Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

McCarthy, K. D., & de Vellis, J. (1980) · The Journal of Cell Biology · doi:10.1083/jcb.85.3.890 · Cited by 3,825

ROCKs: multifunctional kinases in cell behaviour

Riento, K., & Ridley, A. J. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1128 · Cited by 1,941

Blue native PAGE

Wittig, I., Braun, H., & Schägger, H. (2006) · Nature Protocols · doi:10.1038/nprot.2006.62 · Cited by 1,741

MYELINATION IN RAT BRAIN: METHOD OF MYELIN ISOLATION1

Norton, W. T., & Poduslo, S. E. (1973) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1973.tb07519.x · Cited by 1,413

Multipotent CNS Stem Cells Are Present in the Adult Mammalian Spinal Cord and Ventricular Neuroaxis

Weiss, S., Dunne, C., Hewson, J., Wohl, C. A., Wheatley, M., Peterson, A. C., & Reynolds, B. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07599.1996 · Cited by 1,219

Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination

Lappe-Siefke, C., Goebbels, S., Gravel, M., Nicksch, E., Lee, J., Braun, P. E., Griffiths, I. R., & Nave, K.-A. (2003) · Nature Genetics · doi:10.1038/ng1095 · Cited by 1,036

Axonal Swellings and Degeneration in Mice Lacking the Major Proteolipid of Myelin

Griffiths, I., Klugmann, M., Anderson, T., Yool, D., Thomson, C., Schwab, M. H., Schneider, A., Zimmermann, F., McCulloch, M., Nadon, N., et al. (1998) · Science · doi:10.1126/science.280.5369.1610 · Cited by 889

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

Kuhlmann, T., Miron, V., Cuo, Q., Wegner, C., Antel, J., & Bruck, W. (2008) · Brain · doi:10.1093/brain/awn096 · Cited by 864

Why does remyelination fail in multiple sclerosis?

Franklin, R. J. M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn917 · Cited by 862

Remyelination is extensive in a subset of multiple sclerosis patients

Patrikios, P., Stadelmann, C., Kutzelnigg, A., Rauschka, H., Schmidbauer, M., Laursen, H., Sorensen, P. S., Bruck, W., Lucchinetti, C., & Lassmann, H. (2006) · Brain · doi:10.1093/brain/awl217 · Cited by 807

Sphingosylphosphorylcholine induces stress fiber formation via activation of Fyn-RhoA-ROCK signaling pathway in fibroblasts

Xu, D., Kishi, H., Kawamichi, H., Kajiya, K., Takada, Y., & Kobayashi, S. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.09.013 · Cited by 25

Extracellular Acidic pH Inhibits Oligodendrocyte Precursor Viability, Migration, and Differentiation

Jagielska, A., Wilhite, K. D., & Vliet, K. J. V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076048 · Cited by 24

Fyn Kinase in Alzheimer’s Disease: Unraveling Molecular Mechanisms and Therapeutic Implications

Meur, S., & Karati, D. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04286-2 · Cited by 24

Involvement of the guanine nucleotide exchange factor Vav3 in central nervous system development and plasticity

Ulc, A., Gottschling, C., Schäfer, I., Wegrzyn, D., van Leeuwen, S., Luft, V., Reinhard, J., & Faissner, A. (2017) · Biological Chemistry · doi:10.1515/hsz-2016-0275 · Cited by 25

Distinct origins, gene expression and function of microglia and monocyte-derived macrophages in CNS myelin injury and regeneration

Davies, C. L., & Miron, V. E. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.06.016 · Cited by 24

Oligodendrocytes Do Not Export NAA-Derived Aspartate In Vitro

Amaral, A. I., Hadera, M. G., Kotter, M., & Sonnewald, U. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1985-y · Cited by 23

Attempts to Overcome Remyelination Failure: Toward Opening New Therapeutic Avenues for Multiple Sclerosis

Motavaf, M., Sadeghizadeh, M., & Javan, M. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0472-6 · Cited by 25

The Role of the Oligodendrocyte Lineage in Acute Brain Trauma

Scheller, A., Bai, X., & Kirchhoff, F. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2343-4 · Cited by 22

