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The effect of iron binding on the ability of crocidolite asbestos to catalyze DNA single-strand breaks

Hardy, Jeanne A., Aust, Ann E.·1995·Carcinogenesis
DOI 10.1093/carcin/16.2.319
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Abstract

Crocidolite or crocidolite pretreated with desferrioxamine-B (DF crocidolite) was exposed to ferrous chloride solutions to determine whether iron could be bound from solution. Native crocidolite was capable of binding up to 57 nmol Fe2+/mg fiber in 60 min, while the DF crocidolite was capable of binding only 5.5 nmol Fe2+/mg fiber. The rate of iron binding for the first 5 min of exposure was independent of the concentration of iron in the solution, suggesting that there was a group of rapidly saturable sites, approximately 1.5 x 10(18) binding sites/m2 crocidolite surface, which were responsible for the immediate binding. This process was followed by a slower binding phase, likely occurring at other sites. Crocidolite and DF crocidolite, with various amounts of iron bound, were assayed for their abilities to catalyze the formation of DNA single-strand breaks (SSBs) in phi X174 RFI DNA. Native crocidolite with additional iron bound did not significantly change in its ability to cause DNA SSBs in 15 or 30 min incubations, even though more iron could be mobilized from the iron-treated crocidolite at 4 or 24 h. DF crocidolite, after the addition of iron, had a significantly increased ability to form DNA SSBs. DF crocidolite with 0, 3.0 or 5.5 mmol Fe2+/mg catalyzed the formation of DNA SSBs in 21, 42 or 51% of the DNA respectively in the presence of EDTA and ascorbate. Fibers were also incubated in tissue culture medium with or without iron salts. The fibers incubated in the iron…

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Authors
Hardy, J. A., & Aust, A. E.
Venue
Carcinogenesis
Publisher
Oxford University Press (OUP)
Published
1995
Volume
16
Issue
2
Pages
319-325
ISSN
  • 0143-3334
  • 1460-2180
DOI
10.1093/carcin/16.2.319
Cited by
63
References
0
Language
en

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