Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology
Spangenberg, Elizabeth E., Lee, Rafael J., Najafi, Allison R., Rice, Rachel A., Elmore, Monica R. P., Blurton-Jones, Mathew, West, Brian L., Green, Kim N.·2016·Brain
Cited by (695)
Items 301–400 of 695
- Systemic microbial TLR2 agonists induce neurodegeneration in Alzheimer’s disease miceNeta Lax, Nina Fainstein, Yossi Nishri, Ayal Ben‐Zvi, Tamir Ben‐Hur · 2020 · Journal of Neuroinflammation
- Microglia and Their Promising Role in Ischemic Brain Injuries: An UpdateLuting Yu, Xiaojuan Su, Shiping Li, Fengyan Zhao, Dezhi Mu, Yi Qu · 2020 · Frontiers in Cellular Neuroscience
- Alzheimer’s disease-associated β-amyloid does not protect against herpes simplex virus 1 infection in the mouse brainOlga V. Bocharova, Narayan Prasad Pandit, Kara Molesworth, Aidan Fisher, Olga Mychko, Natallia Makarava, Ilia V. Baskakov · 2021 · Journal of Biological Chemistry
- Oxidative stress, the immune response, synaptic plasticity, and cognition in transgenic models of Alzheimer diseasePaola Cristina Bello-Medina, Diego Alexander González-Franco, Isaac Vargas-Rodríguez, Sofía Y. Díaz-Cintra · 2021 · Neurología (English Edition)
- Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic NeurodegenerationObst, Juliane, Simon, Emilie, Martin-Estebane, Maria, Pipi, Elena, Barkwill, Liana M., Gonzalez-Rivera, Ivette, Buchanan, Fergus, Prescott, Alan R., Faust, Dorte, Fox, Simon et al. · 2020 · Frontiers in Immunology
- Distinct patterns of glia repair and remyelination in antibody‐mediated demyelination models of multiple sclerosis and neuromyelitis opticaYiting Liu, Katherine S. Given, Gregory P. Owens, Wendy B. Macklin, Jeffrey L. Bennett · 2018 · Glia
- CD200 dysfunction in neuron contributes to synaptic deficits and cognitive impairmentDepeng Feng, Anqi Huang, Wei Yan, Dezhe Chen · 2019 · Biochemical and Biophysical Research Communications
- Neuronal loss and microgliosis are restricted to the core of Aβ deposits in mouse models of Alzheimer's diseaseZhang, Jing, Wu, Na, Wang, Shubo, Yao, Zitong, Xiao, Fuchuan, Lu, Jing, Chen, Baian · 2021 · Aging Cell
- Plants, Plants, and More Plants: Plant-Derived Nutrients and Their Protective Roles in Cognitive Function, Alzheimer’s Disease, and Other DementiasDing, Helen, Reiss, Allison B., Pinkhasov, Aaron, Kasselman, Lora J. · 2022 · Medicina
- APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microgliaPreman, Pranav, Moechars, Daan, Fertan, Emre, Wolfs, Leen, Serneels, Lutgarde, Shah, Disha, Lamote, Jochen, Poovathingal, Suresh, Snellinx, An, Mancuso, Renzo et al. · 2024 · EMBO Molecular Medicine
- Ependymal Vps35 Promotes Ependymal Cell Differentiation and Survival, Suppresses Microglial Activation, and Prevents Neonatal HydrocephalusKong-yan Wu, Fu‐Lei Tang, Daehoon Lee, Yang Zhao, Hyunjin Song, Xiaojuan Zhu, Lin Mei, Wen‐Cheng Xiong · 2020 · Journal of Neuroscience
- Partial microglial depletion is associated with impaired hippocampal synaptic and cognitive function in young and aged ratsBrittney Yegla, Jake Sondag Boles, Ashok Kumar, Thomas C. Foster · 2021 · Glia
- Stress induces microglia-associated synaptic circuit alterations in the dorsomedial prefrontal cortexTaohui Liu, Ju Lu, Kacper Łukasiewicz, Bing‐Xing Pan, Yi Zuo · 2021 · Neurobiology of Stress
