-Obadia, N., Rollnik, J., Wallace, M., et al. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.03.010 · Cited by 230 · see citing works
Decreased Gray Matter Volumes in the Cingulo-Frontal Cortex and the Amygdala in Patients With Fibromyalgia
Burgmer, M., Gaubitz, M., Konrad, C., Wrenger, M., Hilgart, S., Heuft, G., & Pfleiderer, B. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181a32da0 · Cited by 237 · see citing works
Reduced Brainstem Inhibition during Anticipated Pelvic Visceral Pain Correlates with Enhanced Brain Response to the Visceral Stimulus in Women with Irritable Bowel Syndrome
Berman, S. M., Naliboff, B. D., Suyenobu, B. Y., Labus, J. S., Stains, J., Ohning, G., Kilpatrick, L. A., Bueller, J. A., Ruby, K., Jarcho, J. M., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2500-07.2008 · Cited by 233 · see citing works
Somatic and vicarious pain are represented by dissociable multivariate brain patterns
Krishnan, A., Woo, C., Chang, L. J., Ruzic, L. L., Gu, X., López‐Solà, M., Jackson, P. L., Pujol, J., Fan, J., & Wager, T. D. (2016) · eLife · doi:10.7554/elife.15166 · Cited by 233 · see citing works
Pain sensitivity and fMRI pain-related brain activity in Alzheimer's disease
Cole, L. J., Farrell, M. J., Duff, E. P., Barber, J. B., Egan, G. F., & Gibson, S. J. (2006) · Brain · doi:10.1093/brain/awl228 · Cited by 229 · see citing works
Reward deficiency and anti-reward in pain chronification
Borsook, D., Linnman, C., Faria, V., Strassman, A. M., Becerra, L. R., & Elman, I. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.033 · Cited by 227 · see citing works
Fibromyalgia: from pathophysiology to therapy
Schmidt‐Wilcke, T., & Clauw, D. J. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.98 · Cited by 231 · see citing works
Early Breastfeeding Experiences and Postpartum Depression
Watkins, S., Meltzer-Brody, S. E., Zolnoun, D., & Stuebe, A. M. (2011) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e3182260a2d · Cited by 227 · see citing works
Pain-related Catastrophizing in Healthy Women Is Associated With Greater Temporal Summation of and Reduced Habituation to Thermal Pain
Edwards, R. R., Smith, M. T., Stonerock, G. L., & Haythornthwaite, J. A. (2006) · Clinical Journal of Pain · doi:10.1097/01.ajp.0000210914.72794.bc · Cited by 224 · see citing works
Clinical biopsychosocial physiotherapy assessment of patients with chronic pain: The first step in pain neuroscience education
Wijma, A. J., van Wilgen, C. P., Meeus, M., & Nijs, J. (2016) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2016.1194651 · Cited by 222 · see citing works
Imaging pain
Tracey, I. (2008) · British Journal of Anaesthesia · doi:10.1093/bja/aen102 · Cited by 223 · see citing works
A Psychophysical Study of Auditory and Pressure Sensitivity in Patients With Fibromyalgia and Healthy Controls
Geisser, M. E., Glass, J. M., Rajcevska, L. D., Clauw, D. J., Williams, D. A., Kileny, P. R., & Gracely, R. H. (2008) · Journal of Pain · doi:10.1016/j.jpain.2007.12.006 · Cited by 217 · see citing works
Self-citation
Pain and analgesia: the value of salience circuits
Borsook, D., Edwards, R., Elman, I., Becerra, L., & Levine, J. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.02.003 · Cited by 215 · see citing works
Effects of catastrophizing on pain perception and pain modulation
Weissman-Fogel, I., Sprecher, E., & Pud, D. (2008) · Experimental Brain Research · doi:10.1007/s00221-007-1206-7 · Cited by 214 · see citing works
The effect of catastrophizing and depression on chronic pain – a prospective cohort study of temporomandibular muscle and joint pain disorders
Velly, A. M., Look, J. O., Carlson, C. R., Lenton, P. A., Kang, W., Holcroft, C., & Fricton, J. (2011) · Pain · doi:10.1016/j.pain.2011.07.004 · Cited by 214 · see citing works
