The Oxygen Paradox, the French Paradox, and age-related diseases
Open accessAbstract
A paradox is a seemingly absurd or impossible concept, proposition, or theory that is often difficult to understand or explain, sometimes apparently self-contradictory, and yet ultimately correct or true. How is it possible, for example, that oxygen "a toxic environmental poison" could be also indispensable for life (Beckman and Ames Physiol Rev 78(2):547-81, 1998; Stadtman and Berlett Chem Res Toxicol 10(5):485-94, 1997)?: the so-called Oxygen Paradox (Davies and Ursini 1995; Davies Biochem Soc Symp 61:1-31, 1995). How can French people apparently disregard the rule that high dietary intakes of cholesterol and saturated fats (e.g., cheese and paté) will result in an early death from cardiovascular diseases (Renaud and de Lorgeril Lancet 339(8808):1523-6, 1992; Catalgol et al. Front Pharmacol 3:141, 2012; Eisenberg et al. Nat Med 22(12):1428-1438, 2016)?: the so-called, French Paradox. Doubtless, the truth is not a duality and epistemological bias probably generates apparently self-contradictory conclusions. Perhaps nowhere in biology are there so many apparently contradictory views, and even experimental results, affecting human physiology and pathology as in the fields of free radicals and oxidative stress, antioxidants, foods and drinks, and dietary recommendations; this is particularly true when issues such as disease-susceptibility or avoidance, "healthspan," "lifespan," and ageing are involved. Consider, for example, the apparently paradoxical observation that treatment with low doses of a substance that is toxic at high concentrations may actually induce transient adaptations that protect against a subsequent exposure to the same (or similar) toxin. This particular paradox is now mechanistically explained as "Adaptive Homeostasis" (Davies Mol Asp Med 49:1-7, 2016; Pomatto et al. 2017a; Lomeli et al. Clin Sci (Lond) 131(21):2573-2599, 2017; Pomatto and Davies 2017); the non-damaging process by which an apparent toxicant can activate biological signal transduction pathways to increase expression of protective genes, by mechanisms that are completely different from those by which the same agent induces toxicity at high concentrations. In this review, we explore the influences and effects of paradoxes such as the Oxygen Paradox and the French Paradox on the etiology, progression, and outcomes of many of the major human age-related diseases, as well as the basic biological phenomenon of ageing itself.
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Under an imbalanced redox state, increased mitochondrial reactive oxygen species production may modify arterial walls and be followed by an inflammatory environment.
“Under conditions of an imbalanced redox state, increased mitochondrial ROS production might lead to modifications of the arterial walls180, followed by an inflammatory environment181.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [181]
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BackgroundInfluentialNormalization of NAD + Redox Balance as a Therapy for Heart Failure
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Metabolic signaling by lactate in the brain
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Nitric Oxide Synthase Expression in Bone Cells
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“…expressed in bone marrow stromal cells, osteoblasts, osteocytes, and osteoclasts (Helfrich et al. 1997), while inducible NOS (iNOS) has been observed in fetal bone (Hukkanen et al. 1999)—suggesting a role in skeletal development, but not constitutively in normal adult bone (Fox and Chow 1998).”
BackgroundHuman Apolipoprotein E4 Domain Interaction
Dong, L.-M., & Weisgraber, K. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.32.19053 · Cited by 318 · cited 10× · see citing works
“In vitro oxidation of either apoA1 or HDL particles by MPO impairs their cholesterol acceptor function.”
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PINK1 and Parkin: emerging themes in mitochondrial homeostasis.
McWilliams, T. G., & Muqit, M. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.03.013 · Cited by 315 · cited 2× · see citing works
“Mutations in this genetic pathway are implicated in Parkinson disease characteristic dopaminergic degeneration (McWilliams and Muqit 2017).”
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Self-citationNutrient intake and cataract extraction in women: a prospective study.
