DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis

The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks

Niedernhofer, L. J., Odijk, H., Budzowska, M., van Drunen, E., Maas, A., Theil, A. F., de Wit, J., Jaspers, N. G. J., Beverloo, H. B., Hoeijmakers, J. H. J., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.5776-5787.2004 · Cited by 493 · see citing works

Specialized DNA Polymerases, Cellular Survival, and the Genesis of Mutations

Friedberg, E. C., Wagner, R., & Radman, M. (2002) · Science · doi:10.1126/science.1070236 · Cited by 443 · see citing works

High acetaldehyde levels in saliva after ethanol consumption: methodological aspects and pathogenetic implications

Homann, N. (1997) · Carcinogenesis · doi:10.1093/carcin/18.9.1739 · Cited by 318 · see citing works

Perspectives in mutation epidemiology: 3. Contribution of chromosome abnormalities to human morbidity and mortality and some comments upon surveillance of chromosome mutation rates

Hook, E. B. (1983) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/0165-1110(83)90038-6 · Cited by 283 · see citing works

Detection of DNA adducts of acetaldehyde in peripheral white blood cells of alcohol abusers

Fang, J. (1997) · Carcinogenesis · doi:10.1093/carcin/18.4.627 · Cited by 281 · see citing works

A plethora of lesion-replicating DNA polymerasesPreprint

Woodgate, R. (1999) · Genes & Development · doi:10.1101/gad.13.17.2191 · Cited by 246 · see citing works

Inhalation toxicity of acetaldehyde in rats. III. Carcinogenicity study

Woutersen, R. A., Appelman, L. M., Garderen-Hoetmer, A. V., & Feron, V. J. (1986) · Toxicology · doi:10.1016/0300-483x(86)90201-5 · Cited by 234 · see citing works

Identification of DNA adducts of acetaldehyde

Wang, M., McIntee, E. J., Cheng, G., Shi, Y., Villalta, P. W., & Hecht, S. S. (2000) · Chemical Research in Toxicology · doi:10.1021/tx000118t · Cited by 232 · see citing works

Loss of DNA–protein crosslinks from formaldehyde-exposed cells occurs through spontaneous hydrolysis and an active repair process linked to proteosome function

Quievryn, G., & Zhitkovich, A. (2000) · Carcinogenesis · doi:10.1093/carcin/21.8.1573 · Cited by 195 · see citing works

DNA Interchain Cross-Links Formed by Acrolein and Crotonaldehyde

Kozekov, I. D., Nechev, L. V., Moseley, M. S., Harris, C. M., Rizzo, C. J., Stone, M. P., & Harris, T. M. (2002) · Journal of the American Chemical Society · doi:10.1021/ja020778f · Cited by 193 · see citing works

Loss of DNA–protein crosslinks from formaldehyde-exposed cells occurs through spontaneous hydrolysis and an active repair process linked to proteosome function

Quievryn, G., & Zhitkovich, A. (2000) · Carcinogenesis · doi:10.1093/carcin/21.5.573 · Cited by 182 · see citing works

Genetic Polymorphisms of Alcohol and Aldehyde Dehydrogenases and Risk for Esophageal and Head and Neck Cancers

Yokoyama, A. (2003) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyg026 · Cited by 168 · see citing works

Challenging Dogma: Thresholds for Genotoxic Carcinogens? The Case of Vinyl Acetate

Hengstler, J. G., Bogdanffy, M. S., Bolt, H. M., & Oesch, F. (2003) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.140219 · Cited by 155 · see citing works

1,N 2-Deoxyguanosine Adducts of Acrolein, Crotonaldehyde, and trans-4-Hydroxynonenal Cross-link to Peptides via Schiff Base Linkage

Kurtz, A., & Lloyd, R. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212012200 · Cited by 139 · see citing works

Effects of Alcohol and Oxidative Stress on Liver Pathology: The Role of the Mitochondrion

Cahill, A., CUNNINGHAM, C. C., Adachi, M., Ishii, H., Bailey, S. M., Fromenty, B., & Davies, A. M. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02621.x · Cited by 137 · see citing works

Polyamines stimulate the formation of mutagenic 1,N2-propanodeoxyguanosine adducts from acetaldehyde

Theruvathu, J. A. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki661 · Cited by 135 · see citing works

Development of a 32 P-postlabelling method for the analysis of adducts arising through the reaction of acetaldehyde with 2′-deoxyguanosine-3′-monophosphate and DNA

Fang, J., & Vaca, C. E. (1995) · Carcinogenesis · doi:10.1093/carcin/16.9.2177 · Cited by 129 · see citing works

1,N2-propanodeoxyguanosine adducts: potential new biomarkers of smoking-induced DNA damage in human oral tissue.

Nath, R. G., Ocando, J. E., Guttenplan, J. B., & Chung, F. (1998) · PubMed · Cited by 127 · see citing works

Comprehensive Handbook of Alcohol Related Pathology

(2005) · Elsevier eBooks · doi:10.1016/b978-0-12-564370-2.x5000-4 · Cited by 124 · see citing works

Detection of 1, N2-propanodeoxyguanosine adducts as potential endogenous DNA lesions in rodent and human tissues.

