The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Dopaminergic modulation of high-level cognition in Parkinson's disease: the role of the prefrontal cortex revealed by PET
Abstract
This study examined the effects of L-dopa medication in patients with Parkinson's disease on cortical and subcortical blood flow changes during two tasks known to involve frontostriatal circuitry. Eleven patients with Parkinson's disease were scanned on two occasions, one ON L-dopa medication and one OFF L-dopa medication, during performance of the Tower of London planning task and a related test that emphasized aspects of spatial working memory. L-dopa-induced decreases were observed in the right dorsolateral prefrontal cortex during performance of both the planning and the spatial working memory tasks compared with the visuomotor control task. Conversely, L-dopa-induced blood flow increases were observed in the right occipital lobe during the memory task relative to the control task. Data from age-matched healthy volunteers demonstrated that L-dopa effectively normalized blood flow in these regions in the patient group. Moreover, a significant correlation was found between L-dopa-induced, planning related blood flow decreases in the right dorsolateral prefrontal cortex and L-dopa-induced changes in performance on the planning task. These data suggest that L-dopa ameliorates high-level cognitive deficits in Parkinson's disease by inducing relative blood flow changes in the right dorsolateral prefrontal cortex.
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Citations
Cites
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Hoehn, M. M., & Yahr, M. D. (1967) · Neurology · doi:10.1212/wnl.17.5.427 · Cited by 12,107
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BackgroundModulation of memory fields by dopamine Dl receptors in prefrontal cortex
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Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey
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D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory
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Cited by
Inverted-U–Shaped Dopamine Actions on Human Working Memory and Cognitive Control
Cools, R., & D'Esposito, M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.028 · Cited by 1,673
Self-citationCools, R. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.024 · Cited by 903
Self-citationMattay, V. S., Goldberg, T. E., Fera, F., Hariri, A. R., Tessitore, A., Egan, M. F., Kolachana, B., Callicott, J. H., & Weinberger, D. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931309100 · Cited by 893
Mental fatigue and the control of cognitive processes: effects on perseveration and planning
van der Linden, D., Frese, M., & Meijman, T. F. (2003) · Acta Psychologica · doi:10.1016/s0001-6918(02)00150-6 · Cited by 646
Cognitive Impairment in Parkinson’s Disease: The Dual Syndrome Hypothesis
Kehagia, A. A., Barker, R. A., & Robbins, T. W. (2013) · Neurodegenerative Diseases · doi:10.1159/000341998 · Cited by 573
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Metadata
- Authors
- Cools, R., Stefanova, E., Barker, R. A., Robbins, T. W., & Owen, A. M.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-03-01
- Volume
- 125
- Issue
- 3
- Pages
- 584-594
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2147659195
- Cited by
- 396
- References
- 13
- FWCI
- 14.02
- Type
- journal article
- Language
- en
- Open access
- closed
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