- Astrocytes & Astrocyte derived Extracellular Vesicles in Morphine Induced Amyloidopathy: Implications for Cognitive Deficits in Opiate AbusersSusmita Sil, Seema Singh, Divya T. Chemparathy, Ernest T. Chivero, Lila Gordon, Shilpa J. Buch · 2021 · Aging and Disease
- How the gut microbiota impacts neurodegenerative diseases by modulating CNS immune cellsPhilipp Schaible, Julia Henschel, Daniel Erny · 2025 · Journal of Neuroinflammation
- Aging-related modifications to G protein-coupled receptor signaling diversityJaana van Gastel, Hanne Leysen, Jan Boddaert, Laura Vangenechten, Louis M. Luttrell, Bronwen Martin, Stuart R. Maudsley · 2020 · Pharmacology & Therapeutics
- Neuroinflammation across the Spectrum of Neurodegenerative Diseases: Mechanisms and Therapeutic FrontiersKaryme M. Alemán-Villa, David A. Armienta-Rojas, Josué Camberos-Barraza, Ángel Radamés Rábago-Monzón, Alejandro Camacho-Zamora, Juan Fidel Osuna‐Ramos, Javier A. Magaña‐Gómez, Alma Marlene Guadrón‐Llanos, Loranda Calderón-Zamora, Claudia Desireé Norzagaray-Valenzuela et al. · 2025 · NeuroImmunoModulation
- Entanglement of CCR5 and Alzheimer’s DiseaseTianwen Li, Jianhong Zhu · 2019 · Frontiers in Aging Neuroscience
- Impaired Parahippocampal Gyrus–Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer DiseaseLin Zhu, Zan Wang, Zhanhong Jeff Du, Xinyang Qi, Hao Shu, Duan Liu, Fan Su, Qing Ye, Xuemei Liu, Zheng Zhou et al. · 2020 · Neuroscience Bulletin
- Does Siponimod Exert Direct Effects in the Central Nervous System?Markus Kipp · 2020 · Cells
- Microbial pathogens induce neurodegeneration in Alzheimer’s disease mice: protection by microglial regulationTal Ganz, Nina Fainstein, Amit Elad, Marva Lachish, Smadar Goldfarb, Ofira Einstein, Tamir Ben‐Hur · 2022 · Journal of Neuroinflammation
- Pharmacological Depletion of Microglia Leads to a Dose-Dependent Reduction in Inflammation and Senescence in the Aged Murine BrainMilan R. Stojiljkovic, Christian W. Schmeer, Otto Wilhelm Witte · 2022 · Neuroscience
- The role of microglial autophagy in Parkinson’s diseaseRui Zhu, Yuyi Luo, Shangang Li, Zhengbo Wang · 2022 · Frontiers in Aging Neuroscience
- The Critical Role of IL‐10 in the Antineuroinflammatory and Antioxidative Effects of Rheum tanguticum on Activated MicrogliaJie Meng, Junjun Ni, Zhou Wu, Muzhou Jiang, Aiqin Zhu, Hong Qing, Hiroshi Nakanishi · 2018 · Oxidative Medicine and Cellular Longevity
- Csf1 Deficiency Dysregulates Glial Responses to Demyelination and Disturbs CNS White Matter RemyelinationWylot, Bartosz, Mieczkowski, Jakub, Niedziolka, Sylwia, Kaminska, Bozena, Zawadzka, Malgorzata · 2019 · Cells
- Cellular Localization of Kynurenine 3-Monooxygenase in the Brain: Challenging the DogmaKorrapati V. Sathyasaikumar, Verónica Pérez de la Cruz, Benjamín Pineda, Gustavo Ignacio Vázquez Cervantes, Daniela Ramírez Ortega, David W. Donley, Paul L. Severson, Brian L. West, Flaviano Giorgini, Jonathan H. Fox et al. · 2022 · Antioxidants
- Disease-associated microglial activation prevents photoreceptor degeneration by suppressing the accumulation of cell debris and neutrophils in degenerating rat retinasJuncai He, Yan Fu, Lingling Ge, Jiaman Dai, Yajie Fang, Yijian Li, Xianliang Gu, Zui Tao, Ting Zou, Minghui Li et al. · 2022 · Theranostics
- Repopulated microglia induce expression of Cxcl13 with differential changes in Tau phosphorylation but do not impact amyloid pathologyBerke Karaahmet, Linh Le, Monique S. Mendes, Ania Katarzyna Majewska, M. Kerry O’Banion · 2022 · Journal of Neuroinflammation