Are Motor Control and Regulation Problems Part of the ASD Motor Profile? A Handwriting Study

Grace, N., Johnson, B. P., Rinehart, N., & Enticott, P. G. (2018) · Developmental Neuropsychology · doi:10.1080/87565641.2018.1504948 · Cited by 25

Myelin-based inhibitors of oligodendrocyte myelination: clues from axonal growth and regeneration

Mei, F., Chong, S. Y. C., & Chan, J. R. (2013) · Neuroscience Bulletin · doi:10.1007/s12264-013-1319-x · Cited by 26

Histone Deacetylase SIRT1 Mediates C5b-9-Induced Cell Cycle in Oligodendrocytes

Tatomir, A., Rao, G. G., Boodhoo, D., Vlaicu, S. I., Beltrand, A., Anselmo, F., Rus, V., & Rus, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00619 · Cited by 22

mTORC2 Loss in Oligodendrocyte Progenitor Cells Results in Regional Hypomyelination in the Central Nervous System

Dahl, K. D., Hathaway, H. A., Almeida, A. R., Bourne, J. N., Brown, T. L., Finseth, L. T., Wood, T. L., & Macklin, W. B. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0010-22.2022 · Cited by 22

The N‐terminal domain of the myelin enzyme 2′,3′‐cyclic nucleotide 3′‐phosphodiesterase: direct molecular interaction with the calcium sensor calmodulin

Myllykoski, M., Itoh, K., Kangas, S. M., Heape, A. M., Kang, S.-U., Lübec, G., Kursula, I., & Kursula, P. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12000 · Cited by 22

Physical forces in myelination and repair: a question of balance?

Bauer, N. G., & ffrench‐Constant, C. (2009) · Journal of Biology · doi:10.1186/jbiol169 · Cited by 22

Mechanisms Underlying Non-Pharmacological Dementia Prevention Strategies: A Translational Perspective

Alanko, V., Udeh‐Momoh, C. T., Kivipelto, M., & Matton, A. (2022) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2022.9 · Cited by 22

Myelin Proteome Analysis: Methods and Implications for the Myelin Cytoskeleton

Jahn, O., Tenzer, S., Bartsch, N., Patzig, J., & Werner, H. B. (2012) · Neuromethods · doi:10.1007/978-1-62703-266-7_15 · Cited by 24

Role of Fyn Kinase Inhibitors in Switching Neuroinflammatory Pathways

Marotta, G., Basagni, F., Rosini, M., & Minarini, A. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867329666211221153719 · Cited by 21

Laminin-511 Activates the Human Induced Pluripotent Stem Cell Survival via α6β1 Integrin-Fyn-RhoA-ROCK Signaling

Nakashima, Y., & Tsukahara, M. (2022) · Stem Cells and Development · doi:10.1089/scd.2022.0010 · Cited by 22

SCISSOR—Spinal Cord Injury Study on Small molecule-derived Rho inhibition: a clinical study protocol

Kopp, M. A., Liebscher, T., Watzlawick, R., Martus, P., Laufer, S., Blex, C., Schindler, R., Jungehulsing, G. J., Knüppel, S., Kreutzträger, M., et al. (2016) · BMJ Open · doi:10.1136/bmjopen-2015-010651 · Cited by 21

Growth arrest specific protein 6 alleviated white matter injury after experimental ischemic stroke

Jia, J., Xu, S., Hu, J., Gan, Y., Sun, M., Xia, S., Bao, X., Zhang, M., & Xu, Y. (2023) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x231205078 · Cited by 19

P2Y12 receptor expression is a critical determinant of functional responsiveness to ATX’s MORFO domain

Dennis, J., Morgan, M., Graf, M. R., & Fuss, B. (2011) · Purinergic Signalling · doi:10.1007/s11302-011-9283-2 · Cited by 19

A DEAD‐box RNA helicase Ddx54 protein in oligodendrocytes is indispensable for myelination in the central nervous system

Zhan, R., Yamamoto, M., Ueki, T., Yoshioka, N., Tanaka, K., Morisaki, H., Seiwa, C., Yamamoto, Y., Kawano, H., Tsuruo, Y., et al. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23162 · Cited by 19

