Diabetes medications and risk of Parkinson’s disease: a cohort study of patients with diabetes
Open accessAbstract
The elevated risk of Parkinson’s disease in patients with diabetes might be mitigated depending on the type of drugs prescribed to treat diabetes. Population data for risk of Parkinson’s disease in users of the newer types of drugs used in diabetes are scarce. We compared the risk of Parkinson’s disease in patients with diabetes exposed to thiazolidinediones (glitazones), glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase 4 (DPP4) inhibitors, with the risk of Parkinson’s disease of users of any other oral glucose lowering drugs. A population-based, longitudinal, cohort study was conducted using historic primary care data from The Health Improvement Network. Patients with a diagnosis of diabetes and a minimum of two prescriptions for diabetes medications between January 2006 and January 2019 were included in our study. The primary outcome was the first recording of a diagnosis of Parkinson’s disease after the index date, identified from clinical records. We compared the risk of Parkinson’s disease in individuals treated with glitazones or DPP4 inhibitors and/or GLP-1 receptor agonists to individuals treated with other antidiabetic agents using a Cox regression with inverse probability of treatment weighting based on propensity scores. Results were analysed separately for insulin users. Among 100 288 patients [mean age 62.8 years (standard deviation 12.6)], 329 (0.3%) were diagnosed with Parkinson’s disease during the median follow-up of 3.33 years. The incidence of Parkinson’s disease was 8 per 10 000 person-years in 21 175 patients using glitazones, 5 per 10 000 person-years in 36 897 patients using DPP4 inhibitors and 4 per 10 000 person-years in 10 684 using GLP-1 mimetics, 6861 of whom were prescribed GTZ and/or DPP4 inhibitors prior to using GLP-1 mimetics. Compared with the incidence of Parkinson’s disease in the comparison group (10 per 10 000 person-years), adjusted results showed no evidence of any association between the use of glitazones and Parkinson’s disease [incidence rate ratio (IRR) 1.17; 95% confidence interval (CI) 0.76–1.63; P = 0.467], but there was strong evidence of an inverse association between use of DPP4 inhibitors and GLP-1 mimetics and the onset of Parkinson’s disease (IRR 0.64; 95% CI 0.43–0.88; P < 0.01 and IRR 0.38; 95% CI 0.17–0.60; P < 0.01, respectively). Results for insulin users were in the same direction, but the overall size of this group was small. The incidence of Parkinson’s disease in patients diagnosed with diabetes varies substantially depending on the treatment for diabetes received. The use of DPP4 inhibitors and/or GLP-1 mimetics is associated with a lower rate of Parkinson’s disease compared to the use of other oral antidiabetic drugs.
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Diabetic patients receiving GLP-1R agonists are associated with a lower risk of developing PD.
“diabetic patients receiving GLP-1R agonists are associated with a lower risk of developing PD.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [615]
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Austin, P. C. (2011) · Multivariate Behavioral Research · doi:10.1080/00273171.2011.568786 · Cited by 12,242 · see citing works
Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease
Yun, S. P., Kam, T.-I., Panicker, N., Kim, S., Oh, Y., Park, J.-S., Kwon, S.-H., Park, Y. J., Karuppagounder, S. S., Park, H., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0051-5 · Cited by 1,123 · see citing works
Prevalence of Parkinson’s disease across North America
Marras, C., Beck, J. C., Bower, J. H., Roberts, E. M., Ritz, B. R., Ross, G. W., Abbott, R. D., Savica, R., Eeden, S. K. V. D., Willis, A. W., et al. (2018) · npj Parkinson s Disease · doi:10.1038/s41531-018-0058-0 · Cited by 972 · see citing works
Athauda, D., Maclagan, K., Skene, S. S., Bajwa-Joseph, M., Letchford, D., Chowdhury, K., Hibbert, S., Budnik, N., Zampedri, L., Dickson, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31585-4 · Cited by 889 · cited 3× · see citing works
“The positive markers from this population study seem to be further supported by the findings of potential disease modifying effects of two single centre phase 2 interventional studies (Aviles-Olmos et al., 2014; Athauda et al., 2017).”
BackgroundResultSelf-citationBlak, B., Thompson, M., Dattani, H., & Bourke, A. (2011) · Journal of Innovation in Health Informatics · doi:10.14236/jhi.v19i4.820 · Cited by 630 · see citing works
Exenatide and the treatment of patients with Parkinson's disease
Aviles-Olmos, I., Dickson, J., Kefalopoulou, Z., Djamshidian, A., Ell, P., Soderlund, T., Whitton, P., Wyse, R., Isaacs, T., Lees, A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68295 · Cited by 529 · see citing works
Self-citationInsulin resistance and Parkinson’s disease: A new target for disease modification?
