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Cited by 62Hemispheric Asymmetry in NeuroscienceSchizophrenia research and treatmentHallucinations in medical conditions

Decreased language lateralization is characteristic of psychosis, not auditory hallucinations

Diederen, Kelly M. J., De Weijer, Antoin D., Daalman, Kirstin, Blom, Jan Dirk, Neggers, Sebastiaan F. W., Kahn, René S., Sommer, Iris E. C.·2010·Brain
DOI 10.1093/brain/awq313
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Abstract

Decreased language lateralization is a well-replicated finding in psychotic patients. It is currently unclear, however, whether this abnormality is related to a particular symptom of psychosis or to psychosis in general. It has been argued that decreased language lateralization may be related to auditory verbal hallucinations. To elucidate this, these hallucinations should be studied in isolation. Thirty-five patients with a psychotic disorder, 35 non-psychotic subjects with relatively isolated auditory verbal hallucinations and 35 healthy control subjects participated in this study. All subjects were scanned on a 3T magnetic resonance imaging scanner, while covertly performing a paced verbal fluency task. In order to measure performance on the task, one additional task block was presented during which subjects had to generate words overtly. In addition to calculating language lateralization indices, group-wise brain activation during verbal fluency was compared between the three groups. Task performance was nearly maximal for all groups and did not differ significantly between the groups. Compared with the healthy control subjects and non-psychotic subjects with auditory verbal hallucinations, language lateralization was significantly reduced for the patient group. In addition, the patients displayed significantly greater activity in the right precentral gyrus and left insula when compared with the healthy control subjects and the non-psychotic subjects with auditory verbal hallucinations. Furthermore, the patients showed greater activity in the right superior parietal lobule when compared with the healthy control subjects. Lateralization indices did not differ significantly between the non-psychotic subjects with auditory verbal hallucinations and the healthy control subjects. Moreover, there were no significant differences in brain activation during verbal fluency between the two non-psychotic groups. As language lateralization was not significantly reduced in the non-psychotic individuals with auditory verbal hallucinations, a direct relationship between auditory verbal hallucinations and decreased language lateralization can not be established at present.

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  • AVHs in nonpatients are associated with more typical neural organization of language processes than in clinical groups.

    “Areas of active research interest include understanding the relation between clinical and nonclinical AVHs (Johns et al., 2014), including findings that AVHs in nonpatients are associated with more typical neural organization of language processes than in clinical groups (Diederen, De Weijer, et al., 2010).”

    From Inner Speech: Development, Cognitive Functions, Phenomenology, and Neurobiology (2015) · cites this paper as Diederen, De Weijer, et al., 2010

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Research works printed but not linked: 51