A new in vitro mouse oligodendrocyte precursor cell migration assay reveals a role for integrin-linked kinase in cell motility

O’Meara, R. W., Cummings, S. E., Michalski, J., & Kothary, R. (2016) · BMC Neuroscience · doi:10.1186/s12868-016-0242-2 · Cited by 22

Aorta-Derived Mesoangioblasts Differentiate into the Oligodendrocytes by Inhibition of the Rho Kinase Signaling Pathway

Wang, L., Kamath, A. M., Frye, J., Iwamoto, G. A., Chun, J. L., & Berry, S. E. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0124 · Cited by 18

Myelin matters: proteomic insights into white matter disorders

Werner, H. B., & Jahn, O. (2010) · Expert Review of Proteomics · doi:10.1586/epr.09.105 · Cited by 19

B-cells expressing NgR1 and NgR3 are localized to EAE-induced inflammatory infiltrates and are stimulated by BAFF

Bakhuraysah, M. M., Theotokis, P., Lee, J. Y., Alrehaili, A. A., Aui, P.-M., Figgett, W. A., Azari, M. F., Abou-Afech, J.-P., Mackay, F., Siatskas, C., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-82346-6 · Cited by 18

The Role of Vesicle Trafficking and Release in Oligodendrocyte Biology

Reiter, C. R., & Bongarzone, E. R. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02913-2 · Cited by 17

LINGO-1 and Neurodegeneration: Pathophysiologic Clues for Essential Tremor?

Zhou, Z., Sathiyamoorthy, S., & Tan, E. (2011) · Europe PMC (PubMed Central) · doi:10.7916/d8pz57jv · Cited by 17

WNK1 is involved in Nogo66 inhibition of OPC differentiation

Zhang, Z., Li, J., Wang, Q.-J., Zhao, W.-Q., Hong, J., Lou, S., & Xu, X. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.03.003 · Cited by 17

Activation of the niacin receptor HCA2 reduces demyelination and neurofilament loss, and promotes functional recovery after spinal cord injury in mice

Yang, R., He, J., & Wang, Y. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.08.020 · Cited by 18

Embracing oligodendrocyte diversity in the context of perinatal injury

Cunningham, L. A., Newville, J., & Jantzie, L. L. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.217320 · Cited by 20

Ganglion Cell Topography Indicates Pre- or Postnatal Damage to the Retro-Geniculate Visual System, Predicts Visual Field Function and May Identify Cerebral Visual Impairment in Children – A Multiple Case Study

Jacobson, L. K., Lennartsson, F., & Nilsson, M. (2019) · Neuro-Ophthalmology · doi:10.1080/01658107.2019.1583760 · Cited by 17

Axon cytoskeleton proteins specifically modulate oligodendrocyte growth and differentiation in vitro

Fressinaud, C., Bergès, R., & Eyer, J. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.10.011 · Cited by 18

Neuroinflammation: An Oligodendrocentric View

Festa, L. K., Jordan‐Sciutto, K. L., & Grinspan, J. B. (2025) · Glia · doi:10.1002/glia.70007 · Cited by 18

Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism

Hansford, R., Buller, S. A., Tsang, A. H. K., Benoit, S., Roberts, A. G., Erskine, E., Brown, T., Pirro, V., Reimann, F. M., Harada, N., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.07.009 · Cited by 19

The role of foam cells in spinal cord injury: challenges and opportunities for intervention

Wang, X., Li, Z., Du, H., Liu, W.-B., Zhang, C.-J., Xu, X., Ke, H., Peng, R., Yang, D., Li, J., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1368203 · Cited by 16

Differential Gene Expression Associated with Soybean Oil Level in the Diet of Pigs

Fanalli, S. L., da Silva, B. P. M., Gomes, J. D., de Almeida, V. V., Freitas, F. A. O., Moreira, G. C. M., Silva‐Vignato, B., Afonso, J., Reecy, J. M., Koltes, J. E., et al. (2022) · Animals · doi:10.3390/ani12131632 · Cited by 16

