The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Functional role of estrogen metabolism in target cells: review and perspectives
Abstract
Cytochrome P450 enzymes that metabolize estrogens are expressed in the mammary gland, uterus, brain and other target tissues for estrogen action, and this results in the formation of hydroxylated estrogens in these tissues. Estradiol metabolites formed in target tissues at or near estrogen receptors may either be inactive or have important biological effects, and changes in the activities of estrogen-metabolizing enzymes in target tissues may profoundly influence estrogen action. Although some active estrogen metabolites exert hormonal effects in target tissues by interaction with the classical estrogen receptor, other metabolites appear to elicit unique biological responses that are not associated with activation of this receptor. Therefore, some of the many actions of estradiol may not be caused by estradiol per se, but may result from the formation of active estrogen metabolite(s) which function as local mediators or may activate their own unique receptors or effectors. This is an important area in need of more research. The present paper represents a review of the literature and perspectives by the authors on the functional role of estrogen metabolism in target tissues.
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Cites
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Cited by
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Cytochrome P450-mediated metabolism of estrogens and its regulation in human
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Schiffer, L., Barnard, L., Baranowski, E. S., Gilligan, L. C., Taylor, A. E., Arlt, W., Shackleton, C. H. L., & Storbeck, K.-H. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105439 · Cited by 450
Gut microbial molecules in behavioural and neurodegenerative conditions
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Metadata
- Authors
- Zhu, B.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-01-01
- Volume
- 19
- Issue
- 1
- Pages
- 1-27
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2107410297
- Cited by
- 971
- References
- 16
- FWCI
- 25.41
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