Nath, R. G., Ocando, J. E., & Chung, F. (1996) · PubMed · Cited by 122 · see citing works

Acetaldehyde, but not ethanol, induces sister chromatid exchanges in chinese hamster cells in vitro

Obe, G., & Ristow, H. (1977) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(77)90213-5 · Cited by 115 · see citing works

Duplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct

Mao, H. Z., Schnetz‐Boutaud, N. C., Weisenseel, J. P., Marnett, L. J., & Stone, M. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6615 · Cited by 114 · see citing works

Increased cancer risk in heavy drinkers with the alcohol dehydrogenase 1C*1 allele, possibly due to salivary acetaldehyde

Visapää, J.-P., Götte, K., Benesova, M., Li, J., Homann, N., Conradt, C., Inoue, H., Tisch, M., Hörrmann, K., Väkeväinen, S., et al. (2004) · Gut · doi:10.1136/gut.2003.018994 · Cited by 114 · see citing works

NMR Characterization of a DNA Duplex Containing the Major Acrolein-derived Deoxyguanosine Adduct γ-OH-1,-N 2-Propano-2′-deoxyguanosine

Santos, C. D. L., Zaliznyak, T., & Johnson, F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009028200 · Cited by 112 · see citing works

Genetic effects of ethanol

Obe, G., & Anderson, D. (1987) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/0165-1110(87)90003-0 · Cited by 110 · see citing works

Specific tandem GG to TT base substitutions induced by acetaldehyde are due to intra-strand crosslinks between adjacent guanine bases

Matsuda, T., Kawanishi, M., Matsui, S., Yagi, T., & Takebe, H. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.7.1769 · Cited by 110 · see citing works

Demethylation of 3-Methylthymine in DNA by Bacterial and Human DNA Dioxygenases

Koivisto, P., Robins, P., Lindahl, T. L., & Sedgwick, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407960200 · Cited by 101 · see citing works

Mutagenesis by Acrolein-Derived Propanodeoxyguanosine Adducts in Human Cells

Yang, I.-Y., Chan, G., Miller, H., Huang, Y., Torres, M. C., Johnson, F., & Moriya, M. (2002) · Biochemistry · doi:10.1021/bi0264723 · Cited by 100 · see citing works

Induction of chromosomal aberrations in peripheral lymphocytes of human blood in vitro, and of SCEs in bone-marrow cells of mice in vivo by ethanol and its metabolite acetaldehyde

Obe, G., Natarajan, A. T., Meyers, M., & den Hertog, A. (1979) · Mutation Research/Genetic Toxicology · doi:10.1016/0165-1218(79)90160-5 · Cited by 99 · see citing works

Studies of the reaction of acetaldehyde with deoxynucleosides

Vaca, C. E., Fang, J., & Schweda, E. K. H. (1995) · Chemico-Biological Interactions · doi:10.1016/0009-2797(95)03632-v · Cited by 93 · see citing works

Translesion Synthesis past Acrolein-derived DNA Adduct, γ-Hydroxypropanodeoxyguanosine, by Yeast and Human DNA Polymerase η

Minko, I. G., Washington, M. T., Kanuri, M., Prakash, L., Prakash, S., & Lloyd, R. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207774200 · Cited by 87 · see citing works

Responses to the Major Acrolein-derived Deoxyguanosine Adduct inEscherichia coli

Yang, I.-Y., Hossain, M., Miller, H., Khullar, S., Johnson, F., Grollman, A. P., & Moriya, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008918200 · Cited by 85 · see citing works

Immunohistochemical detection of 1, N6 -ethenodeoxyadenosine in nuclei of human liver affected by diseases predisposing to hepato-carcinogenesis

Frank, A., Seitz, H. K., Bartsch, H., Frank, N., & Nair, J. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh089 · Cited by 84 · see citing works

Effective Utilization of N2-Ethyl-2‘-deoxyguanosine Triphosphate during DNA Synthesis Catalyzed by Mammalian Replicative DNA Polymerases

Matsuda, T., Terashima, I., Matsumoto, Y., Yabushita, H., Matsui, S., & Shibutani, S. (1998) · Biochemistry · doi:10.1021/bi982134j · Cited by 83 · see citing works

The Effects of Chronic Ethanol Consumption on Carcinogen Metabolism and on O6‐Methylguanine Transferase‐Mediated Repair of Alkylated DNA

Garro, A. J., Espina, N. G., Farinati, F., & Salvagnini, M. (1986) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1986.tb05184.x · Cited by 78 · see citing works

The usefulness of cytogenetic biomarkers as intermediate endpoints in carcinogenesis

Hagmar, L., Strömberg, U., Tinnerberg, H., & Mikoczy, Z. (2001) · International Journal of Hygiene and Environmental Health · doi:10.1078/1438-4639-00071 · Cited by 73 · see citing works

The interplay of Fanconi anemia proteins in the DNA damage response

Wang, X., & D’Andrea, A. D. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.04.005 · Cited by 71 · see citing works

Role of 1,N2-propanodeoxyguanosine adducts as endogenous DNA lesions in rodents and humans.