Inhibition of TROY Promotes OPC Differentiation and Increases Therapeutic Efficacy of OPC Graft for Spinal Cord Injury

Sun, L., Liu, S., Sun, Q., Li, Z., Xu, F., Hou, C., Harada, T., Chu, M., Xu, K., Feng, X., et al. (2014) · Stem Cells and Development · doi:10.1089/scd.2013.0563 · Cited by 16

Targeting Remyelination in Spinal Cord Injury: Insights and Emerging Therapeutic Strategies

Mamun, A. A., Zhou, Q., Geng, P., Wang, S., Shao, C., & Xiao, J. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70193 · Cited by 15

Neurofilament‐tubulin binding site peptide NFL‐TBS.40–63 increases the differentiation of oligodendrocytes in vitro and partially prevents them from lysophosphatidyl choline toxiciy

Fressinaud, C., & Eyer, J. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23308 · Cited by 18

New insights into an old story

Speranza, A., & Scoccianti, V. (2012) · Plant Signaling & Behavior · doi:10.4161/psb.20674 · Cited by 15

Remyelination in PNS and CNS: current and upcoming cellular and molecular strategies to treat disabling neuropathies

Momenzadeh, S., & Jami, M. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06755-6 · Cited by 14

Cellular response to micropatterned growth promoting and inhibitory substrates

Belkaïd, W., Thostrup, P., Yam, P. T., Juźwik, C. A., Ruthazer, E. S., Dhaunchak, A. S., & Colman, D. (2013) · BMC Biotechnology · doi:10.1186/1472-6750-13-86 · Cited by 14

Factors that retard remyelination in multiple sclerosis with a focus on TIP30: a novel therapeutic target

Nakahara, J., Aiso, S., & Suzuki, N. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903307491 · Cited by 14

Establishment of a simple one-step method for oligodendrocyte progenitor cell preparation from rodent brains

Yoshida, A., Takashima, K., Shimonaga, T., Kadokura, M., Nagase, S., & Koda, S. (2020) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2020.108798 · Cited by 12

Oligodendrocyte progenitor cells differentiation induction with MAPK / ERK inhibitor fails to support repair processes in the chronically demyelinated CNS

Ganz, T., Zveik, O., Fainstein, N., Lachish, M., Rechtman, A., Sofer, L., Brill, L., Ben‐Hur, T., & Vaknin‐Dembinsky, A. (2023) · Glia · doi:10.1002/glia.24453 · Cited by 13

Chemische Kontrolle des Schicksals und Entwicklungspotenzials von Stammzellen

Lyssiotis, C. A., Lairson, L. L., Boitano, A. E., Wurdak, H., Zhu, S., & Schultz, P. G. (2010) · Angewandte Chemie · doi:10.1002/ange.201004284 · Cited by 13

Enhancing axonal myelination in seniors: A review exploring the potential impact cannabis has on myelination in the aged brain

Murray, C. J., Vecchiarelli, H. A., & Tremblay, M. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1119552 · Cited by 12

Targeting the AKT/mTOR/p70S6K Pathway for Oligodendrocyte Differentiation and Myelin Regeneration in Neurological Disorders

Chen, G., & Li, C. (2023) · Current Neurovascular Research · doi:10.2174/0115672026274954230919070115 · Cited by 13

Neuroprotective strategies in multiple sclerosis: a status update and emerging paradigms

Coclitu, C., Constantinescu, C. S., & Tănăsescu, R. (2025) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2025.2510405 · Cited by 12

Rnh1 promotes differentiation and myelination via RhoA in oligodendrocytes

Zhao, C., Liu, Y., Que, H., Yang, S., Liu, T., Liu, Z. Q., Hui, H., & Liu, S. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1625-7 · Cited by 12

Multiple Sclerosis and Other Acquired Demyelinating Diseases of the Central Nervous SystemPreprint

Kornberg, M. D., & Calabresi, P. A. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041374 · Cited by 17

Nogo receptor-Fc delivered by haematopoietic cells enhances neurorepair in a multiple sclerosis model