Alteration of cortical excitability in patients with fibromyalgia
Mhalla, A., de Andrade, D. C., Baudic, S., Perrot, S., & Bouhassira, D. (2010) · Pain · doi:10.1016/j.pain.2010.03.009 · Cited by 210 · see citing works
Brain imaging of pain: state of the art
Morton, D. L., Jones, A. K. P., & Sandhu, J. (2016) · Journal of Pain Research · doi:10.2147/jpr.s60433 · Cited by 211 · see citing works
Determining anatomical connectivities between cortical and brainstem pain processing regions in humans: A diffusion tensor imaging study in healthy controls
Hadjipavlou, G., Dunckley, P., Behrens, T. E. J., & Tracey, I. (2006) · Pain · doi:10.1016/j.pain.2006.02.027 · Cited by 203 · see citing works
A role for fMRI in optimizing CNS drug development
Borsook, D., Becerra, L. R., & Hargreaves, R. J. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2027 · Cited by 203 · see citing works
Catastrophizing and depressive symptoms as prospective predictors of outcomes following total knee replacement
Edwards, R. R., Haythornthwaite, J. A., Smith, M. T., Klick, B., & Katz, J. N. (2009) · Pain Research and Management · doi:10.1155/2009/273783 · Cited by 202 · see citing works
Altered brain structure and function correlate with disease severity and pain catastrophizing in migraine patients
Hubbard, C. S., Khan, S. A., Keaser, M. L., Mathur, V. A., Goyal, M., & Seminowicz, D. A. (2014) · eneuro · doi:10.1523/eneuro.0006-14.2014 · Cited by 184 · see citing works
Treatment of central sensitization in patients with ‘unexplained’chronic pain: An update
Nijs, J., Malfliet, A., Ickmans, K., Baert, I., & Meeus, M. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.925446 · Cited by 195 · see citing works
Association of catastrophizing with interleukin-6 responses to acute pain
Edwards, R. R., Kronfli, T., Haythornthwaite, J. A., Smith, M. T., McGuire, L. M., & Page, G. G. (2008) · Pain · doi:10.1016/j.pain.2008.07.024 · Cited by 197 · see citing works
Neural correlates of painful genital touch in women with vulvar vestibulitis syndrome
Pukall, C. F., Strigo, I. A., Binik, Y. M., Amsel, R., Khalifé, S., & Bushnell, C. M. (2005) · Pain · doi:10.1016/j.pain.2005.02.020 · Cited by 192 · see citing works
Pain Catastrophizing and Function In Individuals With Chronic Musculoskeletal Pain
Martínez-Calderón, J., Jensen, M. P., Morales‐Asencio, J. M., & Luque-Suárez, A. (2019) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000676 · Cited by 196 · see citing works
Cerebral processing of pain in school-aged children with neonatal nociceptive input: An exploratory fMRI study
Hohmeister, J., Kröll, A., Wollgarten-Hadamek, I., Zohsel, K., Demirakça, S., Flor, H., & Hermann, C. (2010) · Pain · doi:10.1016/j.pain.2010.04.004 · Cited by 186 · see citing works
Associations Between Catastrophizing and Endogenous Pain-Inhibitory Processes: Sex Differences
Goodin, B. R., McGuire, L. M., Allshouse, M., Stapleton, L. M., Haythornthwaite, J. A., Burns, N., Mayes, L. A., & Edwards, R. R. (2008) · Journal of Pain · doi:10.1016/j.jpain.2008.08.012 · Cited by 185 · see citing works
Psychological Factors and Conditioned Pain Modulation
Nahman‐Averbuch, H., Nir, R., Sprecher, E., & Yarnitsky, D. (2015) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000296 · Cited by 184 · see citing works
Fear of Pain, Pain Catastrophizing, and Acute Pain Perception: Relative Prediction and Timing of Assessment
Hirsh, A. T., George, S. Z., Bialosky, J. E., & Robinson, M. E. (2008) · Journal of Pain · doi:10.1016/j.jpain.2008.03.012 · Cited by 180 · see citing works
Fibromyalgia: An Afferent Processing Disorder Leading to a Complex Pain Generalized Syndrome
Smith, H. S. (2011) · Pain Physician · doi:10.36076/ppj.2011/14/e217 · Cited by 198 · see citing works