Fl, C., Zhang, L., Je, O., & Rg, N. (1999) · PubMed · Cited by 61 · see citing works

Effect of alcohol on gastrointestinal cell regeneration as a possible mechanism in alcohol-associated carcinogenesis

Simanowski, U. A., Stickel, F., Maier, H., Gärtner, U., & Seitz, H. K. (1995) · Alcohol · doi:10.1016/0741-8329(94)00091-3 · Cited by 59 · see citing works

Reaction kinetics of DNA—histone crosslinking by vinyl acetate and acetaldehyde

Kuykendall, J. R., & Bogdanffy, M. S. (1992) · Carcinogenesis · doi:10.1093/carcin/13.11.2095 · Cited by 56 · see citing works

Enzymatic measurement of ethanol or NAD in acid extracts of biological samples

Cornell, N. W., & Veech, R. L. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90029-5 · Cited by 50 · see citing works

Mammalian Translesion DNA Synthesis across an Acrolein-derived Deoxyguanosine Adduct

Yang, I.-Y., Miller, H., Wang, Z., Frank, E. G., Ohmori, H., Hanaoka, F., & Moriya, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212535200 · Cited by 49 · see citing works

Miscoding Potential of the N2-Ethyl-2‘-deoxyguanosine DNA Adduct by the Exonuclease-Free Klenow Fragment of Escherichia coli DNA Polymerase I

Terashima, I., Matsuda, T., Fang, T.-W., Suzuki, N., Kobayashi, J., Kohda, K., & Shibutani, S. (2001) · Biochemistry · doi:10.1021/bi002719p · Cited by 48 · see citing works

The N2-Ethylguanine and the O6-Ethyl- and O6-Methylguanine Lesions in DNA: Contrasting Responses from the “Bypass” DNA Polymerase η and the Replicative DNA Polymerase α

Perrino, F. W., Blans, P., Harvey, S. E., Gelhaus, S. L., McGrath, C. E., Akman, S. A., Jenkins, G. S., LaCourse, W. R., & Fishbein, J. C. (2003) · Chemical Research in Toxicology · doi:10.1021/tx034164f · Cited by 48 · see citing works

Cancer risk assessment for the environmental mutagen and carcinogen crotonaldehyde on the basis of TD(50) and comparison with 1,N(2)-propanodeoxyguanosine adduct levels.

Eder, E., & Budiawan, B. (2001) · PubMed · Cited by 46 · see citing works

Analysis of Vinyl Acetate Metabolism in Rat and Human Nasal Tissues by an in Vitro Gas Uptake Technique

Bogdanffy, M. S., Sarangapani, R., Kimbell, J. S., Frame, S. R., & Plowchalk, D. R. (1998) · Toxicological Sciences · doi:10.1093/toxsci/46.2.235 · Cited by 39 · see citing works

Histones accelerate the cyclic 1,N2-propanoguanine adduct-formation of DNA by the primary metabolite of alcohol and carcinogenic crotonaldehyde

Sako, M., Inagaki, S., Esaka, Y., & Deyashiki, Y. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(03)00800-x · Cited by 29 · see citing works

PROBLEMS INVOLVED IN THE DETERMINATION OF ENDOGENOUS ACETALDEHYDE IN HUMAN BLOOD

FUKUNAGA, T., SILLANAUKEE, P., & ERIKSSON, C. J. P. (1993) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a045430 · Cited by 26 · see citing works

Cellular function of the Fanconi anemia pathway

D’Andrea, A. D. (2001) · Nature Medicine · doi:10.1038/nm1201-1259a · Cited by 13 · see citing works

Chemo- and regio-selective modifications of nucleic acids by acetaldehyde and crotonaldehyde

Sako, M., Yaekura, I., & Deyashiki, Y. (2002) · Nucleic Acids Symposium Series · doi:10.1093/nass/2.1.21 · Cited by 10 · see citing works

DNA Damage Resulting from Alcohol Abuse with Special Reference to the Brain

Brooks, P. J., Theruvathu, J. A., & Nath, R. G. (2005) · Elsevier eBooks · doi:10.1016/b978-012564370-2/50084-2 · Cited by 1 · see citing works

Head and neck squamous cell carcinoma

Johnson, D. E., Burtness, B. A., Leemans, C. R., Lui, V. W. Y., Bauman, J. E., & Grandis, J. R. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-00224-3 · Cited by 4,294 · see citing works

Causes and consequences of replication stress

Zeman, M. K., & Cimprich, K. A. (2014) · Nature Cell Biology · doi:10.1038/ncb2897 · Cited by 2,079 · see citing works

DNA interstrand crosslink repair and cancer

Deans, A. J., & West, S. C. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3088 · Cited by 1,019 · see citing works

Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification

Reghupaty, S. C., Fisher, P. B., & Sarkar, D. (2020) · Advances in cancer research · doi:10.1016/bs.acr.2020.10.001 · Cited by 865 · see citing works

Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily

Marchitti, S. A., Brocker, C. N., Stagos, D., & Vasiliou, V. (2008) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.4.6.697 · Cited by 806 · see citing works

Aldehyde dehydrogenases in cellular responses to oxidative/electrophilicstress

Singh, S. P., Brocker, C. N., Koppaka, V., Chen, Y., Jackson, B. C., Matsumoto, A., Thompson, D. C., & Vasiliou, V. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.11.010 · Cited by 634 · see citing works

Pathogenesis of alcoholic liver disease: Role of oxidative metabolism

Ceni, E., Mello, T., & Galli, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i47.17756 · Cited by 521 · see citing works

Molecular Pathology of Head and Neck Cancer: Implications for Diagnosis, Prognosis, and Treatment