Athauda, D. S., & Foltynie, T. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.10.001 · Cited by 333 · see citing works
Self-citationMotor and Cognitive Advantages Persist 12 Months After Exenatide Exposure in Parkinson’s Disease
Avilés-Olmos, I., Dickson, J. C., Kefalopoulou, Z. M., Djamshidian, A., Kahan, J., Ell, P. J., Whitton, P. S., Wyse, R. K. H., Isaacs, T., Lees, A. J., et al. (2014) · Journal of Parkinson s Disease · doi:10.3233/jpd-140364 · Cited by 300 · see citing works
Self-citationHow valid is the clinical diagnosis of Parkinson's disease in the community?
Schrag, A. E. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.73.5.529 · Cited by 300 · see citing works
Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial
(2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00144-1 · Cited by 286 · see citing works
Leyrat, C., Seaman, S. R., White, I. R., Douglas, I., Smeeth, L. L., Kim, J., Resche‐Rigon, M., Carpenter, J. R., & Williamson, E. (2017) · Statistical Methods in Medical Research · doi:10.1177/0962280217713032 · Cited by 254 · see citing works
Diabetes and Risk of Parkinson’s Disease
Cereda, E., Barichella, M., Pedrolli, C., Klersy, C., Cassani, E., Caccialanza, R., & Pezzoli, G. (2011) · Diabetes Care · doi:10.2337/dc11-1584 · Cited by 247 · see citing works
Association between diabetes and subsequent Parkinson disease: A record-linkage cohort study
De Pablo-Fernandez, E., Goldacre, R., Pakpoor, J., Noyce, A. J., & Warner, T. T. (2018) · Neurology · doi:10.1212/wnl.0000000000005771 · Cited by 242 · see citing works
Potential Role of Glucagon-Like Peptide-1 (GLP-1) in Neuroprotection
Hölscher, C. (2012) · CNS Drugs · doi:10.2165/11635890-000000000-00000 · Cited by 191 · see citing works
Identifying periods of acceptable computer usage in primary care research databases
Horsfall, L., Walters, K., & Petersen, I. (2013) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3368 · Cited by 148 · see citing works
GLP-1’s role in neuroprotection: a systematic review
Erbil, D., Eren, C. Y., Demirel, Ç., Küçüker, M. U., Solaroğlu, İ., & Eser, H. Y. (2019) · Brain Injury · doi:10.1080/02699052.2019.1587000 · Cited by 128 · see citing works
Brauer, R., Bhaskaran, K., Chaturvedi, N., Dexter, D. T., Smeeth, L. L., & Douglas, I. (2015) · PLoS Medicine · doi:10.1371/journal.pmed.1001854 · Cited by 124 · see citing works
Self-citationGlitazone use associated with reduced risk of Parkinson's disease
Brakedal, B., Flønes, I. H., Reiter, S. F., Torkildsen, Ø., Dölle, C., Aßmus, J., Haugarvoll, K., & Tzoulis, C. (2017) · Movement Disorders · doi:10.1002/mds.27128 · Cited by 108 · see citing works
Body Mass Index, Diabetes, and the Risk of Parkinson's Disease
Jeong, S., Han, K., Kim, D., Rhee, S. Y., Jang, W., & Shin, D. W. (2019) · Movement Disorders · doi:10.1002/mds.27922 · Cited by 104 · see citing works
Svenningsson, P., Wirdefeldt, K., Yin, L., Fang, F., Markaki, I., Efendić, S., & Ludvigsson, J. F. (2016) · Movement Disorders · doi:10.1002/mds.26734 · Cited by 103 · see citing works
Tran, K., Park, Y. I., Pandya, S., Muliyil, N. J., Jensen, B. D., Huynh, K., & Nguyen, Q. P. H. (2017) · PubMed Central · Cited by 102 · see citing works
A Practical Guide for Using Propensity Score Weighting in R
Olmos, A., & Govindasamy, P. (2020) · ScholarWorks@UMassAmherst (University of Massachusetts Amherst) · doi:10.7275/jjtm-r398 · Cited by 88 · see citing works
A prospective study of alcoholism and the risk of Parkinson?s disease
Hernán, M. Á., Logroscino, G., & guez, L. A. G. A. R. (2004) · Journal of Neurology · doi:10.1007/s00415-004-1705-4 · Cited by 58 · see citing works
Fang, F., Zhan, Y., Zhuo, Y., Yin, D., Li, K., & Wang, Y. (2018) · Journal of Diabetes · doi:10.1111/1753-0407.12646 · Cited by 40 · see citing works
Thiazolidinediones and Parkinson Disease: A Cohort Study
Connolly, J. G., Bykov, K., & Gagne, J. J. (2015) · American Journal of Epidemiology · doi:10.1093/aje/kwv109 · Cited by 39 · see citing works
Impact of small vessel disease on severity of motor and cognitive impairment in Parkinson’s disease
Schwartz, R. S., Halliday, G. M., Soh, D., Cordato, D. J., & Kril, J. J. (2018) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2018.10.029 · Cited by 24 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Joint Formulary Committee. British National Formulary 77: March-September; 2019. London: Pharmaceutical Press.
