Cited by 1,068Pharmacogenetics and Drug MetabolismParkinson's Disease Mechanisms and TreatmentsNeurotransmitter Receptor Influence on Behavior

Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors

Männistö, Pekka T., Kaakkola, Seppo·1999·Pharmacological Reviews

Integrity signals

Registry

Crossref · 10.1016/s0031-6997(24)01423-6

Cites

356 of 356 references verified0 citation errors · 0 not checkable

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Authors
Männistö, P. T., & Kaakkola, S.
Affiliations
University of Eastern Finland (FI)
Venue
Pharmacological Reviews
Publisher
Elsevier BV
Published
1999-12
Volume
51
Issue
4
Pages
593-628
ISSN
0031-6997 (ISSN-L)
OpenAlex
W2131721815
Cited by
1,068
References
356
Citations by year
2026: 18 · 2025: 19 · 2024: 14 · 2023: 19 · 2022: 19 · 2021: 35 · 2020: 42 · 2019: 41 · 2018: 38 · 2017: 56 · 2016: 52 · 2015: 48 · 2014: 58 · 2013: 68 · 2012: 58
FWCI
15.59
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacological Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
catechol-O-methyltransferase, COMT inhibitors, enzyme kinetics, clinical efficacy
MeSH terms
Animals, Catechol O-Methyltransferase, Clinical Trials as Topic, Enzyme Inhibitors, Humans, Catechol O-Methyltransferase Inhibitors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

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