Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The rs4680 Val158Met SNP leads to reduced COMT enzymatic activity in Met carriers.
“The common rs4680 Val 158 Met single nucleotide polymorphism (SNP) leads to a reduction of COMT enzymatic activity in Met carriers (6-8).”
From Influence of the COMT genotype on working memory and brain activity changes during development (2011) · cites this paper as [7]
Cites
Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y.-M., Szumlanski, C. L., & Weinshilboum, R. M. (1996) · Pharmacogenetics · doi:10.1097/00008571-199606000-00007 · Cited by 1,788 · see citing works
Enzymatic O-methylation of epinephrine and other catechols
Axelrod, J., & Tomchick, R. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64731-3 · Cited by 1,283 · see citing works
Lotta, T. I., Vidgren, J., Tilgmann, C., Ulmanen, I., Melén, K., Julkunen, I., & Taskinen, J. (1995) · Biochemistry · doi:10.1021/bi00013a008 · Cited by 1,167 · see citing works
Functional role of estrogen metabolism in target cells: review and perspectives
Zhu, B. T. (1998) · Carcinogenesis · doi:10.1093/carcin/19.1.1 · Cited by 964 · see citing works
Age at first birth and breast cancer risk.
MacMahon, B., Cole, P. T., Lin, T. M., Lowe, C. R., Mirra, A. P., Ravnihar, B., Salber, E. J., Valaoras, V. G., & Yuasa, S. (1970) · Europe PMC (PubMed Central) · Cited by 878 · see citing works
Gogos, J. A., Morgan, M., Luine, V., Santha, M., Ogawa, S., Pfaff, D., & Karayiorgou, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9991 · Cited by 864 · see citing works
Fotsis, T., Zhang, Y., Pepper, M. S., Adlercreutz, H., Montesano, R., Nawroth, P. P., & Schweigerer, L. (1994) · Nature · doi:10.1038/368237a0 · Cited by 730 · see citing works
Molecular origin of cancer: Catechol estrogen-3,4-quinones as endogenous tumor initiators
Cavalieri, E. L., Stack, D. E., Devanesan, P. D., Todorović, R., Dwivedy, I., Higginbotham, S. M., Johansson, S. L., Patil, K. D., Gross, M. L., Gooden, J. K., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10937 · Cited by 728 · see citing works
17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.
Hayes, C. L., Spink, D. C., Spink, B. C., Cao, J. Q., Walker, N. J., & Sutter, T. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9776 · Cited by 631 · see citing works
Catecholamine metabolism: basic aspects and clinical significance.
Kopin, I. J. (1985) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06859-0 · Cited by 582 · see citing works
Catechol-O-Methyl Transferase: Pharmacological Aspects and Physiological Role
Guldberg, H. C., & Marsden, C. A. (1975) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06681-5 · Cited by 557 · see citing works
Klauber, N., Parangi, S., Flynn, E. A., Hamel, E., & D’Amato, R. J. (1997) · PubMed · Cited by 524 · see citing works
Characterization of 21 newly established esophageal cancer cell lines
Shimada, Y., Imamura, M., Wagata, T., Yamaguchi, N., & Tobe, T. (1992) · Cancer · doi:10.1002/1097-0142(19920115)69:2 · Cited by 494 · see citing works
Feigelson, H., & Henderson, B. (1996) · Carcinogenesis · doi:10.1093/carcin/17.11.2279 · Cited by 416 · see citing works
D’Amato, R. J., Lin, C. M., Flynn, E. A., Folkman, J., & Hamel, E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3964 · Cited by 407 · see citing works
Crystal structure of catechol O-methyltransferase
Vidgren, J., Svensson, L., & Liljas, A. (1994) · Nature · doi:10.1038/368354a0 · Cited by 403 · see citing works
Papolos, D. F., Faedda, G. L., Veit, S., Goldberg, R. B., Morrow, B. E., Kucherlapati, R., & Shprintzen, R. J. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.12.1541 · Cited by 357 · see citing works
Nutl, J. G., & Fellman, J. H. (1984) · Clinical Neuropharmacology · doi:10.1097/00002826-198403000-00002 · Cited by 357 · see citing works
Carcinogenicity of catechol estrogens in Syrian hamsters
Liehr, J. G., Wan-Fen, F., Sirbasku, D. A., & Ari-Ulubelen, A. (1986) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(86)90080-4 · Cited by 356 · see citing works
TENHUNEN, J., SALMINEN, M., LUNDSTRÖM, K., KIVILUOTO, T., SAVOLAINEN, R., & ULMANEN, I. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb19083.x · Cited by 331 · see citing works
Entacapone enhances the response to levodopa in parkinsonian patients with motor fluctuations
Rinne, U. K., Larsen, J. O., Sidén, Å., Worm-Petersen, J., & The Nomecomt Study Group* (1998) · Neurology · doi:10.1212/wnl.51.5.1309 · Cited by 326 · see citing works
Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells
Spink, D. C. (1998) · Carcinogenesis · doi:10.1093/carcin/19.2.291 · Cited by 310 · see citing works
Entacapone improves motor fluctuations in levodopa‐ treated Parkinson's disease patients
(1997) · Annals of Neurology · doi:10.1002/ana.410420511 · Cited by 308 · see citing works
Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice
Bradlow, H. L., Michnovicz, J. J., TELANG, N. T., et al. (1991) · Carcinogenesis · doi:10.1093/carcin/12.9.1571 · Cited by 307 · see citing works
Karayiorgou, M., Altemus, M., Galke, B. L., Goldman, D., Murphy, D. L., Ott, J., & Gogos, J. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4572 · Cited by 304 · see citing works
Free radical generation by redox cycling of estrogens
Liehr, J. G., & Roy, D. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90108-u · Cited by 298 · see citing works
Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1→q11.2
Grossman, M. H., Emanuel, B. S., & Budarf, M. L. (1992) · Genomics · doi:10.1016/0888-7543(92)90316-k · Cited by 296 · see citing works
Lavigne, J. A., Helzlsouer, K. J., Huang, H. Y., et al. (1997) · PubMed · Cited by 283 · see citing works
BALL, P., KNUPPEN, R., HAUPT, M., & BREUER, H. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-34-4-736 · Cited by 280 · see citing works
Estrogen Metabolism and Excretion in Oriental and Caucasian Women
Adlercreutz, H., Gorbach, S. L., Goldin, B. R., Woods, M. N., Dwyer, J. T., & Hämäläinen, E. K. (1994) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/86.14.1076 · Cited by 251 · see citing works
Human liver catechol-O-methyltransferase pharmacogenetics
Boudíková, B., Szumlanski, C. L., Maidak, B. L., & Weinshilboum, R. M. (1990) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1990.166 · Cited by 248 · see citing works
Nutt, J. G., Woodward, W. R., Beckner, R. M., Stone, C. K., Berggren, K., Carter, J. H., Gancher, S. T., Hammerstad, J. P., & Gordin, A. (1994) · Neurology · doi:10.1212/wnl.44.5.913 · Cited by 247 · see citing works
Inheritance of low erythrocyte catechol-o-methyltransferase activity in man.