- National Institute for Health and Care Excellence (NICE). NICE Guideline. Type 2 Diabetes in Adults: Management. 2015 www.nice.org.uk/guidance/ng28 (24 July 2020, date last accessed). 26741015
Cited by
Sorted by citations
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works
GLP-1 Receptor Agonists: Beyond Their Pancreatic Effects
Zhao, X., Wang, M., Wen, Z., Lu, Z., Cui, L., Fu, C., Xue, H., Liu, Y., & Zhang, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.721135 · Cited by 463 · see citing works
Trial of Lixisenatide in Early Parkinson’s Disease
Meissner, W. G., Remy, P., Giordana, C., Maltête, D., Derkinderen, P., Houéto, J.-L., Anheim, M., Benatru, I., Boraud, T., Brefel-Courbon, C., et al. (2024) · New England Journal of Medicine · doi:10.1056/nejmoa2312323 · Cited by 369 · see citing works
Kopp, K. O., Glotfelty, E. J., Li, Y., & Greig, N. H. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106550 · Cited by 298 · see citing works
Ramasubbu, K., & Rajeswari, V. D. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04587-x · Cited by 249 · see citing works
Type 2 Diabetes as a Determinant of Parkinson's Disease Risk and Progression
Chohan, H., Senkevich, K., Patel, R. K., Bestwick, J. P., Jacobs, B. M., Bandres Ciga, S., Gan‐Or, Z., & Noyce, A. J. (2021) · Movement Disorders · doi:10.1002/mds.28551 · Cited by 228 · see citing works
Vijiaratnam, N., Girges, C., Auld, G., McComish, R., King, A., Skene, S. S., Hibbert, S., Wong, A., Melander, S., Gibson, R., et al. (2025) · The Lancet · doi:10.1016/s0140-6736(24)02808-3 · Cited by 181 · see citing works
Self-citationAntidiabetic agents as a novel treatment for Alzheimer’s and Parkinson’s disease
Nowell, J., Blunt, E., Gupta, D., & Edison, P. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101979 · Cited by 179 · see citing works
Luo, A., Xie, Z., Wang, Y., Wang, X., Li, S., Yan, J., Zhan, G., Zhou, Z., Zhao, Y., & Li, S. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104642 · Cited by 167 · see citing works
Lipid pathway dysfunction is prevalent in patients with Parkinson’s disease
Galper, J., Dean, N. J., Pickford, R., Lewis, S. J. G., Halliday, G. M., Kim, W. S., & Dzamko, N. L. (2022) · Brain · doi:10.1093/brain/awac176 · Cited by 159 · see citing works
McGarry, A., Rosanbalm, S., Leinonen, M., Olanow, C. W., To, D., Bell, A., Lee, D., Chang, J., Dubow, J., Dhall, R., et al. (2024) · The Lancet Neurology · doi:10.1016/s1474-4422(23)00378-2 · Cited by 153 · see citing works
The heterogeneity of Parkinson’s disease
Wüllner, U., Borghammer, P., Choe, C., Csóti, I., Falkenburger, B. H., Gasser, T., Lingor, P., & Riederer, P. F. (2023) · Journal of Neural Transmission · doi:10.1007/s00702-023-02635-4 · Cited by 132 · see citing works
The Prion-Like Spreading of Alpha-Synuclein in Parkinson’s Disease: Update on Models and Hypotheses
Jan, A., Gonçalves, N. P., Vægter, C. B., Jensen, P. H., & Ferreira, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158338 · Cited by 126 · see citing works
Mui, J. V., Zhou, J., Lee, S., Leung, K. S. K., Lee, T. T. L., Chou, O. H. I., Tsang, S. L., Wai, A. K. C., Liu, T., Wong, W. T., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.747620 · Cited by 114 · see citing works
GLP-1 Receptor Agonists: A New Treatment in Parkinson’s Disease
Kalinderi, K., Papaliagkas, V. T., & Fidani, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073812 · Cited by 109 · see citing works
α-Synuclein pathology as a target in neurodegenerative diseases
Park, H.-J., Kam, T., Dawson, V. L., & Dawson, T. M. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-01043-w · Cited by 113 · see citing works
Therapeutics in the Pipeline Targeting α-Synuclein for Parkinson's Disease