- Repopulated retinal microglia promote Müller glia reprogramming and preserve visual function in retinal degenerative miceXuan Cheng, Hui Gao, Zui Tao, Zhiyuan Yin, Zhe Cha, Xiaona Huang, Yikui Zhang, Yuxiao Zeng, Juncai He, Lingling Ge et al. · 2023 · Theranostics
- “Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interactionHaonan Zheng, Cunzheng Zhang, Jindong Zhang, Liping Duan · 2023 · Protein & Cell
- Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD MiceZiying Xu, Sepideh Kiani Shabestari, Savannah Barannikov, Kevin F. Bieniek, Mathew M. Blurton-Jones, Juan Pablo Palavicini, Xianlin Han · 2025 · Nature Communications
- Neurotropin reduces memory impairment and neuroinflammation via BDNF/NF-κB in a transgenic mouse model of Alzheimer's disease.Wenli Fang, Wang Liao, Yuqiu Zheng, Xiaoyun Huang, Xueling Weng, Shengnuo Fan, Xiaoyu Chen, Xing‐Mei Zhang, Jianjun Chen, Songhua Xiao et al. · 2019 · Europe PMC (PubMed Central)
- Activated microglia–induced neuroinflammatory cytokines lead to photoreceptor apoptosis in Aβ-injected miceJing Wu, Ge Gao, Fanjun Shi, Hai Xie, Qian Yang, Dandan Liu, Sichang Qu, Haifeng Qin, Chaoyang Zhang, Guo‐Tong Xu et al. · 2021 · Journal of Molecular Medicine
- The Microglial Response to Neurodegenerative DiseaseWilbur M. Song, Marco Colonna · 2018 · Advances in immunology
- Microglia Mediate Synaptic Material Clearance at the Early Stage of Rats With Retinitis PigmentosaJuncai He, Congjian Zhao, Jiaman Dai, Chuan Huang Weng, Baishijiao Bian, Yu Long Gong, Lingling Ge, Yajie Fang, Hui Liu, Haiwei Xu et al. · 2019 · Frontiers in Immunology
- Bridging the Gap between Alzheimer’s Disease and Alzheimer’s-like Diseases in AnimalsAnita Gołaszewska, Wojciech Bik, T. Motyl, Arkadiusz Orzechowski · 2019 · International Journal of Molecular Sciences
- All roads lead to heterogeneity: The complex involvement of astrocytes and microglia in the pathogenesis of Alzheimer’s diseaseMarie‐Kim St‐Pierre, Jared VanderZwaag, Sophia M. Loewen, Marie‐Ève Tremblay · 2022 · Frontiers in Cellular Neuroscience
- The Transcription Factor XBP1 in Memory and Cognition: implications in Alzheimer’s DiseaseMoustapha Cissé, Eric Duplan, Frédéric Checler · 2016 · Molecular Medicine
- Lessons Learned about Neurodegeneration from Microglia and Monocyte Depletion StudiesHarald Lund, Melanie Pieber, Robert Adam Harris · 2017 · Frontiers in Aging Neuroscience
- Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in APPSwe/PSEN1M146V transgenic miceMedawar, Evelyn, Benway, Tiffanie A., Liu, Wenfei, Hanan, Taylor A., Haslehurst, Peter, James, Owain T., Yap, Kenrick, Muessig, Laurenz, Moroni, Fabia, Nahaboo Solim, Muzammil A. et al. · 2019 · EBioMedicine
- Colony-stimulating factor 1 receptor signaling in the central nervous system and the potential of its pharmacological inhibitors to halt the progression of neurological disordersTarale, Prashant, Alam, Mahabub Maraj · 2022 · Inflammopharmacology
- GPR34 Knockdown Relieves Cognitive Deficits and Suppresses Neuroinflammation in Alzheimer's Disease via the ERK/NF-κB SignalLulu Lin, Guijun Song, Hui Zhang, Yan Yin, Shi-Meng Xin, Li Ding, Yu Li · 2023 · Neuroscience
- Microglia across evolution: from conserved origins to functional divergenceTakashi Shimizu, Marco Prinz · 2025 · Cellular and Molecular Immunology
- Microglia in Alzheimer’s DiseasePatrick Süß, Johannes C. M. Schlachetzki · 2020 · Current Alzheimer Research
