Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy
Abstract
Leakage of the blood-brain barrier (BBB) is associated with various neurological disorders, including temporal lobe epilepsy (TLE). However, it is not known whether alterations of the BBB occur during epileptogenesis and whether this can affect progression of epilepsy. We used both human and rat epileptic brain tissue and determined BBB permeability using various tracers and albumin immunocytochemistry. In addition, we studied the possible consequences of BBB opening in the rat for the subsequent progression of TLE. Albumin extravasation in human was prominent after status epilepticus (SE) in astrocytes and neurons, and also in hippocampus of TLE patients. Similarly, albumin and tracers were found in microglia, astrocytes and neurons of the rat. The BBB was permeable in rat limbic brain regions shortly after SE, but also in the latent and chronic epileptic phase. BBB permeability was positively correlated to seizure frequency in chronic epileptic rats. Artificial opening of the BBB by mannitol in the chronic epileptic phase induced a persistent increase in the number of seizures in the majority of rats. These findings indicate that BBB leakage occurs during epileptogenesis and the chronic epileptic phase and suggest that this can contribute to the progression of epilepsy.
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Changes in blood-brain barrier permeability may lead to progression of epilepsy making it more difficult to treat.
“On the other hand, changes in BBB permeability may lead to progression of epilepsy making it more difficult to treat (621, 622).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [622]
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- Authors
- van Vliet, E. A., da Costa Araujo, S., Redeker, S., van Schaik, R., Aronica, E., & Gorter, J. A.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Stichting Epilepsie Instellingen Nederland (NL)
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-02-01
- Volume
- 130
- Issue
- 2
- Pages
- 521-534
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2112937635
- Cited by
- 775
- References
- 0
- Citations by year
- 2026: 21 · 2025: 30 · 2024: 28 · 2023: 42 · 2022: 44 · 2021: 55 · 2020: 48 · 2019: 41 · 2018: 34 · 2017: 44 · 2016: 44 · 2015: 37 · 2014: 47 · 2013: 41 · 2012: 63
- FWCI
- 17.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- blood-brain barrier disruption, temporal lobe epilepsy, epilepsy progression, epileptogenesis, status epilepticus, albumin extravasation, blood-brain barrier permeability, seizure frequency, hippocampus, microglia, astrocytes, limbic system
- MeSH terms
- Acute Disease, Adolescent, Adult, Albumins, Animals, Blood-Brain Barrier, Brain, Chronic Disease, Coloring Agents, Electroencephalography, Epilepsy, Temporal Lobe, Evans Blue, Fluoresceins, Humans, Male, Middle Aged, Organic Chemicals, Permeability, Status Epilepticus, Rats, Sprague-Dawley, Disease Progression, Rats
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