Hankinson, S. E., Stampfer, M. J., Seddon, J. M., Colditz, G. A., ROSNER, B. A., Speizer, F. E., & Willett, W. C. (1992) · BMJ · doi:10.1136/bmj.305.6849.335 · Cited by 312 · see citing works
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Free radicals as triggers of brain edema formation after stroke
Heo, J. H., Han, S., & Lee, S. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.03.035 · Cited by 306 · cited 1× · see citing works
“Even following the immediate danger of a stroke, free radicals continue to exert detrimental effects that lead to other complications such as brain edema, which can result from disruption of the blood brain barrier leading to fluid accumulation (Heo et al. 2005).”
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Physical Activity and Cancer Outcomes: A Precision Medicine Approach
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Oxidative stress in malignant melanoma and non-melanoma skin cancer
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Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages
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Self-citationResistance to Paclitaxel Is Proportional to Cellular Total Antioxidant Capacity
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Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration
Malek, G., Johnson, L. V., Mace, B. E., Saloupis, P., Schmechel, D. E., Rickman, D. W., Toth, C. A., Sullivan, P. M., & Rickman, C. B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503015102 · Cited by 284 · see citing works
Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering
Κιτσαρά, Μ., Agbulut, O., Kontziampasis, D., Chen, Y., & Menasché, P. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.11.014 · Cited by 284 · cited 1× · see citing works
“The principle of tissue engineering mainly relies upon the promotion of cells growth on a bio-inspired scaffold that mimics both physical and chemical properties of cardiac tissues (Kitsara et al. 2016).”
BackgroundSelf-citationA prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women
Chasan‐Taber, L., Willett, W. C., Seddon, J. M., Stampfer, M. J., ROSNER, B. A., Colditz, G. A., Speizer, F. E., & Hankinson, S. E. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.4.509 · Cited by 283 · see citing works
Lactate: A Preferred Fuel for Human Brain Metabolism in Vivo
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Cholesterol in the retina: The best is yet to come
Pikuleva, I. A., & Curcio, C. A. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.03.002 · Cited by 282 · cited 3× · see citing works
“These observations and experimental data led to the hypothesis that drusen lesions develop secondary to a deficit in the reverse cholesterol transport (RCT) similar to atherosclerotic plaques (Pikuleva and Curcio 2014; Malek et al. 2005; Ong et al. 2001).”
BackgroundDavies, N. J., Batehup, L., & Thomas, R. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.423 · Cited by 277 · cited 1× · see citing works
“In addition, patients’ diet and physical activity levels are known to modulate the efficiency of these anticancer treatments, but the molecular mechanisms remain unknown (Friedenreich et al. 2010; Davies et al. 2011).”
BackgroundTsutsumi, C., Sonoda, K.-H., Egashira, K., Qiao, H., Hisatomi, T., Nakao, S., Ishibashi, M., Charo, I. F., Sakamoto, T., Murata, T., et al. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0902436 · Cited by 277 · see citing works
Etiology and Pathogenesis of Rheumatoid Arthritis
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Lau, Y.-S., Patki, G., Das-Panja, K., Le, W.-D., & Ahmad, S. O. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07626.x · Cited by 275 · see citing works
Human<i>APOE</i>Isoform-Dependent Effects on Brain β-Amyloid Levels in PDAPP Transgenic Mice
Bales, K. R., Liu, F., Wu, S., Lin, S., Koger, D., DeLong, C., Hansen, J. C., Sullivan, P. M., & Paul, S. M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0887-09.2009 · Cited by 274 · see citing works
Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy
Yamamoto, M., Yang, G., Hong, C., Liu, J., Holle, E., Yu, X., Wagner, T. E., Vatner, S. F., & Sadoshima, J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17700 · Cited by 274 · see citing works
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Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy
Duan, X., Wen, Z., Shen, H., Shen, M., & Chen, G. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/1203285 · Cited by 270 · see citing works
The Relationship of Cardiovascular Disease and Its Risk Factors to Age-related Maculopathy
Klein, R., Klein, R., & Franke, T. M. (1993) · Ophthalmology · doi:10.1016/s0161-6420(93)31634-9 · Cited by 262 · cited 31× · see citing works
“Our study also sheds an interesting light on the puzzling differences of the APOE isoform association with AMD (McKay et al. 2011) and Alzheimer disease (Mahley and Rall 2000), two major age-related neurodegenerative diseases: In Alzheimer disease, the APOE4-allele is associated with greater β-amyloid burden, possibly…”
BackgroundInfluentialTotal oxidative/anti-oxidative status and relation to bone mineral density in osteoporosis
Altındağ, Ö., Erel, Ö., Soran, N., Çelık, H., & Selek, Ş. (2007) · Rheumatology International · doi:10.1007/s00296-007-0452-0 · Cited by 261 · see citing works
Epidemiologic evidence of a role for the antioxidant vitamins and carotenoids in cataract prevention
Jacques, P. F., & Chylack, L. T. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.1.352s · Cited by 261 · cited 1× · see citing works
“Dietary supplementation of vitamin C has been associated with reduced risk of developing age-related cataracts (Yoshida et al. 2007; Jacques and Chylack 1991; Hankinson et al. 1992).”