Weinshilboum, R. M., & Raymond, F. A. (1977) · Europe PMC (PubMed Central) · Cited by 247 · see citing works
Eisenhofer, G., Keiser, H. R., Friberg, P., Mezey, É., Huynh, T., Hiremagalur, B., Ellingson, T., Duddempudi, S., Eijsbouts, A. M. M., & Lenders, J. W. M. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4870 · Cited by 242 · see citing works
Risk factors for breast cancer in Chinese women in Shanghai.
Yuan, J., Yu, M. C., Ross, R. K., Gao, Y., & Henderson, B. E. (1988) · PubMed · Cited by 233 · see citing works
“On‐off” phenomenon with levodopa therapy in parkinsonism
Fahn, S. (1974) · Neurology · doi:10.1212/wnl.24.5.431 · Cited by 230 · see citing works
Genotoxic effects of estrogens
Liehr, J. G. (1990) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/0165-1110(90)90018-7 · Cited by 226 · see citing works
Estrogen carcinogenesis in Syrian hamster tissues: role of metabolism.
Jj, L., & Li, S. A. (1987) · PubMed · Cited by 220 · see citing works
Strous, R. D., Bark, N. M., Parsia, S. S., Volavka, J., & Lachman, H. M. (1997) · Psychiatry Research · doi:10.1016/s0165-1781(96)03111-3 · Cited by 217 · see citing works
Fishman, J., & Martucci, C. P. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-3-611 · Cited by 215 · see citing works
Liehr, J. G., Ricci, M. J., Jefcoate, C. R., et al. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9220 · Cited by 210 · see citing works
O-Methylation of Catechol Amines in Vivo
Axelrod, J., Senoh, S., & Witkop, B. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64730-1 · Cited by 207 · see citing works
Kurth, M., Adler, C. H., Saint‐Hilaire, M., Singer, C., Waters, C., LeWitt, P. A., CHERNIK, D. A., Dorflinger, E. E., & Yoo, K. (1997) · Neurology · doi:10.1212/wnl.48.1.81 · Cited by 205 · see citing works
Genetic polymorphisms in catechol-O-methyltransferase, menopausal status, and breast cancer risk.
Thompson, P. A., Shields, P. G., Freudenheim, J. L., et al. (1998) · PubMed · Cited by 203 · see citing works
Lachman, H. M., Nolan, K. A., Mohr, P., Saito, T., & Volavka, J. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.6.835 · Cited by 198 · see citing works
Dopamine and the Kidney: Ten Years on
Lee, M. R. (1993) · Clinical Science · doi:10.1042/cs0840357 · Cited by 197 · see citing works
Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form.
Bertocci, B., Miggiano, V., Prada, M. D., Dembić, Z., Lahm, H. W., & Malherbe, P. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.4.1416 · Cited by 194 · see citing works
Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation
Jellinck, P. H., Gekforkert, P., Riddick, D. S., et al. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90258-x · Cited by 191 · see citing works
Tiihonen, J., Hallikainen, T., Lachman, H., Saito, T., Volavka, J., Kauhanen, J., Salonen, J. T., Ryynänen, O.-P., Koulu, M., Karvonen, M. K., et al. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000509 · Cited by 189 · see citing works
Cushman, M., He, H.-M., Katzenellenbogen, J. A., Lin, C. M., & Hamel, E. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00012a003 · Cited by 183 · see citing works
Cass, W. A., Zahniser, N. R., Flach, K. A., & Gerhardt, G. A. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb07469.x · Cited by 174 · see citing works
Cloning and Characterization of Human Placental Catechol--Methyltransferase cDNA
LUNDSTR, K., Salminen, M., Jalanko, A., Savolainen, R., & Ulmanen, I. (1991) · DNA and Cell Biology · doi:10.1089/dna.1991.10.181 · Cited by 169 · see citing works
Characteristics of catechol O-methyltransferase (COMT) and properties of selective COMT inhibitors
Männistö, P. T., Ulmanen, I., Lundstrom, K. H., Taskinen, J., Tenhunen, J., Tilgmann, C., & Kaakkola, S. (1992) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7144-0_9 · Cited by 168 · see citing works
Self-citationSyvänen, A., Tilgmann, C., Rinne, J., & Ulmanen, I. (1997) · Pharmacogenetics (London) · doi:10.1097/00008571-199702000-00009 · Cited by 168 · see citing works
Tolcapone and fulminant hepatitis
Assal, F., Spahr, L., Hadengue, A., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(05)61511-5 · Cited by 168 · see citing works
Rajput, A. H., Martin, W. R. W., Saint‐Hilaire, M., Dorflinger, E. E., & Pedder, S. C. J. (1997) · Neurology · doi:10.1212/wnl.49.4.1066 · Cited by 168 · see citing works
Cerebral Metabolism of 6–[ 18 F]Fluoro‐l‐3,4‐Dihydroxyphenylalanine in the Primate
Firnau, G., Sood, S. K., Chirakal, R. V., et al. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb05629.x · Cited by 167 · see citing works
Kirov, G., Murphy, K. C., Arranz, M. J., Jones, I. R., McCandles, F., Kunugi, H., Murray, R. M., McGuffin, P., Collier, D. A., Owen, M. J., et al. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000385 · Cited by 167 · see citing works
Papolos, D. F., Veit, S., Faedda, G. L., Saito, T., & Lachman, H. M. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000410 · Cited by 166 · see citing works
Cytochrome P-450-mediated redox cycling of estrogens.
