Brain endothelial dysfunction in cerebral adrenoleukodystrophy

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280 · see citing works

Development, maintenance and disruption of the blood-brain barrier

Obermeier, B., Daneman, R., & Ransohoff, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3407 · Cited by 2,452 · see citing works

Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration

Rafii, S., & Lyden, D. C. (2003) · Nature Medicine · doi:10.1038/nm0603-702 · Cited by 1,572 · see citing works

Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters

Mosser, J., Douar, A.-M., Sarde, C.-O., Kioschis, P., Feil, R., Moser, H., Poustka, A.-M., Mandel, J.-L., & Aubourg, P. (1993) · Nature · doi:10.1038/361726a0 · Cited by 1,202 · see citing works

Inflammatory cortical demyelination in early multiple sclerosis.

Lucchinetti, C. F., Popescu, B. F. G., Bunyan, R. F., Moll, N. M., Roemer, S. F., Lassmann, H., Brück, W., Parisi, J. E., Scheithauer, B. W., Giannini, C., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1100648 · Cited by 1,103 · see citing works

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

Ajami, B., Bennett, J. L., Krieger, C., McNagny, K. M., & Rossi, F. M. V. (2011) · Nature Neuroscience · doi:10.1038/nn.2887 · Cited by 1,061 · see citing works

Autoimmune T cell responses in the central nervous system

Goverman, J. M. (2009) · Nature reviews. Immunology · doi:10.1038/nri2550 · Cited by 1,025 · see citing works

Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients

Sørensen, T. L., Tani, M., Jensen, J. S., Pierce, V., Lucchinetti, C. F., Folcik, V. A., Qin, S., Rottman, J., Sellebjerg, F. T., Strieter, R. M., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5150 · Cited by 994 · see citing works

Endothelial cell diversity revealed by global expression profiling

Chi, J., Chang, H. Y., Haraldsen, G., Jahnsen, F. L., Troyanskaya, O. G., Chang, D. S., Wang, Z., Rockson, S. G., van de Rijn, M., Botstein, D., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1434429100 · Cited by 773 · see citing works

A cell culture model of the blood-brain barrier.

Rubin, L. L., Hall, D. E., Porter, S., Barbu, K., Cannon, C., Horner, H. C., Janatpour, M. J., Liaw, C. W., Manning, K., & Morales, J. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.115.6.1725 · Cited by 765 · see citing works

Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies.

Eberhard, A., Kahlert, S., Goede, V., Hemmerlein, B., Plate, K. H., & Augustin, H. G. (2000) · PubMed · Cited by 746 · see citing works

Blood-brain barrier disruption in multiple sclerosis

Minagar, A., & Alexander, J. S. (2003) · Multiple Sclerosis · doi:10.1191/1352458503ms965oa · Cited by 685 · see citing works

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

Prinz, M., Priller, J., Sisodia, S. S., & Ransohoff, R. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2923 · Cited by 674 · see citing works

Trafficking of immune cells in the central nervous system

Wilson, E. H., Weninger, W., & Hunter, C. A. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41911 · Cited by 521 · see citing works

c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progressionPreprint

Baudino, T. A., McKay, C., Pendeville, H., Nilsson, J. A., Maclean, K. H., White, E. L., Davis, A. C., Ihle, J. N., & Cleveland, J. L. (2002) · Genes & Development · doi:10.1101/gad.1024602 · Cited by 516 · see citing works

siRNA and Innate Immunity

Robbins, M., Judge, A. D., & MacLachlan, I. (2009) · Oligonucleotides · doi:10.1089/oli.2009.0180 · Cited by 453 · see citing works

The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein superfamily.

Kamijo, K., Taketani, S., Yokota, S., Osumi, T., & Hashimoto, T. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39595-x · Cited by 391 · see citing works

Function of the c-Myc Oncogenic Transcription Factor

Dang, C. V., Resar, L. M. S., Emison, E. S., Kim, S., Li, Q., Prescott, J. E., Wonsey, D. R., & Zeller, K. I. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4686 · Cited by 377 · see citing works

Neurovascular signalling defects in neurodegeneration

Zacchigna, S., Lambrechts, D., & Carmeliet, P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2336 · Cited by 345 · see citing works

Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis

Rosenberg, G. A., Dencoff, J. E., Correa, N., Reiners, M., & Ford, C. C. (1996) · Neurology · doi:10.1212/wnl.46.6.1626 · Cited by 278 · see citing works

Abnormal Endothelial Tight Junctions in Active Lesions and Normal‐appearing White Matter in Multiple Sclerosis

Plumb, J., McQuaid, S., Mirakhur, M., & Kirk, J. (2002) · Brain Pathology · doi:10.1111/j.1750-3639.2002.tb00430.x · Cited by 274 · see citing works

Analysis of MRI patterns aids prediction of progression in X-linked adrenoleukodystrophy

Loes, D. J., Fatemi, A., Melhem, E. R., Gupte, N., Bezman, L., Moser, H. W., & Raymond, G. V. (2003) · Neurology · doi:10.1212/01.wnl.0000079050.91337.83 · Cited by 268 · see citing works

Cytokines, nitric oxide, and cGMP modulate the permeability of an in vitro model of the human blood–brain barrier

Wong, D. K., Dorovini‐Zis, K., & Vincent, S. R. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.08.008 · Cited by 264 · see citing works

Microvascular abnormality in relapsing-remitting multiple sclerosis: perfusion MR imaging findings in normal-appearing white matter

Law, M., Saindane, A. M., Ge, Y., Babb, J. S., Johnson, G., Mannon, L. J., Herbert, J., & Grossman, R. I. (2004) · Radiology · doi:10.1148/radiol.2313030996 · Cited by 242 · cited 2× · see citing works

CCR1+/CCR5+ mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis

Trebst, C., Lykke Sørensen, T., Kivisäkk, P., Cathcart, M. K., Hesselgesser, J., Horuk, R., Sellebjerg, F., Lassmann, H., & Ransohoff, R. M. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63017-9 · Cited by 242 · see citing works

Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells

Varvel, N. H., Grathwohl, S. A., Baumann, F., Liebig, C., Bosch, A., Brawek, B., Thal, D. R., Charo, I. F., Heppner, F. L., Aguzzi, A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210150109 · Cited by 240 · see citing works

Pathophysiology of X-linked adrenoleukodystrophy

Berger, J., Forss-Petter, S., & Eichler, F. S. (2014) · Biochimie · doi:10.1016/j.biochi.2013.11.023 · Cited by 238 · see citing works

Homing to central nervous system vasculature by antigen-specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination.