BackgroundOverview of skin aging and photoaging.
Helfrich, Y. R., Sachs, D. L., & Voorhees, J. J. (2008) · PubMed · Cited by 255 · see citing works
Anderson, D. H., Ozaki, S., Nealon, M., Neitz, J., Mullins, R. F., Hageman, G. S., & Johnson, L. V. (2001) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(00)00961-2 · Cited by 255 · see citing works
Flaherty, J. T., Pitt, B., Gruber, J. W., Heuser, R. R., ROTHBAUM, D. A., Burwell, L. R., George, B. S., Kereiakes, D. J., Deitchman, D., & Gustafson, N. (1994) · Circulation · doi:10.1161/01.cir.89.5.1982 · Cited by 255 · see citing works
Champy, P., Höglinger, G. U., Féger, J., Gleye, C., Hocquemiller, R., Laurens, A., Guérineau, V., Laprévôte, O., Medja, F., Lombès, A., et al. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02138.x · Cited by 254 · see citing works
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“The key biological mechanism by which sun exposure leads to photoaging is the generation of reactive oxygen species (Gilchrest 2013; Yaar and Gilchrest 2012; Krutmann 2000).”
BackgroundCutaneous responses to environmental stressors
Valacchi, G., Sticozzi, C., Pecorelli, A., Cervellati, F., Cervellati, C., & Maioli, E. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06724.x · Cited by 243 · see citing works
Delcourt, C., Michel, F., Colvez, A., Lacroux, A., Delage, M., & Vernet, M.-H. (2001) · Ophthalmic Epidemiology · doi:10.1076/opep.8.4.237.1613 · Cited by 241 · see citing works
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“…only 5% of the joint mass. Ageing results in cell senescence (Musumeci et al. 2015), loss of chondrocyte phenotype and thus abnormal remodeling of the extracellular matrix (Quintero et al. 1984; Lotz et al. 2010), and age-related changes in the extracellular matrix (Bhosale and Richardson 2008).”
BackgroundReducing falls and resulting hip fractures among older women
Stevens, J. A., & Olson, S. J. (2000) · Home Care Provider · doi:10.1067/mhc.2000.109232 · Cited by 241 · cited 2× · see citing works
“At least half of hip fracture patients never regain their previous function (Stevens and Olson 2000), and post-hip fracture mortality at 1 year remains as high as 33% (Roche et al.”
BackgroundInhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy
Yamamoto, M., Yang, G., Hong, C., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317700 · Cited by 239 · see citing works
Heterogeneity in Cancer Metabolism: New Concepts in an Old Field
Gentric, G., Mieulet, V., & Mechta‐Grigoriou, F. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6750 · Cited by 237 · cited 2× · see citing works
“The type of tumor, the context of tumor’s microenvironment, and the nature of stimuli will determine if reactive oxygen species will shift the balance toward a pro-survival or pro-death response (Gentric et al. 2017; Costa et al. 2014).”
