Franklin, Robin J. M.

Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brain

Hammond, T. R., Dufort, C., Dissing-Olesen, L., Giera, S., Young, A., Wysoker, A., Walker, A. J., Segel, M., Nemesh, J., Saunders, A., et al. (2018) · Immunity

Neuroinflammation and Neurodegeneration MechanismsSingle-cell and spatial transcriptomics

Cited by 2,225

Remyelination in the CNS: from biology to therapy

Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 1,544

Debris clearance by microglia: an essential link between degeneration and regeneration

Neumann, H., Kotter, M. R., & Franklin, R. J. M. (2008) · Brain

Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

Cited by 1,111

Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation

Kotter, M. R., Li, W.-W., Zhao, C., & Franklin, R. J. M. (2006) · The Journal of Neuroscience

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 768

CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination

Zawadzka, M., Rivers, L. E., Fancy, S. P. J., Zhao, C., Tripathi, R., Jamen, F., Young, K., Goncharevich, A., Pohl, H., Rizzi, M., et al. (2010) · Cell stem cell

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 650

Rejuvenation of Regeneration in the Aging Central Nervous System

Ruckh, J. M., Zhao, J.-W., Shadrach, J. L., van Wijngaarden, P., Rao, T. N., Wagers, A. J., & Franklin, R. J. M. (2012) · Cell Stem Cell

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 649

Regenerating CNS myelin — from mechanisms to experimental medicines

Franklin, R. J. M., & ffrench-Constant, C. (2017) · Nature Reviews Neuroscience

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 647

Neuronal vulnerability and multilineage diversity in multiple sclerosis

Schirmer, L., Velmeshev, D., Holmqvist, S., Kaufmann, M., Werneburg, S., Jung, D., Vistnes, S., Stockley, J. H., Young, A., Steindel, M., et al. (2019) · Nature

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 638

The Age-Related Decrease in CNS Remyelination Efficiency Is Attributable to an Impairment of Both Oligodendrocyte Progenitor Recruitment and Differentiation

Sim, F. J., Zhao, C., Penderis, J., & Franklin, R. J. M. (2002) · The Journal of Neuroscience

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 625

Retinoid X receptor gamma signaling accelerates CNS remyelination

Huang, J. K., Jarjour, A. A., Nait Oumesmar, B., Kerninon, C., Williams, A., Krezel, W., Kagechika, H., Bauer, J., Zhao, C., Evercooren, A. B.-V., et al. (2011) · Nature Neuroscience

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 547

Regulatory T cells promote myelin regeneration in the central nervous system

Dombrowski, Y., O'Hagan, T., Dittmer, M., Penalva, R., Mayoral, S. R., Bankhead, P., Fleville, S., Eleftheriadis, G., Zhao, C., Naughton, M., et al. (2017) · Nature Neuroscience

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 533

Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer’s disease risk genes

Schwartzentruber, J., Cooper, S., Liu, J. Z., Barrio-Hernandez, I., Bello, E., Kumasaka, N., Young, A. M. H., Franklin, R. J. M., Johnson, T., Estrada, K., et al. (2021) · Nature Genetics

Alzheimer's disease research and treatmentsGenetic Associations and Epidemiology

Cited by 532

Niche stiffness underlies the ageing of central nervous system progenitor cells

Segel, M., Neumann, B., Hill, M. F. E., Weber, I. P., Viscomi, C., Zhao, C., Young, A., Agley, C. C., Thompson, A. J., Gonzalez, G. A., et al. (2019) · Nature

Neurogenesis and neuroplasticity mechanismsCellular Mechanics and Interactions

Cited by 532

Metformin restores CNS remyelination capacity by rejuvenating aged stem cells

Neumann, B., Baror, R., Zhao, C., Segel, M., Dietmann, S., Rawji, K. S., Foerster, S., McClain, C. R., Chalut, K., van Wijngaarden, P., et al. (2019) · Cell Stem Cell

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 449

Single Cell Sequencing Reveals Glial Specific Responses to Tissue Processing & Enzymatic Dissociation in Mice and Humans

Marsh, S. E., Kamath, T., Walker, A. J., Dissing-Olesen, L., Hammond, T. R., Young, A. M. H., Abdulraouf, A., Nadaf, N., Dufort, C., Murphy, S., et al. (2020) · Nature Neuroscience

Single-cell and spatial transcriptomicsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 430

bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS

Arnett, H. A., Fancy, S. P. J., Alberta, J. A., Zhao, C., Plant, S. R., Kaing, S., Raine, C. S., Rowitch, D. H., Franklin, R. J. M., & Stiles, C. D. (2004) · Science

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 416

Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination

Kotter, M. R., Setzu, A., Sim, F. J., Van Rooijen, N., & Franklin, R. J. M. (2001) · Glia

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 385

Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination

Fancy, S. P. J., Harrington, E. P., Yuen, T. J., Silbereis, J. C., Zhao, C., Baranzini, S. E., Bruce, C. C., Otero, J. J., Huang, E. J., Nusse, R., et al. (2011) · Nature Neuroscience

Neurogenesis and neuroplasticity mechanismsNeonatal and fetal brain pathology

Cited by 349

Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination

Woodruff, R. H., Fruttiger, M., Richardson, W. D., & Franklin, R. J. M. (2004) · Molecular and Cellular Neuroscience

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 335

Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression

Kotter, M. R., Zhao, C., van Rooijen, N., & Franklin, R. J. M. (2005) · Neurobiology of Disease

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 331

Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells

Mi, S., Miller, R. H., Tang, W., Lee, X., Hu, B., Wu, W., Zhang, Y., Shields, C. B., Zhang, Y., Miklasz, S., et al. (2009) · Annals of Neurology

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 300

Remyelination in Experimental Models of Toxin-Induced Demyelination

Blakemore, W. F., & Franklin, R. J. M. (2008) · Current Topics in Microbiology and Immunology

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 275

Ageing and multiple sclerosis

Graves, J. S., Krysko, K. M., Hua, L. H., Absinta, M., Franklin, R. J. M., & Segal, B. M. (2023) · The Lancet Neurology

Multiple Sclerosis Research StudiesPsoriasis: Treatment and Pathogenesis

Cited by 260

Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination

Chong, S. Y. C., Rosenberg, S. S., Fancy, S. P. J., Zhao, C., Shen, Y.-A. A., Hahn, A. T., McGee, A. W., Xu, X., Zheng, B., Zhang, L. I., et al. (2012) · Proceedings of the National Academy of Sciences

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 232