Raine, C. S., Cannella, B., Duijvestijn, A. M., & Cross, A. H. (1990) · PubMed · Cited by 229 · see citing works

Blood–Brain Barrier Disruption in Humans Is Independently Associated With Increased Matrix Metalloproteinase-9

Barr, T. L., Latour, L. L., Lee, K., Schaewe, T. J., Luby, M. L., Chang, G. S., El-Zammar, Z., Alam, S., Hallenbeck, J. M., Kidwell, C. S., et al. (2009) · Stroke · doi:10.1161/strokeaha.109.570515 · Cited by 226 · see citing works

Changes in cerebral perfusion precede plaque formation in multiple sclerosis: a longitudinal perfusion MRI study

Wuerfel, J. T. (2003) · Brain · doi:10.1093/brain/awh007 · Cited by 225 · see citing works

A close relative of the adrenoleukodystrophy (ALD) gene codes for a peroxisomal protein with a specific expression pattern.

Lombard-Platet, G., Savary, S., Sarde, C. O., Mandel, J. L., & Chimini, G. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1265 · Cited by 222 · see citing works

Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy

Fourcade, S., Lopez-Erauskin, J., Galino, J., Duval, C., Naudi, A., Jove, M., Kemp, S., Villarroya, F., Ferrer, I., Pamplona, R., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn085 · Cited by 214 · see citing works

X-Linked adrenoleukodystrophy: overview and prognosis as a function of age and brain magnetic resonance imaging abnormality. A study involving 372 patients

Moser, H. W., Loes, D. J., Melhem, E. R., Raymond, G. V., Bezman, L., Cox, C. S., & Lu, S.-E. (2000) · Neuropediatrics · doi:10.1055/s-2000-9236 · Cited by 210 · see citing works

Brain conditioning is instrumental for successful microglia reconstitution following hematopoietic stem cell transplantation

Capotondo, A., Milazzo, R., Politi, L. S., Quattrini, A., Palini, A. G., Plati, T., Merella, S., Nonis, A., Serio, C. D., Montini, E., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205858109 · Cited by 207 · see citing works

X-linked adrenoleukodystrophy: Clinical, biochemical and pathogenetic aspects

Berger, J., & Gärtner, J. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.07.010 · Cited by 199 · see citing works

Dexamethasone regulation of matrix metalloproteinase expression in CNS vascular endothelium

Harkness, K. A. (2000) · Brain · doi:10.1093/brain/123.4.698 · Cited by 195 · see citing works

Antigen presentation in the peripheral nervous system: Schwann cells present endogenous myelin autoantigens to lymphocytes

Wekerle, H., Schwab, M. E., Linington, C., & Meyermann, R. (1986) · European Journal of Immunology · doi:10.1002/eji.1830161214 · Cited by 184 · see citing works

Newborn screening for X-linked adrenoleukodystrophy (X-ALD): Validation of a combined liquid chromatography–tandem mass spectrometric (LC–MS/MS) method

Hubbard, W. C., Moser, A. B., Liu, A. C., Jones, R. O., Steinberg, S. J., Lorey, F., Panny, S. R., Vogt Jr., R. F., Macaya, D., & Turgeon, C. T. (2009) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2009.03.010 · Cited by 177 · see citing works

Adrenoleukodystrophy-Related Protein Can Compensate Functionally for Adrenoleukodystrophy Protein Deficiency (X-ALD): Implications for Therapy

Netik, A., Forss-Petter, S., Holzinger, A., Molzer, B., Unterrainer, G., & Berger, J. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.5.907 · Cited by 148 · see citing works

Transforming Growth Factor-β Signaling Alters Substrate Permeability and Tight Junction Protein Expression at the Blood-Brain Barrier during Inflammatory Pain

Ronaldson, P. T., DeMarco, K. M., Sanchez‐Covarrubias, L., Solinsky, C. M., & Davis, T. P. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.32 · Cited by 144 · see citing works

Down-regulation of LFA-1 Adhesion Receptors by C- myc Oncogene in Human B Lymphoblastoid Cells

Inghirami, G., Grignani, F., Sternas, L. A., Lombardi, L., Knowles, D. M., & Dalla‐Favera, R. (1990) · Science · doi:10.1126/science.2237417 · Cited by 135 · see citing works

Changes of serum sICAM-1 and MMP-9 induced by rIFNβ-1b treatment in relapsing-remitting MS

Trojano, M., Avolio, C., Liuzzi, G. M., Ruggieri, M., Defazio, G., Liguori, M., Santacroce, M. P., Paolicelli, D., Giuliani, F., Riccio, P., et al. (1999) · Neurology · doi:10.1212/wnl.53.7.1402 · Cited by 125 · see citing works

Basic Fibroblast Growth Factor–Induced Angiogenic Phenotype in Mouse Endothelium

Bastaki, M., Nelli, E., Dell’Era, P., Rusnati, M., Molinari-Tosatti, M. P., Parolini, S., Auerbach, R., Ruco, L., Possati, L., & Presta, M. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.3.454 · Cited by 122 · see citing works

X-linked adrenoleukodystrophy: the role of contrast-enhanced MR imaging in predicting disease progression.

(2000) · PubMed Central · Cited by 114 · see citing works

Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: A paradigm for multifactorial neurodegenerative diseases?