Ye, S., Theotokis, P., Lee, J. Y., Kim, M. J., Nheu, D., Ellen, O., Bedford, T., Ramanujam, P., Wright, D. K., McDonald, S. J., et al. (2023) · Brain Communications · doi:10.1093/braincomms/fcad108 · Cited by 11

Modulation of OPC Mitochondrial Function by Inhibiting USP30 Promotes Their Differentiation

Soung, A., Kyauk, R. V., Pandey, S., Shen, Y. A., Reichelt, M., Lin, H., Jiang, Z., Kirshnamoorthy, P., Foreman, O., Lauffer, B. E. L., et al. (2024) · Glia · doi:10.1002/glia.24648 · Cited by 11

How does Nogo receptor influence demyelination and remyelination in the context of multiple sclerosis?

Rashidbenam, Z., Öztürk, E., Pagnin, M., Theotokis, P., Grigoriadis, N., & Petratos, S. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1197492 · Cited by 12

Quantification of oligodendrocyte progenitor cells in human and cat optic nerve: Implications for endogenous repair in multiple sclerosis

Jennings, A. R., & Carroll, W. M. (2010) · Glia · doi:10.1002/glia.21018 · Cited by 10

Cytoskeletal Signal-Regulated Oligodendrocyte Myelination and Remyelination

Miyata, S. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9636-7_3 · Cited by 10

Forced Remyelination Promotes Axon Regeneration in a Rat Model of Spinal Cord Injury

Zawadzka, M., Yeghiazaryan, M., Niedziółka, S. M., Miazga, K., Kwaśniewska, A., Bekisz, M., & Sławińska, U. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010495 · Cited by 9

Constraint-Induced Movement Therapy Promotes Myelin Remodeling and Motor Function by Mediating Sox2/Fyn Signals in Rats With Hemiplegic Cerebral Palsy

Fu, C., Tang, H., Liu, L., Huang, Y., Zhou, H., Huang, S., Peng, T., Zeng, P., Yang, X., He, L., et al. (2024) · Physical Therapy · doi:10.1093/ptj/pzae011 · Cited by 9

Oligodendrocyte progenitor cells' fate after neonatal asphyxia—Puzzling implications for the development of hypoxic–ischemic encephalopathy

Janowska, J., Gargaś, J., Zajdel, K., Wieteska, M., Lipinski, K. A., Ziemka‐Nałęcz, M., Frontczak‐Baniewicz, M., & Sypecka, J. (2024) · Brain Pathology · doi:10.1111/bpa.13255 · Cited by 10

Chemical biology in stem cell research

Choi, Y., & Nam, T. (2012) · Archives of Pharmacal Research · doi:10.1007/s12272-012-0208-6 · Cited by 8

The Contribution of Empathy to Ethics

Songhorian, S. (2019) · International Journal of Philosophical Studies · doi:10.1080/09672559.2019.1619266 · Cited by 8

Rnd3 is necessary for the correct oligodendrocyte differentiation and myelination in the central nervous system

Madrigal, M. P., Ballester‐Lurbe, B., Gómez, O., Moreno‐Bravo, J. A., Puelles, E., Jurado, S., García‐Verdugo, J. M., Pérez‐Roger, I., & Terrado, J. (2021) · Brain Structure and Function · doi:10.1007/s00429-021-02419-0 · Cited by 7

Rho-Kinase Inhibition Improves the Outcome of Focal Subcortical White Matter Lesions

Aykan, S. A., Xie, H., Zheng, Y. Z., Chung, D. Y., Kura, S., Lai, J. H., Erdogan, T. D., Morais, A., Tamim, I., Yagmur, D., et al. (2022) · Stroke · doi:10.1161/strokeaha.121.037358 · Cited by 7

Promotive Effects of Yokukansan, a Traditional Japanese Medicine, on Proliferation and Differentiation of Cultured Mouse Cortical Oligodendrocytes

Ueki, T., Ikarashi, Y., Kawakami, Z., Mizoguchi, K., & Kase, Y. (2014) · Pharmacology & Pharmacy · doi:10.4236/pp.2014.57077 · Cited by 7