Liehr, J. G., Ulubelen, A. A., & Strobel, H. W. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75968-7 · Cited by 161 · see citing works
Ball, P., & Knüppen, R. (1980) · PubMed · Cited by 158 · see citing works
Scanlon, P. D., Raymond, F. A., & Weinshilboum, R. M. (1979) · Science · doi:10.1126/science.758679 · Cited by 153 · see citing works
Nissinen, E., Lindén, I., Schultz, E., et al. (1992) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00173538 · Cited by 148 · see citing works
Daniels, J. K., Williams, N. M., Williams, J. H., Jones, L. A., Cardno, A. G., Murphy, K. C., Spurlock, G., Riley, B. P., Scambler, P. J., Asherson, P. J., et al. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.2.268 · Cited by 147 · see citing works
Low activity allele of catechol-o-methyltransferase gene and Japanese unipolar depression
Ohara, K., Nagai, M., Suzuki, Y., & Ohara, K. (1998) · Neuroreport · doi:10.1097/00001756-199805110-00009 · Cited by 145 · see citing works
Seegers, J. C., Aveling, M.-L., van Aswegen, C. H., et al. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90455-x · Cited by 145 · see citing works
Synthesis of some novel potent and selective catechol O-methyltransferase inhibitors
Bäckström, R., Honkanen, E., Pippuri, A., et al. (1989) · Journal of Medicinal Chemistry · doi:10.1021/jm00124a017 · Cited by 145 · see citing works
Ruottinen, H., & Rinne, U. K. (1996) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.60.1.36 · Cited by 145 · see citing works
Baas, H. K. J., Beiske, A. G., Ghika, J.-A., Jackson, M., Oertel, W. H., Poewe, W. H., & Ransmayr, G. N. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.63.4.421 · Cited by 144 · see citing works
Tolcapone in stable Parkinson's disease: Efficacy and safety of long-term treatment
Waters, C., Kurth, M., Bailey, P., et al. (1997) · Neurology · doi:10.1212/wnl.49.3.665 · Cited by 144 · see citing works
The Role of Estrogen in Mammary Carcinogenesisa
Fishman, J., Osborne, M. P., & TELANG, N. T. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb12113.x · Cited by 140 · see citing works
Rationale for Selective COMT Inhibitors as Adjuncts in the Drug Treatment of Parkinson's Disease
Männistö, P. T., & Kaakkola, S. (1990) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1990.tb00756.x · Cited by 139 · see citing works
Self-citationRivett, A. J., Eddy, B. J., & Roth, J. A. (1982) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1982.tb11490.x · Cited by 136 · see citing works
Adler, C. H. (1998) · Archives of Neurology · doi:10.1001/archneur.55.8.1089 · Cited by 136 · see citing works
Neuropharmacology of S-adenosyl-L-methionine
Baldessarini, R. J. (1987) · The American Journal of Medicine · doi:10.1016/0002-9343(87)90860-6 · Cited by 134 · see citing works
Effects of 17 beta-estradiol metabolites on cell cycle events in MCF-7 cells.
Lottering, M.-L., Haag, M., & Seegers, J. C. (1992) · PubMed · Cited by 132 · see citing works
Tolcapone improves motor function in parkinsonian patients with the"wearing-off" phenomenon
Rajput, A. H., Martin, W. R. W., Saint‐Hilaire, M., Dorflinger, E. E., & Pedder, S. C. J. (1998) · Neurology · doi:10.1212/wnl.50.5_suppl_5.s54 · Cited by 132 · see citing works
Cloning, expression and structure of catechol-O-methyltransferase
Lundstrom, K. H., Tenhunen, J., Tilgmann, C., Karhunen, T., Panula, P., & Ulmanen, I. (1995) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(95)00071-2 · Cited by 131 · see citing works
Dannan, G. A., Porubek, D. J., Nelson, S. D., et al. (1986) · Endocrinology · doi:10.1210/endo-118-5-1952 · Cited by 131 · see citing works
Roth, J. A. (1992) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/bfb0036121 · Cited by 128 · see citing works
Kaakkola, S., Gordin, A., & Männistö, P. T. (1994) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(94)90082-5 · Cited by 128 · see citing works
Self-citationKunugi, H., Nanko, S., Ueki, A., Otsuka, E., Hattori, M., Hoda, F., Vallada, H., Arranz, M. J., & Collier, D. A. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13289-4 · Cited by 128 · see citing works
Kerlan, V., Dréano, Y., Bercovici, J. P., Beaune, P. H., Floch, H. H., & Berthou, F. (1992) · Biochemical Pharmacology · doi:10.1016/0006-2952(92)90068-t · Cited by 128 · see citing works
Ker�nen, T., Gordin, A., Karlsson, M., et al. (1994) · European Journal of Clinical Pharmacology · doi:10.1007/bf00199880 · Cited by 127 · see citing works
Preferential transmission of the high activity allele of COMT in schizophrenia
Li, T., Sham, P. C., Vallada, H., Xie, T., Tang, X., Murray, R. M., Liu, X., & Collier, D. A. (1996) · Psychiatric Genetics · doi:10.1097/00041444-199623000-00005 · Cited by 127 · see citing works
Ruottinen, H., & Rinne, U. K. (1996) · Clinical Neuropharmacology · doi:10.1097/00002826-199619040-00001 · Cited by 127 · see citing works
Stereochemical course of the transmethylation catalyzed by catechol O-methyltransferase.