Galea, E., Launay, N., Portero-Otin, M., Ruiz, M., Pamplona, R., Aubourg, P., Ferrer, I., & Pujol, A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.02.005 · Cited by 108 · see citing works

Immunobiology of the blood-brain barrier

Miller, D. W. (1999) · Journal of NeuroVirology · doi:10.3109/13550289909021286 · Cited by 105 · see citing works

Human Brain Microvascular Endothelial Cells and Umbilical Vein Endothelial Cells Differentially Facilitate Leukocyte Recruitment and Utilize Chemokines for T Cell Migration

Man, S., Ubogu, E. E., Williams, K. A., Tucky, B. H., Callahan, M. K., & Ransohoff, R. M. (2008) · Clinical and Developmental Immunology · doi:10.1155/2008/384982 · Cited by 100 · see citing works

Advanced glycation end-products induce basement membrane hypertrophy in endoneurial microvessels and disrupt the blood–nerve barrier by stimulating the release of TGF-β and vascular endothelial growth factor (VEGF) by pericytes

Shimizu, F., Sano, Y., Haruki, H., & Kanda, T. (2011) · Diabetologia · doi:10.1007/s00125-011-2107-7 · Cited by 100 · see citing works

Phospholipids in X-linked adrenoleukodystrophy white matter: Fatty acid abnormalities before the onset of demyelination

Theda, C., Moser, A. B., Powers, J. M., & Moser, H. W. (1992) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(92)90028-j · Cited by 99 · see citing works

cDNA cloning and mRNA expression of the human adrenoleukodystrophy related protein (ALDRP), a peroxisomal ABC transporter

Holzinger, A., Kammerer, S., Berger, J., & Roscher, A. A. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7391 · Cited by 92 · see citing works

Current and Future Pharmacological Treatment Strategies in X‐Linked Adrenoleukodystrophy

Berger, J., Pujol, A., Aubourg, P. R., & Forss‐Petter, S. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2010.00393.x · Cited by 90 · see citing works

Head trauma can initiate the onset of adreno-leukodystrophy

Raymond, G. V., Seidman, R., Monteith, T. S., Kolodny, E., Sathe, S., Mahmood, A., & Powers, J. M. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.11.005 · Cited by 90 · see citing works

Progress in X-linked adrenoleukodystrophy

Moser, H. W., Dubey, P., & Fatemi, A. S. (2004) · Current Opinion in Neurology · doi:10.1097/00019052-200406000-00005 · Cited by 78 · see citing works

Expression of MMP-2, MMP-7, MMP-9, MMP-10 and MMP-11 in human astrocytic and oligodendroglial gliomas.

Thorns, V., Walter, G. F., & Thorns, C. (2003) · PubMed · Cited by 76 · see citing works

X-linked adrenoleukodystrophy: very long-chain fatty acid metabolism is severely impaired in monocytes but not in lymphocytes

Weber, F. D., Wiesinger, C., Forss-Petter, S., Regelsberger, G., Einwich, A., Weber, W. H. A., Kohler, W., Stockinger, H., & Berger, J. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddt645 · Cited by 63 · see citing works

Magnetic Resonance Imaging Detection of Lesion Progression in Adult Patients With X-linked Adrenoleukodystrophy

Eichler, F., Mahmood, A., Loes, D. J., Bezman, L., Lin, D., Moser, H. W., & Raymond, G. V. (2007) · Archives of Neurology · doi:10.1001/archneur.64.5.659 · Cited by 60 · see citing works

IL-1β and TGF-β weaken the placental barrier through destruction of tight junctions: An in vivo and in vitro study

Tossetta, G., Paolinelli, F., Avellini, C., Salvolini, E., Ciarmela, P., Lorenzi, T., Emanuelli, M., Toti, P., Giuliante, R., Gesuita, R., et al. (2014) · Placenta · doi:10.1016/j.placenta.2014.03.016 · Cited by 57 · see citing works

Correlating Quantitative MR Imaging with Histopathology in X-Linked Adrenoleukodystrophy

van der Voorn, J. P., Pouwels, P. J. W., Powers, J. M., Kamphorst, W., Martin, J. J., Troost, D., Spreeuwenberg, M. D., Barkhof, F., & van der Knaap, M. S. (2011) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2327 · Cited by 51 · see citing works

Serum and cerebrospinal fluid levels of soluble adhesion molecules in multiple sclerosis: predominant intrathecal release of vascular cell adhesion molecule-1

Droogan, A. G., McMillan, S. A., DOUGLAS, J., & Hawkins, S. A. (1996) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00174-3 · Cited by 50 · see citing works

Hypoperfusion predicts lesion progression in cerebral X-linked adrenoleukodystrophy

Musolino, P. L., Rapalino, O., Caruso, P., Caviness, V. S., & Eichler, F. S. (2012) · Brain · doi:10.1093/brain/aws206 · Cited by 37 · see citing works

Cerebrospinal Fluid Matrix Metalloproteinases Are Elevated in Cerebral Adrenoleukodystrophy and Correlate with MRI Severity and Neurologic Dysfunction

Thibert, K. A., Raymond, G. V., Nascene, D. R., Miller, W. P., Tolar, J., Orchard, P. J., & Lund, T. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050430 · Cited by 34 · see citing works

Abcd2 Is a Strong Modifier of the Metabolic Impairments in Peritoneal Macrophages of Abcd1-Deficient Mice

Muneer, Z., Wiesinger, C., Voigtländer, T., Werner, H. B., Berger, J., & Forss-Petter, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108655 · Cited by 33 · cited 3× · see citing works

Very‐late‐onset adrenoleukodystrophy: Possible precipitation of demyelination by cerebral contusion

Weller, M., Liedtke, W., Petersen, D., Opitz, H., & Poremba, M. (1992) · Neurology · doi:10.1212/wnl.42.2.367 · Cited by 33 · see citing works

X‐linked adrenoleukodystrophy mice demonstrate abnormalities in cholesterol metabolism

Weinhofer, I., Forss‐Petter, S., Kunze, M., Žigman, M., & Berger, J. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.09.014 · Cited by 32 · see citing works

Therapeutic effects of normal cells on ABCD1 deficient cells in vitro and hematopoietic cell transplantation in the X-ALD mouse model

Yamada, T., Ohyagi, Y., Shinnoh, N., Kikuchi, H., Osoegawa, M., Ochi, H., Kira, J., & Furuya, H. (2003) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2003.11.006 · Cited by 24 · see citing works

Antigen processing of myelin basic protein is required prior to recognition by T cells inducing EAE

Cross, A. H., Dolich, S., & Raine, C. S. (1990) · Cellular Immunology · doi:10.1016/0008-8749(90)90183-r · Cited by 18 · see citing works

An adult case of adrenoleukodystrophy with features of olivo-ponto-cerebellar atrophy: II. Lipid biochemical studies.