  1. Andreasen NC, Flaum M, Arndt S. The Comprehensive Assessment of Symptoms and History (Cash) -An Instrument for Assessing Diagnosis and Psychopathology. Arch Gen Psychiatry 1992; 49: 615-23.
  2. Angrilli A, Spironelli C, Elbert T, Crow TJ, Marano G, Stegagno L. Schizophrenia as Failure of Left Hemispheric Dominance for the Phonological Component of Language. PLoS One 2009; 4: e4507.
  3. Artiges E, Martinot JL, Verdys M, ttar-Levy D, Mazoyer B, Tzourio N, et al. Altered Hemispheric Functional Dominance During Word Generation in Negative Schizophrenia. Schizophr Bull 2000; 26: 709-21.
  4. Bhojraj TS, Francis AN, Rajarethinam R, Eack S, Kulkarni S, Prasad KM, et al. Verbal fluency deficits and altered lateralization of language brain areas in individuals genetically predisposed to schizophrenia. Schizophr Res 2009; 115: 202-08.
  5. Boksman K, Thyberge J, Williamson P, Drost DJ, Malla A, Densmore M, et al. A 4.0-T fMRI study of brain connectivity during word fluency in first-episode schizophrenia. Schizophr Res 2005; 75: 247-63.
  6. Bruder G, Rabinowicz E, Towey J, Brown A, Kaufmann CA, Amador X, et al. Smaller right ear (left hemisphere) advantage for dichotic fused words in patients with schizophrenia. Am J Psychiatry 1995; 152: 932-35.
  7. Corbetta M, Akbudak E, Conturo TE, Snyder AZ, Ollinger JM, Drury HA, et al. A common network of functional areas for attention and eye movements. Neuron 1998; 21: 761-73.
  8. Costafreda SG, Fu CHY, Picchioni M, Kane F, McDonald C, Prata DP, et al. Increased Inferior Frontal Activation During Word Generation: a Marker of Genetic Risk for Schizophrenia but not Bipolar Disorder? Hum Brain Mapp 2009; 30: 3287.
  9. Crow TJ. Invited commentary on: Functional anatomy of verbal fluency in people with schizophrenia and those at genetic risk: the genetics of asymmetry and psychosis. Br J Psychiatry 2000; 176: 61-3.
  10. Culham JC, Kanwisher NG. Neuroimaging of cognitive functions in human parietal cortex. Curr Opin Neurobiol 2001; 11: 157-63.
  11. Curtis VA, Bullmore ET, Brammer MJ, Wright IC, Williams SCR, Morris RG, et al. Attenuated Frontal Activation During a Verbal Fluency Task in Patients With Schizophrenia. Am J Psychiatry 1998; 155: 1056-63.
  12. Daalman K, Boks MP, Diederen KM, de Weijer AD, Bloma JD, Kahn RS, et al. Same Or Different? Auditory Verbal Hallucinations in Healthy and Psychotic Individuals. Psychological Med; in press.
  13. Diederen KMJ, Neggers SFW, Daalman K, Blom JD, Goekoop R, Kahn RS, et al. Deactivation of the parahippocampal gyrus preceding auditory hallucinations in schizophrenia. Am J Psychiatry 2010; 167: 427-35.
  14. Dierks T, Linden DEJ, Jandl M, Formisano E, Goebel R, Lanfermann H, et al. Activation of Heschl's Gyrus during auditory hallucinations. Neuron 1999; 22: 615-21.
  15. Dollfus S, Razafimandimby A, Delamillieure P, Brazo P, Joliot M, Mazoyer B, et al. Atypical hemispheric specialization for language in right-handed schizophrenia patients. Biol Psychiatry 2005; 57: 1020-8.
  16. Endicott J, Spitzer RL, Fleiss JL, Cohen J. Global Assessment Scale - Procedure for Measuring Overall Severity of Psychiatric Disturbance. Arch Gen Psychiatry 1976; 33: 766-71.
  17. First MB, Spitzer RL, Gibbon M, Williams JBW. The Structured Clinical Interview for Dsm-Iii-R Personality-Disorders (Scid-Ii). 1. Description. J Pers Disord 1995; 9: 83-91.
  18. Frith CD, Friston KJ, Herold S, Silbersweig D, Fletcher P, Cahill C, et al. Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task. Br J Psychiatry 1995; 167: 343-9.
  19. Fu CHY, Suckling J, Williams SCR, Andrew CM, Vythelingum GN, McGuire PK. Effects of Psychotic State and Task Demand on Prefrontal Function in Schizophrenia: An fMRI Study of Overt Verbal Fluency. Am J Psychiatry 2005; 162: 485-94.