BackgroundSelf-citationRoy, K., Wu, Y., Meitzler, J. L., Juhasz, A. N., Liu, H., Jiang, G., Lu, J., Antony, S., & Doroshow, J. H. (2015) · Clinical Science · doi:10.1042/cs20140542 · Cited by 231 · see citing works
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Research works printed but not linked: 2
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Cited by
Sorted by citations
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990 · see citing works
Charlton, N. C., Mastyugin, M., Török, B., & Török, M. (2023) · Molecules · doi:10.3390/molecules28031057 · Cited by 278 · see citing works
“The so-called “French Paradox” especially increased interest in dietary small molecule antioxidants after it was noted that despite high saturated fat and alcohol intake, Mediterranean populations are less likely to develop coronary heart disease [42].”
BackgroundOxInflammation: From Subclinical Condition to Pathological Biomarker
Valacchi, G., Virgili, F., Cervellati, C., & Pecorelli, A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00858 · Cited by 206 · see citing works
“Possible leaks from this outpost can be then countered by further repair systems such as proteinases, lipases, DNA repair enzymes (Davies et al., 2017).”
BackgroundMelatonin: Clinical Perspectives in Neurodegeneration
Cardinali, D. P. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00480 · Cited by 200 · see citing works
“Although the regular intake of antioxidants has been proposed for prevention of neurodegeneration, its effectiveness, however, has been questioned (3).”
BackgroundMarcucci, G., Domazetovic, V., Nediani, C., Ruzzolini, J., Favre, C., & Brandi, M. L. (2023) · Antioxidants · doi:10.3390/antiox12020373 · Cited by 191 · see citing works
“It has also been demonstrated that ROS stimulates osteoclastogenesis through RANKL as reported in human stromal cells [26,81].”
BackgroundNeuroprotective Activities of Curcumin in Parkinson’s Disease: A Review of the Literature
Nebrisi, E. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011248 · Cited by 165 · see citing works
“Although oxygen is very fundamental for any living system, it is inherently harmful at the same time, a phenomenon known as “the oxygen paradox” [100,101].”
BackgroundInflammation in Neurological Disorders: The Thin Boundary Between Brain and Periphery
Cervellati, C., Trentini, A., Pecorelli, A., & Valacchi, G. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8076 · Cited by 137 · see citing works
The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis
Tudorachi, N. B., Totu, E. E., Fifere, A., Ardeleanu, V., Mocanu, V., Mircea, C., Işıldak, İ., Smilkov, K., & Cărăușu, E. M. (2021) · Antioxidants · doi:10.3390/antiox10060985 · Cited by 135 · see citing works
“ROS could affect the musculoskeletal system, including multiple cellular structures at the bone level [64].”
BackgroundOxidative stress and antioxidants in the pathophysiology of malignant melanoma
Obrador, E., Liu-Smith, F., Dellinger, R. W., Salvador, R., Meyskens, F. L., & Estrela, J. M. (2019) · Biological Chemistry · doi:10.1515/hsz-2018-0327 · Cited by 119 · see citing works
“Of course, this balance depends on concentration as too high a concentration of the reactive species can be toxic (Davies et al., 2017).”
BackgroundAnti-aging properties of Dendrobium nobile Lindl.: From molecular mechanisms to potential treatments
Nie, X., Chen, Y., Li, W., & Lu, Y. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112839 · Cited by 115 · see citing works
Hussain, M. S., Gupta, G., Mishra, R., Patel, N. K., Gupta, S. K., Alzarea, S. I., Kazmi, I. A., Kumbhar, P., Disouza, J., Dureja, H., et al. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155157 · Cited by 114 · see citing works
Exercise, redox system and neurodegenerative diseases
Quan, H., Koltai, E., Suzuki, K., Aguiar, A. S., Pinho, R. A., Boldogh, I. R., Berkes, I., & Radak, Z. O. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165778 · Cited by 88 · see citing works
Lawrence, G. D. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab013 · Cited by 84 · see citing works
“The wide array of ROS and lipid peroxidation products are implicated in oxidative stress, aging, and many diseases (29, 30).”