Woodard, R. W., Tsai, M., Floss, H. G., et al. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70536-5 · Cited by 122 · see citing works
Distribution of catechol-O-methyltransferase expression in human central nervous system
Hong, J., Shu-Leong, H., Tao, X., & Lap-Ping, Y. (1998) · Neuroreport · doi:10.1097/00001756-199808240-00033 · Cited by 121 · see citing works
Distribution of catechol-O-methyltransferase enzyme in rat tissues.
Karhunen, T., Tilgmann, C., Ulmanen, I., Julkunen, I., & Panula, P. (1994) · Journal of Histochemistry & Cytochemistry · doi:10.1177/42.8.8027527 · Cited by 120 · see citing works
New selective COMT inhibitors: useful adjuncts for Parkinson's disease?
Männistö, P. T., & Kaakkola, S. (1989) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(89)90075-8 · Cited by 119 · see citing works
Self-citation[34] Catechol O-methyltransferase
Borchardt, R. T. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)77036-8 · Cited by 118 · see citing works
Molecular cloning and characterization of rat liver catechol-O-methyltransferase
Salminen, M., Lundstrom, K. H., Tilgmann, C., Savolainen, R., Kalkkinen, N., & Ulmanen, I. (1990) · Gene · doi:10.1016/0378-1119(90)90231-f · Cited by 118 · see citing works
Catechol-O-methyltransferase and breast cancer risk
Millikan, R. C. (1998) · Carcinogenesis · doi:10.1093/carcin/19.11.1943 · Cited by 118 · see citing works
Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat
Nissinen, E., Lindén, I., Schultz, E., et al. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90614-0 · Cited by 116 · see citing works
Catechol-O-methyltransferase activity: A determinant of levodopa response
Reilly, D. K., Rivera‐Calimlim, L., & Dyke, D. V. (1980) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1980.161 · Cited by 115 · see citing works
Kaakkola, S., Teräväinen, H., Ahtila, S., et al. (1994) · Neurology · doi:10.1212/wnl.44.1.77 · Cited by 115 · see citing works
Self-citationGenetics of red cell COMT activity: Analysis of thermal stability and family data
Spielman, R. S., Weinshilboum, R. M., & Opitz, J. M. (1981) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320100311 · Cited by 115 · see citing works
Dingemanse, J., Jorga, K. M., Zürcher, G., et al. (1995) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1995.tb05781.x · Cited by 114 · see citing works
Martucci, C. P., & Fishman, J. (1976) · Steroids · doi:10.1016/0039-128x(76)90054-4 · Cited by 113 · see citing works
Borgulya, J., Bruderer, H., Bernauer, K., et al. (1989) · Helvetica Chimica Acta · doi:10.1002/hlca.19890720511 · Cited by 113 · see citing works
Miller, J. W., Shukitt‐Hale, B., Villalobos‐Molina, R., et al. (1997) · Clinical Neuropharmacology · doi:10.1097/00002826-199702000-00007 · Cited by 112 · see citing works
Merriam, G. R., MacLusky, N. J., Picard, M. K., & Naftolin, F. N. (1980) · Steroids · doi:10.1016/0039-128x(80)90062-8 · Cited by 111 · see citing works
Keränen, T., Gordin, A., Harjola, V., et al. (1993) · Clinical Neuropharmacology · doi:10.1097/00002826-199304000-00007 · Cited by 110 · see citing works
Rivett, A. J., Francis, A., & Roth, J. A. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb12673.x · Cited by 109 · see citing works
Roberts, J. W., Cora‐Locatelli, G., Bravi, D., et al. (1993) · Neurology · doi:10.1212/wnl.43.12.2685 · Cited by 107 · see citing works
Karayiorgou, M., Gogos, J. A., Galke, B. L., Wolyniec, P. S., Nestadt, G., Antonarakis, S. E., Kazazian, H. H., Housman, D. E., & Pulver, A. E. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00202-3 · Cited by 107 · see citing works
Dingemanse, J., Jorga, K. M., Schmitt, M., Gieschke, R., Fotteler, B., Zürcher, G., Prada, M. D., & van Brummelen, P. (1995) · Clinical Pharmacology & Therapeutics · doi:10.1016/0009-9236(95)90035-7 · Cited by 106 · see citing works
Kunugi, H., Vallada, H., Hoda, F., Kirov, G., Gill, M., Aitchison, K. J., Ball, D., Arranz, M. J., Murray, R. M., & Collier, D. A. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00366-6 · Cited by 106 · see citing works
Ulmanen, I., Peränen, J., Tenhunen, J., Tilgmann, C., Karhunen, T., Panula, P., Bernasconi, L., Aubry, J., & Lundstrom, K. H. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.0452a.x · Cited by 105 · see citing works
No association between anxiety disorders and catechol-O-methyltransferase polymorphism
Ohara, K., Nagai, M., Suzuki, Y., Ochiai, M., & Ohara, K. (1998) · Psychiatry Research · doi:10.1016/s0165-1781(98)00062-6 · Cited by 105 · see citing works
Zhu, B. T., & Liehr, J. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.3.1357 · Cited by 105 · see citing works
Cholinergic-dopaminergic interactions in cognitive performance
