Cited by 158Alcoholism and Thiamine DeficiencySubstance Abuse Treatment and OutcomesAlcohol Consumption and Health Effects

Hippocampus Volume Loss Due to Chronic Heavy Drinking

Beresford, Thomas P., Arciniegas, David B., Alfers, Julie, Clapp, Lori, Martin, Brandon, Du, Yiping, Liu, Dengfeng, Shen, Dinggang +1 more·2006·Alcoholism: Clinical and Experimental Research

Abstract

Objective: No clear consensus exists regarding the effect of sustained, heavy drinking on hippocampal volume. Our prior work hypothesized significantly lowered total hippocampus volumes in heavy chronically drinking alcohol‐dependent (AD) subjects compared with light‐drinking nondependent control subjects matched for age and gender. Method: Using a series of applicable exclusion criteria culled from previous published studies, we measured hippocampal volumes from MRI scan data acquired on a 3T scanner and subjected those data to automated volume analysis blind to the drinking history. Results: Comparison with AD test (n=8) and non‐AD control (n=8) subjects found significant lessening in total (p=0.020) and left (p=0.010) hippocampal volumes with a near‐significant difference on the right (p=0.051). Linear regression demonstrated that neither total brain volume nor intracranial volume affected the hippocampus measures. Conclusions: These data support the view that heavy drinking exerts a unique and selectively injurious effect on the hippocampus. Further study in larger samples must verify this in a search for possible mechanisms of injury.

Integrity signals

Registry

Crossref · 10.1111/j.1530-0277.2006.00223.x

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The RAVENS approach has been extensively validated and applied in various studies.

    “The RAVENS approach has been extensively validated and applied in various studies (Resnick et al. 2000;Beresford et al. 2006;Gur et al. 2006;Driscoll et al. 2009).”

    From Imaging Patterns of Brain Development and their Relationship to Cognition (2015) · cites this paper as Beresford et al. 2006

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Beresford, T. P., Arciniegas, D. B., Alfers, J., Clapp, L., Martin, B., Du, Y., Liu, D., Shen, D., & Davatzikos, C.
Affiliations
  • United States Department of Veterans Affairs (US)
  • University of Colorado Anschutz (US)
  • University of Pennsylvania (US)
Corresponding author
Beresford, Thomas P.
Venue
Alcoholism: Clinical and Experimental Research
Publisher
Wiley
Published
2006-10-11
Volume
30
Issue
11
Pages
1866-1870
ISSN
  • 0145-6008 (ISSN-L)
  • 1530-0277
OpenAlex
W2087763856
Cited by
158
References
27
Citations by year
2025: 7 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 12 · 2019: 16 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 8 · 2014: 13 · 2013: 14 · 2012: 8
FWCI
6.26
Type
journal article
Language
en
Open access
closed
Locations
  • Alcoholism Clinical and Experimental Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Alcohol Abuse and Alcoholism (R21AA014010, R21-AA14010)
Topics
  • Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
hippocampal volume, heavy drinking, chronic alcohol consumption, alcoholism, hippocampal atrophy, brain volume
MeSH terms
Adult, Alcoholism, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Psychiatric Status Rating Scales, Regression Analysis, Skull

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review