Taketomi, T., Hara, A., Kitazawa, N., Takada, K., & Nakamura, H. M. (1987) · PubMed · Cited by 4 · see citing works

Adrenoleukodystrophy—Neuroendocrine pathogenesis and redefinition of natural history

Kemp, S., Huffnagel, I. C., Linthorst, G. E., Wanders, R. J., & Engelen, M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.90 · Cited by 275 · see citing works

Blood-brain barrier transport machineries and targeted therapy of brain diseases

Barar, J., Rafi, M. A., Pourseif, M. M., & Omidi, Y. (2016) · Bioimpacts · doi:10.15171/bi.2016.30 · Cited by 259 · see citing works

The physiological functions of human peroxisomes

Wanders, R. J. A., Baes, M., Ribeiro, D., Ferdinandusse, S., & Waterham, H. R. (2023) · Physiological Reviews · doi:10.1152/physrev.00051.2021 · Cited by 228 · see citing works

X‐linked adrenoleukodystrophy: Pathology, pathophysiology, diagnostic testing, newborn screening and therapies

Turk, B. R., Theda, C., Fatemi, A. S., & Moser, A. B. (2020) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10003 · Cited by 206 · see citing works

Peroxisomes in brain development and function

Berger, J., Dorninger, F., Forss-Petter, S., & Kunze, M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.12.005 · Cited by 194 · see citing works

Precision drug delivery to the central nervous system using engineered nanoparticles

Gao, J., Xia, Z. J., Gunasekar, S., Jiang, C., Karp, J. M., & Joshi, N. (2024) · Nature Reviews Materials · doi:10.1038/s41578-024-00695-w · Cited by 162 · see citing works

Inherited and acquired disorders of myelin: The underlying myelin pathology

Duncan, I. D., & Radcliff, A. B. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.04.002 · Cited by 137 · see citing works

Tight junctions and their regulation by non-coding RNAs

Zhao, X., Zeng, H., Lei, L., Tong, X., Yang, L., Yang, Y., Li, S., Zhou, Y., Luo, L., Huang, J., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.45885 · Cited by 96 · see citing works

The “Frail” Brain Blood Barrier in Neurodegenerative Diseases: Role of Early Disruption of Endothelial Cell-to-Cell Connections

Maiuolo, J., Gliozzi, M., Musolino, V., Scicchitano, M., Carresi, C., Scarano, F., Bosco, F., Nucera, S., Ruga, S., Zito, M. C., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092693 · Cited by 85 · see citing works

7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD

Nury, T., Zarrouk, A., Ragot, K., Debbabi, M., Riedinger, J., Véjux, A., Aubourg, P. R., & Lizard, G. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.03.037 · Cited by 84 · see citing works

Impaired plasticity of macrophages in X-linked adrenoleukodystrophy

Weinhofer, I., Zierfuss, B., Hametner, S., Wagner, M., Popitsch, N., Machacek, C., Bartolini, B., Zlabinger, G., Ohradanova-Repic, A., Stockinger, H., et al. (2018) · Brain · doi:10.1093/brain/awy127 · Cited by 72 · see citing works

MRI brain lesions in asymptomatic boys with X-linked adrenoleukodystrophy

Liberato, A. P., Mallack, E. J., Aziz-Bose, R., Hayden, D., Lauer, A., Caruso, P. A., Musolino, P. L., & Eichler, F. S. (2019) · Neurology · doi:10.1212/wnl.0000000000007294 · Cited by 69 · see citing works

Neurofilament light chain as a potential biomarker for monitoring neurodegeneration in X-linked adrenoleukodystrophy

Weinhofer, I., Rommer, P. S., Zierfuss, B., Altmann, P., Foiani, M. S., Heslegrave, A., Zetterberg, H., Gleiß, A., Musolino, P. L., Gong, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22114-2 · Cited by 69 · see citing works

Microglial dysfunction as a key pathological change in adrenomyeloneuropathy

Gong, Y., Sasidharan, N., Laheji, F., Frosch, M., Musolino, P., Tanzi, R., Kim, D. Y., Biffi, A., El Khoury, J., & Eichler, F. (2017) · Annals of Neurology · doi:10.1002/ana.25085 · Cited by 54 · see citing works

Development of PPARγ Agonists for the Treatment of Neuroinflammatory and Neurodegenerative Diseases: Leriglitazone as a Promising Candidate

Pizcueta, P. M., Vergara, C., Emanuele, M., Vilalta, A., Rodríguez‐Pascau, L., & Martinell, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043201 · Cited by 55 · see citing works

Repurposing Vorinostat for the Treatment of Disorders Affecting Brain

Athira, K. V., Sadanandan, P., & Chakravarty, S. (2021) · NeuroMolecular Medicine · doi:10.1007/s12017-021-08660-4 · Cited by 52 · see citing works

Modeling and rescue of defective blood–brain barrier function of induced brain microvascular endothelial cells from childhood cerebral adrenoleukodystrophy patients

Lee, C. A. A., Seo, H. S., Armien, A. G., Bates, F. S., Tolar, J., & Azarin, S. M. (2018) · Fluids and Barriers of the CNS · doi:10.1186/s12987-018-0094-5 · Cited by 52 · see citing works

ABCD1 dysfunction alters white matter microvascular perfusion

Lauer, A., Da, X., Hansen, M. B., Boulouis, G., Ou, Y., Cai, X., Liberato Celso Pedrotti, A., Kalpathy-Cramer, J., Caruso, P., Hayden, D. L., et al. (2017) · Brain · doi:10.1093/brain/awx262 · Cited by 48 · see citing works