Pai, S. I., & Westra, W. H. (2008) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092158 · Cited by 509 · see citing works

The Alcohol Flushing Response: An Unrecognized Risk Factor for Esophageal Cancer from Alcohol Consumption

Brooks, P. J., Enoch, M.-A., Goldman, D., Li, T.-K., & Yokoyama, A. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000050 · Cited by 480 · see citing works

Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury

Rungratanawanich, W., Qu, Y., Wang, X., Essa, M. M., & Song, B.-J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00561-7 · Cited by 411 · see citing works

Alcohol and Cancer: Epidemiology and Biological Mechanisms

Rumgay, H., Murphy, N., Ferrari, P., & Soerjomataram, I. (2021) · Nutrients · doi:10.3390/nu13093173 · Cited by 398 · see citing works

Acetaldehyde adducts in alcoholic liver disease

Setshedi, M., Wands, J. R., & de la Monte, S. M. (2010) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.3.12288 · Cited by 365 · see citing works

Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress

Seitz, H. K., & Stickel, F. (2006) · Biological Chemistry · doi:10.1515/bc.2006.047 · Cited by 326 · see citing works

Current topics in the epidemiology of oral cavity and oropharyngeal cancers

Gillison, M. L. (2007) · Head & Neck · doi:10.1002/hed.20573 · Cited by 305 · see citing works

Neurotoxicity and Metabolism of the Catecholamine-Derived 3,4-Dihydroxyphenylacetaldehyde and 3,4-Dihydroxyphenylglycolaldehyde: The Role of Aldehyde Dehydrogenase

Marchitti, S. A., Deitrich, R. A., & Vasiliou, V. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.2.1 · Cited by 282 · see citing works

Oxidative Stress and Inflammation: Essential Partners in Alcoholic Liver Disease

Ambade, A., & Mandrekar, P. (2012) · International Journal of Hepatology · doi:10.1155/2012/853175 · Cited by 249 · see citing works

Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach

Soeteman‐Hernández, L. G., STEEG, H. V., Luijten, M., & van Benthem, J. (2009) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2009.07.002 · Cited by 249 · see citing works

Mouse models of hepatocellular carcinoma: an overview and highlights for immunotherapy research

Brown, Z. J., Heinrich, B., & Greten, T. F. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0033-6 · Cited by 246 · see citing works

Aldehyde dehydrogenases and cancer stem cells

Xu, X., Chai, S., Wang, P., Zhang, C., Yang, Y., Yang, Y., & Wang, K. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.08.018 · Cited by 205 · see citing works

Mode of action-based risk assessment of genotoxic carcinogens

Hartwig, A., Arand, M., Epe, B., Guth, S., Jahnke, G., Lampen, A., Martus, H., Monien, B. H., Rietjens, I. M. C. M., Schmitz‐Spanke, S., et al. (2020) · Archives of Toxicology · doi:10.1007/s00204-020-02733-2 · Cited by 205 · see citing works

Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: epidemiology, clinical findings, and prevention

Morita, M., Kumashiro, R., Kubo, N., Nakashima, Y., Yoshida, R., Yoshinaga, K., Saeki, H., Emi, Y., Kakeji, Y., Sakaguchi, Y., et al. (2010) · International Journal of Clinical Oncology · doi:10.1007/s10147-010-0056-7 · Cited by 195 · see citing works

Formation of acetaldehyde-derived DNA adducts due to alcohol exposure

Yu, H.-S., Oyama, T., Isse, T., Kitagawa, K., Pham, T.-T.-P., Tanaka, M., & Kawamoto, T. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.08.005 · Cited by 168 · see citing works

Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

Ralph, S. J., Rodríguez‐Enríquez, S., Neužil, J., & Moreno‐Sánchez, R. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.12.006 · Cited by 165 · see citing works

Acetaldehyde and the genome: Beyond nuclear DNA adducts and carcinogenesis

Brooks, P. J., & Zakhari, S. (2013) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21824 · Cited by 157 · see citing works

Lysine metabolism in mammalian brain: an update on the importance of recent discoveries

Hallen, A., Jamie, J. F., & Cooper, A. J. L. (2013) · Amino Acids · doi:10.1007/s00726-013-1590-1 · Cited by 147 · see citing works

A review of emission products from bioethanol and its blends with gasoline. Background for new guidelines for emission control

Manzetti, S., & Andersen, O. (2014) · Fuel · doi:10.1016/j.fuel.2014.09.101 · Cited by 137 · see citing works

ALDH1A3, a metabolic target for cancer diagnosis and therapy

Duan, J., Cai, J., Guo, Y., Bian, X., & Yu, S. (2016) · International Journal of Cancer · doi:10.1002/ijc.30091 · Cited by 131 · see citing works

Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway

Martínez, D. L., Liang, C., & Cohn, M. A. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2218-x · Cited by 126 · see citing works

Molecular Mechanisms of Acetaldehyde-Mediated Carcinogenesis in Squamous Epithelium

Mizumoto, A., Ohashi, S., Hirohashi, K., Amanuma, Y., Matsuda, T., & Muto, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091943 · Cited by 127 · see citing works

The Intra-S Checkpoint Responses to DNA Damage

Iyer, D., & Rhind, N. (2017) · Genes · doi:10.3390/genes8020074 · Cited by 113 · see citing works

Ethanol and its Halal status in food industries

Alzeer, J., & Hadeed, K. A. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.10.018 · Cited by 116 · see citing works

Liver Cancer and Alcohol

Grewal, P., & Viswanathen, V. A. (2012) · Clinics in Liver Disease · doi:10.1016/j.cld.2012.08.011 · Cited by 116 · see citing works

Disulfiram’s anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase

Skrott, Z., Majera, D., Gursky, J., Buchtova, T., Hajduch, M., Mistrik, M., & Bartek, J. (2019) · Oncogene · doi:10.1038/s41388-019-0915-2 · Cited by 115 · see citing works

Aldehyde Dehydrogenase Inhibitors for Cancer Therapeutics

Dinavahi, S. S., Bazewicz, C. G., Gowda, R., & Robertson, G. P. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.08.002 · Cited by 114 · see citing works

Oral micro-organisms in the etiology of cancer

Meurman, J. H., & Uittamo, J. (2008) · Acta Odontologica Scandinavica · doi:10.1080/00016350802446527 · Cited by 115 · see citing works

Mitochondrial dynamics and nonalcoholic fatty liver disease (NAFLD): new perspectives for a fairy-tale ending?

Longo, M., Meroni, M., Paolini, E., Macchi, C., & Dongiovanni, P. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154708 · Cited by 112 · see citing works

Alcohol and Risk of Breast Cancer by Histologic Type and Hormone Receptor Status in Postmenopausal Women: The NIH-AARP Diet and Health Study

Lew, J., Freedman, N. D., Leitzmann, M. F., Brinton, L. A., Hoover, R. N., Hollenbeck, A. R., Schatzkin, A. G., & Park, Y. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp120 · Cited by 113 · see citing works

Diosmin protects against ethanol-induced hepatic injury via alleviation of inflammation and regulation of TNF-α and NF-κB activation

Tahir, M., Rehman, M. U., Lateef, A., Khan, R., Khan, A. Q., Qamar, W., Ali, F. D. R., O’Hamiza, O., & Sultana, S. (2013) · Alcohol · doi:10.1016/j.alcohol.2012.12.010 · Cited by 109 · see citing works

Acetaldehyde-Mediated Neurotoxicity: Relevance to Fetal Alcohol Spectrum Disorders

Tong, M., Longato, L., Nguyen, Q.-G., Chen, W. C., Spaisman, A., & de la Monte, S. M. (2011) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2011/213286 · Cited by 106 · see citing works

Acetaldehyde disrupts tight junctions in Caco-2 cell monolayers by a protein phosphatase 2A-dependent mechanism

Dunagan, M., Chaudhry, K., Samak, G., & Rao, R. K. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00526.2011 · Cited by 103 · see citing works

Laboratory Models Available to Study Alcohol‐Induced Organ Damage and Immune Variations: Choosing the Appropriate Model

D'Souza, N. B., Kovacs, E. J., Witte, P. D., Spies, C., Littleton, J. M., de Villiers, W. J. S., Lott, A. J., Plackett, T. P., Lanzke, N., & Meadows, G. G. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01234.x · Cited by 100 · see citing works

Acetaldehyde-induced mitochondrial dysfunction sensitizes hepatocytes to oxidative damage

Farfán-Labonne, B. E., Gutiérrez, M., Gómez-Quiroz, L. E., Fainstein, M. K., Bucio, L., Souza, V., Flores, O., Ortíz-Ortega, V. M., Hernández, E., Kershenobich, D., et al. (2009) · Cell Biology and Toxicology · doi:10.1007/s10565-008-9115-5 · Cited by 97 · see citing works

Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERCC6 and RAD23B but not by polymorphisms in five other nucleotide excision repair genes

Abbasi, R., Ramroth, H., Becher, H., Dietz, A., Schmezer, P., & Popanda, O. (2009) · International Journal of Cancer · doi:10.1002/ijc.24442 · Cited by 96 · see citing works

DNA crosslinking damage and cancer - a tale of friend and foe.

Huang, Y., & Li, L. (2013) · PubMed · doi:10.3978/j.issn.2218-676x.2013.03.01 · Cited by 96 · see citing works

Candida virulence and ethanol‐derived acetaldehyde production in oral cancer and non‐cancer subjects

Alnuaimi, A. D., Ramdzan, A., Wiesenfeld, D., O’brien-simpson, N. M., Kolev, S. D., Reynolds, E. C., & McCullough, M. J. (2016) · Oral Diseases · doi:10.1111/odi.12565 · Cited by 94 · see citing works

Tobacco smoking, alcohol drinking, betel quid chewing, and the risk of head and neck cancer in an East Asian population

Lee, Y. A., Li, S., Chen, Y., Li, Q., Chen, C., Hsu, W., Lou, P., Zhu, C., Pan, J., Shen, H., et al. (2018) · Head & Neck · doi:10.1002/hed.25383 · Cited by 93 · see citing works

Pathogenesis of Alcohol-Associated Liver Disease

Osna, N. A., Rasineni, K., Ganesan, M., Donohue, T. M., & Kharbanda, K. K. (2022) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2022.05.004 · Cited by 92 · see citing works

Alcohol and Head and Neck Cancer: Updates on the Role of Oxidative Stress, Genetic, Epigenetics, Oral Microbiota, Antioxidants, and Alkylating Agents