- Suppression of Microgliosis With the Colony-Stimulating Factor 1 Receptor Inhibitor PLX3397 Does Not Attenuate Memory Defects During Epileptogenesis in the RatSeason K. Wyatt‐Johnson, Alexandra L. Sommer, Kevin Shim, Amy L. Brewster · 2021 · Frontiers in Neurology
- Comparative analysis of neuroinflammatory pathways in Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis: insights into similarities and distinctionsJulia Doroszkiewicz, Izabela Winkel, Barbara Mroczko · 2025 · Frontiers in Neuroscience
- Estrés oxidativo, respuesta inmune, plasticidad sináptica y cognición en modelos transgénicos de la enfermedad de AlzheimerPaola Cristina Bello-Medina, Diego Alexander González-Franco, Isaac Vargas-Rodríguez, Sofía Y. Díaz-Cintra · 2019 · Neurología
- Restorative therapy using microglial depletion and repopulation for central nervous system injuries and diseasesWeipeng Shi, Jing Zhang, Zhen Shang, Yingze Zhang, Yanzhi Xia, Haitao Fu, Tengbo Yu · 2022 · Frontiers in Immunology
- Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing miceSuzanne Lam, Anne‐Sophie Hérard, Susana Boluda, Fanny Petit, Sabiha Eddarkaoui, Karine Cambon, The Brainbank Neuro-CEB Neuropathology Network, Franck Letournel, Marie‐Laure Martin‐Négrier, Maxime Faisant et al. · 2022 · Acta Neuropathologica Communications
- Experimentally induced diabetes worsens neuropathology, but not learning and memory, in middle aged 3xTg miceEmi Hayashi-Park, Bria N. Ozment, Chelsea M. Griffith, Haiying Zhang, Peter R. Patrylo, Gregory M. Rose · 2016 · Behavioural Brain Research
- Targeting Microglial Population Dynamics in Alzheimer’s Disease: Are We Ready for a Potential Impact on Immune Function?Martin-Estebane, Maria, Gomez-Nicola, Diego · 2020 · Frontiers in Cellular Neuroscience
- Diphtheria toxin induced but not CSF1R inhibitor mediated microglia ablation model leads to the loss of CSF/ventricular spaces in vivo that is independent of cytokine upregulationBedolla, Alicia, Taranov, Aleksandr, Luo, Fucheng, Wang, Jiapeng, Turcato, Flavia, Fugate, Elizabeth M., Greig, Nigel H., Lindquist, Diana M., Crone, Steven A., Goto, June et al. · 2022 · Journal of Neuroinflammation
- The protective effect of propofol against TNF-α-induced apoptosis was mediated via inhibiting iNOS/NO production and maintaining intracellular Ca2+ homeostasis in mouse hippocampal HT22 cellsZheng Xu, Yan Lü, Jiaqiang Wang, Xiaowei Ding, Jiawei Chen, Changhong Miao · 2017 · Biomedicine & Pharmacotherapy
- Amyloid-β in Alzheimer’s disease – front and centre after all?Caroline Weglinski, Alexander F. Jeans · 2022 · Neuronal Signaling
- Non-canonical pathways associated to Amyloid beta and tau protein dyshomeostasis in Alzheimer’s disease: A narrative reviewAnna Maggiore, Valentina Latina, Maria D’Erme, Giuseppina Amadoro, Roberto Coccurello · 2024 · Ageing Research Reviews
- A Longitudinal PET/MRI Study of Colony-Stimulating Factor 1 Receptor–Mediated Microglia Depletion in Experimental StrokeCristina Barca, Amanda J. Kiliaan, Claudia Foray, Lydia Wachsmuth, Sven Hermann, Cornelius Faber, Michael Andreas Schäfers, Maximilian Wiesmann, Andreas Hans Jacobs, Bastian Zinnhardt · 2021 · Journal of Nuclear Medicine
- Unraveling the complex role of microglia in Alzheimer’s disease: amyloid β metabolism and plaque formationSho Takatori, Mayuna Kondo, Taisuke Tomita · 2025 · Inflammation and Regeneration