A zebrafish model of X-linked adrenoleukodystrophy recapitulates key disease features and demonstrates a developmental requirement for abcd1 in oligodendrocyte patterning and myelination

Strachan, L. R., Stevenson, T. J., Freshner, B., Keefe, M. D., Miranda Bowles, D., & Bonkowsky, J. L. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx249 · Cited by 46 · see citing works

The brain penetrant PPARγ agonist leriglitazone restores multiple altered pathways in models of X-linked adrenoleukodystrophy

Rodríguez-Pascau, L., Vilalta, A., Cerrada, M., Traver, E., Forss-Petter, S., Weinhofer, I., Bauer, J., Kemp, S., Pina, G., Pascual, S., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abc0555 · Cited by 40 · see citing works

Research progress on pyroptosis and its effect on the central nervous system

Hao, W., & Feng, C. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106333 · Cited by 40 · see citing works

PPARγ activation ameliorates cognitive impairment and chronic microglial activation in the aftermath of r-mTBI

Pearson, A., Koprivica, M., Eisenbaum, M., Ortiz, C., Browning, M., Vincennie, T., Tinsley, C., MULLAN, M. J., Crawford, F., & Ojo, J. O. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03173-w · Cited by 39 · see citing works

ZO-1 expression is suppressed by GM-CSF via miR-96/ERG in brain microvascular endothelial cells

Zhang, H., Zhang, S., Zhang, J., Liu, D., Wei, J., Fang, W., Zhao, W., Chen, Y., & Shang, D. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17702668 · Cited by 37 · see citing works

Framework Nucleic Acid Nanomaterials for Central Nervous System Therapies: Design for Barrier Penetration, Targeted Delivery, Cellular Uptake, and Endosomal Escape

Chen, X., Luo, X., Yin, W., Cui, W., He, Y., Tian, T., & Lin, Y. (2025) · ACS Nano · doi:10.1021/acsnano.5c03945 · Cited by 36 · see citing works

Management of adrenoleukodystrophy: From pre-clinical studies to the development of new therapies

Ma, C. Y., Li, C., Zhou, X., Zhang, Z., Jiang, H., Liu, H., Chen, H. J., Tse, H., Liao, C., & Lian, Q. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112214 · Cited by 28 · see citing works

Hematopoietic stem-cell gene therapy is associated with restored white matter microvascular function in cerebral adrenoleukodystrophy

Lauer, A., Speroni, S. L., Choi, M., Da, X., Duncan, C., McCarthy, S., Krishnan, V., Lusk, C. A., Rohde, D., Hansen, M. B., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37262-w · Cited by 26 · see citing works

Overview of Inflammation in Neurometabolic Diseases

Grabowski, G. A. (2017) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2017.08.005 · Cited by 25 · see citing works

A defect in the peroxisomal biogenesis in germ cells induces a spermatogenic arrest at the round spermatid stage in mice

Brauns, A.-K., Heine, M., Tödter, K., Baumgart‐Vogt, E., Lüers, G. H., & Schumacher, U. (2019) · Scientific Reports · doi:10.1038/s41598-019-45991-6 · Cited by 25 · see citing works

Vorinostat in the acute neuroinflammatory form of X‐linked adrenoleukodystrophy

Zierfuss, B., Weinhofer, I., Kühl, J., Köhler, W., Bley, A. E., Zauner, K., Binder, J., Martinović, K., Seiser, C., Hertzberg, C., et al. (2020) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51015 · Cited by 23 · see citing works

Deciphering the modifiers for phenotypic variability of X-linked adrenoleukodystrophy

Palakuzhiyil, S. V., Christopher, R., & Chandra, S. R. (2020) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v11.i3.99 · Cited by 24 · see citing works

Concurrent axon and myelin destruction differentiates X-linked adrenoleukodystrophy from multiple sclerosis

Bergner, C. G., Genc, N., Hametner, S., Franz, J., van der Meer, F., Mitkovski, M., Weber, M. S., Stoltenburg‐Didinger, G., Kühl, J., Köhler, W., et al. (2021) · Glia · doi:10.1002/glia.24042 · Cited by 23 · see citing works

Neurological diseases at the blood-brain barrier: Stemming new scientific paradigms using patient-derived induced pluripotent cells

Page, S., Patel, R., Raut, S., & Al-Ahmad, A. J. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.12.009 · Cited by 22 · see citing works

The pathology of X-linked adrenoleukodystrophy: Tissue specific changes as a clue to pathophysiology

Yska, H. A. F., Engelen, M., & Bugiani, M. (2024) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-024-03105-0 · Cited by 20 · see citing works

Endocrine dysfunction in adrenoleukodystrophy

Engelen, M., Kemp, S., & Eichler, F. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819973-2.00018-6 · Cited by 19 · see citing works

Restoring brain barriers: an innovative approach for treating neurological disorders

Lemarchant, S., Engelhardt, B., Cicchetti, F., Bix, G. J., Janus, A., Godfrin, Y., Blasco, H., Campbell, M., & Jacquet, A. D. R. (2025) · Fluids and Barriers of the CNS · doi:10.1186/s12987-025-00688-z · Cited by 16 · see citing works

X-linked Adrenoleukodystrophy: Pathology, Pathophysiology, Diagnostic Testing, Newborn Screening, and Therapies

Turk, B. R., Theda, C., Fatemi, A. S., & Moser, A. B. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2019.11.002 · Cited by 17 · see citing works

Cerebral adrenoleukodystrophy: a demyelinating disease that leaves the door wide open: Figure 1

Aubourg, P. (2015) · Brain · doi:10.1093/brain/awv271 · Cited by 15 · see citing works

Eif2b3 mutants recapitulate phenotypes of vanishing white matter disease and validate novel disease alleles in zebrafish

Lee, Y., Kim, S. H., Ben‐Mahmoud, A., Kim, O.-H., Choi, T., Lee, K., Ku, B., Eum, J., Kee, Y., Lee, S., et al. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab033 · Cited by 15 · see citing works