Ferraguti, G., Terracina, S. A., Petrella, C., Greco, A., Minni, A., Lucarelli, M., Agostinelli, E., Ralli, M., VINCENTIIS, M. D., Raponi, G., et al. (2022) · Antioxidants · doi:10.3390/antiox11010145 · Cited by 90 · see citing works

Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome

Oka, Y., Hamada, M., Nakazawa, Y., Muramatsu, H., Okuno, Y., Higasa, K., Shimada, M., Takeshima, H., Hanada, K., Hirano, T., et al. (2020) · Science Advances · doi:10.1126/sciadv.abd7197 · Cited by 92 · see citing works

Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol

Matsuda, T., Matsumoto, A., Uchida, M., Kanaly, R. A., Misaki, K., Shibutani, S., Kawamoto, T., Kitagawa, K., Nakayama, K. I., Tomokuni, K., et al. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm057 · Cited by 88 · see citing works

DNA Repair Single-Nucleotide Polymorphisms in Colorectal Cancer and their Role as Modifiers of the Effect of Cigarette Smoking and Alcohol in the Singapore Chinese Health Study

Stern, M. C., Conti, D. V., Siegmund, K. D., Corral, R., Yuan, J., Koh, W., & Yu, M. C. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0268 · Cited by 84 · see citing works

Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAAreceptors as an opportunity for drug development?

Wallner, M., & Olsen, R. W. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.32 · Cited by 82 · see citing works

Squamous Cell Carcinoma of the Esophagus

Codipilly, D. C., & Wang, K. K. (2022) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2022.06.005 · Cited by 81 · see citing works

Acetaldehyde production from ethanol and glucose by non-Candidaalbicans yeasts in vitro

Nieminen, M. T., Uittamo, J., Salaspuro, M. P., & Rautemaa‐Richardson, R. (2009) · Oral Oncology · doi:10.1016/j.oraloncology.2009.08.002 · Cited by 81 · see citing works

Alcohol consumption and digestive tract cancer

Haas, S., Ye, W., & Löhr, M. J. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283566699 · Cited by 81 · see citing works

Quantitative Determination of Acetaldehyde in Foods Using Automated Digestion with Simulated Gastric Fluid Followed by Headspace Gas Chromatography

Uebelacker, M., & Lachenmeier, D. W. (2011) · Journal of Automated Methods and Management in Chemistry · doi:10.1155/2011/907317 · Cited by 79 · see citing works

Alcohol metabolism and oesophageal cancer: a systematic review of the evidence

Matejcic, M., Gunter, M. J., & Ferrari, P. (2017) · Carcinogenesis · doi:10.1093/carcin/bgx067 · Cited by 79 · see citing works

Association of the Frequency and Quantity of Alcohol Consumption With Gastrointestinal Cancer

Yoo, J. E., Shin, D. W., Han, K., Kim, D., Jeong, S., Koo, H. Y., Yu, S. J., Park, J., & Choi, K. S. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.20382 · Cited by 78 · see citing works

Formaldehyde and Other Aldehydes

Leikauf, G. D. (2008) · doi:10.1002/9780470442890.ch9 · Cited by 78 · see citing works

Roles of alcohol and tobacco exposure in the development of hepatocellular carcinoma

Purohit, V., Rapaka, R. S., Kwon, O. S., & Song, B. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.10.009 · Cited by 76 · see citing works

XPA A23G, XPC Lys939Gln, XPD Lys751Gln and XPD Asp312Asn polymorphisms, interactions with smoking, alcohol and dietary factors, and risk of colorectal cancer

Hansen, R. D., Sørensen, M., Tjønneland, A. M., Overvad, K., Wallin, H., Raaschou‐Nielsen, O., & Vogel, U. B. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2007.02.002 · Cited by 76 · see citing works

Gene–gene and gene–environment interactions between alcohol drinking habit and polymorphisms in alcohol‐metabolizing enzyme genes and the risk of head and neck cancer in Japan

Hiraki, A., Matsuo, K., Wakai, K., Suzuki, T., Hasegawa, Y., & Tajima, K. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00505.x · Cited by 76 · see citing works

The influence of biological and lifestyle factors on circulating cell-free DNA in blood plasma

Yuwono, N. L., Warton, K., & Ford, C. E. (2021) · eLife · doi:10.7554/elife.69679 · Cited by 71 · see citing works

Alcohol and Aldehyde Dehydrogenase Polymorphisms and a New Strategy for Prevention and Screening for Cancer in the Upper Aerodigestive Tract in East Asians

Yokoyama, A., Omori, T., & Yokoyama, A. (2010) · The Keio Journal of Medicine · doi:10.2302/kjm.59.115 · Cited by 73 · see citing works

Alcohol, Aldehydes, Adducts and Airways

Sapkota, M., & Wyatt, T. (2015) · Biomolecules · doi:10.3390/biom5042987 · Cited by 72 · see citing works

Nrf2 in alcoholic liver disease

Sun, J. Y., Fu, J., Li, L., Chen, C., Wang, H., Hou, Y., Xu, Y., & Pi, J. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.08.019 · Cited by 70 · see citing works