Levin, E. D., McGurk, S. R., Rose, J. E., & Butcher, L. L. (1990) · Behavioral and Neural Biology · doi:10.1016/0163-1047(90)90639-n · Cited by 102 · see citing works
Cognitive improvement during Tolcapone treatment in Parkinson's disease
Gasparini, M., Fabrizio, E., Bonifati, V., & Meco, G. (1997) · Journal of Neural Transmission · doi:10.1007/bf01285556 · Cited by 98 · see citing works
Merello, M., Lees, A. J., Webster, R. A., Bovingdon, M., & Gordin, A. (1994) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.2.186 · Cited by 98 · see citing works
Different in vivo properties of three new inhibitors of catechol O‐methyltransferase in the rat
Männistö, P. T., Tuomainen, P. M., & Tuominen, R. K. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09020.x · Cited by 98 · see citing works
Self-citationCumming, P. D., Brown, E. E., Damsma, G., & Fibiger, H. C. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb11026.x · Cited by 98 · see citing works
Rivett, A. J., & Roth, J. A. (1982) · Biochemistry · doi:10.1021/bi00537a006 · Cited by 98 · see citing works
The effect of entacapone (OR‐611) on brain [ 18 F]‐6‐L‐fluorodopa metabolism
Sawle, G. V., Burn, D. J., Morrish, P., et al. (1994) · Neurology · doi:10.1212/wnl.44.7.1292 · Cited by 98 · see citing works
Jeffery, D., & Roth, J. A. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb02755.x · Cited by 96 · see citing works
Li, J. J., Li, S. A., Oberley, T. D., et al. (1995) · PubMed · Cited by 95 · see citing works
Hamel, E., Lin, C. M., Flynn, E. A., et al. (1996) · Biochemistry · doi:10.1021/bi951559s · Cited by 94 · see citing works
Ohmori, O., Shinkai, T., Kojima, H., Terao, T., Suzuki, T., Mita, T., & Abe, K. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00100-1 · Cited by 92 · see citing works
Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers
van Aswegen, C. H., Purdy, R. H., & Wittliff, J. L. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90380-4 · Cited by 92 · see citing works
Li, T., Vallada, H., Curtis, D., Arranz, M. J., Xu, K., Cai, G., Deng, H., Liu, J., Murray, R. M., Liu, X., et al. (1997) · Pharmacogenetics · doi:10.1097/00008571-199710000-00002 · Cited by 91 · see citing works
Wikberg, T., Vuorela, A., Ottoila, P., et al. (1993) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)07341-6 · Cited by 90 · see citing works
Zürcher, G., Hh, K., Kettler, R., et al. (1990) · PubMed · Cited by 89 · see citing works
Hardie, R. J., Malcolm, S., Lees, A., et al. (1986) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1986.tb02913.x · Cited by 87 · see citing works
Effects of COMT inhibitors on striatal dopamine metabolism: a microdialysis study
Kaakkola, S., & Wurtman, R. J. (1992) · Brain Research · doi:10.1016/0006-8993(92)91003-w · Cited by 86 · see citing works
Self-citationBradlow, H. L., Sepkovic, D. W., TELANG, N. T., et al. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb12121.x · Cited by 83 · see citing works
No Association between Parkinson's Disease and Low-Activity Alleles of CatecholO-Methyltransferase
Hoda, F., Nicholl, D. J., Bennett, P., et al. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1731 · Cited by 83 · see citing works
Myllyl�, V. V., Sotaniemi, K. A., Illi, A., et al. (1993) · European Journal of Clinical Pharmacology · doi:10.1007/bf00315512 · Cited by 83 · see citing works
2-METHOXYESTRONE, A NEW METABOLITE OF ESTRADIOL-17β IN MAN
Kraychy, S., & Gallagher, T. F. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70636-4 · Cited by 83 · see citing works
The new biology of steroid hormones
(1992) · General and Comparative Endocrinology · doi:10.1016/0016-6480(92)90037-k · Cited by 82 · see citing works
Winqvist, R., Lundstrom, K. H., Salminen, M., Laatikainen, M., & Ulmanen, I. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000133262 · Cited by 80 · see citing works
The pharmacology of Parkinson's disease: Basic aspects and recent advances
Prada, M. D., Keller, H. H., Pieri, L., et al. (1984) · Cellular and Molecular Life Sciences · doi:10.1007/bf01946641 · Cited by 78 · see citing works
McLeod, H. L., Fang, L., Luo, X., et al. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22361-8 · Cited by 78 · see citing works
Lau, E. Y., & Bruice, T. C. (1998) · Journal of the American Chemical Society · doi:10.1021/ja9827447 · Cited by 77 · see citing works
Ascending afferent regulation of rat midbrain dopamine neurons
Kelland, M. D., Freeman, A. S., Rubin, J. R., & Chiodo, L. A. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90121-q · Cited by 77 · see citing works
The role of monoamine oxidase and catechol O-methyltransferase in dopaminergic neurotransmission.