Pathology of the neurovascular unit in leukodystrophies

Zarekiani, P., Breur, M., Wolf, N. I., de Vries, H. E., van der Knaap, M. S., & Bugiani, M. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01206-6 · Cited by 16 · see citing works

Endothelial cell dysfunction in globoid cell leukodystrophy

Belleri, M., & Presta, M. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23744 · Cited by 15 · see citing works

New Silent Cerebral Infarction in Patients with Acute Non-Cerebral Amyloid Angiopathy Intracerebral Hemorrhage as a Predictor of Recurrent Cerebrovascular Events

Wang, Y., & Zhang, G. (2019) · Medical Science Monitor · doi:10.12659/msm.914423 · Cited by 12 · see citing works

Failure of intrathecal allogeneic mesenchymal stem cells to halt progressive demyelination in two boys with cerebral adrenoleukodystrophy

Gupta, A. O., Orchard, P. J., Miller, W. P., Nascene, D. R., Raymond, G. V., Loes, D. J., McKenna, D. H., & Lund, T. C. (2020) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0304 · Cited by 12 · see citing works

Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy

Bougnères, P., & Le Stunff, C. (2025) · Genes · doi:10.3390/genes16050590 · Cited by 11 · see citing works

Role of Basal Forebrain Neurons in Adrenomyeloneuropathy in Mice and Humans

Gong, Y., Laheji, F., Berenson, A., Li, Y., Moser, A., Qian, A., Frosch, M., Sadjadi, R., Hahn, R., Maguire, C. A., et al. (2024) · Annals of Neurology · doi:10.1002/ana.26849 · Cited by 11 · see citing works

Loes Score: Clinical and Radiological Profile of 22 Patients of X-Linked Adrenoleukodystrophy: Case Series from a Single Center

Kumar, S., Sait, H., Polipalli, S. K., Pradhan, G., Pruthi, S., & Kapoor, S. (2021) · Indian journal of radiology and imaging - new series/Indian journal of radiology and imaging/Indian Journal of Radiology & Imaging · doi:10.1055/s-0041-1734366 · Cited by 10 · see citing works

Cerebral adrenoleukodystrophy is associated with loss of tolerance to profilin

Orchard, P. J., Nascene, D. R., Gupta, A. O., Taisto, M. E., Higgins, L., Markowski, T. W., & Lund, T. C. (2019) · European Journal of Immunology · doi:10.1002/eji.201848043 · Cited by 10 · see citing works

Lysosomal cholesterol accumulation is commonly found in most peroxisomal disorders and reversed by 2-hydroxypropyl-β-cyclodextrin

Dong, L.-W., Xiao, J., Liu, S., Deng, G., Liao, Y.-C., Chu, B., Zhao, X., Song, B., & Luo, J. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2260-4 · Cited by 10 · see citing works

Safety and efficacy of leriglitazone in childhood cerebral adrenoleukodystrophy (NEXUS): an interim analysis of an open-label, phase 2/3 trial

García‐Cazorla, À., Sevin, C., Ribeiro‐Constante, J., Yazbeck, E., Rosewich, H., Jimenez, S., Chiang, G. C.-Y., Rapalino, O., Caruso, P. A., Balentine, D., et al. (2025) · EClinicalMedicine · doi:10.1016/j.eclinm.2025.103265 · Cited by 9 · see citing works

Reduced Intellectual Ability in Offspring Born from Preeclamptic Mothers: A Prospective Cohort Study

Liu, L., Lin, Z., Zheng, B., Wang, L., Zou, J., Wu, S., Jiang, Z., Jin, Q., Lai, X., & Lin, P. (2020) · Risk Management and Healthcare Policy · doi:10.2147/rmhp.s277521 · Cited by 9 · see citing works

Late onset adrenoleukodystrophy: A review related clinical case report

Paláu-Hernández, S., Rodríguez‐Leyva, I., & Shiguetomi-Medina, J. M. (2019) · eNeurologicalSci · doi:10.1016/j.ensci.2019.01.007 · Cited by 8 · see citing works

A Novel Mouse Model for Cerebral Inflammatory Demyelination in X‐Linked Adrenoleukodystrophy: Insights into Pathogenesis and Potential Therapeutic Targets

Hashemi, E., Srivastava, I. N., Aguirre, A., Yoseph, E., Kaushal, E., Awani, A., Ryu, J. K., Akassoglou, K., Talebian, S., Chu, P., et al. (2024) · Annals of Neurology · doi:10.1002/ana.27117 · Cited by 8 · see citing works

Decision Making in Adrenoleukodystrophy

van Haren, K. P., & Engelen, M. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.0095 · Cited by 8 · see citing works

X-linked adrenoleukodystrophy in a chimpanzee due to an ABCD1 mutation reported in multiple unrelated humans

Curiel, J., Steinberg, S. J., Bright, S., Snowden, A., Moser, A. B., Eichler, F., Dubbs, H. A., Hacia, J. G., Ely, J. J., Bezner, J., et al. (2017) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2017.08.012 · Cited by 8 · see citing works

Hematopoietic stem cell therapy and ex vivo gene therapy for X-linked adrenoleukodystrophy

Eichler, F., & Kuehl, J.-S. (2024) · Handbook of clinical neurology · doi:10.1016/b978-0-323-90242-7.00018-3 · Cited by 7 · see citing works

Drug discovery for X‐linked adrenoleukodystrophy: An unbiased screen for compounds that lower very long‐chain fatty acids

Moser, A. B., Liu, Y., Shi, X., Schrifl, U., Hiebler, S., Fatemi, A. S., Braverman, N., Steinberg, S. J., & Watkins, P. A. (2021) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30014 · Cited by 7 · see citing works

Adrenoleukodystrophy: Current understanding of disease mechanisms, diagnosis, and therapeutic advances–a recent review

Jain, C. K., Maurya, S., & Tripathi, P. K. (2025) · Brain and Development · doi:10.1016/j.braindev.2025.104476 · Cited by 7 · see citing works