Influence of kinesiophobia and catastrophizing on pain and disability in anterior knee pain patients
Doménech, J., Sanchis‐Alfonso, V., López, L., & Espejo, B. (2012) · Knee Surgery Sports Traumatology Arthroscopy · doi:10.1007/s00167-012-2238-5 · Cited by 181 · see citing works
Review of Cognitive Dysfunction in Fibromyalgia: A Convergence on Working Memory and Attentional Control Impairments
Glass, J. M. (2009) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2009.06.002 · Cited by 176 · see citing works
Mind-body interactions in pain: the neurophysiology of anxious and catastrophic pain-related thoughts
Campbell, C. M., & Edwards, R. R. (2009) · Translational research · doi:10.1016/j.trsl.2008.12.002 · Cited by 175 · see citing works
Central Nervous System Reorganization in a Variety of Chronic Pain States: A Review
Henry, D. E., Chiodo, A. E., & Yang, W. (2011) · PM&R · doi:10.1016/j.pmrj.2011.05.018 · Cited by 172 · see citing works
Pathophysiology of endometriosis-associated pain: A review of pelvic and central nervous system mechanisms
Coxon, L., Horne, A. W., & Vincent, K. (2018) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2018.01.014 · Cited by 170 · see citing works
Can neuroimaging studies identify pain endophenotypes in humans?
Tracey, I. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.4 · Cited by 166 · see citing works
The relationship between catastrophizing and altered pain sensitivity in patients with chronic low-back pain
Meints, S. M., Mawla, I., Napadow, V., Kong, J., Gerber, J. A., Chan, S., Wasan, A. D., Kaptchuk, T. J., McDonnell, C., Carrière, J. S., et al. (2018) · Pain · doi:10.1097/j.pain.0000000000001461 · Cited by 166 · see citing works
The somatosensory link in fibromyalgia: functional connectivity of the primary somatosensory cortex is altered by sustained pain and is associated with clinical/autonomic dysfunction
Kim, J., Loggia, M. L., Cahalan, C. M., Harris, R. E., Beissner, F., Garcia, R. G., Kim, H., Barbieri, R., Wasan, A. D., Edwards, R. R., et al. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39043 · Cited by 161 · see citing works
Psychological pain treatment in fibromyalgia syndrome: efficacy of operant behavioural and cognitive behavioural treatments
Thieme, K., Flor, H., & Turk, D. C. (2006) · Arthritis Research & Therapy · doi:10.1186/ar2010 · Cited by 167 · see citing works
Altered brain activity during pain processing in fibromyalgia
Burgmer, M., Pogatzki-Zahn, E. M., Gaubitz, M., Wessoleck, E., Heuft, G., & Pfleiderer, B. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.09.008 · Cited by 165 · see citing works
Endogenous opioidergic dysregulation of pain in fibromyalgia: a PET and fMRI study
Schrepf, A., Harper, D., Harte, S. E., Wang, H., Ichesco, E., Hampson, J. P., Zubieta, J., Clauw, D. J., & Harris, R. E. (2016) · Pain · doi:10.1097/j.pain.0000000000000633 · Cited by 163 · see citing works
Depression and pain
Michael, J. R. (2009) · Frontiers in bioscience · doi:10.2741/3585 · Cited by 163 · see citing works
Differential endogenous pain modulation in complex-regional pain syndrome
Seifert, F. C., Kiefer, G., DeCol, R., Schmelz, M., & Maihöfner, C. (2009) · Brain · doi:10.1093/brain/awn346 · Cited by 161 · see citing works
Enhanced Presurgical Pain Temporal Summation Response Predicts Post-Thoracotomy Pain Intensity During the Acute Postoperative Phase
Weissman‐Fogel, I., Granovsky, Y., Crispel, Y., Ben‐Nun, A., Best, L. A., Yarnitsky, D., & Granot, M. (2009) · Journal of Pain · doi:10.1016/j.jpain.2008.12.009 · Cited by 154 · see citing works
Changes in catastrophizing and kinesiophobia are predictive of changes in disability and pain after treatment in patients with anterior knee pain