BackgroundOxidative stress as a possible pathogenic cofactor of post-menopausal osteoporosis
Bonaccorsi, G., Piva, I., Greco, P., & Cervellati, C. (2018) · The Indian Journal of Medical Research · doi:10.4103/ijmr.ijmr_524_18 · Cited by 81 · see citing works
Implications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution
Barbouti, A., Vasileiou, P. V. S., Evangelou, K., Vlasis, K. G., Papoudou‐Bai, A., Gorgoulis, V. G., & Kanavaros, P. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/7986071 · Cited by 83 · see citing works
“Aerobic organisms use additionally lipid- and water-soluble antioxidant “sacrificial” compounds such as vitamins C and E, carotenoids, and glutathione (GSH) that are preferentially oxidized to preserve more important biomolecules, as well as defense mechanisms that remove or repair oxidized cellular components [64].”
BackgroundInfluentialRanking Biomarkers of Aging by Citation Profiling and Effort Scoring
Hartmann, A., Hartmann, C., Secci, R., Hermann, A., Fuellen, G., & Walter, M. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.686320 · Cited by 81 · see citing works
“Such hallmarks of aging as discussed here were observed in various organs and tissues (Stadtman and Berlett, 1997; Baraibar and Friguet, 2013; Davies et al., 2017).”
BackgroundHyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics
Fu, Q., Duan, R., Sun, Y., & Li, Q. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102352 · Cited by 71 · see citing works
Melatonin as a Chronobiotic and Cytoprotective Agent in Parkinson’s Disease
Perez‐Lloret, S., & Cardinali, D. P. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.650597 · Cited by 64 · see citing works
“Hence, the effectiveness of administering antioxidants for neurodegeneration prevention has been proposed but albeit questioned (Davies et al., 2017).”
BackgroundGeriatric Medicine and Gerontology
Zawada, E. T. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.77654 · Cited by 64 · see citing works
Tian, W., Yang, L., Liu, Y., He, J., Yang, L., Zhang, Q., Liu, F., Li, J., Liu, J., Sumi, S., et al. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.01.018 · Cited by 54 · see citing works
Resveratrol Action on Lipid Metabolism in Cancer
Kisková, T., & Kassayová, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112704 · Cited by 53 · see citing works
Lundquist, A. J., Parizher, J., Petzinger, G., & Jakowec, M. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24430 · Cited by 45 · see citing works
“In the context of normal brain function, exercise can act as a mechanism for brain maintenance, allowing motor and cognitive learning to occur (Davies et al., 2017).”
BackgroundSelf-citationMolecular Targets in Alzheimer’s Disease
Bjørklund, G., Aaseth, J., Dadar, M., & Chirumbolo, S. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1563-9 · Cited by 46 · see citing works
The role of NOX4 in pulmonary diseases
Li, Z., Xu, S., Feng, Y., Cheng, Y., Xiong, J., Zhou, Y., & Guan, C. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30005 · Cited by 43 · see citing works
Self-citationEvaluating the link between Paraoxonase-1 levels and Alzheimer's disease development
Cervellati, C., Valacchi, G., Tisato, V., Zuliani, G., & Marsillach, J. (2019) · Minerva Medica · doi:10.23736/s0026-4806.18.05875-5 · Cited by 40 · see citing works
Salvagno, M., Coppalini, G., Taccone, F. S., Strapazzon, G., Mrakic‐Sposta, S., Rocco, M., Khalifé, M., & Balestra, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010082 · Cited by 39 · see citing works
“New evidence about oncologic progression has shown that cancer cells may evolve into a hypermetabolic state, which can be sustained even in the presence of a limited oxygen supply [76,77].”
BackgroundSystemic and skin-targeting beneficial effects of lycopene-enriched ice cream: A pilot study
Chernyshova, M. P., Pristensky, D. V., Lozbiakova, M. V., Chalyk, N. E., Bandaletova, T. Y., & Petyaev, I. M. (2018) · Journal of Dairy Science · doi:10.3168/jds.2018-15282 · Cited by 39 · see citing works
“Lycopene concentration in serum samples was measured using HPLC (Diwadkar-Navsariwala et al., 2003) with modifications.”