Napolitano, A., Cesura, A. M., & Prada, M. D. (1995) · PubMed · Cited by 75 · see citing works
Eklöf, A., Holtbäck, U., Sundelöf, M., et al. (1997) · Kidney International · doi:10.1038/ki.1997.390 · Cited by 75 · see citing works
Karhunen, T., Tilgmann, C., Ulmanen, I., & Panul, P. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11337-v · Cited by 75 · see citing works
Ro 40-7592: inhibition of COMT in rat brain and extracerebral tissues
Zürcher, G., Colzi, A., & Prada, M. D. (1990) · Springer eBooks · doi:10.1007/978-3-7091-9113-2_51 · Cited by 74 · see citing works
Catechol-O-methyltransferase activity in human and rat small intestine
Nissinen, E., Tuominen, R. K., Perhoniemi, V. J., & Kaakkola, S. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90330-x · Cited by 74 · see citing works
Self-citationLack of association of functional cathechol-O-methyltransferase gene polymorphism in schizophrenia
Strous, R. D., Bark, N. M., Woerner, M. G., & Lachman, H. M. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00474-x · Cited by 74 · see citing works
Tenhunen, J., Salminen, M., Jalanko, A., UKKONEN, S., & Ulmanen, I. (1993) · DNA and Cell Biology · doi:10.1089/dna.1993.12.253 · Cited by 74 · see citing works
Catechol-O-methyl Transferase in Epidermis, Dermis and Whole Skin*
Bamshad, J. (1969) · Journal of Investigative Dermatology · doi:10.1038/jid.1969.59 · Cited by 73 · see citing works
Relationship of sleep abnormalities to patient genotypes in Prader-Willi syndrome
Vgontzas, A. N., Kales, A., Seip, J. R., Mascari, M. J., Bixler, E. O., Myers, D. C., Vela‐Bueno, A., & Rogan, P. K. (1996) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19960920)67:5 · Cited by 73 · see citing works
Association analysis of the catechol O-methyltransferase gene and bipolar affective disorder
Gutiérrez, B., Bertranpetit, J., Guillamat, R., Vallès, V., Arranz, M. J., Kerwin, R., & Fañanás, L. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.1.113 · Cited by 73 · see citing works
Schultz, E., & Nissinen, E. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90673-4 · Cited by 72 · see citing works
Ruottinen, H., & Rinne, U. K. (1996) · Clinical Neuropharmacology · doi:10.1097/00002826-199619030-00004 · Cited by 70 · see citing works
Nissinen, E., Kaheinen, P., Penttilä, K. E., et al. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01431-3 · Cited by 69 · see citing works
Moreau, J., Borgulya, J., Jenck, F., et al. (1994) · Behavioural Pharmacology · doi:10.1097/00008877-199406000-00012 · Cited by 69 · see citing works
Liljequist, R., Haapalinna, A., Ahlander, M., Li, Y. H., & Männistö, P. T. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)80989-8 · Cited by 69 · see citing works
Self-citationRivera‐Calimlim, L., & Reilly, D. K. (1984) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1984.116 · Cited by 68 · see citing works
Maruyama, W., Naoi, M., & Narabayashi, H. (1996) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(96)00049-4 · Cited by 66 · see citing works
Garris, P. A., & Wightman, R. M. (1995) · Synapse · doi:10.1002/syn.890200311 · Cited by 66 · see citing works
Kaakkola, S., & Wurtman, R. J. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb05831.x · Cited by 66 · see citing works
Self-citationKaakkola, S., M�nnist�, P. T., & Nissinen, E. (1987) · Journal of Neural Transmission · doi:10.1007/bf01244343 · Cited by 65 · see citing works
Self-citationAcquas, E., Carboni, E., de Ree, R. H. A., et al. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb08907.x · Cited by 64 · see citing works
The Clinical Picture and Plasma Levodopa Metabolite Profile of Parkinsonian Nonresponders
Rivera‐Calimlim, L. (1977) · Archives of Neurology · doi:10.1001/archneur.1977.00500160042007 · Cited by 64 · see citing works
McLeod, H. L., Syvänen, A.-C., Githanga, J. N., et al. (1998) · PubMed · Cited by 64 · see citing works
The metabolism of L‐3–0‐methyldopa, aprecursor of dopa in man
Kuruma, I., Bartholini, G., Tissot, R., et al. (1971) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1971124678 · Cited by 64 · see citing works
Potentiation of the l-Dopa effect in man by the use of catechol-O-methyltransferase inhibitors
Ericsson, A. (1971) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(71)90088-8 · Cited by 63 · see citing works
Dingemanse, J., Jorga, K. M., Zürcher, G., et al. (1996) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050068 · Cited by 63 · see citing works
Bioactive 6-Nitronorepinephrine Identified in Mammalian Brain
Shintani, F., Kinoshita, T., Kanba, S., ISHIKAWA, T., Suzuki, E., Sasakawa, N., Kato, R., Asai, M., & Nakaki, T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.23.13561 · Cited by 63 · see citing works
Oestradiol 16 alpha-hydroxylase: a risk marker for breast cancer.
Bradlow, H. L., Re, H., & Jf, F. (1986) · PubMed · Cited by 61 · see citing works
Tenhunen, J., & Ulmanen, I. (1993) · Biochemical Journal · doi:10.1042/bj2960595 · Cited by 59 · see citing works
Properties of novel effective and highly selective inhibitors of catechol-O-methyltransferase
Männistö, P. T., Kaakkola, S., Nissinen, E., et al. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90258-5 · Cited by 58 · see citing works
Self-citationTolcapone added to levodopa in stable parkinsonian patients: A double‐blind placebo‐controlled study
Dupont, E., Burgunder, J., Findley, L. J. J., et al. (1997) · Movement Disorders · doi:10.1002/mds.870120615 · Cited by 58 · see citing works
Holden, J. E., Doudet, D. J., Endres, C. J., Chan, G. L.-Y., Morrison, K., Vingerhoets, F. J. G., Snow, B. J., Pate, B. D., Sossi, V., Buckley, K. R., et al. (1997) · PubMed · Cited by 58 · see citing works
Lee, R. V. (1990) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(90)90142-c · Cited by 57 · see citing works
Maj, J., Rogóż, Z., Skuza, G., et al. (1990) · Journal of Neural Transmission - Parkinsons Disease and Dementia Section · doi:10.1007/bf02260898 · Cited by 57 · see citing works
Ahtila, S., Kaakkola, S., Gordin, A., et al. (1995) · Clinical Neuropharmacology · doi:10.1097/00002826-199502000-00006 · Cited by 55 · see citing works
Self-citationMetabolites of 6-[18F]fluoro-L-dopa in human blood.