Jasutkar, H. G., Oh, S. E., & Mouradian, M. M. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000133 · Cited by 102 · see citing works
Brakedal, B., Toker, L., Haugarvoll, K., & Tzoulis, C. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00280-4 · Cited by 98 · see citing works
Parkinson’s disease and diabetes mellitus: common mechanisms and treatment repurposing
Labandeira, C. M., Bau, A. F., Ron, D. A., Álvarez, E., Alba, P. V., Garma, J. L., & Rodriguez-Perez, A. I. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.332122 · Cited by 96 · see citing works
GLP-1 receptor agonists effect on cognitive function in patients with and without type 2 diabetes
Monney, M., Jornayvaz, F. R., & Gariani, K. (2023) · Diabetes & Metabolism · doi:10.1016/j.diabet.2023.101470 · Cited by 99 · see citing works
Glucose metabolism impairment in Parkinson’s disease
Dai, C., Tan, C., Zhao, L., Liang, Y., Liu, G., Liu, H., Zhong, Y., Liu, Z., Mo, L., Liu, X., et al. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110672 · Cited by 89 · see citing works
Alrouji, M., Al-Kuraishy, H. M., Al-Gareeb, A. I., Alexiou, A. T., Papadakis, M., Jabir, M. S., Saad, . M., & Batiha, G. E. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17784 · Cited by 85 · see citing works
Vijiaratnam, N., Girges, C., Auld, G., Chau, M., Maclagan, K., King, A., Skene, S., Chowdhury, K., Hibbert, S., Morris, H., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-047993 · Cited by 84 · see citing works
Self-citationType 2 Diabetes and Parkinson's Disease: A Focused Review of Current Concepts
Cullinane, P. W., Pablo‐Fernández, E. D., König, A., Outeiro, T. F., Jaunmuktane, Z., & Warner, T. T. (2022) · Movement Disorders · doi:10.1002/mds.29298 · Cited by 73 · see citing works
Álvarez, M. M., Cano-Herrera, G., Martínez, M. F. O., Gonzales-Portillo, J. V., Monroy, G. R., Pérez, R. M., Torres-Ríos, J. A., van Tienhoven, X. A., Bernot, E. M. G., Salazar, F. E., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137183 · Cited by 68 · see citing works
A nationwide cohort study on diabetes severity and risk of Parkinson disease
Han, K., Kim, B., Lee, S. H., & Kim, M. K. (2023) · npj Parkinson's Disease · doi:10.1038/s41531-023-00462-8 · Cited by 67 · see citing works
Associations Between Diabetes Mellitus and Neurodegenerative Diseases
Szablewski, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020542 · Cited by 74 · see citing works
Ferrari, F., Moretti, A., & Villa, R. F. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108277 · Cited by 61 · see citing works
Lin, K.-J., Wang, T., Chen, S., Lin, K.-L., Liou, C., Lan, M., Chuang, Y., Chuang, J., Wang, P., Lee, J., et al. (2021) · Antioxidants · doi:10.3390/antiox10121935 · Cited by 60 · see citing works
Cao, B., Zhang, Y., Chen, J., Wu, P., Dong, Y., & Wang, Y. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00879-1 · Cited by 57 · see citing works
The role of nutrition on Parkinson’s disease: a systematic review
Bianchi, V. E., Rizzi, L., & Somaa, F. A. (2022) · Nutritional Neuroscience · doi:10.1080/1028415x.2022.2073107 · Cited by 57 · see citing works
Sánchez‐Gómez, A., Díaz, Y., Duarte‐Salles, T., Compta, Y., & Martı́, M. J. (2021) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2021.06.002 · Cited by 54 · see citing works
Therapeutic application of GLP-1 and GIP receptor agonists in Parkinson’s disease
Yang, X., Feng, P., Ji, R., Ren, Y., Wei, W., & Hölscher, C. (2022) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2022.2079492 · Cited by 51 · see citing works
Yu, H., Sun, T., He, X., Wang, Z., Zhao, K., An, J., Wen, L., Li, J., Li, W., & Feng, J. (2022) · Aging and Disease · doi:10.14336/ad.2022.0325 · Cited by 51 · see citing works
Sphingolipid metabolism in brain insulin resistance and neurological diseases