Alcohol and Hepatocellular Carcinoma: Adding Fuel to the Flame

Ramadori, P., Cubero, F. J., Liedtke, C., Trautwein, C., & Nevzorova, Y. A. (2017) · Cancers · doi:10.3390/cancers9100130 · Cited by 70 · see citing works

Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress

Marchitti, S. A., Brocker, C. N., Orlicky, D. J., & Vasiliou, V. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.08.004 · Cited by 68 · see citing works

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

Tacconi, E. M., Lai, X., Folio, C., Porru, M., Zonderland, G., Badie, S., Michl, J., Sechi, I., Rogier, M., Matía, V., et al. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201607446 · Cited by 69 · see citing works

Demonstration of ethanol‐induced protein adducts in oral leukoplakia (pre‐cancer) and cancer

Warnakulasuriya, S., Parkkila, S., Nagao, T., Preedy, V. R., Pasanen, M., Koivisto, H., & Niemelä, O. J. (2008) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2007.00605.x · Cited by 68 · see citing works

Polymorphisms of Alcohol Dehydrogenase‐1B and Aldehyde Dehydrogenase‐2 and the Blood and Salivary Ethanol and Acetaldehyde Concentrations of Japanese Alcoholic Men

Yokoyama, A., Tsutsumi, E., Imazeki, H., Suwa, Y., Nakamura, C., & Yokoyama, A. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01202.x · Cited by 68 · see citing works

Identification of N-Acetyltaurine as a Novel Metabolite of Ethanol through Metabolomics-guided Biochemical Analysis

Shi, X., Yao, D., & Chen, C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.312199 · Cited by 66 · see citing works

[13C2]- Acetaldehyde Promotes Unequivocal Formation of 1,N2-Propano-2′-deoxyguanosine in Human Cells

Garcia, C. C. M., Angeli, J. P. F., Freitas, F. P., Gomes, O. F., de Oliveira, T. F., Loureiro, A. P. D. M., Mascio, P. D., & de Medeiros, M. H. G. (2011) · Journal of the American Chemical Society · doi:10.1021/ja2004686 · Cited by 66 · see citing works

Aldehyde-Associated Mutagenesis─Current State of Knowledge

Vijayraghavan, S., & Saini, N. (2023) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.3c00045 · Cited by 64 · see citing works

Steatotic Liver Disease: Metabolic Dysfunction, Alcohol, or Both?

Staufer, K., & Stauber, R. E. (2023) · Biomedicines · doi:10.3390/biomedicines11082108 · Cited by 63 · see citing works

Rescue from replication stress during mitosis

Fragkos, M., & Naim, V. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1288322 · Cited by 60 · see citing works

Breast cancer prevention in premenopausal women: role of the Mediterranean diet and its components

Laudisio, D., Barrea, L., Muscogiuri, G., Annunziata, G., Colao, A., & Savastano, S. (2019) · Nutrition Research Reviews · doi:10.1017/s0954422419000167 · Cited by 62 · see citing works

Aldehyde-Induced DNA and Protein Adducts as Biomarker Tools for Alcohol Use Disorder

Heymann, H. M., Gardner, A. M., & Gross, E. R. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.12.003 · Cited by 60 · see citing works

Aldehyde Dehydrogenase 3B1 (ALDH3B1): Immunohistochemical Tissue Distribution and Cellular-specific Localization in Normal and Cancerous Human Tissues

Marchitti, S. A., Orlicky, D. J., Brocker, C. N., & Vasiliou, V. (2010) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2010.955773 · Cited by 59 · see citing works

Rosmarinic acid as a protective agent against genotoxicity of ethanol in mice

de Oliveira, N. C. D., Sarmento, M. D. S., Nunes, E. A., Porto, C., da Rosa, D. P., Bona, S., Rodrigues, G., Marroni, N. P., Pereira, P., Picada, J. N., et al. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.01.028 · Cited by 60 · see citing works

Leptin in hepatocellular carcinoma

Wang, S.-N. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i46.5801 · Cited by 59 · see citing works

The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment

Rietjens, I. M. C. M., Michael, A., Bolt, H. M., Bourdoux, S., Andrea, H., Nils, H., Kalisch, C., Angela, M., Pellegrino, G. M., Ribera, D., et al. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03242-0 · Cited by 57 · see citing works

Combination of ADH 1 B *2/ ALDH 2*2 polymorphisms alters acetaldehyde‐derived DNA damage in the blood of J apanese alcoholics

Yukawa, Y., Muto, M., Hori, K., Nagayoshi, H., Yokoyama, A., Chiba, T., & Matsuda, T. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02360.x · Cited by 59 · see citing works

Quantitative structure carcinogenicity relationship for detecting structural alerts in nitroso-compounds

Helguera, A. M., González, M. P., Cordeiro, M. N. D. S., & Cabrera‐Pérez, M. Á. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.02.021 · Cited by 59 · see citing works

Alcohol Intake and Risk of Incident Melanoma: A Pooled Analysis of Three Prospective Studies in the United States

Rivera, A., Nan, H., Li, T., Qureshi, A. A., & Cho, E. (2016) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-0303 · Cited by 59 · see citing works

Systematic review with meta‐analysis: race‐specific effects of alcohol and tobacco on the risk of oesophageal squamous cell carcinoma

Prabhu, A., Obi, K. O., & Rubenstein, J. H. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12514 · Cited by 58 · see citing works