MethodNègre‐Salvayre, A., & Salvayre, R. (2022) · Antioxidants · doi:10.3390/antiox11112281 · Cited by 38 · see citing works
Nutritional Barriers to the Adherence to the Mediterranean Diet in Non-Mediterranean Populations
Sam-Yellowe, T. Y. (2024) · Foods · doi:10.3390/foods13111750 · Cited by 34 · see citing works
“The relationship between eating patterns, in particular the association of dietary fats and the risk of chronic non-infectious diseases was established by these major studies [7,8].”
BackgroundMethodBorbély, É., Payrits, M., Hunyady, Á., Mező, G., & Pintér, E. (2019) · GeroScience · doi:10.1007/s11357-019-00083-1 · Cited by 30 · see citing works
4-Hydroxynonenal Contributes to Fibroblast Senescence in Skin Photoaging Evoked by UV-A Radiation
Swiader, A., Camaré, C., Guerby, P., Salvayre, R., & Nègre‐Salvayre, A. (2021) · Antioxidants · doi:10.3390/antiox10030365 · Cited by 29 · see citing works
Are melatonin doses employed clinically adequate for melatonin-induced cytoprotection?
Cardinali, D. P. (2019) · Melatonin Research · doi:10.32794/mr11250025 · Cited by 29 · see citing works
Glycerylphytate compounds with tunable ion affinity and osteogenic properties
Mora‐Boza, A., López-Donaire, M. L., Saldaña, L., Vilaboa, N. E., Vázquez‐Lasa, B., & Román, J. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-48015-5 · Cited by 28 · see citing works
Galaup, C., Picard, C., Couderc, F., Gilard, V., & Collin, F. (2021) · FEBS Journal · doi:10.1111/febs.15859 · Cited by 28 · see citing works
Melanoma in the liver: Oxidative stress and the mechanisms of metastatic cell survival
Obrador, E., Salvador, R., López‐Blanch, R., Jihad-Jebbar, A., Alcácer, J., Benlloch, M., Pellicer, J. A., & Estrela, J. M. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.05.001 · Cited by 27 · see citing works
Geltinger, F., Tevini, J., Briza, P., Geiser, A., Bischof, J., Richter, K., Felder, T., & Rinnerthaler, M. (2020) · GeroScience · doi:10.1007/s11357-019-00103-0 · Cited by 26 · see citing works
Nirmal, N. P., Mahale, K. R., Rathod, N. B., Siddiqui, S. A., & Dhar, B. K. (2024) · Process Safety and Environmental Protection · doi:10.1016/j.psep.2024.11.106 · Cited by 25 · see citing works
Oxidative Stress in Urolithiasis
Boonla, C. (2018) · InTech eBooks · doi:10.5772/intechopen.75366 · Cited by 24 · see citing works
Fratantonio, D., Speciale, A., Molonia, M. S., Bashllari, R., Palumbo, M. A., Saija, A., Cimino, F., Monastra, G., & Virgili, F. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.08.003 · Cited by 25 · see citing works
Szegeczki, V., Bauer, B., Jüngling, A., Fulop, B. D., Vágó, J., Perényi, H., Tarantini, S., Tamás, A., Zákány, R., Reglődi, D., et al. (2019) · GeroScience · doi:10.1007/s11357-019-00097-9 · Cited by 22 · see citing works
Therapeutic potential of melatonin and its derivatives in aging and neurodegenerative diseases
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“Oxidative stress is associated with aging and various pathological conditions including cardiovascular and neurodegenerative diseases, macular degeneration, autoimmune disorders, and cancer (Davies et al. 2017; Liguori et al. 2018; Martin et al. 1996; Pham-Huy et al. 2008; Xiong et al. 2011).”
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Modeling oxidative stress on neuronal dendrites and dendritic spines
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- Authors
- Davies, J. M. S., Cillard, J., Friguet, B., Cadenas, E., Cadet, J., Cayce, R., Fishmann, A., Liao, D., Bulteau, A.-L., Derbré, F., Rébillard, A., Burstein, S., Hirsch, E., Kloner, R. A., Jakowec, M., Petzinger, G., Sauce, D., Sennlaub, F., Limon, I., Ursini, F., Maiorino, M., Economides, C., Pike, C. J., Cohen, P., Salvayre, A. N., Halliday, M. R., Lundquist, A. J., Jakowec, N. A., Mechta-Grigoriou, F., Mericskay, M., Mariani, J., Li, Z., Huang, D., Grant, E., Forman, H. J., Finch, C. E., Sun, P. Y., Pomatto, L. C. D., Agbulut, O., Warburton, D., Neri, C., Rouis, M., Cillard, P., Capeau, J., Rosenbaum, J., & Davies, K. J. A.
