Network analysis of auditory hallucinations in nonpsychotic individuals
Open accessAbstract
Background: Auditory verbal hallucinations (AVH) are a cardinal feature of schizophrenia and can severely disrupt behavior and decrease quality of life. Identification of areas with high functional connectivity (so‐called hub regions) that are associated with the predisposition to hallucinate may provide potential targets for neuromodulation in the treatment of AVH. Methods: Resting‐state fMRI scans during which no hallucinations had occurred were acquired from 29 nonpsychotic individuals with AVH and 29 matched controls. These nonpsychotic individuals with AVH provide the opportunity to study AVH without several confounds associated with schizophrenia, such as antipsychotic medication use and other symptoms related to the illness. Hub regions were identified by assessing weighted connectivity strength and betweenness centrality across groups using a permutation analysis. Results: Nonpsychotic individuals with AVH exhibited increased functioning as hub regions in the temporal cortices and the posterior cingulate/precuneus, which is an important area in the default mode network (DMN), compared to the nonhallucinating controls. In addition, the right inferior temporal gyrus, left paracentral lobule and right amygdala were less important as a hub region in the AVH group. Conclusions: These results suggest that the predisposition to hallucinate may be related to aberrant functioning of the DMN and the auditory cortices. Hum Brain Mapp 35:1436–1445, 2014. © 2013 Wiley Periodicals, Inc.
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In resting-state networks, the role of the amygdala tends to decrease, and its connectivity with the left temporoparietal region is reduced, which is generally overactive during AVHs.
“Moreover, Van Lutterveld and colleagues found that, in resting-state networks, the role of the amygdala tends to decrease, and Vercammen found its reduced connectivity with the left temporoparietal region, which is recognised to be generally overactive during AVHs [76, 77].”
From The “common” experience of voice-hearing and its relationship with shame and guilt: a systematic review (2022) · cites this paper as [76]
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“Moreover, Van Lutterveld and colleagues found that, in resting-state networks, the role of the amygdala tends to decrease, and Vercammen found its reduced connectivity with the left temporoparietal region, which is recognised to be generally overactive during AVHs [76, 77].”
Background
- Authors
- van Lutterveld, R., Diederen, K. M. J., Otte, W. M., & Sommer, I. E.
- Affiliations
- Department of Psychiatry, University Medical Center, Utrecht, the Netherlands and Rudolf Magnus Institute of Neuroscience, Utrecht, the Netherlands
- University Medical Center Utrecht (NL)
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2013-02-21
- Volume
- 35
- Issue
- 4
- Pages
- 1436-1445
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6869060
- OpenAlex
- W1906405192
- Cited by
- 68
- References
- 70
- Citations by year
- 2026: 1 · 2024: 5 · 2023: 1 · 2022: 6 · 2021: 7 · 2020: 11 · 2019: 7 · 2018: 5 · 2017: 6 · 2016: 2 · 2015: 7 · 2014: 7 · 2013: 3
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- auditory verbal hallucinations, hub regions, functional connectivity, default mode network, posterior cingulate cortex, precuneus, temporal cortex, inferior temporal gyrus, paracentral lobule, amygdala, resting-state fMRI, neuromodulation, schizophrenia risk
- MeSH terms
- Adult, Brain, Brain Mapping, Female, Hallucinations, Head, Humans, Magnetic Resonance Imaging, Male, Movement, Rest, Signal Processing, Computer-Assisted, Speech Perception, Artifacts
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