MARCKS is Necessary for Oligodendrocyte Precursor Cell Maturation

Zhang, Z., Ma, F.-F., Zhang, H., & Xu, X. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2324-7 · Cited by 7

Retrogeniculate Lesion of the Visual Pathways: Retinal Optical Coherence Tomography Angiography Shows Evidence of Transsynaptic Retrograde Degeneration

Pellegrini, F., Interlandi, E., Pichi, F., & Lee, A. G. (2019) · Neuro-Ophthalmology · doi:10.1080/01658107.2019.1617748 · Cited by 7

Endogenous Remyelination in the CNS

Franklin, R. J. M., Zhao, C., Lubetzki, C., & ffrench‐Constant, C. (2012) · Springer eBooks · doi:10.1007/978-1-4614-2218-1_4 · Cited by 7

Myosin superfamily members during myelin formation and regeneration

Yamazaki, R., & Ohno, N. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16202 · Cited by 6

Prognostic Factors for Recovery of Vision in Canine Optic Neuritis of Unknown Etiology: 26 Dogs (2003–2018)

Posporis, C., Beltrán, E., Dunning, M., Espadas, I., Gillespie, S., Barry, A. T., & Wessmann, A. (2019) · Frontiers in Veterinary Science · doi:10.3389/fvets.2019.00415 · Cited by 8

A neuronal Slit1-dependent program rescues oligodendrocyte differentiation and myelination under chronic hypoxic conditions

Dai, W., Nian, X., Zhou, Z., Du, A., Liu, Q., Jia, S., Yan, L., Li, D., Lu, X., Zhu, Y., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115467 · Cited by 5

Myelin sheath injury and repairment after subarachnoid hemorrhage

Chen, M., Guo, P., Ru, X., Chen, Y., Zuo, S., & Feng, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1145605 · Cited by 5

Evaluation of Pupil Fields Using a Newly Developed Perimeter in Glaucoma Patients

戸塚, 和., Asakawa, K., Ishikawa, H., & Shoji, N. (2018) · Current Eye Research · doi:10.1080/02713683.2018.1562078 · Cited by 5

Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases

Hou, X.-Q., Wang, L., Wang, F.-G., Zhao, X., & Zhang, H. (2017) · Genes · doi:10.3390/genes8050135 · Cited by 4

Oligodendrocyte: Structure, Function and Pathology

Patro, N., Patro, I. K., & Tandon, P. (2022) · Springer eBooks · doi:10.1007/978-981-16-8313-8_3 · Cited by 5

Title: Immunotherapy; a ground-breaking remedy for spinal cord injury with stumbling blocks: An overview

Saeed, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1110008 · Cited by 4

Promoting the Differentiation of Neural Progenitor Cells into Oligodendrocytes through the Induction of Olig2 Expression: A Transcriptomic Study Using RNA-seq Analysis

Pieczonka, K., Khazaei, M., & Fehlings, M. G. (2023) · Cells · doi:10.3390/cells12091252 · Cited by 5

Quaking Protein in Myelin Maintenance and Regeneration in the Central Nervous System

Thomas, L., Pasquini, M. V. G., & Pasquini, L. A. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05144-5 · Cited by 4

The role of type I collagen in white matter injury

Yamazaki, R., & Ohno, N. (2025) · Anatomical Science International · doi:10.1007/s12565-025-00881-y · Cited by 3

Engineered lesion-homing liposomes encapsulating Rosuvastatin enhance spinal cord injury repair by preventing the formation of foamy macrophages

Liu, Z., Zhao, J., Wen, H., Qin, Y., Zheng, L., Sun, Y. X., He, R., Zu, A., Wu, T., Jiang, L., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114308 · Cited by 3

Local delivery of AdipoRon from self-assembled microparticles to inhibit myelin lipid uptake and to promote lipid efflux from rat macrophages

Shultz, R. B., Hai, N., & Zhong, Y. (2024) · Journal of Neural Engineering · doi:10.1088/1741-2552/ad29d5 · Cited by 3

White Matter Repair in Subcortical Stroke

Sözmen, E. G., & Carmichael, S. T. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9123-1_12 · Cited by 3

