Timing is everything: tau imaging across stages of Alzheimer’s disease
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This scientific commentary refers to ‘18F-MK-6240 PET for early and late detection of neurofibrillary tangles’, by Pascoal et al. (doi:10.1093/brain/awaa180).
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Tau-PET provides information beyond other imaging modalities or fluid biomarkers, including in vivo assessment of Braak stages indicating tau pathology progression.
“Furthermore, tau‐PET provides information beyond what can be captured by other imaging modalities or fluid biomarkers, including in vivo assessment of Braak stages, which indicates the progression of tau pathology throughout the brain. 17 , 18”
From Machine learning prediction of tau‐PET in Alzheimer's disease using plasma, MRI, and clinical data (2025) · cites this paper as [18]
The main text (page unavailable) describes in vivo Braak staging with tau PET and suggests it may offer advantages over MRI and amyloid PET. It does not compare tau PET with fluid biomarkers. It also cautions that the study was cross-sectional and that tracking progression through Braak stages over time remains to be confirmed. (LLM, conf=0.88)
Experimental — accuracy not yet measuredTau-PET provides information beyond what can be captured by other imaging modalities or fluid biomarkers, including in vivo assessment of Braak stages, which indicates the progression of tau pathology throughout the brain.
“Furthermore, tau‐PET provides information beyond what can be captured by other imaging modalities or fluid biomarkers, including in vivo assessment of Braak stages, which indicates the progression of tau pathology throughout the brain. 17 , 18”
From Machine learning prediction of tau‐PET in Alzheimer's disease using plasma, MRI, and clinical data (2025) · cites this paper as [18]
The commentary (page not provided) says tau PET can stage tau deposition in vivo and that its regional pattern recapitulates the spread of pathology across Braak stages. It also suggests an advantage over MRI and amyloid PET, but does not compare tau PET with fluid biomarkers. Because the study discussed was cross-sectional, the commentary says tracking progression within individuals over time still needs confirmation. (LLM, conf=0.86)
Experimental — accuracy not yet measured
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Cites
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Tau PET imaging in neurodegenerative tauopathies—still a challenge
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Research works printed but not linked: 1
- [9]9. Pascoal TA, Therriault J, Benedet AL, Savard M, Lussier FZ, Chamoun M, et al. 18F- MK-6240 PET for early and late detection of neurofibrillary tangles. Brain 2020; 143: 2818-30.
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Vanderlinden, G., Ceccarini, J., Vande Casteele, T., Michiels, L., Lemmens, R., Triau, E., Serdons, K., Tournoy, J., Koole, M., Vandenbulcke, M., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01672-x · Cited by 47 · see citing works
Machine learning prediction of tau‐PET in Alzheimer's disease using plasma, MRI, and clinical data
Karlsson, L., Vogel, J., Arvidsson, I., Åström, K., Strandberg, O., Seidlitz, J., Bethlehem, R. A. I., Stomrud, E., Ossenkoppele, R., Ashton, N. J., et al. (2025) · Alzheimer's & Dementia · doi:10.1002/alz.14600 · Cited by 43 · see citing works
Pathological Mechanisms and Molecular Imaging Advances in Alzheimer’s Disease
Liu, C., Meng, Y., Liu, R., Wang, Z., & Zhao, H. (2025) · Clinical Interventions in Aging · doi:10.2147/cia.s534015 · Cited by 8 · see citing works
Duan, Y., Fu, Y., Wu, Z., Zheng, W., Lv, G., Chen, L., Wu, J., Han, Z., Dai, Q., Gu, Q., et al. (2026) · Brain Health · doi:10.1002/brh2.70008
- Authors
- Forsberg Morén, A., & Varrone, A.
- Affiliations
- Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden
- Region Stockholm (SE)
- Corresponding author
- Varrone, Andrea
- ORCID
- Varrone, Andrea
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-09-01
- Volume
- 143
- Issue
- 9
- Pages
- 2634-2636
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W3087501654
- Cited by
- 4
- References
- 9
- Citations by year
- 2026: 1 · 2025: 2 · 2022: 1
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- tau PET imaging, [18F]MK-6240, neurofibrillary tangles, Alzheimer's disease, disease staging, early detection, amyloid imaging
- MeSH terms
- Alzheimer Disease, Humans, Isoquinolines, Neurofibrillary Tangles, tau Proteins, Positron-Emission Tomography
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