Doménech, J., Sanchis‐Alfonso, V., & Espejo, B. (2014) · Knee Surgery Sports Traumatology Arthroscopy · doi:10.1007/s00167-014-2968-7 · Cited by 155 · see citing works
Alteration in pain modulation in women with persistent pain after lumpectomy: influence of catastrophizing
Edwards, R. R., Mensing, G., Cahalan, C., Greenbaum, S., Narang, S., Belfer, I., Schreiber, K. L., Campbell, C., Wasan, A. D., & Jamison, R. N. (2013) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2012.06.016 · Cited by 150 · see citing works
From acute musculoskeletal pain to chronic widespread pain and fibromyalgia: Application of pain neurophysiology in manual therapy practice
Nijs, J., & Houdenhove, B. V. (2008) · Manual Therapy · doi:10.1016/j.math.2008.03.001 · Cited by 147 · see citing works
The relation between cognitive factors and levels of pain and disability in chronic low back pain patients presenting for physiotherapy
Woby, S. R., Roach, N. K., Urmston, M., & Watson, P. (2007) · European Journal of Pain · doi:10.1016/j.ejpain.2007.01.005 · Cited by 148 · see citing works

Brain processing of pain and expectancy of relief in fibromyalgia is modulated by catastrophizing
Loggia, M. L., Renella, C. B., Kim, J., Cahalan, C., Gollub, R. L., Wasan, A. D., Edwards, R. R., & Napadow, V. (2013) · Journal of Pain · doi:10.1016/j.jpain.2013.01.531
Posterior cingulate cortex is a key neural substrate for pain catastrophizing in fibromyalgia
Lee, J., Protsenko, E., Lazaridiou, A., Franceschelli, O., Ellingsen, D., Mawla, I., Isenburg, K., Loggia, M. L., Wasan, A. D., Edwards, R. R., et al. (2018) · Journal of Pain · doi:10.1016/j.jpain.2017.12.039 · Cited by 1 · see citing works
Cerebral Activation and Catastrophizing During Pain Anticipation in Patients With Fibromyalgia
Burgmer, M., Petzke, F. W., Giesecke, T., Gaubitz, M., Heuft, G., & Pfleiderer, B. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318236588a · Cited by 71 · see citing works
Catastrophizing Interferes with Cognitive Modulation of Pain in Women with Fibromyalgia
Ellingson, L. D., Stegner, A. J., Schwabacher, I. J., Lindheimer, J. B., & Cook, D. B. (2018) · Pain Medicine · doi:10.1093/pm/pny008 · Cited by 73 · see citing works
(208) Catastrophizing cognitions promote proinflammatory cytokine responses to acute pain in fibromyalgia
Franceschelli, O., Cahalan, C., Martel, M., & Edwards, R. (2015) · Journal of Pain · doi:10.1016/j.jpain.2015.01.123

Authors: Gracely, R. H.
Affiliations: University of Michigan (US)
Corresponding author: Gracely, R. H.
Venue: Brain
Publisher: Oxford University Press (OUP)
Published: 2004-01-14
Volume: 127
Issue: 4
Pages: 835-843
ISSN: 0006-8950 (ISSN-L)
1460-2156
DOI: 10.1093/brain/awh098
OpenAlex: W2114943199
Cited by: 892
References: 45
Citations by year: 2026: 28 · 2025: 25 · 2024: 31 · 2023: 40 · 2022: 28 · 2021: 20 · 2020: 47 · 2019: 40 · 2018: 49 · 2017: 36 · 2016: 43 · 2015: 43 · 2014: 45 · 2013: 43 · 2012: 34
FWCI: 18.94
Type: journal article
Language: en
Open access: closed
Locations: Brain (publishedVersion)
PubMed (publishedVersion)
Funders: Georgetown University
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Keywords: pain catastrophizing, fibromyalgia, brain activation, claustrum, anterior cingulate cortex, dorsolateral prefrontal cortex, cerebellum, somatosensory cortex, insula, lentiform nucleus, depression, attention to pain, emotional response to pain, secondary somatosensory cortex
MeSH terms: Adaptation, Psychological, Adolescent, Adult, Brain, Depression, Female, Fibromyalgia, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Pain, Pain Measurement, Perception

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pain catastrophizing and neural responses to pain among persons with fibromyalgia

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks