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Detection of DNA adducts of acetaldehyde in peripheral white blood cells of alcohol abusers
Abstract
The effect of alcohol drinking on the formation of DNA adducts of acetaldehyde, the primary oxidative metabolite of ethanol, was investigated in humans. DNA was isolated from granulocytes and lymphocytes from 24 alcoholic patients and 12 control subjects. DNA adduct levels were measured by 32P-postlabelling using reversed-phase HPLC with on-line detection of radioactivity. A large interindividual variation in adduct levels was observed. The average adduct levels in granulocyte and lymphocyte DNA from alcoholic patients were 3.4 +/- 3.8 and 2.1 +/- 0.8 adducts/10(7) nucleotides (n = 24), respectively. These levels were 13- and 7-fold higher than the corresponding levels in control subjects (P<0.001). The average adduct level in granulocyte DNA from alcoholic patients was 60% higher than in lymphocyte DNA (P<0.01). Our results, in conjunction with the genotoxicity of acetaldehyde, thus suggest the formation of DNA adducts of acetaldehyde as a plausible mechanism explaining the involvement of alcohol drinking in carcinogenesis.
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Citations
Cited by
Boffetta, P., & Hashibe, M. (2006) · The Lancet Oncology · doi:10.1016/s1470-2045(06)70577-0 · Cited by 877
DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis
Brooks, P. J., & Theruvathu, J. A. (2005) · Alcohol · doi:10.1016/j.alcohol.2005.03.009 · Cited by 382
Acetaldehyde adducts in alcoholic liver disease
Setshedi, M., Wands, J. R., & de la Monte, S. M. (2010) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.3.12288 · Cited by 365
Seitz, H. K., & Stickel, F. (2010) · Genes & Nutrition · doi:10.1007/s12263-009-0154-1 · Cited by 306
Wang, M., Yu, N., Chen, L., Villalta, P. W., Hochalter, J. B., & Hecht, S. S. (2006) · Chemical Research in Toxicology · doi:10.1021/tx0502948 · Cited by 133
Metadata
- Authors
- Fang, J.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-04-01
- Volume
- 18
- Issue
- 4
- Pages
- 627-632
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2135455427
- Cited by
- 279
- References
- 0
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fang, J. (1997). Detection of DNA adducts of acetaldehyde in peripheral white blood cells of alcohol abusers. Carcinogenesis. https://doi.org/10.1093/carcin/18.4.627
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