Mei, M., Liu, M., Mei, Y., Zhao, J., & Li, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1243132 · Cited by 50 · see citing works
Martinez, A., Sánchez-Martínez, Á., Pickering, J. T., Twyning, M. J., Terriente-Félix, A., Chen, P., Chen, C., & Whitworth, A. J. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00701-3 · Cited by 52 · see citing works
Li, Y., Glotfelty, E. J., Karlsson, T. E., Fortuno, L. V., Harvey, B. K., & Greig, N. H. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15521 · Cited by 47 · see citing works
Uyar, M., Lezius, S., Buhmann, C., Pötter‐Nerger, M., Schulz, R. J., Meier, S., Gerloff, C. P., Kühle, J., & Choe, C. (2022) · Movement Disorders · doi:10.1002/mds.29009 · Cited by 46 · see citing works
Parkinson’s Disease and Sugar Intake—Reasons for and Consequences of a Still Unclear Craving
Haas, J., Berg, D., Bosy‐Westphal, A., & Schaeffer, E. (2022) · Nutrients · doi:10.3390/nu14153240 · Cited by 46 · see citing works
Stepping up to meet the challenge of freezing of gait in Parkinson’s disease
Lewis, S. J. G., Factor, S. A., Giladi, N., Nieuwboer, A., Nutt, J. G., & Hallett, M. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00298-x · Cited by 44 · see citing works
Lisco, G., Tullio, A. D., Iovino, M., Disoteo, O., Guastamacchia, E., Giagulli, V. A., & Triggiani, V. (2023) · Biomedicines · doi:10.3390/biomedicines11112993 · Cited by 44 · see citing works
Pablo‐Fernández, E. D., Courtney, R. J., Rockliffe, A., Gentleman, S., Holton, J. L., & Warner, T. T. (2021) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12728 · Cited by 43 · see citing works
Li, Z., Chen, X., Vong, J. S. L., Zhao, L., Huang, J., Yan, L. Y. C., Ip, B., Wing, Y. K., Lai, H.-M., Mok, V. C. T., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02208-9 · Cited by 42 · see citing works
Alpha synuclein post translational modifications: potential targets for Parkinson’s disease therapy?
Brembati, V., Faustini, G., Longhena, F., & Bellucci, A. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1197853 · Cited by 42 · see citing works
Tang, H., Lu, Y., Okun, M. S., Donahoo, W. T., Ramirez‐Zamora, A., Wang, F., Huang, Y., Armstrong, M. J., Svensson, M., Virnig, B. A., et al. (2024) · Movement Disorders · doi:10.1002/mds.29992 · Cited by 44 · see citing works
Ng, V. W. S., Man, K. K. C., Gao, L., Chan, E. W., Lee, E. H. M., Hayes, J., & Wong, I. C. K. (2021) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.5318 · Cited by 42 · see citing works
Self-citationFrom metabolism to mind: The expanding role of the GLP-1 receptor in neurotherapeutics
Roy, A., Dawson, V. L., & Dawson, T. M. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00712 · Cited by 41 · see citing works
Qin, X., Zhang, X., Li, P., Wang, M., Li, Y., Bao, Z., & Liu, Q. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.678649 · Cited by 41 · see citing works
Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson′s disease
Yu, H., Sun, T., Wang, Z., Li, H., Xu, D., An, J., Wen, L.-L., Li, J., Li, W., & Feng, J. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.360242 · Cited by 38 · see citing works
Wu, P., Dong, Y., Chen, J., Guan, T., Cao, B., Zhang, Y., Qi, Y., Guan, Z., & Wang, Y. (2022) · Neurotoxicity Research · doi:10.1007/s12640-021-00460-9 · Cited by 38 · see citing works
Glucagon-like peptide-1 receptor agonists for major neurocognitive disorders
Giorgi, R. D., Ghenciulescu, A., Yotter, C. N., Taquet, M., & Koychev, I. G. (2025) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2024-335593 · Cited by 39 · see citing works
Parkinson Disease: Translating Insights from Molecular Mechanisms to Neuroprotection
Pirooznia, S. K., Rosenthal, L. S., Dawson, V. L., & Dawson, T. M. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000189 · Cited by 36 · see citing works
PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats
Ya, Z., Wang, Y., Wu, Y., Tao, C., Xu, R., Chen, Y., Qian, L., Xu, T., & Lian, X. (2022) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2022.11.006 · Cited by 33 · see citing works
Arbo, B. D., Schimith, L. E., dos Santos, M. G., & Hort, M. A. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174800 · Cited by 33 · see citing works
Evolving Landscape of Parkinson’s Disease Research: Challenges and Perspectives
Tenchov, R., Sasso, J. M., & Zhou, Q. A. (2025) · ACS Omega · doi:10.1021/acsomega.4c09114 · Cited by 33 · see citing works
Drug repurposing strategies of relevance for Parkinson’s disease
Fletcher, E. J. R., Kaminski, T. W., Williams, G. H., & Duty, S. (2021) · Pharmacology Research & Perspectives · doi:10.1002/prp2.841 · Cited by 30 · see citing works
Glucagon-Like Peptide 1 Receptor Agonists – Potential Game Changers in the Treatment of Glaucoma?
Mouhammad, Z. A., Vohra, R., Horwitz, A., Thein, A., Andreasen, J. R., Cvenkel, B., Williams, P. A., Azuara‐Blanco, A., & Kolko, M. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.824054 · Cited by 30 · see citing works
Kreiner, F. F., von Scholten, B. J., Kurtzhals, P., & Gough, S. C. L. (2023) · Aging Cell · doi:10.1111/acel.13818 · Cited by 27 · see citing works
McIntyre, R. S., Rasgon, N., Goldberg, J. F., Wong, S., Le, G. H., Mansur, R. B., Rosenblat, J. D., Teopiz, K. M., & Stahl, S. M. (2025) · CNS Spectrums · doi:10.1017/s1092852925000124 · Cited by 32 · see citing works
The promise of GLP-1 receptor agonists for neurodegenerative diseases
Athauda, D. S., Greig, N. H., Meissner, W. G., Foltynie, T., & Gandhi, S. (2026) · Journal of Clinical Investigation · doi:10.1172/jci194745 · Cited by 30 · see citing works
Self-citationMicroRNAs, Parkinson’s Disease, and Diabetes Mellitus
Wang, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062953 · Cited by 28 · see citing works
Labandeira, C. M., Bau, A. F., Ron, D. A., Muñoz, A., Losada, G. A., Koukoulis, A., Romero-López, J., & Rodriguez-Perez, A. I. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100914 · Cited by 28 · see citing works
Zhang, P., Mao, C., Sun, A., Yang, Y., Hou, Y., Fu, Z., Tousi, B., Leverenz, J. B., Pieper, A. A., Luo, Y., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70639 · Cited by 26 · see citing works
Piątkowska‐Chmiel, I., Herbet, M., Gawrońska‐Grzywacz, M., Pawłowski, K., Ostrowska-Leśko, M., & Dudka, J. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06341-7 · Cited by 30 · see citing works
Yu, S., Wang, Y., Shen, H., Bae, E.-K., Li, Y., Sambamurti, K., Tones, M. A., Zaleska, M. M., Hoffer, B. J., & Greig, N. H. (2024) · GeroScience · doi:10.1007/s11357-024-01116-0 · Cited by 26 · see citing works
Deischinger, C., Dervić, E., Kaleta, M., Klimek, P., & Kautzky‐Willer, A. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-202486 · Cited by 26 · see citing works
Update to the Treatment of Parkinson’s Disease Based on the Gut-Brain Axis Mechanism
Sun, X., Li, X., Wang, Z., & Xie, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.878239 · Cited by 26 · see citing works
Nédelec, T., Couvy‐Duchesne, B., Darves‐Bornoz, A., Couronné, R., Monnet, F., Gantzer, L., Lekens, B., Wu, Y., Villain, N., Schrag, A. E., et al. (2023) · Annals of Neurology · doi:10.1002/ana.26670 · Cited by 26 · see citing works
GLP-1, Parkinson’s Disease, and Neuroprotection
Standaert, D. G. (2024) · New England Journal of Medicine · doi:10.1056/nejme2401743 · Cited by 26 · see citing works
Thiazolidinedione use and risk of Parkinson’s disease in patients with type 2 diabetes mellitus
Zhao, H.-Y., Zhuo, L., Sun, Y., Shen, P., Lin, H., & Zhan, S. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00406-8 · Cited by 25 · see citing works