- Functional role of brain-engrafted macrophages against brain injuriesXi Feng, Elma S. Frias, Maria Serena Paladini, David Chen, Zoe Boosalis, McKenna Becker, Sonali Gupta, Sharon Liu, Nalin M. Gupta, Susanna Rosi · 2021 · Journal of Neuroinflammation
- Strategies for Manipulating Microglia to Determine Their Role in the Healthy and Diseased BrainBijay Parajuli, Schuichi Koizumi · 2022 · Neurochemical Research
- Discovery of a CSF-1R inhibitor and PET tracer for imaging of microglia and macrophages in the brainBerend van der Wildt, Jessica Klockow, Zheng Miao, Samantha T. Reyes, Jun Hyung Park, Bin Shen, Frederick T. Chin · 2022 · Nuclear Medicine and Biology
- The Beneficial Effect of Mitochondrial Transfer Therapy in 5XFAD Mice via Liver–Serum–Brain ResponseSahar Sweetat, Keren Nitzan, Nir Suissa, Yael Haimovich, Michal Lichtenstein, Samar Zabit, Sandrine Benhamron, Karameh Akarieh, Kumudesh Mishra, Dinorah Barasch et al. · 2023 · Cells
- Repurposing of pexidartinib for microglia depletion and renewalMarc-Philipp Weyer, Jenny Strehle, Michael K. E. Schäfer, Irmgard Tegeder · 2023 · Pharmacology & Therapeutics
- Brain-specific targeted delivery of therapeutic agents using metal–organic framework-based nanomedicineZongsu Han, Muzhaozi Yuan, Nguyen Nguyen, Hong-Cai “Joe” Zhou, James E. Hubbard, Ya Wang · 2024 · Coordination Chemistry Reviews
- Food allergy induces alteration in brain inflammatory status and cognitive impairmentsZhou Liqing, Long Chen, Xiaohuan Li, Tingyu Li, Zhifang Dong, Yu Tian Wang · 2018 · Behavioural Brain Research
- Microglial ROCK is essential for chronic methylmercury‐induced neurodegenerationYouichi Shinozaki, Yosuke Danjo, Schuichi Koizumi · 2019 · Journal of Neurochemistry
- Microglial depletion exacerbates motor impairment and dopaminergic neuron loss in a 6-OHDA model of Parkinson's diseasePereira, Carolina Parga Martins, Francis-Oliveira, José, Singulani, Monique Patricio, Ferreira, Ana Flávia Fernandes, Britto, Luiz Roberto G. · 2023 · Journal of Neuroimmunology
- Synaptic Pruning in Alzheimer’s Disease: Role of the Complement SystemFrederic H. Brucato, Daniel E. Benjamin · 2020 · Global Journal of Medical Research
- Emerging Roles of Microglia in Neuro-vascular Unit: Implications of Microglia-Neurons InteractionsZhe Ding, Shaohui Guo, Lihui Luo, Yueying Zheng, Shuyuan Gan, Xianhui Kang, Xiaomin Wu, Shengmei Zhu · 2021 · Frontiers in Cellular Neuroscience
- Exogenous lipase administration alters gut microbiota composition and ameliorates Alzheimer’s disease-like pathology in APP/PS1 miceAriane Menden, Davane Hall, Coral Hahn-Townsend, Courtney Ann Broedlow, Utsav Joshi, Andrew Pearson, Fiona Crawford, James E. Evans, Nichole R. Klatt, Stefan Crynen et al. · 2022 · Scientific Reports
- Targeting the NLRP3 inflammasome in cochlear macrophages protects against hearing loss in chronic suppurative otitis mediaViktoria Schiel, Ritwija Bhattacharya, Ankur Gupta, Kourosh Eftekharian, Anping Xia, Peter L. Santa Maria · 2024 · Journal of Neuroinflammation
- Stearoyl-CoA desaturase-1: a potential therapeutic target for neurological disordersMelanie Loix, Sam Vanherle, Marta Turri, Stephan Kemp, Karl J. L. Fernandes, Jerome J. A. Hendriks, Jeroen F. J. Bogie · 2024 · Molecular Neurodegeneration
- Single-Nucleus RNA Sequencing Reveals the Spatiotemporal Dynamics of Disease-Associated Microglia in Amyotrophic Lateral SclerosisLu-Xi Chen, Mei-Di Zhang, Haifeng Xu, Hai-Qin Ye, Dian-Fu Chen, Pei‐Shan Wang, Zhi-Wei Bao, Sheng-Mei Zou, Yong-Ting Lv, Zhi‐Ying Wu et al. · 2024 · Research