Basic Science Review: Nitric Oxide—Releasing Prosthetic Materials

Varu, V. N., Tsihlis, N. D., & Kibbe, M. R. (2008) · Vascular and Endovascular Surgery · doi:10.1177/1538574408322752 · Cited by 58 · see citing works

Alcohol and breast cancer

Starek‐Świechowicz, B., Budziszewska, B., & Starek, A. (2022) · Pharmacological Reports · doi:10.1007/s43440-022-00426-4 · Cited by 57 · see citing works

Antioxidant effects of Se-glutathione peroxidase in alcoholic liver disease

Shen, Y., Huang, H., Wang, Y., Yang, R., & Ke, X. (2022) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2022.127048 · Cited by 56 · see citing works

Alcohol consumption and risk of glioblastoma; evidence from the Melbourne collaborative cohort study

Baglietto, L., Giles, G. G., English, D. R., Karahalios, A., Hopper, J. L., & Severi, G. (2010) · International Journal of Cancer · doi:10.1002/ijc.25770 · Cited by 56 · see citing works

Pueraria lobata (Kudzu root) hangover remedies and acetaldehyde-associated neoplasm risk

McGregor, N. (2007) · Alcohol · doi:10.1016/j.alcohol.2007.07.009 · Cited by 56 · see citing works

Review of the complications associated with treatment of oropharyngeal cancer: a guide for the dental practitioner.

Turner, L. N., Mupparapu, M., & Akintoye, S. O. (2013) · PubMed · doi:10.3290/j.qi.a29050 · Cited by 55 · see citing works

XRCC1, XRCC3, and XPD Polymorphisms as Modifiers of the Effect of Smoking and Alcohol on Colorectal Adenoma Risk

Stern, M. C., Siegmund, K. D., Conti, D. V., Corral, R., & Haile, R. W. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0381 · Cited by 55 · see citing works

DNA damage and neurotoxicity of chronic alcohol abuse

Kruman, I. I., Henderson, G. I., & Bergeson, S. E. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2012.011421 · Cited by 54 · see citing works

Increased formation of gastric N2-ethylidene-2′-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol

Nagayoshi, H., Matsumoto, A., Nishi, R., Kawamoto, T., Ichiba, M., & Matsuda, T. (2008) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2008.11.009 · Cited by 53 · see citing works

Single-nucleotide polymorphisms in DNA repair genes and association with breast cancer risk in the web study

Roberts, M., Shields, P. G., Ambrosone, C. B., Nie, J., Marian, C., Krishnan, S., Goerlitz, D. S., Modali, R. V., Seddon, M., Lehman, T. A., et al. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr096 · Cited by 53 · see citing works

Bioanalytical and Mass Spectrometric Methods for Aldehyde Profiling in Biological Fluids

Dator, R., Solivio, M. J., Villalta, P. W., & Balbo, S. (2019) · Toxics · doi:10.3390/toxics7020032 · Cited by 54 · see citing works

Untapped “-omics”: the microbial metagenome, estrobolome, and their influence on the development of breast cancer and response to treatment

Komorowski, A. S., & Pezo, R. C. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-019-05472-w · Cited by 54 · see citing works

Impact of alcohol consumption with polymorphisms in alcohol‐metabolizing enzymes on pancreatic cancer risk in Japanese

Kanda, J., Matsuo, K., Suzuki, T., Kawase, T., Hiraki, A., Watanabe, M., Mizuno, N., Sawaki, A., Yamao, K., Tajima, K., et al. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.01044.x · Cited by 53 · see citing works

Fermentative 2‐carbon metabolism produces carcinogenic levels of acetaldehyde in C andida albicans

Marttila, E., Bowyer, P., Sanglard, D., Uittamo, J., Kaihovaara, P., Salaspuro, M. P., Richardson, M. D., & Rautemaa‐Richardson, R. (2013) · Molecular Oral Microbiology · doi:10.1111/omi.12024 · Cited by 53 · see citing works

Acetaldehyde-DNA Adducts: Implications for the Molecular Mechanism of Alcohol-Related Carcinogenesis

Brooks, P. J., & Theruvathu, J. A. (2006) · KARGER eBooks · doi:10.1159/000095017 · Cited by 3 · see citing works

Implications of Acetaldehyde-Derived DNA Adducts for Understanding Alcohol-Related Carcinogenesis

Balbo, S., & Brooks, P. J. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-09614-8_5 · Cited by 50 · see citing works

Polyamines stimulate the formation of mutagenic 1,N2-propanodeoxyguanosine adducts from acetaldehyde

Theruvathu, J. A. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki661 · Cited by 135 · see citing works

Time course of DNA adduct formation in peripheral blood granulocytes and lymphocytes after drinking alcohol. Mutagenesis 27

Balbo, S., Meng, L., Bliss, R. L., Jensen, J. A., Hatsukami, D. K., & Hecht, S. S. (2012)

Increased levels of the acetaldehyde-derived DNA adductN2-ethyldeoxyguanosine in oral mucosa DNA from Rhesus monkeys exposed to alcohol

Balbo, S., Cervera‐Juanes, R. P., Khariwala, S. S., Baker, E. J., Daunais, J. B., & Grant, K. A. (2016) · Mutagenesis · doi:10.1093/mutage/gew016 · Cited by 35 · see citing works