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Cited by 624

The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.

Robot-based hand motor therapy after stroke

Open access
Takahashi, C. D., Der-Yeghiaian, L., Le, V., Motiwala, R. R., Cramer, S. C.·2008·Brain

Abstract

Robots can improve motor status after stroke with certain advantages, but there has been less emphasis to date on robotic developments for the hand. The goal of this study was to determine whether a hand-wrist robot would improve motor function, and to evaluate the specificity of therapy effects on brain reorganization. Subjects with chronic stroke producing moderate right arm/hand weakness received 3 weeks therapy that emphasized intense active movement repetition as well as attention, speed, force, precision and timing, and included virtual reality games. Subjects initiated hand movements. If necessary, the robot completed movements, a feature available at all visits for seven of the subjects and at the latter half of visits for six of the subjects. Significant behavioural gains were found at end of treatment, for example, in Action Research Arm Test (34 +/- 20 to 38 +/- 19, P< 0.0005) and arm motor Fugl-Meyer score (45 +/- 10 to 52 +/- 10, P < 0.0001). Results suggest greater gains for subjects receiving robotic assistance in all sessions as compared to those receiving robotic assistance in half of sessions. The grasp task practiced during robotic therapy, when performed during functional MRI, showed increased sensorimotor cortex activation across the period of therapy, while a non-practiced task, supination/pronation, did not. A robot-based therapy showed improvements in hand motor function after chronic stroke. Reorganization of motor maps during the current therapy was task-specific, a finding useful when considering generalization of rehabilitation therapy.

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Metadata

Authors
Takahashi, C. D., Der-Yeghiaian, L., Le, V., Motiwala, R. R., & Cramer, S. C.
Venue
Brain
Published
2008-02-01
Volume
131
Issue
2
Pages
425-437
ISSN
  • 0006-8950 (ISSN-L)
  • 1460-2156
OpenAlex
W2136192280
Cited by
624
References
101
FWCI
25.95
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Robot-based hand motor therapy after stroke. https://app.cochat.ai/papers/10.1093/brain/awm311
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Takahashi, C. D., Der-Yeghiaian, L., Le, V., Motiwala, R. R., & Cramer, S. C. (2008). Robot-based hand motor therapy after stroke. Brain. https://doi.org/10.1093/brain/awm311

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.