Firnau, G., Sood, S. K., Chirakal, R. V., et al. (1988) · PubMed · Cited by 55 · see citing works
Suchar, L. A., Chang, R. L., Rosen, R. T., et al. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24305-1 · Cited by 54 · see citing works
Codding, P. W. (1998) · Springer eBooks · doi:10.1007/978-94-015-9028-0 · Cited by 54 · see citing works
Ishikawa, T., DHAWAN, V. M., Chaly, T., et al. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199609000-00010 · Cited by 53 · see citing works
Catechol-O-methyltransferase genotype and susceptibility to Parkinson's disease in Japan
Yoritaka, A., Hattori, N., Yoshino, H., et al. (1997) · Journal of Neural Transmission · doi:10.1007/bf01294732 · Cited by 53 · see citing works
Fotsis, T. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)90380-3 · Cited by 53 · see citing works
Simultaneous MAO‐B and COMT inhibition in L ‐dopa‐treated patients with parkinson's disease
Lyytinen, J., Kaakkola, S., Ahtila, S., Tuomainen, P. M., & Teräväinen, H. (1997) · Movement Disorders · doi:10.1002/mds.870120404 · Cited by 52 · see citing works
Self-citationOntogenic aspects of liver and kidney catechol‐O‐ methyltransferase sensitivity to tolcapone
Vieira‐Coelho, M. A., & Soares-da-Silva, P. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15220.x · Cited by 52 · see citing works
Waldmeier, P. C., Buchle, A.-M., & Steulet, A.-F. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90222-i · Cited by 51 · see citing works
Tilgmann, C., Melén, K., Lundstrom, K. H., Jalanko, A., Julkunen, I., Kalkkinen, N., & Ulmanen, I. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb17112.x · Cited by 50 · see citing works
Concentration and occupancy of dopamine transporters in cocaine abusers with [11C]cocaine and PET
Logan, J., Volkow, N. D., Fowler, J. S., Wang, G., Fischman, M. W., Foltin, R. W., Abumrad, N. N., Vitkun, S. A., Gatley, S. J., Pappas, N. R., et al. (1997) · Synapse · doi:10.1002/(sici)1098-2396(199712)27:4 · Cited by 50 · see citing works
Zürcher, G., Dingemanse, J., & Prada, M. D. (1993) · PubMed · Cited by 50 · see citing works
The effect of estradiol on catechol-O-methyltransferase activity in rat liver
Cohn, C. K., & Axelrod, J. (1971) · Life Sciences · doi:10.1016/0024-3205(71)90335-3 · Cited by 49 · see citing works
Eshleman, A. J., Stewart, E., Evenson, A. K., et al. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69041459.x · Cited by 49 · see citing works
Bui, Q. D., Neisz, J., & Hershey, M. S. (1989) · Endocrinology · doi:10.1210/endo-124-2-1085 · Cited by 48 · see citing works
G/A1947 polymorphism in catechol‐O‐methyltransferase (COMT) gene in Parkinson's disease
Xie, T., Ho, S. L., Li, L. S. W., & Ma, O. C. K. (1997) · Movement Disorders · doi:10.1002/mds.870120325 · Cited by 48 · see citing works
Antioxidant properties of nitecapone (OR-462)
Suzuki, Y., Tsuchiya, M., Safadi, A., Kagan, V. E., & Packer, L. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90146-8 · Cited by 47 · see citing works
Mammalian small molecule methyltransferases: Their structural and functional features
Fujioka, M. (1992) · International Journal of Biochemistry · doi:10.1016/0020-711x(92)90287-b · Cited by 47 · see citing works
Catechol-O-methyltransferase in vitiligo
Poole, I. C. L., van den Wijngaard, R. M. J. G. J., Smit, N. P. M., et al. (1994) · Archives of Dermatological Research · doi:10.1007/bf00370732 · Cited by 47 · see citing works
Acute Administration of Levodopa-Benserazide and Tolcapone, a COMT Inhibitor, in Parkinsonʼs Disease
Limousin, P. D., Pollak, P., Pfefen, J. P., et al. (1995) · Clinical Neuropharmacology · doi:10.1097/00002826-199506000-00006 · Cited by 47 · see citing works
Hauser, R. A., Molho, E., Shale, H. M., et al. (1998) · Movement Disorders · doi:10.1002/mds.870130406 · Cited by 47 · see citing works
Zhu, B. T., Roy, D., & Liehr, J. G. (1993) · Endocrinology · doi:10.1210/endo.132.2.8381068 · Cited by 47 · see citing works
Laihinen, A., Rinne, J. O., Rinne, U. K., et al. (1992) · Neurology · doi:10.1212/wnl.42.1.199 · Cited by 46 · see citing works
Budygin, E. A., Gainetdinov, R. R., Kilpatrick, M., et al. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00084-9 · Cited by 46 · see citing works
Radioimmunoassay of 2-hydroxyestrone
Ball, P., Emons, G., Haupt, O., et al. (1978) · Steroids · doi:10.1016/0039-128x(78)90117-4 · Cited by 46 · see citing works
Kaakkola, S., Gordin, A., Järvinen, M., et al. (1990) · Clinical Neuropharmacology · doi:10.1097/00002826-199010000-00005 · Cited by 46 · see citing works
Self-citationMalherbe, P., Bertocci, B., Caspers, P., Zürcher, G., & Prada, M. D. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10054.x · Cited by 45 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020 · see citing works
Caspi, A., Moffitt, T. E., Cannon, M., McClay, J., Murray, R., Harrington, H., Taylor, A., Arseneault, L., Williams, B., Braithwaite, A., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.026 · Cited by 1,409 · see citing works
Mattay, V. S., Goldberg, T. E., Fera, F., Hariri, A. R., Tessitore, A., Egan, M. F., Kolachana, B., Callicott, J. H., & Weinberger, D. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931309100 · Cited by 893 · see citing works
The Neurodevelopmental Hypothesis of Schizophrenia, Revisited
Fatemi, S. H., & Folsom, T. D. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn187 · Cited by 860 · see citing works
Nackley, A. G., Shabalina, S. A., Tchivileva, I. E., Satterfield, K., Korchynskyi, O., Makarov, S. S., Maixner, W., & Diatchenko, L. (2006) · Science · doi:10.1126/science.1131262 · Cited by 848 · see citing works
Catechol- <i>O</i> -Methyltransferase Genotype and Dopamine Regulation in the Human Brain
Akil, M., Kolachana, B. S., Rothmond, D. A., Hyde, T. M., Weinberger, D. R., & Kleinman, J. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02008.2003 · Cited by 325 · see citing works
Tolcapone improves cognition and cortical information processing in normal human subjects
Apud, J. A., Mattay, V., Chen, J., Kolachana, B. S., Callicott, J. H., Rasetti, R., Alce, G., Iudicello, J. E., Akbar, N., Egan, M. F., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301227 · Cited by 242 · see citing works
Reinforcement learning in depression: a review of computational research
Chen, C., Takahashi, T., Nakagawa, S., Inoue, T., & Kusumi, I. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.005 · Cited by 233 · see citing works
Krumsiek, J., Suhre, K., Evans, A. M., Mitchell, M. W., Mohney, R. P., Milburn, M. V., Wägele, B., Römisch-Margl, W., Illig, T., Adamski, J., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003005 · Cited by 197 · see citing works
“COMT is responsible for the inactivation of catecholamines such as L-dopa and various neuroactive drugs by O-methylation [35].”