Plasma lipidomic patterns associated with disease activity in chronic inflammatory demyelinating polyradiculoneuropathy (LIPID-CIDP)

Brinke, K. A. D., Borsch, L.-M., Klose, C. D., Zschüntzsch, J., Vinhoven, L., Nietert, M. M., Lattau, S. S. J., & Fitzner, D. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2025.100903 · Cited by 2

Single nuclei RNAseq analysis of HD mouse models and human brain reveals impaired oligodendrocyte maturation and potential role for thiamine metabolismPreprint

Lim, R. G., Al‐Dalahmah, O., Wu, J., Gold, M. P., Reidling, J. C., Tang, G., Adam, M., Dansu, D. K., Park, H.-J., Casaccia, P., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.27.497613 · Cited by 2

Alpha synuclein-mediated cytoskeletal dysfunction impairs myelination in human oligodendrocytes

Wihan, J., Battis, K., Hoffmann, A., Windener, F., Himmler, M., Varghese, A., Koller, A., Karnatz, I., Schubert, D. W., Zunke, F., et al. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02933-z · Cited by 1

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Lu, W., Jiang, M., Zhuang, J., Song, J., Zhou, C., Zhou, Y., Zhu, Z., Wu, A., Sheng, S., Zhu, S., et al. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03743-0 · Cited by 1

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Pourabdolhossein, F., Javan, M., Mirnajafi-Zadeh, S. J., Dehghan, S., Sherafat, M. A., Mozafari, S., & Ahmadiani, A. (2011) · KAUMS Journal · Cited by 1

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Kroner, A., Kleinschnitz, C., Stadelmann, C., Raab, P., Stangel, M., Trebst, C., Voß, E. V., & Cordes, A.-L. (2011) · Springer eBooks · doi:10.1007/978-3-642-20477-7_1 · Cited by 1

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de Faria, J. P., Azevedo, M. M., Bausch‐Fluck, D., Seixas, A. I., Domingues, H. S., Monteiro, A., Pedrioli, P. G. A., Lopes, E., Fernandes, R., Zhao, C., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.24.436006 · Cited by 1

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Vereyken, E. J. F., Dijkstra, C. D., & Teunisse, C. E. (2011) · InTech eBooks · doi:10.5772/30525

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Maier, O. (2012) · InTech eBooks · doi:10.5772/37892

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Natrajan, M. S., Bielekova, B., & Franklin, R. J. M. (2015) · Wiley eBooks · doi:10.1002/9781118732748.ch13

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Stadelmann, C., & Brück, W. (2015) · Elsevier eBooks · doi:10.1016/b978-3-437-22083-8.00004-3

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de Monasterio‐Schrader, P. (2012) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-1450

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Jha, S. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/e2yp-8441

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COHAN, S. L., Lucassen, E. B., Smoot, K. E., Kresa-Reahl, K., Romba, M. C., & Linch, S. N. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816475-4.00010-0

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Nejad, R. K. (2021) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-8737

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Weiner, M. W. (2022) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2022.94

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Brandão‐Teles, C., Carregari, V. C., Reis‐de‐Oliveira, G., Smith, B. J., Chaves, Y. C., Santos, A. V. S., Pinheiro, E. M. D. C., Oliveira, C. C., Vieira, A. S., Crunfli, F., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.16304

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Kotter, M., Baer, A. S., & Syed, Y. (2009) · German Medical Science (German Research Foundation) · doi:10.3205/09dgnc349

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Baer, A. S. (2008)

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Pedraza, C. E., Taylor, C. M., Pereira, A., Seng, M., Tham, C., Izrael, M., & Webb, M. (2014) · ASN NEURO · doi:10.1177/1759091414538134 · Cited by 55

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Pedraza, C. E., Taylor, C., Pereira, A., Seng, M., Tham, C.-S., Izrael, M., & Webb, M. (2016)

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Baer, R. S., Syed, Y. A., Kang, S. U., Mitteregger, D., Vig, R., ffrench‐Constant, C., Franklin, R. J. M., Altmann, F., Lübec, G., & Kotter, M. R. (2013)