- The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer's diseaseVictoria E. von Saucken, Taylor R. Jay, Gary E. Landreth · 2020 · Neurobiology of Disease
- Inflammatory Foreign Body Response Induced by Neuro-Implants in Rat Cortices Depleted of Resident Microglia by a CSF1R Inhibitor and Its ImplicationsAviv Sharon, Maciej M. Jankowski, Nava Shmoel, Hadas Erez, Micha E. Spira · 2021 · Frontiers in Neuroscience
- Bystanders or not? Microglia and lymphocytes in aging and strokeAnjali Chauhan, JustinN Nguyen · 2022 · Neural Regeneration Research
- Vascular Dysfunction in Alzheimer’s Disease: Alterations in the Plasma Contact and Fibrinolytic SystemsAna Badimon, Daniel Torrente, Erin H. Norris · 2023 · International Journal of Molecular Sciences
- Microglial Cathepsin B and Porphyromonas gingivalis Gingipains as Potential Therapeutic Targets for Sporadic Alzheimer’s DiseaseHiroshi Nakanishi, Saori Nonaka, Zhou Wu · 2020 · CNS & Neurological Disorders - Drug Targets
- Alzheimer’s Disease, Sleep Disordered Breathing, and Microglia: Puzzling out a Common LinkTyler Kent Ulland, Andrea C. Ewald, Andrew O. Knutson, Kaitlyn M. Marino, Stephanie M. C. Smith, Jyoti J. Watters · 2021 · Cells
- Microglia-Synapse Pathways: Promising Therapeutic Strategy for Alzheimer’s DiseaseJingdun Xie, Haitao Wang, Ting Lin, Bingtian Bi · 2017 · BioMed Research International
- Hypoperfusion is a potential inducer of immunosuppressive network in Alzheimer's diseaseAntero Salminen · 2020 · Neurochemistry International
- The Dual Nature of Microglia in Alzheimer’s Disease: A Microglia-Neuron Crosstalk PerspectiveXie, Zhen, Meng, Jie, Wu, Zhou, Nakanishi, Hiroshi, Hayashi, Yoshinori, Kong, Wei, Lan, Fei, Narengaowa, Yang, Qinghu, Qing, Hong et al. · 2023 · The Neuroscientist
- The Role of Microglial Depletion Approaches in Pathological Condition of CNSFatemeh Tahmasebi, Shirin Barati · 2023 · Cellular and Molecular Neurobiology
- Multi-dimensional deep learning drives efficient discovery of novel neuroprotective peptides from walnut protein isolatesLike Lin, Cong Li, Li Zhang, Yujiao Zhang, Lu Gao, Tingting Li, Lihua Jin, Yehua Shen, Difeng Ren · 2023 · Food & Function
- Reversal of β -Amyloid-Induced Microglial Toxicity In Vitro by Activation of Fpr2/3Edward S. Wickstead, Husnain A. Karim, Roberta E. Manuel, C.S. Biggs, Stephen J. Getting, Simon McArthur · 2020 · Oxidative Medicine and Cellular Longevity
- Inhibiting the Cholesterol Storage Enzyme ACAT1/SOAT1 in Myelin Debris-Treated Microglial Cell Lines Activates the Gene Expression of Cholesterol Efflux Transporter ABCA1Thao Nguyen Thanh Huynh, Matthew C. Havrda, George J. Zanazzi, Catherine C.Y. Chang, Ta‐Yuan Chang · 2024 · Biomolecules
- Microglia depletion reduces neurodegeneration and remodels extracellular matrix in a mouse Parkinson’s disease model triggered by α-synuclein overexpressionZhen Zhang, Kun Niu, Taoying Huang, Jiali Guo, Gongbikai Xarbat, Xiaoli Gong, Yunke Gao, Feiyang Liu, Cheng Shan, Wenting Su et al. · 2025 · npj Parkinson s Disease
- Haploinsufficiency of microglial MyD88 ameliorates Alzheimer's pathology and vascular disorders in APP / PS1 ‐transgenic miceWenqiang Quan, Qinghua Luo, Wenlin Hao, Inge Tomic, Tomomi Furihata, Walter Schulz‐Schaeffer, Michael Dieter Menger, Klaus C Fassbender, Yang Liu · 2021 · Glia
