The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
The impact of deep brain stimulation on executive function in Parkinson's disease
Abstract
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or the internal segment of the globus pallidus (GPi) improves Parkinson's disease and increases frontal blood flow. We assessed the effects of bilateral DBS on executive function in Parkinson's disease patients, seven with electrodes implanted in the STN and six in the GPi. Patients were assessed off medication with stimulators off, on and off again. The groups showed differential change with stimulation on the Reitan Trail-Making test (TMT B) (STN more improved) and on some measures of random number generation and Wisconsin Card Sorting (STN improved, GPi worse with stimulation). Across the groups, stimulation speeded up responding (Stroop control trial, TMT A) and improved performance on paced serial addition and missing digit tests. Conversely, conditional associative learning became more errorful with stimulation across the two groups. In general, change in performance with stimulation was significant for the STN but not the GPi group. These results support two opposite predictions. In support of current models of Parkinson's disease, 'releasing the brake' on frontal function with DBS improved aspects of executive function. Conversely, disruption of basal ganglia outflow during DBS impaired performance on tests requiring changing behaviour in novel contexts as predicted by Marsden and Obeso in 1994.
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Citations
Cites
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Stroop, J. R. (1935) · Journal of Experimental Psychology · doi:10.1037/h0054651 · Cited by 18,622
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Hoehn, M. M., & Yahr, M. D. (1967) · Neurology · doi:10.1212/wnl.17.5.427 · Cited by 12,107
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527
Validity of the Trail Making Test as an Indicator of Organic Brain Damage
Reitan, R. M. (1958) · Perceptual and Motor Skills · doi:10.2466/pms.1958.8.3.271 · Cited by 7,928
The functional anatomy of basal ganglia disorders
Albin, R. L., Young, A. B., & Penney, J. B. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90074-x · Cited by 5,353
Functional architecture of basal ganglia circuits: neural substrates of parallel processing
Alexander, G. E., & Crutcher, M. D. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90107-l · Cited by 4,131
Primate models of movement disorders of basal ganglia origin
DeLong, M. R. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90110-v · Cited by 3,824
Unified Parkinson's Disease Rating Scale
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Cited by
Krack, P., Batir, A., Van Blercom, N., Chabardes, S., Fraix, V., Ardouin, C., Koudsie, A., Limousin, P. D., Benazzouz, A., LeBas, J. F., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035275 · Cited by 2,249
Self-citationPerlmutter, J. S., & Mink, J. W. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112824 · Cited by 1,073
Pathophysiology of the basal ganglia in Parkinson's disease
Obeso, J. A., Rodriguez-Oroz, M. C., Rodriguez, M., Lanciego, J. L., Artieda, J., Gonzalo, N., & Olanow, C. W. (2000) · Trends in Neurosciences · doi:10.1016/s1471-1931(00)00028-8 · Cited by 844
Self-citationA fronto–striato–subthalamic–pallidal network for goal-directed and habitual inhibition
Jahanshahi, M., Obeso, I., Rothwell, J. C., & Obeso, J. A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4038 · Cited by 521
Self-citationFunkiewiez, A. (2004) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2002.009803 · Cited by 572
Metadata
- Authors
- Jahanshahi, M., Ardouin, C. M. A., Brown, R. G., Rothwell, J. C., Obeso, J., Albanese, A., Rodriguez-Oroz, M. C., Moro, E., Benabid, A. L., Pollak, P., & Limousin-Dowsey, P.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-06
- Volume
- 123
- Issue
- 6
- Pages
- 1142-1154
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2142625367
- Cited by
- 425
- References
- 68
- FWCI
- 15.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jahanshahi, M., Ardouin, C. M. A., Brown, R. G., Rothwell, J. C., Obeso, J., Albanese, A., Rodriguez-Oroz, M. C., Moro, E., Benabid, A. L., Pollak, P., & Limousin-Dowsey, P. (2000). The impact of deep brain stimulation on executive function in Parkinson's disease. Brain. https://doi.org/10.1093/brain/123.6.1142
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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