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Cited by 128Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsMemory and Neural Mechanisms

In vivo neuropathology of the hippocampal formation in AD: a radial mapping MR-based study

Frisoni, G.B., Sabattoli, F., Lee, A.D., Dutton, R.A., Toga, A.W., Thompson, P.M.·2006·NeuroImage
DOI 10.1016/j.neuroimage.2006.03.015
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Abstract

Early involvement of the hippocampal formation is the biological basis of the typical learning deficit in Alzheimer's disease (AD). However, the hippocampal formation is unevenly affected by AD pathology, deposits of plaques and tangles being particularly dense in the CA1 field and subiculum. The aim of the study was to locate in vivo the structural changes within the hippocampal formation in AD patients of mild to moderate severity. A group of 28 AD patients and 40 cognitively intact persons (age 74 +/- 9 and 71 +/- 7 years) underwent T1-weighted high-resolution MR scans. The hippocampal formation was isolated by manually tracing on 35 coronal slices the outlines of the hippocampus proper and subiculum after registration to a common stereotactic space. Group differences were assessed with algorithms developed ad hoc that make use of three-dimensional parametric surface mesh models. In AD patients, significant atrophic changes amounting to tissue loss of 20% or more were found in regions of the hippocampal formation corresponding to the CA1 field and part of the subiculum. Regions corresponding to the CA2-3 fields were remarkably spared. We conclude that the regions of the hippocampal formation that we found atrophic in AD patients are those known to be affected from pathological studies. This study supports the possibility of carrying out in vivo macroscopic neuropathology of the hippocampus with MR imaging in the neurodegenerative dementias.

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  • The predominance of atrophy in CA1 (and to a lesser extent in the subiculum) in patients with clinical AD or aMCI has already been shown in vivo using a variety of neuroimaging approaches.

    “Using a variety of neuroimaging approaches such as radial atrophy (Frisoni et al., 2006), large-deformation high-dimensional brain mapping (Wang et al., 2003), voxel-based morphometry (Chételat et al., 2008) or manual delineation (Mueller et al., 2010), the predominance of atrophy in CA1 (and to a lesser extent in the subiculum) in patients with clinical AD or aMCI has already been shown in vivo.”

    From Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer's disease and semantic dementia (2013) · cites this paper as Frisoni et al., 2006

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Authors
Frisoni, G. B., Sabattoli, F., Lee, A. D., Dutton, R. A., Toga, A. W., & Thompson, P. M.
Affiliations
  • Centro San Giovanni di Dio Fatebenefratelli (IT)
  • University of California, Los Angeles (US)
Corresponding author
Frisoni, G.B.
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2006-08
Volume
32
Issue
1
Pages
104-110
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2006.03.015
OpenAlex
W2079838870
Cited by
128
References
32
Citations by year
2025: 1 · 2023: 1 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 4 · 2017: 8 · 2016: 5 · 2015: 16 · 2014: 5 · 2013: 8 · 2012: 12
FWCI
9.56
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (P50AG016570)
  • National Institute of General Medical Sciences (U54 GM 072978)
  • National Institute of Biomedical Imaging and Bioengineering (R21 EB 01651)
  • National Center for Research Resources (P41RR013642, R21RR019771, P41 RR13642)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
Alzheimer's disease, hippocampal formation, hippocampal atrophy, CA1 field, subiculum, hippocampal neurodegeneration, neurodegenerative dementia
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Brain Mapping, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values, Sensitivity and Specificity, Neurofibrillary Tangles, Age of Onset, Plaque, Amyloid

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