Volumetry of hippocampus and amygdala with high-resolution MRI and three-dimensional analysis software: minimizing the discrepancies between laboratories
Abstract
Within the medial temporal lobe, both the hippocampus and amygdala are frequently targeted by researchers and clinicians for volumetric analysis based on magnetic resonance imaging (MRI). However, different data acquisition techniques, analysis software and anatomical boundaries have in the past made it difficult to compare results of MRI studies from different laboratories. In order to reduce these differences, a segmentation protocol was established with 40 healthy normal control subjects recently scanned in our laboratory. Data acquisition was performed with a three-dimensional gradient echo technique, and scans were corrected for non-uniformity and registered into standard stereotaxic space prior to segmentation. Volumetric analysis was performed manually using three-dimensional software that allows simultaneous analysis of sagittal, coronal and horizontal images. Intra- and inter-rater coefficients yielded correlation coefficients comparable with other protocols. The hippocampal volume was larger in the right hemisphere (3324 versus 3208 mm(3)), while no interhemispheric differences for the amygdala (1154 versus 1160 mm(3)) could be observed. Most importantly, results from recent segmentation protocols for hippocampus and amygdala seem to approach each other with regard to mean volumes and interhemispheric differences. This indicates that the advances in scanning technique, volume preparation and segmentation protocols allow a more precise definition of medial temporal lobe structures with MRI, and that results for mean volumes for hippocampus and amygdala from different laboratories will eventually become comparable.
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The segmentation protocol for the assessment of hippocampal volume has been validated in a number of projects.
“The segmentation protocol for the assessment of hippocampal volume has recently been developed by our group, and we have since been able to validate it in a number of projects (Pruessner et al., 2000(Pruessner et al., , 2001(Pruessner et al., , 2002)).”
From Self-esteem, locus of control, hippocampal volume, and cortisol regulation in young and old adulthood (2005) · cites this paper as Pruessner et al., 2000
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Imaging the Human Medial Temporal Lobe with High-Resolution fMRI
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Diagnostic utility of hippocampal size and mean diffusivity in amnestic MCI.
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Self-citationAbnormal size of the amygdala predicts impaired emotional memory in major depressive disorder
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In vivo neuropathology of the hippocampal formation in AD: a radial mapping MR-based study
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FMRI activations of amygdala, cingulate cortex, and auditory cortex by infant laughing and crying
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Jones, S. L., Dufoix, R., Laplante, D. P., Elgbeili, G., Patel, R., Chakravarty, M. M., King, S., & Pruessner, J. C. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00144 · Cited by 92 · see citing works
Self-citationHippocampal volume is an independent predictor of cognitive performance in CADASIL
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Hippocampal Size and Memory Functioning in Children and Adolescents with Congenital Hypothyroidism
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A comparison of accurate automatic hippocampal segmentation methods
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- Authors
- Pruessner, J. C.
- Affiliations
- Montreal Neurological Institute and Hospital (CA)
- Corresponding author
- Pruessner, J.C.
- ORCID
- Pruessner, J.C.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-04-01
- Volume
- 10
- Issue
- 4
- Pages
- 433-442
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2155492919
- Cited by
- 706
- References
- 67
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 13 · 2023: 10 · 2022: 13 · 2021: 24 · 2020: 20 · 2019: 22 · 2018: 23 · 2017: 27 · 2016: 31 · 2015: 40 · 2014: 33 · 2013: 41 · 2012: 44
- FWCI
- 19.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- KOPS (University of Konstanz) (submittedVersion)
- Funders
- McGill University
- Deutsche Forschungsgemeinschaft
- Topics
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- hippocampus, amygdala, brain volumetry, medial temporal lobe, inter-rater reliability, interlaboratory comparison, hemispheric lateralization, gradient echo MRI
- MeSH terms
- Adolescent, Adult, Amygdala, Female, Hippocampus, Humans, Laboratories, Magnetic Resonance Imaging, Male, Reference Values, Sex Factors, Software, Reproducibility of Results
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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