Neural correlates of the misattribution of speech in schizophrenia
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Background: The neurocognitive basis of auditory verbal hallucinations is unclear. Aims: To investigate whether people with a history of such hallucinations would misattribute their own speech as external and show differential activation in brain areas implicated in hallucinations compared with people without such hallucinations. Method: Participants underwent functional magnetic resonance imaging (fMRI) while listening to pre-recorded words. The source (self/non-self) and acoustic quality (undistorted/distorted) were varied across trials. Participants indicated whether the speech they heard was their own or that of another person. Twenty people with schizophrenia (auditory verbal hallucinations n =10, no hallucinations n =10) and healthy controls ( n =11) were tested. Results: The hallucinator group made more external misattributions and showed altered activation in the superior temporal gyrus and anterior cingulate compared with both other groups. Conclusions: The misidentification of self-generated speech in patients with auditory verbal hallucinations is associated with functional abnormalities in the anterior cingulate and left temporal cortex. This may be related to impairment in the explicit evaluation of ambiguous auditory verbal stimuli.
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Auditory hallucinations are related to inner-speech self-monitoring impairments (comparator model).
“in line with the “comparator model” theory, positing that AHs are related to inner-speech self-monitoring impairments.[37][38][39]”
From Are hallucinations due to an imbalance between excitatory and inhibitory influences on the brain? (2016) · cites this paper as [39]
Monitoring of one's own speech, overt or covert, is related to activity in auditory cortical regions such as the lateral temporal lobe, including the superior temporal gyri.
“monitoring of one's own speech, overt or covert, is related to activity in auditory cortical regions such as the lateral temporal lobe, including the superior temporal gyri (STG)”
From Auditory verbal hallucinations as atypical inner speech monitoring, and the potential of neurostimulation as a treatment option (2013) · cites this paper as Allen et al., 2007
Hallucinating patients did not show differential activity in the left superior temporal gyrus between hearing their own or another's voice.
“These findings, however, did not apply to hallucinating patients, who did not show differential activity in this area between hearing their own or another's voice (Allen et al., 2007).”
From Auditory verbal hallucinations as atypical inner speech monitoring, and the potential of neurostimulation as a treatment option (2013) · cites this paper as Allen et al., 2007
In healthy controls and non-hallucinating patients with schizophrenia, the left superior temporal gyrus was generally active when other-produced speech was listened to, whereas this was not the case when self-produced speech was listened to.
“in healthy controls and non-hallucinating patients with schizophrenia, the left superior temporal gyrus was generally active when other-produced speech was listened to, whereas this was not the case when self-produced speech was listened to.”
From Auditory verbal hallucinations as atypical inner speech monitoring, and the potential of neurostimulation as a treatment option (2013) · cites this paper as Allen et al., 2007
Conscious evaluation of stimuli, perhaps involving the anterior cingulate cortex, may underlie external misattributions.
“Allen et al. (2007) suggest that this reflects conscious evaluation of the stimuli, perhaps involving the anterior cingulate cortex (ACC), which has strong connectivity with the temporal cortex (Petrides and Pandya, 1988).”
From Auditory verbal hallucinations as atypical inner speech monitoring, and the potential of neurostimulation as a treatment option (2013) · cites this paper as Allen et al., 2007
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- Authors
- Allen, P., Amaro, E., Fu, C. H. Y., Williams, S. C. R., Brammer, M. J., Johns, L. C., & McGuire, P. K.
- Affiliations
- King's College London (GB)
- Corresponding author
- Allen, Paul
- ORCID
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2007-02
- Volume
- 190
- Issue
- 2
- Pages
- 162-169
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2103549467
- Cited by
- 147
- References
- 45
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 7 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 7 · 2018: 8 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 6 · 2013: 9 · 2012: 11
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- auditory verbal hallucinations, schizophrenia, superior temporal gyrus, anterior cingulate cortex, source monitoring, auditory perception, neural correlates
- MeSH terms
- Adult, Auditory Perception, Hallucinations, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Schizophrenic Psychology, Speech, Case-Control Studies
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