Language production in the non-dominant hemisphere as a potential source of auditory verbal hallucinations
Abstract
Sir, in his comment, Dr Craig (2009a) raises an interesting hypothesis. He poses that an important aspect of auditory verbal hallucinations, namely the experience of the alien or non-self origin, results from an imbalance between the anterior cingulated gyrus and the anterior insula in the right hemisphere. This non-self aspect of auditory verbal hallucinations is an important and characteristic factor inducing patients to attribute the voices they experience to an external source, be it humans, spirits or demons. This attribution to a non-self source increases fear and delusional belief and greatly contributes to psychopathology (García-Montes et al., 2004; Engh et al., 2009). Understanding the neurobiology of the non-self aspect would therefore be helpful in elucidating the pathophysiology of auditory verbal hallucinations and perhaps, as Craig stated, have consequences for future therapy. The lack of activity in the right anterior cingulated cortex during the experience of auditory verbal hallucinations was correctly observed by Craig. In fact, post hoc region of interest (ROI) analysis of this area demonstrated no significant activation, neither in the left nor in the right anterior cingulated gyrus, although there was bilateral activity in the middle cingulated region and the superior frontal gyri during auditory verbal hallucinations. In contrast, the verbal fluency task induced robust activity in the bilateral anterior cingulated area (left more than right) in the same subjects. We agree with Craig that the striking absence of anterior cingulated activity during auditory verbal hallucinations may reflect the lack of conscious control the patients had over these experiences.
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Owing to the role of Broca's area in the inhibitory process, its relationship with simple repetition is considered plausible.
“Owing to the role of Broca's area in the inhibitory process, its relationship with simple repetition is considered plausible [74].”
From The “common” experience of voice-hearing and its relationship with shame and guilt: a systematic review (2022) · cites this paper as [74]
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Self-citation
- Authors
- Sommer, I. E., & Diederen, K. M.
- Corresponding author
- Sommer, I. E.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-03-31
- Volume
- 132
- Issue
- 10
- Pages
- e124-e124
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2129785568
- Cited by
- 30
- References
- 30
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 4 · 2021: 1 · 2018: 2 · 2015: 2 · 2013: 4 · 2012: 2
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Keywords
- auditory verbal hallucinations, non-dominant hemisphere, right hemisphere, anterior cingulate cortex, anterior insula, verbal fluency, conscious control
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