- Phenomic Microglia Diversity as a Druggable Target in the Hippocampus in Neurodegenerative DiseasesDaniele Lana, Giada Magni, Elisa Landucci, Gary L. Wenk, Domenico Edoardo Pellegrini-Giampietro, Maria Grazia Giovannini · 2023 · International Journal of Molecular Sciences
- Synergism of ApoE4 and systemic infectious burden is mediated by the APOE ‐ NLRP3 axis in Alzheimer's diseaseXueting Liu, Chen Xiu, Na Zhao, Fan Geng, Meng‐Meng Zhu, Qingguo Ren · 2024 · Psychiatry and Clinical Neurosciences
- Umbilical Cord Mesenchymal Stem Cells Conditioned Medium Promotes Aβ25-35 phagocytosis by Modulating Autophagy and Aβ-Degrading Enzymes in BV2 CellsZhihao Xu, Wenbin Nan, Xiaoyue Zhang, Yuliang Sun, Jichao Yang, Kecheng Lu, Yalin Liu, Yaoxin Gao, Fen Yang, Wenchao Mao et al. · 2018 · Journal of Molecular Neuroscience
- Overexpression and activation of colony‐stimulating factor 1 receptor in the SIV/macaque model of HIV infection and neuroHIVDerek L. Irons, Timothy Meinhardt, Carolina Allers, Marcelo J. Kuroda, Woong‐Ki Kim · 2019 · Brain Pathology
- The final frontier: Transient microglia reduction after cosmic radiation exposure mitigates cognitive impairments and modulates phagocytic activityRosi, Susanna · 2018 · Brain Circulation
- Recent advances in colony stimulating factor-1 receptor (CSF1R) inhibitorsLing Peng, Zhou Fang, Wen Zhang, Guo-Wu Rao, Quan Zheng · 2025 · Biochemical Pharmacology
- Spinal glial cells in itch modulationMiho Shiratori‐Hayashi, Makoto Tsuda · 2021 · Pharmacology Research & Perspectives
- Okanin from Coreopsis tinctoria Nutt. alleviates cognitive impairment in bilateral common carotid artery occlusion mice by regulating the miR-7/NLRP3 axis in microgliaYan Mi, Jikai Xu, Ruijia Shi, Qingqi Meng, Libin Xu, Yeshu Liu, Tingting Guo, Di Zhou, Jingyu Liu, Wei Li et al. · 2022 · Food & Function
- Aging, sex, metabolic and life experience factors: Contributions to neuro-inflammaging in Alzheimer’s disease researchPasindu Hansana Singhaarachchi, Péter Antal, Frédéric Calon, Carsten Culmsee, Jean-Christophe Delpech, Martin Feldotto, Jorine Geertsema, Emmy E. Hoeksema, Anikó Kőrösi, Sophie Layé et al. · 2024 · Neuroscience & Biobehavioral Reviews
- Microglia signaling in health and disease – Implications in sex-specific brain development and plasticitySubrata Pramanik, Harini Devi M., Saswata Chakrabarty, Berkay Paylar, Ajay Pradhan, Manisha Thaker, Shamini Ayyadhury, Arulmani Manavalan, Per‐Erik Olsson, Gopal Pramanik et al. · 2024 · Neuroscience & Biobehavioral Reviews
- Music compensates for altered gene expression in age-related cognitive disordersAlberto Gómez‐Carballa, Laura Navarro, Jacobo Pardo‐Seco, Xabier Bello, Sara Pischedda, Sandra Viz-Lasheras, Alba Camino‐Mera, María José Currás-Tuala, Isabel Ferreirós-Vidal, Narmeen Mallah et al. · 2023 · Scientific Reports
- Residual microglia following short‐term PLX5622 treatment in 5xFAD mice exhibit diminished NLRP3 inflammasome and mTOR signaling, and enhanced autophagyMaheedhar Kodali, Leelavathi Narayana Madhu, Yogish Somayaji, Sahithi Attaluri, Charles Huard, Prashanta Kumar Panda, Goutham Shankar, Shama Rao, Bing Shuai, Jenny Jaimes Gonzalez et al. · 2024 · Aging Cell
- Neuroimmune interactions in Alzheimer's disease—New frontier with old challenges?Stefan Prokop, Virginia M.‐Y. Lee, John Q. Trojanowski · 2019 · Progress in molecular biology and translational science