  20. Haddock G, McCarron J, Tarrier N, Faragher EB. Scales to measure di- mensions of hallucinations and delusions: the psychotic symptom rating scales (PSYRATS). Psychol Med 1999; 29: 879-89.
  21. Hoffman RE, Hampson M, Wu K, Anderson AW, Gore JC, Buchanan RJ, et al. Probing the pathophysiology of auditory/verbal hallucinations by combining functional magnetic resonance Imaging and Transcranial magnetic stimulation. Cereb Cortex 2007; 17: 2733-43.
  22. Jansen A, Menke R, Sommer J, FUrster AF, Bruchmann S, Hempleman J, et al. The assessment of hemispheric lateralization in functional MRI- Robustness and reproducibility. NeuroImage 2006; 33: 204-17.
  23. Johns LC, Nazroo JY, Bebbington P, Kuipers E. Occurrence of hallucina- tory experiences in a community sample and ethnic variations. British Journal of Psychiatry 2002; 180: 174-8.
  24. Jones HM, Brammer MJ, O'Toole M, Taylor T, Ohlsen RI, Brown RG, et al. Cortical effects of quetiapine in first-episode schizophrenia: A preliminary functional magnetic resonance imaging study. Biol Psychiatry 2004; 56: 938-42.
  25. Kay SR, Fiszbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia. Schizophr Bull 1987; 13: 261-76.
  26. Kircher T, Liddle P, Brammer M, Williams S, Murray R, McGuire P. Reversed lateralization of temporal activation during speech produc- tion in thought disordered patients with schizophrenia. Psychol Med 2002; 32: 439-49.
  27. Larøi F, Marczewski P, Van der Linden M. Further evidence of the multi-dimensionality of hallucinatory predisposition: factor structure of a modified version of the Launay-Slade Hallucinations Scale in a normal sample. Eur Psychiatry 2004; 19: 15-20.
  28. Levitan C, Ward PB, Catts SV. Superior temporal gyral volumes and laterality correlates of auditory hallucinations in schizophrenia. Biol Psychiatry 1999; 46: 955-62.
  29. Li X, Branch CA, DeLisi LE. Language pathway abnormalities in schizo- phrenia: a review of fMRI and other imaging studies. Curr Opin Psychiatry 2009; 22: 131-9.
  30. Loberg EM, Hugdahl K, Green MF. Hemispheric asymmetry in schizo- phrenia: a ''dual deficits'' model. Biol Psychiatry 1999; 45: 76-81.
  31. McGuire PK, Shah GMS, Murray RM. Increased blood-flow in Broca Area during auditory hallucinations in schizophrenia. Lancet 1993; 342: 703-6.
  32. Neggers SFW, Hermans EJ, Ramsey NF. Enhanced sensitivity with fast three-dimensional blood-oxygen-level-dependent functional MRI: comparison of SENSE-PRESTO and 2D-EPI at 3T. NMR in Biomed 2008; 21: 663-76.
  33. Razafimandimby A, Maı ¨za O, Herve ´PY, Lecardeur L, Delamillieure P, Brazo P, et al. Stability of functional language lateralization over time in schizophrenia patients. Schizophr Res 2007; 94: 197-206.
  34. Schaufelberger M, Senhorini MCT, Barreiros MA, Amaro E Jr, Menezes PR, Scazufca M, et al. Frontal and anterior cingulate activa- tion during overt verbal fluency in patients with first episode psychosis. Rev Bras Psiquiatr 2005; 27: 228-32.
  35. Shergill SS, Brammer MJ, Williams SCR, Murray RM, McGuire PK. Mapping auditory hallucinations in schizophrenia using func- tional magnetic resonance imaging. Arch Gen Psychiatry 2000; 57: 1033-8.
  36. Sommer IE, Slotema K, De Weijer A, Aleman A, Kahn S. Fmri-guided tms treatment for medication resistant hallucinations. Schizophr Bull 2007b; 33: 461.
  37. Sommer IEC, Ramsey NF, Kahn RS. Language lateralization in schizo- phrenia, an fMRI study. Schizophr Res 2001a; 52: 57-67.
  38. Sommer IEC, Ramsey NF, Mandl RCW, Kahn RS. Language lateralization in female patients with schizophrenia: an fMRI study. Schizophr Res 2003; 60: 183-90.