- Affiliations
- University of Southern California (US)
- Université de Rennes (FR)
- Centre National de la Recherche Scientifique (FR)
- Université de Sherbrooke (CA)
- Good Samaritan Hospital (US)
- École Normale Supérieure de Lyon (FR)
- Université Rennes 2 (FR)
- Huntington Medical Research Institutes (US)
- Inserm (FR)
- Institut de la Vision (FR)
- University of Padua (IT)
- Université Paris-Sud (FR)
- Corresponding author
- Davies, Kelvin J. A.
- ORCID
- Friguet, Bertrand
- Cadenas, Enrique
- Cadet, Jean
- Bulteau, Anne-Laure
- Rébillard, Amélie
- Kloner, Robert A.
- Jakowec, Michael
- Petzinger, Giselle
- Sauce, Delphine
- Sennlaub, Florian
- Limon, Isabelle
- Ursini, Fulvio
- Maiorino, Matilde
- Pike, Christian J.
- Cohen, Pinchas
- Halliday, Matthew R.
- Lundquist, Adam J.
- Jakowec, Nicolaus A.
- Mericskay, Mathias
- Mariani, Jean
- Li, Zhenlin
- Grant, Ellsworth
- Forman, Henry J.
- Finch, Caleb E.
- Sun, Patrick Y.
- Pomatto, Laura C. D.
- Agbulut, Onnik
- Warburton, David
- Rouis, Mustapha
- Capeau, Jacqueline
- Rosenbaum, Jean
- Davies, Kelvin J. A.
- Venue
- GeroScience
- Published
- 2017-12
- Volume
- 39
- Issue
- 5-6
- Pages
- 499-550
- ISSN
- 2152-4041 (ISSN-L)
- 2509-2715
- 2509-2723
- PMC
- PMC5745211
- OpenAlex
- W2779963304
- Cited by
- 82
- References
- 445
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 9 · 2023: 8 · 2022: 7 · 2021: 13 · 2020: 10 · 2019: 19 · 2018: 7
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- GeroScience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by)
- Funders
- National Science Foundation (#DGE-1418060)
- National Institute of Environmental Health Sciences (#ES023864, #R01ES020812, #D43ES022862, #ES003598)
- Institut National de la Santé et de la Recherche Médicale
- National Institute on Aging (# AG-040753, # AG058068, # P01AG034906, # R01AG034430, # AG052374)
- Agence Nationale de la Recherche
- Université Pierre et Marie Curie
- Université Toulouse III - Paul Sabatier
- Conseil Régional de Bretagne
- Ligue Contre le Cancer
- Fondation de France
- Centre National de la Recherche Scientifique
- Assistance Publique - Hôpitaux de Paris
- U.S. Department of Defense (DOD-PC160353U)
- American Foundation for Aging Research
- Don Roberto Gonzalez and Family Foundation
- National Parkinson Foundation
- National Heart, Lung, and Blood Institute (#U01HL122681)
- Pasadena Guild
- Children's Hospital Los Angeles
- the webb foundation
- The Garland Foundation
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- oxygen paradox, French paradox, free radicals, oxidative stress, antioxidants, cardiovascular disease, age-related diseases, healthspan, lifespan, aging, adaptive homeostasis, hormesis, epigenetics, epigenetic reprogramming, epigenetic drift, epigenetic plasticity, epigenetic memory, epigenetic inheritance, epigenetic noise
- MeSH terms
- Diet, High-Protein, Adaptation, Physiological, Aged, Aged, 80 and over, Aging, Female, France, Free Radicals, Humans, Hypercholesterolemia, Male, Middle Aged, Oxygen, Geriatric Assessment, Oxidative Stress, Risk Assessment
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