MicroRNA and metabolomics signatures for adrenomyeloneuropathy disease severity

Turk, B. R., Poisson, L., Nemeth, C. L., Goodman, J., Moser, A. B., Jones, R. O., Fatemi, A. S., & Singh, J. (2022) · JIMD Reports · doi:10.1002/jmd2.12323 · Cited by 6 · see citing works

Pharmacological modulation of the blood-brain barrier: Mechanisms, therapeutic strategies, and emerging technologies

Pediaditakis, I., Tsakali, S., Lemieux, M. R., Brennan, M., Robinson, W. H., Papapetropoulos, S., & Papapetropoulos, A. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100118 · Cited by 7 · see citing works

Targeting VEGF-mediated blood-brain barrier disruption in advanced cerebral leukodystrophy

Gupta, A. O., Furcich, J. W., Nascene, D. R., Kemp, S., King, C. J., Nolan, E. E., Durose, W. W., Miller, B. S., Orchard, P. J., & Lund, T. C. (2024) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2024.578395 · Cited by 5 · see citing works

Low donor chimerism may be sufficient to prevent demyelination in adrenoleukodystrophy

Ikeda, T., Kawahara, Y., Miyauchi, A., Niijima, H., Furukawa, R., Shimozawa, N., Morimoto, A., Osaka, H., & Yamagata, T. (2021) · JIMD Reports · doi:10.1002/jmd2.12259 · Cited by 5 · see citing works

Multifunctionality of tissue inhibitor of metalloproteinase-1 in central nervous system diseases

Zhong, L., Zhao, L., Tang, Q., Zhang, X., Zhou, M., Luo, J. M., & Wang, Y. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111647 · Cited by 4 · see citing works

Easily misdiagnosed X-linked adrenoleukodystrophy

Wang, Q., Wang, Y., Wang, J., Liu, L.-Y., Gao, J., Hao, G.-Z., Chen, C., Lü, Q., Dun, S., Zhang, Q., et al. (2024) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-024-01669-y · Cited by 4 · see citing works

A scoping review of stem cell models of leukodystrophies: advances in understanding pathophysiological mechanisms

Chapleau, A., Perrier, S., Durcan, T. M., & Bernard, G. (2025) · npj Genomic Medicine · doi:10.1038/s41525-025-00533-0 · Cited by 3 · see citing works

Bone marrow transplantation into Abcd1‐deficient mice: Distribution of donor derived‐cells and biological characterization of the brain of the recipient mice

Morita, M., Kaizawa, T., Yoda, T., Oyama, T., Asakura, R., Matsumoto, S., Nagai, Y., Watanabe, Y., Watanabe, S., Kobayashi, H., et al. (2020) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12346 · Cited by 3 · see citing works

Predicting new silent cerebral infarction after intracerebral hemorrhage using serum white blood cell count.

Wang, Y. (2021) · PubMed Central · doi:10.22088/cjim.12.1.97 · Cited by 3 · see citing works

Fulminating Autoimmune Demyelination with Optic Neuropathy in a Case of Pediatric Cerebral Adrenoleukodystrophy: Case Report and Review of the Literature

Singhapakdi, K., Sharma, K., & Maertens, P. M. (2021) · Journal of Pediatric Neurology · doi:10.1055/s-0041-1727143 · Cited by 3 · see citing works

Measuring early lesion growth in boys with cerebral demyelinating adrenoleukodystrophy

van Haren, K. P., Engelen, M., & Wolf, N. I. (2019) · Neurology · doi:10.1212/wnl.0000000000007256 · Cited by 3 · see citing works

Peroxisomal Disorders

Faust, P. L. (2018) · doi:10.1002/9781119013112.ch31 · Cited by 3 · see citing works

Optical coherence tomography angiography reveals abnormal retinal vascular density and perfusion in patients with X-linked adrenoleukodystrophy: a cross-sectional study

Zhang, L., Yu, Y. F., Liu, T., Li, C., Tan, L., & Wen, S. (2025) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-024-03499-x · Cited by 2 · see citing works

Pyroptosis; igniting neuropsychiatric disorders from mild depression to aging-related neurodegeneration

Hushmandi, K., Reiter, R. J., Farahani, N., Cho, W. C. S., Alimohammadi, M., & Khoshnazar, S. M. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111325 · Cited by 2 · see citing works

Therapeutic Strategies for X-Linked Adrenoleukodystrophy, a Representative Peroxisomal Disorder

Morita, M. (2019) · Springer eBooks · doi:10.1007/978-981-15-1169-1_8 · Cited by 2 · see citing works

Successful Correction of ALD Patient-derived iPSCs Using CRISPR/Cas9Preprint

Jung, E. S., Quan, Z., Chang, M., Hong, W., Kim, J. H., Kim, S. H., You, S., Kim, D., Jang, J., Lee, S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.23.962118 · Cited by 2 · see citing works

Gene Therapy of Adrenomyeloneuropathy: Challenges, Target Cells, and Prospectives

Bougneres, P. F., Stunff, C. L., & Badin, R. A. (2025) · Biomedicines · doi:10.3390/biomedicines13081892 · Cited by 1 · see citing works

Peroxisomal ABCD1 deficiency in mice drives Th1 bias through 25-HC–LXR signaling in CD4+ T cells

Maeda, R., Oishi, M., Nagamori, R., Hikosaka‐Kuniishi, M., Watanabe, S., Lee, J., Morita, M., & So, T. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1722647 · Cited by 1 · see citing works

X-linked adrenoleukodystrophy; Recent Advances in Classification, Diagnosis and Management

정을식, 강훈철, & 고아라 (2016) · Annals of Child Neurology · doi:10.26815/jkcns.2016.24.3.71 · Cited by 1 · see citing works

Mechanisms for Extracellular Matrix-Dependent Blood-Brain Barrier Dysfunction

Hoettles, B. A. (2021) · doi:10.18122/td/1903/boisestate · Cited by 1 · see citing works

Comprehensive Care to Improve Quality of Life: A Case of Childhood Adrenoleukodystrophy