  39. Sommer IEC, vd Veer AJ, Wijkstra J, Boks MPM, Kahn RS. Comparing language lateralization in psychotic mania and psychotic depression to schizophrenia; A functional MRI study. Schizophr Res 2007a; 89: 364-5.
  40. Sommer I, Ramsey N, Kahn R, Aleman A, Bouma A. Handedness, lan- guage lateralisation and anatomical asymmetry in schizophrenia: meta-analysis. Br J Psychiatry 2001b; 178: 344-51.
  41. Sommer IEC, Ramsey NF, Mandl RCW, Van Oel CJ, Kahn RS. Language activation in monozygotic twins discordant for schizophrenia. Br J Psychiatry 2004; 184: 128-35.
  42. Spence SA, Grasby PM, Liddle PF, Stefan MD, Sharma TONM, Murray RM, et al. Functional anatomy of verbal fluency in people with schizophrenia and those at genetic risk: focal dysfunction and distributed disconnectivity reappraised. Br J Psychiatry 2000; 176: 52-60.
  43. Spironelli C, Angrilli A, Stegagno L. Failure of language lateralization in schizophrenia patients: an ERP study on early linguistic components. J Psychiatry Neurosci 2008; 33: 235-43.
  44. Tien AY. Distributions of hallucinations in the population. Soc Psychiatry Psychiatric Epidemiol 1991; 26: 287-92.
  45. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, et al. Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain. NeuroImage 2002; 15: 273-89.
  46. Van de Ven VG, Formisano E, Roder CH, Prvulovic D, Bittner RA, Dietz MG, et al. The spatiotemporal pattern of auditory cortical responses during verbal hallucinations. NeuroImage 2005; 27: 644-55.
  47. Vigneau M, Beaucousin V, Herve ´PY, Duffau H, Crivello F, Houde ´O, et al. Meta-analyzing left hemisphere language areas: Phonology, semantics, and sentence processing. NeuroImage 2006; 30: 1414-32.
  48. Weiss EM, Hofer A, Golaszewski S, Siedentopf C, Brinkhoff C, Kremser C, et al. Brain activation patterns during a verbal fluency test-a functional MRI study in healthy volunteers and patients with schizophrenia. Schizophr Res 2004; 70: 287-91.
  49. Weiss EM, Hofer A, Golaszewski S, Siedentopf C, Felber S, Fleischhacker WW. Language lateralization in unmedicated patients during an acute episode of schizophrenia: A functional MRI study. Psychiatry Res 2006; 146: 185-90.
  50. Worsley KJ, Friston KJ. Analysis of fMRI Time-Series Revisited-Again. NeuroImage 1995; 2: 173-81.
  51. Yurgelun-Todd DA, Waternaux CM, Cohen BM, Gruber SA, English CD, Renshaw PF. Functional magnetic resonance imaging of schizophrenic patients and comparison subjects during word production. Am J Psychiatry 1996; 153: 200-5.

Cited by

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Authors
Diederen, K. M. J., De Weijer, A. D., Daalman, K., Blom, J. D., Neggers, S. F. W., Kahn, R. S., & Sommer, I. E. C.
Affiliations
  • University Medical Center Utrecht (NL)
  • University of Groningen (NL)
ORCID
Venue
Brain
Publisher
Oxford University Press (OUP)
Published
2010-11-19
Volume
133
Issue
12
Pages
3734-3744
ISSN
  • 0006-8950 (ISSN-L)
  • 1460-2156
DOI
10.1093/brain/awq313
OpenAlex
W2118235952
Cited by
62
References
5
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 2 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 9 · 2015: 7 · 2014: 5 · 2013: 8 · 2012: 9
FWCI
4.27
Type
journal article
Language
en
Open access
closed
Locations
  • Brain (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
Keywords
language lateralization, psychosis, auditory verbal hallucinations, verbal fluency, brain activation, left insula, superior parietal lobule
MeSH terms
Adult, Female, Hallucinations, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Psychiatric Status Rating Scales, Psychomotor Performance, Psychotic Disorders, Verbal Behavior, Diagnostic and Statistical Manual of Mental Disorders

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