The retina-brain axis and diabetic retinopathy
Ebrahimi, M., Thompson, P. M., Lauer, A. K., Sivaprasad, S., & Perry, G. L. (2023) · European Journal of Ophthalmology · doi:10.1177/11206721231172229 · Cited by 25 · see citing works
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de la Monte, S. M. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240069 · Cited by 24 · see citing works
Body-wide multi-omic counteraction of aging with GLP-1R agonism
Huang, J., Kwok, A. J., Li, J. C. Y., Chiu, C. L. H., Ip, B. Y. M., Tung, L. Y., Chan, R. C. H., Chan, D. T.-M., Wang, Z., Zheng, X., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.10.014 · Cited by 31 · see citing works
Bergkvist, L., Johnson, M., Mercado, G., Steiner, J. A., Meyerdirk, L. K., Schulz, E., Madaj, Z., Ma, J., Becker, K., Li, Y., et al. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113693 · Cited by 24 · see citing works
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Capucho, A. M., Chegão, A., Martins, F. O., Miranda, H. V., & Conde, S. V. (2022) · Nutrients · doi:10.3390/nu14071425 · Cited by 24 · see citing works
Kopp, K. O., Li, Y., Glotfelty, E. J., Tweedie, D., & Greig, N. H. (2024) · Biomolecules · doi:10.3390/biom14070872 · Cited by 24 · see citing works
Insulin Resistance Is a Modifying Factor for Parkinson's Disease
Žagare, A., Hemedan, A. A., Serra-Almeida, C., Frangenberg, D., Gomez‐Giro, G., Antony, P. M. A., Halder, R., Krüger, R., Glaab, E., Ostaszewski, M., et al. (2024) · Movement Disorders · doi:10.1002/mds.30039 · Cited by 23 · see citing works
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Maanvi, Kumari, S., & Deshmukh, R. R. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175426 · Cited by 23 · see citing works
Lin, Y., Hsu, C., Liu, J., Chang, K., & Huang, J. (2023) · Scientific Reports · doi:10.1038/s41598-023-49870-z · Cited by 23 · see citing works
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Tanvir, A., Jo, J., & Park, S. M. (2024) · Cells · doi:10.3390/cells13221876 · Cited by 47 · see citing works
Gut-Brain Communication in Parkinson’s Disease: Enteroendocrine Regulation by GLP-1
Manfready, R. A., Forsyth, C. B., Voigt, R. M., Hall, D. A., Goetz, C. G., & Keshavarzian, A. (2022) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-022-01196-5 · Cited by 22 · see citing works
Sunnarborg, K., Tiihonen, M., Huovinen, M., Koponen, M., Hartikainen, S. A., & Tolppanen, A. (2022) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.5448 · Cited by 21 · see citing works
Onset and mortality of Parkinson’s disease in relation to type II diabetes
Pezzoli, G., Cereda, E., Amami, P., Colosimo, S., Barichella, M., Sacilotto, G., Zecchinelli, A., Zini, M., Ferri, V., Bolliri, C., et al. (2022) · Journal of Neurology · doi:10.1007/s00415-022-11496-y · Cited by 21 · see citing works
Gunadhar, P., Goodwin, S. M., Livingston, K. A., & Karlsen, M. C. (2023) · American Journal of Lifestyle Medicine · doi:10.1177/15598276231181574 · Cited by 21 · see citing works
Stockmann, O., Ye, L., Greten, S., Chemodanow, D., Wegner, F., & Klietz, M. (2025) · Journal of Neural Transmission · doi:10.1007/s00702-025-02882-7 · Cited by 20 · see citing works
Faizan, M., Sarkar, A., & Singh, M. P. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101727 · Cited by 20 · see citing works
Attenuated Postprandial GLP-1 Response in Parkinson’s Disease
Manfready, R. A., Engen, P. A., Metman, L. V., Sanzo, G., Goetz, C. G., Hall, D. A., Forsyth, C. B., Raeisi, S., Voigt, R. M., & Keshavarzian, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.660942 · Cited by 19 · see citing works
Targeting G Protein-Coupled Receptors in the Treatment of Parkinson's Disease.
