Cited by 674Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

Prinz, Marco, Priller, Josef, Sisodia, Sangram S, Ransohoff, Richard M·2011·Nature Neuroscience

Abstract

The diseased brain hosts a heterogeneous population of myeloid cells, including parenchymal microglia, perivascular cells, meningeal macrophages and blood-borne monocytes. To date, the different types of brain myeloid cells have been discriminated solely on the basis of their localization, morphology and surface epitope expression. However, recent data suggest that resident microglia may be functionally distinct from bone marrow- or blood-derived phagocytes, which invade the CNS under pathological conditions. During the last few years, research on brain myeloid cells has been markedly changed by the advent of new tools in imaging, genetics and immunology. These methodologies have yielded unexpected results, which challenge the traditional view of brain macrophages. On the basis of these new studies, we differentiate brain myeloid subtypes with regard to their origin, function and fate in the brain and illustrate the divergent features of these cells during neurodegeneration.

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Crossref · 10.1038/nn.2923

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  • Several cytokines released by microglia are elevated in neurological disease and help recruit peripheral immune cells into the CNS in pathological states.

    “Many of these cytokines are known to be highly elevated in neurological diseases and/or involved in the recruitment of peripheral immune cells into the CNS under pathological conditions”

    From iPSC-derived human microglia-like cells to study neurological diseases (2017) · cites this paper as Prinz et al., 2011

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Authors
Prinz, M., Priller, J., Sisodia, S. S., & Ransohoff, R. M.
Affiliations
  • University Medical Center Freiburg (DE)
  • Charité – Universitätsmedizin Berlin (DE)
  • University of Chicago (US)
  • Cleveland Clinic (US)
Corresponding author
  • Prinz, Marco
  • Ransohoff, Richard M
Venue
Nature Neuroscience
Published
2011-09-27
Volume
14
Issue
10
Pages
1227-1235
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2071753918
Cited by
674
References
102
Citations by year
2026: 17 · 2025: 23 · 2024: 33 · 2023: 29 · 2022: 37 · 2021: 42 · 2020: 54 · 2019: 39 · 2018: 50 · 2017: 52 · 2016: 64 · 2015: 60 · 2014: 59 · 2013: 65 · 2012: 46
FWCI
4.86
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
microglia, meningeal macrophages, perivascular macrophages, neurodegeneration, myeloid cell heterogeneity, phagocytes, brain macrophages
MeSH terms
Animals, Brain Diseases, Cell Differentiation, Central Nervous System, Humans, Models, Biological, Nerve Degeneration, Signal Transduction, Microglia, Myeloid Cells

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