BackgroundMedina, M. Á., Urdiales, J. L., Rodríguez-Caso, C., Ramírez, F. J., & Sánchez-Jiménez, F. (2003) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/713609209 · Cited by 198 · see citing works
Tunbridge, E., Weickert, C., Kleinman, J., Herman, M., Chen, J., Kolachana, B., Harrison, P., & Weinberger, D. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhl032 · Cited by 197 · see citing works
Influence of the COMT genotype on working memory and brain activity changes during development
Dumontheil, I., Roggeman, C., Ziermans, T., Peyrard-Janvid, M., Matsson, H., Kere, J., & Klingberg, T. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.027 · Cited by 165 · see citing works
Dempster, E. L., Mill, J., Craig, I. W., & Collier, D. A. (2006) · BMC Medical Genetics · doi:10.1186/1471-2350-7-10 · Cited by 129 · see citing works
From an Executive Network to Executive Control: A Computational Model of the<i>n</i>-back Task
Chatham, C. H., Herd, S. A., Brant, A. M., Hazy, T. E., Miyake, A., O'Reilly, R., & Friedman, N. P. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00047 · Cited by 115 · see citing works
Pharmacogenetics of antidepressants
Crisafulli, C., Fabbri, C., Porcelli, S., Drago, A., Spina, E., De Ronchi, D., & Serretti, A. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00006 · Cited by 113 · see citing works
Influence of SLC6A3 and COMT variation on neural activation during response inhibition
Congdon, E., Constable, R. T., Lesch, K. P., & Canli, T. (2009) · Biological Psychology · doi:10.1016/j.biopsycho.2009.03.005 · Cited by 103 · see citing works
Attention-Deficit/Hyperactivity Disorder Pharmacogenomics
McGough, J. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.021 · Cited by 92 · see citing works
Qin, S., Cousijn, H., Rijpkema, M., Luo, J., Franke, B., Hermans, E. J., & Fernández, G. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00016 · Cited by 83 · see citing works
“Second, exposure to highly aversive films in combination with selfreferencing instruction meets the requirements for the physiological stress response in humans, particularly with activation of the sympatho-adrenomedullary system (SAM) and substantial elevation of epinephrine and norepinephrine levels, as described by…”
BackgroundPsychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood
Nemoda, Z., Szekely, A., & Sasvari-Szekely, M. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.04.002 · Cited by 78 · see citing works
Hevir, N., Šinkovec, J., & Rižner, T. L. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.09.011 · Cited by 69 · see citing works
Study of the Catechol‐O‐Methyltransferase (COMT) Gene with High Aggression in Children
Hirata, Y., Zai, C. C., Nowrouzi, B., Beitchman, J. H., & Kennedy, J. L. (2013) · Aggressive Behavior · doi:10.1002/ab.21448 · Cited by 65 · see citing works
Visschers, R. G. J., Luyer, M. D., Schaap, F. G., Olde Damink, S. W. M., & Soeters, P. B. (2013) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32836410a4 · Cited by 60 · see citing works
Association Between Hypnotizability and the Catechol-O-Methyltransferase (COMT) Polymorphism
Szekely, A., Kovacs-Nagy, R., Bányai, É. I., Gősi-Greguss, A. C., Varga, K., Halmai, Z., Ronai, Z., & Sasvari-Szekely, M. (2010) · International Journal of Clinical and Experimental Hypnosis · doi:10.1080/00207141003760827 · Cited by 53 · see citing works
Cerasa, A., Cherubini, A., Quattrone, A., Gioia, M. C., Tarantino, P., Annesi, G., Assogna, F., Caltagirone, C., & Spalletta, G. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.02.040 · Cited by 34 · see citing works
Walder, D. J., Trotman, H. D., Cubells, J. F., Brasfield, J., Tang, Y.-L., & Walker, E. F. (2010) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32833a1ff3 · Cited by 34 · see citing works
Gurvich, C., & Rossell, S. L. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.11.045 · Cited by 33 · see citing works
Lesion of the Cerebellar Noradrenergic Innervation Enhances the Harmaline-Induced Tremor in Rats
Kolasiewicz, W., Kuter, K., Nowak, P., Pastuszka, A., & Ossowska, K. (2011) · The Cerebellum · doi:10.1007/s12311-011-0250-9 · Cited by 14 · see citing works
Montel Hayes, R., Mason, C. E., & Miller, J. J. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1671122 · Cited by 5 · see citing works
- Authors
- Männistö, P. T., & Kaakkola, S.
- Affiliations
- University of Eastern Finland (FI)
- ORCID
- Männistö, Pekka T.
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 1999-12
- Volume
- 51
- Issue
- 4
- Pages
- 593-628
- ISSN
- 0031-6997 (ISSN-L)
- OpenAlex
- W2131721815
- Cited by
- 1,068
- References
- 356
- Citations by year
- 2026: 18 · 2025: 19 · 2024: 14 · 2023: 19 · 2022: 19 · 2021: 35 · 2020: 42 · 2019: 41 · 2018: 38 · 2017: 56 · 2016: 52 · 2015: 48 · 2014: 58 · 2013: 68 · 2012: 58
- FWCI
- 15.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- catechol-O-methyltransferase, COMT inhibitors, enzyme kinetics, clinical efficacy
- MeSH terms
- Animals, Catechol O-Methyltransferase, Clinical Trials as Topic, Enzyme Inhibitors, Humans, Catechol O-Methyltransferase Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review