Jones-Tabah, J. (2022) · Journal of Molecular Biology · doi:10.1016/j.jmb.2022.167927 · Cited by 18 · see citing works
The Dashboard Vitals of Parkinson’s: Not to Be Missed Yet an Unmet Need
Chaudhuri, К. R., Titova, N., Qamar, M. A., Murășan, I., & Falup‐Pecurariu, C. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12121994 · Cited by 18 · see citing works
Wyse, R. K. H., Isaacs, T., Barker, R. A., Cookson, M., Dawson, T. M., Devos, D., Dexter, D. T., Duffen, J., Federoff, H. J., Fiske, B. K., et al. (2024) · Journal of Parkinson s Disease · doi:10.3233/jpd-230363 · Cited by 19 · see citing works
Self-citationZhai, L., Gao, Y., Yang, H., Wang, H., Liao, B., Cheng, Y., Liu, C., Che, J., Xia, K., Zhang, L., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123345 · Cited by 17 · see citing works
Girges, C., Vijiaratnam, N., Athauda, D. S., Auld, G., Gandhi, S., & Foltynie, T. (2021) · Drugs & Aging · doi:10.1007/s40266-021-00853-7 · Cited by 18 · see citing works
Self-citationParkinson Disease and the Gut: A Primer for Gastroenterologists
Sharma, A., Voigt, R. M., Goetz, C. G., & Keshavarzian, A. (2025) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003508 · Cited by 16 · see citing works
Human Glucose Transporters in Health and Selected Neurodegenerative Diseases
Szablewski, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157392 · Cited by 17 · see citing works
O'Brien, J. T., Chouliaras, L., Sultana, J., Taylor, J., Ballard, C. G., on behalf of the RENEWAL Study Group, Aarsland, D., Blanc, F., Boeve, B. F., Brooks, D. J., et al. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01103-7 · Cited by 16 · see citing works
Potential Protective Link Between Type I Diabetes and Parkinson's Disease Risk and Progression
Senkevich, K. A., Alipour, P., Chernyavskaya, E. А., Yu, E., Noyce, A. J., & Gan‐Or, Z. (2023) · Movement Disorders · doi:10.1002/mds.29424 · Cited by 16 · see citing works
Metabolic Dysfunction in Parkinson’s Disease: Unraveling the Glucose–Lipid Connection
Sian‐Hülsmann, J., Riederer, P. F., & Michel, T. M. (2024) · Biomedicines · doi:10.3390/biomedicines12122841 · Cited by 16 · see citing works
Gao, X., Ding, J.-E., Xie, J., & Xu, H. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01499-6 · Cited by 15 · see citing works
Salem, E. A., Alqahtani, S. M., El‐Shoura, E. A. M., Zaghlool, S. S., Abdelzaher, L. A., Mohamed, S. A. M., Alalhareth, I. S., & Sheref, A. A. M. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-03920-7 · Cited by 15 · see citing works
Hajare, S., & Kulkarni, Y. A. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149975 · Cited by 16 · see citing works
- Authors
- Brauer, R., Wei, L., Ma, T., Athauda, D., Girges, C., Vijiaratnam, N., Auld, G., Whittlesea, C., Wong, I., & Foltynie, T.
- Affiliations
- UCL School of Pharmacy (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Department of Clinical and Movement Neurosciences, UCL Institute of Neurology, Queen Square, London, UK
- Corresponding author
- Wei, Li
- ORCID
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-10-01
- Volume
- 143
- Issue
- 10
- Pages
- 3067-3076
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC7794498
- OpenAlex
- W3089728969
- Cited by
- 233
- References
- 26
- Citations by year
- 2026: 31 · 2025: 56 · 2024: 45 · 2023: 33 · 2022: 38 · 2021: 27 · 2020: 3
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Brain (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- The Cure Parkinson's Trust (LW011)
- Cure Parkinson’s Trust
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- Parkinson's disease, antidiabetic drugs, thiazolidinediones, GLP-1 receptor agonists, DPP-4 inhibitors, insulin, drug safety, type 2 diabetes, type 1 diabetes, Health Improvement Network, propensity score matching, inverse probability of treatment weighting, confounding by indication
- MeSH terms
- Aged, Diabetes Mellitus, Type 2, Female, United Kingdom, Humans, Hypoglycemic Agents, Longitudinal Studies, Male, Middle Aged, Parkinson Disease, Risk Factors, Cohort Studies, Glucagon-Like Peptide 1, Dipeptidyl-Peptidase IV Inhibitors
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