The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Striatal dopamine release induced by repetitive transcranial magnetic stimulation of the human motor cortex
Abstract
Brain dopamine is implicated in the regulation of movement, attention, reward and learning. Dysfunction of dopamine plays a role in Parkinson's disease, schizophrenia and drug addiction. It is released in the striatum when dopamine neurons in the midbrain undergo burst firing. Several animal studies have shown that dopamine can also be released under direct control of glutamatergic corticostriatal efferents. However, the existence and physiological significance of this mode of action remain controversial. We have shown previously that repetitive transcranial magnetic stimulation (rTMS) of the human prefrontal cortex led to focal dopamine release in the ipsilateral caudate nucleus, supporting the corticostriatal mode of dopamine release. Using the same experimental approach, we sought to confirm this hypothesis. We used [11C]raclopride and PET to measure changes in extracellular dopamine concentration following rTMS of the motor cortex in six healthy human subjects. rTMS of the left primary motor cortex caused a reduction in [11C]raclopride binding in the left putamen compared with rTMS of the left occipital cortex. There were no changes in binding in the right putamen, caudate nucleus or nucleus accumbens. The area of statistically significant change in binding corresponded closely to the known projection zone of corticostriatal efferents originating in monkey motor cortex. This finding has implications for the functional role of subcortical dopamine.
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Cites
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“Location of the target site To target the same cortical sites in all subjects, a highresolution MRI of each subject's brain was acquired and transformed into standardized stereotaxic space (Talairach and Tournoux, 1988) using automated feature-matching to the MNI template (Collins et al., 1994).”
MethodFunctional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop
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“There is considerable evidence that in vivo binding of benzamide tracers such as [11C]raclopride is inversely proportional to levels of synaptic dopamine at the time of the scan (Dewey et al., 1993; Breier et al., 1997; Endres et al., 1997; Hartvig et al., 1997; Laruelle et al., 1997; Laruelle, 2000).”
BackgroundStrafella, A. P., Paus, T., Barrett, J., & Dagher, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-15-j0003.2001 · Cited by 1,058
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Electrical Stimulation of the Medial Prefrontal Cortex Increases Dopamine Release in the Striatum
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Cited by
Lefaucheur, J.-P., André-Obadia, N., Antal, A., Ayache, S. S., Baeken, C., Benninger, D. H., Cantello, R. M., Cincotta, M., de Carvalho, M., De Ridder, D., et al. (2014) · Clinical Neurophysiology · doi:10.1016/j.clinph.2014.05.021 · Cited by 2,119
The role of dopamine in the pathophysiology of depression
Dunlop, B. W., & Nemeroff, C. B. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.3.327 · Cited by 1,244
The cognitive functions of the caudate nucleus
Grahn, J. A., Parkinson, J. A., & Owen, A. M. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.09.004 · Cited by 940
Noninvasive Human Brain Stimulation
Wagner, T., Valero-Cabre, A., & Pascual-Leone, A. (2007) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.9.061206.133100 · Cited by 873
Neuroplasticity in the context of motor rehabilitation after stroke
Dimyan, M. A., & Cohen, L. G. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.200 · Cited by 732
Metadata
- Authors
- Strafella, A. P.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-09-23
- Volume
- 126
- Issue
- 12
- Pages
- 2609-2615
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2150603122
- Cited by
- 559
- References
- 9
- FWCI
- 9.70
- Type
- journal article
- Language
- en
- Open access
- closed
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