The DOI matches its Crossref record.
Articular cartilage: structure, injuries and review of management
Open accessAbstract
INTRODUCTION: Chondral and osteochondral injuries are commonly seen in today's clinical practice. Articular cartilage provides an ultimate low-friction gliding surface, which none of the artificial constructs have been able to replace successfully. Retrospective review of the knee arthroscopies has revealed an underestimated incidence of this complex problem. Cartilage injuries in the knee joint if left untreated lead to pre-mature early arthritis and affect the activities of daily living. Various different treatment methods of cartilage regeneration have shown encouraging results, but unfortunately none has proved to be the ultimate solution. SOURCES OF DATA: This article re-visits the intricate structure of articular cartilage and reviews the different methods of regeneration described in the literature, based on evidence-based effectiveness. The methods described by their originators and their results are considered gold standards for those methods, as being the best available evidence. AREAS OF AGREEMENT: Majority of the authors agree that cartilage injuries are complex and difficult to treat. If untreated, cartilage defects lead to early osteoarthritis. Great debate still persists about the best available treatment for symptomatic chondral or osteochondral defect(s). AREAS OF CONTROVERSY: The controversy about the management outplays its aetiological theories. Several authors have reported good results with different techniques; however none has proved to be the solution for the problem. GROWING POINTS: Up until 1990, marrow stimulation techniques were routine form of management for chondral defects. However, ever since autologous chondrocyte implantation was successfully introduced in humans, it has provided a new dimension for the treatment of chondral defects. AREAS TIMELY FOR DEVELOPING RESEARCH: The success of any treatment lies in its longevity. The new minimally invasive techniques are being invented. However, timely research, on the basis of randomized controlled trial comparing different methods of cartilage reconstruction is necessary for decision-making in today's evidence-based medical world.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
The influence of structural design of PLGA/collagen hybrid scaffolds in cartilage tissue engineering
Dai, W., Kawazoe, N., Lin, X., Dong, J., & Chen, G. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.11.070 · Cited by 248
Anthropomorphism and Its Adverse Effects on the Distress and Welfare of Companion Animals
Mota-Rojas, D., Mariti, C., Zdeinert, A., Riggio, G., Mora-Medina, P., del Mar Reyes, A., Gazzano, A., Domínguez-Oliva, A., Lezama-García, K., José-Pérez, N., et al. (2021) · Animals · doi:10.3390/ani11113263 · Cited by 95
The Oxygen Paradox, the French Paradox, and age-related diseases
Davies, J. M. S., Cillard, J., Friguet, B., Cadenas, E., Cadet, J., Cayce, R., Fishmann, A., Liao, D., Bulteau, A.-L., Derbré, F., et al. (2017) · GeroScience · doi:10.1007/s11357-017-0002-y · Cited by 82
“…only 5% of the joint mass. Ageing results in cell senescence (Musumeci et al. 2015), loss of chondrocyte phenotype and thus abnormal remodeling of the extracellular matrix (Quintero et al. 1984; Lotz et al. 2010), and age-related changes in the extracellular matrix (Bhosale and Richardson 2008).”
BackgroundFeng, X., Xu, P., Shen, T., Zhang, Y., Ye, J., & Gao, C. (2020) · Journal of Materials Chemistry B · doi:10.1039/c9tb01558b · Cited by 80
Advances and prospects in biomimetic multilayered scaffolds for articular cartilage regeneration
Fu, L., Yang, Z., Gao, C., Li, H., Yuan, Z., Wang, F., Sui, X., Liu, S., & Guo, Q. (2020) · Regenerative Biomaterials · doi:10.1093/rb/rbaa042 · Cited by 65
Ascorbic Acid Provides Protection for Human Chondrocytes against Oxidative Stress
CHANG, Z., HUO, L., LI, P., WU, Y., & ZHANG, P. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4231 · Cited by 62
Metadata
- Authors
- Bhosale, A. M., & Richardson, J. B.
- Venue
- British Medical Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-08-01
- Volume
- 87
- Issue
- 1
- Pages
- 77-95
- ISSN
- 0007-1420 (ISSN-L)
- 1471-8391
- OpenAlex
- W2110052568
- Cited by
- 718
- References
- 0
- FWCI
- 9.63
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