Dharamsi, M. S., Mejia, A. A., & Vargas, C. D. (2022) · HCA Healthcare Journal of Medicine · doi:10.36518/2689-0216.1441

The brain penetrant PPARγ agonist leriglitazone restores multiple altered pathways in models of X-linked adrenoleukodystrophy

Rodríguez‐Pascau, L., Vilalta, A., Cerrada, M., Traver, E., Forss‐Petter, S., Weinhofer, I., Bauer, J., Kemp, S., Pina, G., Pascual, S., et al. (2022) · Yearbook of pediatric endocrinology · doi:10.1530/ey.19.8.10

Maladie héréditaire du métabolisme et allogreffe de cellules souches hématopoïétiques : indication, modalité et suivi. Recommandations de la SFGM-TC

Jubert, C., de Berranger, E., Castelle, M., Dalle, J., Ouachée-Chardin, M., Sevin, C., Yakoub‐Agha, I., & Brassier, A. (2022) · Bulletin du Cancer · doi:10.1016/j.bulcan.2022.09.001

Cerebello-brainstem dominant form of adrenoleukodystrophy with neurological symptom onset triggered by COVID-19

Sugiyama, A., Nakagawa, Y., Mukai, H., Yokota, H., Oda, F., Yamaguchi, A., Ishiwata, K., Izumi, S., Matsukawa, T., Uzawa, A., et al. (2025) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2025.123444

Clinical Applications and Resistance Challenges of PD-1/PD-L1 Inhibitors in Gastric Cancer

杨, 葱. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.1572035

X-linked adrenoleukodystrophy: literature review, description of clinical cases

Alekseeva, V. A., Gavrichenko, A. V., Yakovlev, A. A., Sokolova, M. G., Barantsevich, E. R., & Abramova, A. P. (2025) · The Scientific Notes of the Pavlov University · doi:10.24884/1607-4181-2025-32-2-100-112

Additional file 1 of Easily misdiagnosed X-linked adrenoleukodystrophy

Wang, Q.-H., Wang, Y.-Y., Wang, J., Liu, L.-Y., Gao, J., Hao, G.-Z., Chen, C., Lu, Q., Dun, S., Zhang, Q., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26157086

Additional file 4 of The pathology of X-linked adrenoleukodystrophy: tissue specific changes as a clue to pathophysiology

Yska, H. A. F., Engelen, M., & Bugiani, M. (2024) · Figshare · doi:10.6084/m9.figshare.26699159

Additional file 3 of The pathology of X-linked adrenoleukodystrophy: tissue specific changes as a clue to pathophysiology

Yska, H. A. F., Engelen, M., & Bugiani, M. (2024) · Figshare · doi:10.6084/m9.figshare.26699156

Additional file 2 of The pathology of X-linked adrenoleukodystrophy: tissue specific changes as a clue to pathophysiology

Yska, H. A. F., Engelen, M., & Bugiani, M. (2024) · Figshare · doi:10.6084/m9.figshare.25506745

Additional file 1 of The pathology of X-linked adrenoleukodystrophy: tissue specific changes as a clue to pathophysiology

Yska, H. A. F., Engelen, M., & Bugiani, M. (2024) · Figshare · doi:10.6084/m9.figshare.25506610

Inactivation génique des transporteurs ABC peroxysomaux ABCD1 et ABCD2 dans les cellules microgliales BV-2 : étude de la physiopathogenèse de l’adrénoleucodystrophie liée à l’X.

Raas, Q. (2018) · theses.fr (ABES) · doi:10.70675/21dd2b17z388az4373z866az5229716abfb1

Rapidly progressive childhood cerebral adrenoleukodystrophy following minor trauma: A case report demonstrating plasmalogen decline and lipid disequilibrium

Yamashita, D., Hara, M., Ishii, R., Koike, T., Yuge, K., 藤野, 武., Shimozawa, N., & Yamashita, Y. (2026) · Brain and Development Case Reports · doi:10.1016/j.bdcasr.2026.100152

The Exercise-CTSS-AD Axis: a novel framework for understanding exercise-induced neuroprotection in Alzheimer’s disease

Yang, D., Guo, W., & Wang, B. (2026) · Metabolic Brain Disease · doi:10.1007/s11011-026-01930-9

Catalytic MXene implant interfaces reprogram radiation-induced foreign body response to prevent capsular contracture

Zhang, Y., Lin, Z., Qiao, Y., Yang, Q., Chen, M., Dong, D., Nan, G., Wei, Z., Qi, X., Jiao, Y., et al. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124689

Cerebral adrenoleukodystrophy: a demyelinating disease that leaves the door wide open: Figure 1

Aubourg, P. (2015) · Brain · doi:10.1093/brain/awv271 · Cited by 15 · see citing works

Microvascular Abnormalities in Adrenoleukodystrophy: Effects of ABCD1 Deficiency Upon Brain Endothelium. (S35.005)

Musolino, P. L., Gong, Y., Juliet, S., Jimenez, S., Grabowski, E. F., Lok, J. M., Lo, E. H., Frosch, M. P., & Eichler, F. (2015) · Neurology · doi:10.1212/wnl.84.14_supplement.s35.005

Impaired plasticity of macrophages in X-linked adrenoleukodystrophy

Weinhofer, I., Zierfuss, B., Hametner, S., Wagner, M., Popitsch, N., Machacek, C., Bartolini, B., Zlabinger, G., Ohradanova-Repic, A., Stockinger, H., et al. (2018) · Brain · doi:10.1093/brain/awy127 · Cited by 72 · see citing works

ABCD1 dysfunction alters white matter microvascular perfusion

Lauer, A., Da, X., Hansen, M. B., Boulouis, G., Ou, Y., Cai, X., Liberato Celso Pedrotti, A., Kalpathy-Cramer, J., Caruso, P., Hayden, D. L., et al. (2017) · Brain · doi:10.1093/brain/awx262 · Cited by 48 · see citing works

Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy

Singh, J., Khan, M., & Singh, I. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800321-jlr200 · Cited by 75 · see citing works